Nutraceuticals

Introduction of nutraceuticals with formulation and its benifits
some marketed nutraceuticals
law governing to nutraceuticals

1. NUTRACEUTICALS MADE BY: SUDHANSHU MISHRA M.PHARMA PHARMACEUTICS RAJEEV GANDHI TECHNICAL UNIVERSITY BHOPAL 1

2. CONTENTS DEFINATION BENEFITS OF NUTRACEUTICALS CLASSIFICATION PROBIOTICS PREBIOTICS DIETARY FIBRES ANTIOXIDANTS LAW GOVERNING NUTACEUTICALS IN INDIA AREA COVEREDBY NUTACEUTICALS NUTACEUTICAL MARKET EXAMPLES OF NUTRACEUTICALS AVAILABLE IN MARKET 2

3. DEFINITION- The term nutraceutical was coined by “Stephen Defelice ” NEUTRACEUTICAL is any substance that is a food or part of food and provides medical or health benefits, including the prevention and treatment of disease. The functional component of the food must be standardized in the nutraceutical produced under good manufacturing practices (GMPs). 3

4. NUTRITION REQUIRED FOR HEALTH PHARMACEUTICALS REMEDY FOR SICKNESS/INJURY NUTRACEUTICALS PREVENTATIVE MEDICALAPPROACH Figure: Concept of Nutraceuticals 4

5. BENEFITS OF NEUTRACEUTICALS- May increase the health value of our diet. May help us to live longer. May help us to avoid particular medical conditions. May have a psychological benefit from doing something for oneself. May present food for population with special needs. 5

6. CLASSIFICATION Neutraceuticals can be classified based on- NATURAL SOURCE/FOOD SOURCE PHARMACOLOGICAL CONDITIONS CHEMICAL CONDITION 6

7. Classification Based On Source- PLANT- Tomato,momordica Animal- Shark liver oil, codeliver oil Minerals- Calcium,magnesium,phosphorous Micro-organism- Bifidobacterium,lactobacilli 7

8. Classification Based On Pharmacological action Akkergy relief- Ginko biloba Arthritis support- Glucosaamine Cancer prevention- Flax seed, Green tea Cardiac disease- Garlic Digestive support- Digestive enzyme Diabetic support- Momordica Immunomodulators - Ginseng Prostate support-Tomato lycopene 8

9. Classification Based Chemical Nature- ISOPRENOIDS- Carotinoids , Saponin , Simple Terpine PHENOLIC COMPOUND- Coumarins,Tannins , Lignin, Flavonones PROTIEN- Aminoacids , Indole, Folate, Choline CARBOHYDRATE AND DERIVATIVES- Ascorbic acid, Oligosaccharides MINERALS- Calcium, Selenium, Zinc MICROBIAL-Probiotics, Prebiotic 9

10. Classification Based On Chemical Groups S. NO CLASS EXAMPLES 1. Inorganic mineral supplement Minerals 2. Probiotics Helpful bacteria 3. Prebiotics Digestive enzyme 4. Anti oxidant Natural antioxidant 5. Phytochemicals Fatty acids Omega 3 fatty acids Phenolics Tea polyphenol Lipids Sphingolipis Protien Soyaprotein 6. Herbs Methi,flax seed 10

11. Probiotics- Live microorganisms which, when administered in adequate amount, confer a health benefit on the host. Species of Lactobacillus Bifidobacterium Yeast Saccharomyces cerevisiae Some E.coli and Bacillus species are also used as probiotics 11

12. Prebiotics- Non digestablesubstances that providea beneficial physiological effect for the host by selectively stimulating the favorable growth of a limited number of indigenous bacteria. Commonly known prebiotics are- Oligofructose Insulin Galacto-oligosaccharides Lactulose 12

13. Dietary fibres- Dietaryfibers are of two type- Water insoluble fibers Water soluble fibers Daily recommended intakeis 30-40gms. Sources: Whole graincereals, Wheat product Oats,dried beans, legumes 13

14. Antioxidant- Antioxidant are of 3 categories- True antioxidant Reducing agent Antioxidant synergists Deficiency causes disease like cancer, rheumatoid arthritis,Alzheimer disease, cardiovascular disease. 14

15. Nutraceutical Regulation In INDIA- Nutraceuticals and fuctional food in the recent years have witnessed a tremendous increase in the interest among the consumers due to their potentialof providing health benefits. INDIA is the second largest producer of the food. Although, there were multiple laws and regulations covering the food in india,but there was no single law that could have significantly regulated the functional food. IN 2006,the Indian government passed food safety and standard act to integrate and streamline the many regulations covering nutraceuticals, food and dietary supplement. 15

16. The new regulation ,food safety and standards for food health supplements,nutraceuticals, food for special dietary use,functional food and normal food regulation 2016,is based on and framed from section 22 of the food and safety act that provides- 1.General conditions for the manufacturing and sale of Nutraceuticals,food supplement etc. 2. Various schedule dealing with vitamins,minerals,list of plant ingredient as well comprehensive schedule of additives which is further divided into various sub categories. 3. Comprehensive rules for themanufacturing and sales of food for special healthsupplement,nutraceuticals,special dietary use and normal food. 16

17. Area covered by Nutraceutials- Anti- arthritis Sleeping disorder Digestion problem Osteoorosis Cholestrol lowering Diabetes Prevetion of certain cancer Blood pressure 17

18. NUTRACEUTICAL MARKET- The global nutraceuticals market is divided into the following categories: F unctional food Functional beverage Dietary supplement 18

19. EXAMPLE OF NUTRACEUTICALS CURRENTALY AVAILABLEIN MARKET- VITAMIN ANDMINERAL SUPPLEMENTS; eg- VitaminA(Beta-carotene) ADDITIONAL SUPPLEMENTS: eg- cod liver oil,primroseoil, glucosamine, garlic etc. SPORTS PRODUCT: eg-Glucon-D 19

20. CONCLUSION- Nutraceuticals are presentin most of the food ingredient with varying concentration. Concentration,time and duration of supply of nutraceuticals influence human health. Manupulating the food,concentration of active ingredient can be increased. Diet rich in nutraceuticals along with regular exercise,stress reduction and maintenance of healthy body weight will maximum and reduce disease risk . 20