Omnipaque vs Xenetix.ppt

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1. 1/
GE Presenter and Event /
3/13/2023
Omnipaque vs. Iobitridol (Xenetix)
Head-to-Head trials
Study Comp Year n Procedure Findings
Smet et al
( London, UK)
Iohexol
300 vs.
Iobitridol
300
1996 40 in each
arm
Clinical tolerance and
Diagnostic Efficacy in CE-CT
in Children
AE : 5/40 in Iohexol vs. 6/40 in
Iobitridol ( not statistically significant)
IQ: IQ judged to be good/excellent in
both groups
Drouillard et al
( 7 centers in
France)
Iohexol
350 vs.
Iobitridol
350
1996 140/136
respectively
Efficacy and Safety of both
LOCMs for CE-CT of the head
in adults
AE: 7.1% in Iohexol and 11% in
Iobitridol ( not statistically significant)
IQ: Good-Excellent is 69%/70%
respectively
Legmann et al
( France)
Iohexol
300 vs.
Iobitridol
300
2001 76/71
respectively
CE-CT of the liverwith dual
phase helical CT
Clinical tolerance: Very well
tolerated 75% for Iohexol and 70%
for Iobitridol ( not statistically
significant)
IQ: Good-Excellent in 94% in Iohexol
and 97% in Iobitridol ( not
statistically significant)
Excellent safety
profile

2. 2/
GE Presenter and Event /
3/13/2023
Omnipaque vs. Iobitridol (Xenetix)
Head-to-Head trials
Study Comp Year n Procedure Findings
Fournier et al
( Switzerland)
Iohexol 350
vs. Iobitridol
350 vs.
Iopamidol
370
1996 60 for Xenetix
and 30 each for
Iohexol and
Iopamidl
Clnical efficacy and
efficacy in IVU
AE: Iohexol 10% vs. Iopamidol 35%
vs. Iobitridol 18% ( mostly warmth
feeling when injected)-note not
stated as statistically significant or
not
IQ: Iohexol 93% rated good-excellent
vs. Iopamidol 73% and Iobitridol
63%
Chagnaud et al
(France)
Iohexol 240
vs. Iobitridol
250
1996 35 in each armEfficacy and Safety of
both LOCMs for
Phlebography of Lower
Limbs ( i.e. venograms)
AE: 12 of 35 in Iohexol and 16 of 35 in
Iobitridol ( not statistically signicant)
IQ: rated as equivalent for both
LOCMs
Bouard et al
( France)
Iohexol 240
vs. Iobitridol
250 (I.A.)and
Iobitridol
300 vs.
Iopamidol
300 (I.V.)
1996 30/30 in first
study and
39/40 in 2
nd
study group
DSA-IQ and safety Clinical tolerance: Very well for both
study groups and hence all 3 LOCMs
IQ: Not statistically significant for
both IV and IA studies.
Excellent safety
profile