NOVEL DRUG DELIVERY SYSTEMS (NDDS)

This presentation tells about NDDS, how it differs from CDDS and advantages of NDDS

1. NDDS (NOVEL DRUG DELIVERY SYSTEMS)

2. DRUG DELIVERY Routes of drug administration 0r Drug delivery is a method to administer the compound to achieve therapeutic effects in humans & animals . Conventional drug delivery system (CDDS) & Novel drug delivery system (NDDS ) CDDS from many decades NDDS at present

3. CDDS Common methods of administration are : Non-Invasive methods & Invasive methods

4. Non-Invasive methods Oral route Topical route (Skin) Transmucosal route (Nasal, ophthalmic etc.)

5. Invasive methods Parenteral (Injecting drugs into the systemic circulation by using syringe and needle) SC/IM/IV are the examples

6. Some medications like proteins, peptides, antibodies, vaccines, gene based drugs may not be administered using the common non-invasive routes because they might be susceptible to enzymatic degradation or cannot be absorbed into the systemic circulation efficiently because of their molecular size and charge so as to be therapeutically effective. Example – protein or peptide based drugs are administered using parenteral route

7. Here the use/importance of NDDS begins Some drugs are there which cant be administered CDDS (neither by non-invasive nor by invasive methods ), in that conditions NDDS is used.

8. NDDS It is a combination of advanced technique and new dosage forms, which are therapeutically better than conventional dosage forms and involves medical devices. It improves drug potency, control drug release to give a sustained therapeutic effect NDDS provides greater safety and target a drug to a effected tissue.

9. Advantages of NDDS over CDDS The drawback in conventional dosage forms are : Immediate drug release Causes change in drug level in blood depending upon dosage form . NDDS maintains constant drug concentration in blood within therapeutically effective range

10. MODES OF NDDS Targeted drug delivery system Controlled drug delivery system Modulated drug delivery system

11. TARGETED DRUG DELIVERY SYSTEM The drug is administered/delivered in such a way that the drug is only active in the target area of the body e.g. cancerous tissues in which drug is released over a period of time in a controlled manner

12. CONTROLLED RUG DELIVERY SYSTEM D rug releases for a long period. The rate/speed at which the drug is released is controlled by modification in formulation e.g. N ifedipine Nifedipine is a medicine used to treat high blood pressure, helps to prevent future heart disease, heart attacks and strokes

13. MODULATED DRUG DELIVERY SYSTEM In modulated drug delivery system, the rate of drug release is controlled and modulated by devices such as nebulizer, metered dose inhaler etc . What is Nebulizer? What is MDI (Metered dose inhaler)?

14. NEBULIZER Nebulizer is a drug delivery device used to administer medication in the form of aaerosol /droplets inhaled into the lungs. Nebulizers are commonly used for the treatment of asthma and respiratory diseases or disorders.

15. METERED DOSE INHALER (MDI) A  metered dose inhaler  is a device that delivers a specific amount of medication to the  lungs in the form of aerosolized medicine By inhalation, patients can administer medicine theselves . It is the most commonly used delivery system for treating  asthma and other respiratory diseases.

16. CARRIER DRUGS IN NDDS Nanosomes Liposomes Niosomes Nanoparticles Nanosphere Microsphere Microparticle Microemulsion Nanosuspension Micelles

17. ADVANTAGES OF NDDS F requency of dose can be reduced Increase in drug concentration in blood can be reduced Sustained and consistent drug level in blood can be maintained within therapeutic window B ioavailability can be enhanced A targeted drug delivery can be achieved S ide effects can be reduced Improved patient compliance

18. TAPAN KUMAR MAHATO t [email protected]