Nucleophilic substitution type ( Sn1&sn2) mechanism difference between Sn1& sn2'

Nucleophilic substitution reaction, types, mechanism and difference Sn1&sn2'.
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1. Ram-Eesh Institute of Vocational & Technical Education TOPIC - nucleophilic substitution Submitted by - Anshika maheshwari M.pharm 1st year Submitted to - Dr. Sandeep Bansal sir

2. Nucleophilic substitution “In this chemical reaction when from alkyl hal ide the nucleophilic molecules is replaced by another nucleophilic atom that is called of nucleophilic substitution.”. nucleophilic substitution is a class of chemical reactions in which an electron-rich chemical species (known as a nucleophile) replaces a functional group within another electron-deficient molecule (known as the electrophile). The molecule that contains the electrophile and the leaving functional group is called the substrate. The most general form of the reaction may be given as the following:

3. Types of nucleophilic substitution - There are two type of nucleophilic substitution - SN 1 nucleophilic substitution SN 2 nucleophilic substitution

4. 1- SN 1 nucleophilic substitution - Which rate of reaction depends on the alkyl halide is called as sn 1 r eaction. The SN1 reaction is a nucleophilic substitution reaction where the rate-determining step is unimolecular. It is a type of organic substitution reaction. SN1 stands for substitution nucleophilic unimolecular. Any chemical reaction depends on the alkyl halide . Rate of reaction is directly proportional to alkyl halide.

5. Properties - Two step process First order of reaction Do not depends on nucleophilic substitution but depends on the alkyl halide Territory alkyl halide Same as a sterochemistry

6. 2- SN 2 nucleophilic substitution - The SN2 reaction is a nucleophilic substitution reaction where a bond is broken and another is formed synchronously. Two reacting species are involved in the rate determining step of the reaction. Tho se nucleophilic substitution reaction in which the rate of reaction depends on the alkyl halide or nucleophilic substitution. Rate of reaction is directly proportional to two alkyl halide.

7. Properties- It 's contain primary alkyl halide One step process Formation of transition step Different sterochemistry Second order kinetic reaction This process is depends on nucleophiles and alkyl halide

8. Difference between Sn1 &Sn 2 nucleophilic substitution - It is unimolecular reaction It is two step process Formation of carbonation intermediate take place Rearrangement take place First step is slow and rate determinimg step Racemic mixture is formed Take place protic solvent like water Biomolecu lar reaction Only one step Formation of transition state take place No rearrangement take place Only one step mechanism Wolden inversion take place Take place in first order alkyl halide Favourable in polar aprotic solvent like acetone