Omeprazole

Omeprazole, sold under the brand names Prilosec and Losec, among others, is a medication used in the treatment of gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger–Ellison syndrome.It is also used to prevent upper gastrointestinal bleeding in people who are at high risk. Omeprazole is a proton-pump inhibitor (PPI) and its effectiveness is similar to other PPIs. It can be taken by mouth or by injection into a vein.
Common side effects include nausea, vomiting, headaches, abdominal pain, and increased intestinal gas.[1][9] Serious side effects may include Clostridium difficile colitis, an increased risk of pneumonia, an increased risk of bone fractures, and the potential of masking stomach cancer.[1] It is unclear if it is safe for use in pregnancy.[1] It works by blocking the release of stomach acid.[1]

1. Omeprazole Prepared by: Abdulaziz M.shahbaz

2. omeprazole Generic name:   omeprazole Brand names:   PriLOSEC Dosage forms:   Packet: 2.5mg , 10mg Suspension: 2mg/ml Tablet/capsule: 10mg, 20mg, 40mg Oral disintegrating tablets : 20mg Drug class:   Proton pump inhibitors Rout of administration: Orally capsule Powder for oral suspension Intravenously  , infusion

3. Mechanism of action Omeprazole inhibits secretion of gastric acid by irreversibly blocking the enzyme system of hydrogen/potassium adenosine triphosphatase , the “proton pump” of the gastric parietal cell. resulting in suppression of  gastric acid secretion 

4. uses Peptic ulcer GERD H pylori infection  NSAID induced ulcer Reflux esophagitis  Zollinger-Ellison syndrome Prophylaxis for ulcers 

5. Uses GERD: <1 year : Safety and efficacy not established 5-10 kg: 5 mg PO qDay 10-20 kg: 10 mg PO qDay >20 kg: 20 mg PO qDay

6. Uses Erosive Esophagitis <1 month: Safety and efficacy not established Aged 1 month to <1 year 3 to <5 kg: 2.5 mg qDay 5 to <10 kg: 5 mg qDay ≥10 kg: 10 mg qDay May treat for up to 6 weeks Aged 1-16 years 5 to <10 kg: 5 mg PO qDay 10 to <20 kg: 10 mg PO qDay ≥20 kg: 20 mg PO qDay May treat for 4-8 weeks

7. Adverse Effects Headache (7%) Abdominal pain (5%) Diarrhea (4%) Nausea (4%) Vomiting (3%) Flatulence (3%) Dizziness (2%) Upper respiratory infection (2%) Acid regurgitation (2%) Constipation (2%) Rash (2%) Cough (1%)