Obstructive Sleep Apnea Dr Dimple Makhija Asst Proff Respiratory Medicine
Definition Obstructive Sleep Apnea (OSA) is a sleep-related breathing disorder. Characterized by repetitive episodes of partial or complete upper airway obstruction during sleep. Leads to intermittent hypoxia, fragmented sleep, and excessive daytime sleepiness
Epidemiology Prevalence: ~4% of men, 2% of women • More common in middle-aged and elderly • Increasing incidence with obesity epidemic • Often underdiagnosed in the general population
Pathophysiology Relaxation of pharyngeal muscles during sleep → airway collapse. Causes apnea (complete cessation) or hypopnea (partial obstruction). Intermittent hypoxemia and hypercapnia occur. Increased sympathetic activity and arousals lead to cardiovascular, metabolic, and neurocognitive effects.