Odontogenic keratocyst

ODONTOGENIC KERATOCYST WITH EMPHASIS ON ITS CONTROVERSIES
DR. AMRITHA JAMES

1. ODONTOGENIC KERATOCYST WITH EMPHASIS ON ITS CONTROVERSIES Dr. Amritha James Post Graduate student Dept. of Oral Pathology SRM Dental College

2. CONTENTS

3. 3 CYST

4. 4 ODONTOGENIC KERATOCYST

5. 5 OKC

6. 6 HISTORY

7. 7 EVOLUTION OF TERMINOLOGY

8. WHO CLASSIFICATIONS

9. 9 SOURCES OF EPITHELIUM

10. 10

11. 11 MOLECULAR PATHOGENEISIS

12. 12 ‘TWO-HIT’ VS HAPLOINSUFFICIENCY THEORY

13. 13 EPIGENETIC FACTORS

14. 14 CYST ENLARGEMENT – MURAL GROWTH

15. 15 CLINICAL FEATURES

16. 16 CLINICAL FEATURES

17. 17 RADIOGRAPHIC FEATURES

18. 18 RADIOGRAPHIC TYPES

19. 19 DIFFERENTIAL DIAGNOSIS

20. ASPIRATIONAL FINDINGS

21. 21 HISTOPATHOLOGICAL FEATURES

22. 22

23. 23 TREATMENT AND PROGNOSIS

24. CONTROVERSIES IN OKC 24

25. 25 CYST OR TUMOR?

26. 26 TUMOR?

27. 27 OKC TO KCOT - BEHAVIOR

28. 28 OKC TO KCOT – GROWTH POTENTIAL

29. 29 OKC TO KCOT - HISTOPATH

30. 30 OKC TO KCOT - IHC Hammad HM, Nagrash OM, Safadi RA. Maspin , Syndecan-1, and Ki-67 in the Odontogenic Keratocyst : An Immunohistochemical Analysis. International Journal of Dentistry. 2020 Jul 14;2020.

31. 31 OKC TO KCOT - GENETICS de Freitas Silva BS, Silva LR, de Lima KL, dos Santos AC, Oliveira AC, Dezzen-Gomide AC, Batista AC, Yamamoto-Silva FP. SOX2 and BCL-2 Expressions in Odontogenic Keratocyst and Ameloblastoma . Medicina oral, patologia oral y cirugia bucal . 2020 Mar;25(2):e283.

32. 32 OKC TO KCOT – HISTOCHHEMICAL & MOLECULAR

33. 33 KCOT TO OKC CYST?

34. 34 KCOT TO OKC - BEHAVIOR

35. 35 KCOT TO OKC - HISTOPATH

36. 36 KCOT TO OKC - GENETIC

37. 37 REASONS FOR RECURRENCE

38. 38 REASONS FOR RECURRENCE

39. 40 MALIGNANT TRANSFORMATION POTENTIAL

40. 41 MALIGNANT TRANSFORMATION Keszler A, Piloni MJ. Malignant transformation in odontogenic keratocysts . Case report. Medicina oral: organo oficial de la Sociedad Espanola de Medicina Oral y de la Academia Iberoamericana de Patologia y Medicina Bucal . 2002 Nov 1;7(5):331-5.

41. 42 PATHOGENESIS

42. 43

43. 44 CLINICAL FEATURES Kumchai H, Champion AF, Gates JC. Carcinomatous Transformation of Odontogenic Keratocyst and Primary Intraosseous Carcinoma: A Systematic Review and Report of a Case. Journal of Oral and Maxillofacial Surgery. 2021 Jan 1.

44. 45 CRITERIA

45. 46 Kikuchi K, Ide F, Takizawa S, Suzuki S, Sakashita H, Li TJ, Kusama K. Initial-stage primary intraosseous squamous cell carcinoma derived from odontogenic keratocyst with unusual keratoameloblastomatous change of the maxilla: a case report and literature discussion. Case reports in otolaryngology. 2018 Apr 19;2018.

46. 47 IHC PROFILE

47. 48 CK5,CK14,CK19, SYNDECAN

48. 49 CK13

49. 50 KI-67

50. 51 P53, P63,PCNA

51. 52 BCL2

52. 53 PODOPLANIN

53. 54 SYNDROMIC OKC

54. 55 SYNDROMES ASSOCIATED WITH OKC

55. 56 NEVOID BASAL CELL CARCINOMA

56. 57 NEVOID BASAL CELL CARCINOMA

57. 58 OKC WITH UNUSUAL FEATURES

58. 59 OKC WITH CALCIFICATIONS Naveen F, Tippu SR, Girish KL, Kalra M, Desai V. Maxillary keratocystic odontogenic tumor with calcifications: A review and case report. Journal of oral and maxillofacial pathology: JOMFP. 2011 Sep;15(3):295.

59. 60 OKC WITH CARTILIGENOUS METAPLASIA ESKENDRI J, FELICIANO R, REICH R, FREEDMAN P. CARTILAGENOUS METAPLASIA IN ODONTOGENIC KERATOCYST (OKC): CASE SERIES AND IMMUNOHISTOCHEMICAL ANALYSIS. Oral surgery, oral medicine, oral pathology and oral radiology. 2017 Sep 1;124(3):e203.

60. 61 OKC WITH DENTINOID Naveen F, Tippu SR, Girish KL, Kalra M, Desai V. Maxillary keratocystic odontogenic tumor with calcifications: A review and case report. Journal of oral and maxillofacial pathology: JOMFP. 2011 Sep;15(3):295.

61. 62 OKC WITH GRANULAR CELL CHANGE Deshmukh RS, Bavle RM, Deo PN, Chavan S. Odontogenic keratocyst with granular cell changes: A distinctive finding. Journal of oral and maxillofacial pathology: JOMFP. 2019 Sep;23(3):432.

62. 63 OKC OF BUCCAL MUCOSA Witteveen ME, Flores IL, Karssemakers LH, Bloemena E. Odontogenic keratocysts located in the buccal mucosa: A description of two cases and review of the literature. SAGE open medical case reports. 2019 May;7:2050313X19849828.

63. 64 CONCLUSION

64. 65 FREQUENCY OF OCCURRENCE WITH SYNDROME