organogensis

Developmental biology organogenesis.

1. Organogenesis Name: Mubeen Tahira Mirza Roll No: 881 Semester: 6 th Subject: Analysis of Development Teacher: Dr. Sagheer Ahmad

2. Organogenesis Organogenesis is the process by which ectoderm mesoderm and endoderm develop into the internal organ of the organism . Cells of each germ layer proliferate migrate aggregate and differentiate into various tissues that forms the organs 2

3. Stages in early animal development There are four general stages in early animal development : Fertilization : the process of a single sperm cell combining with single egg cell to form a zygote. Cleavage : rapid, multiple rounds of mitotic cell division where the overall size of the embryo does not increase. The developing embryos is called a blastula following completion of cleavage . Gastrulation : the dramatic rearrangement (movement) of cells in the blastula to create the embryonic tissue layers. These tissue layers will go on to produce the tissues and organs of the adult animal . Organogenesis : the process of organ and tissue formation via cell division and differentiation. 3

4. How does organogenesis occur? The germ layers in organogenesis differ by three processes: • Folds, • Splits, and • Condensation 4

5. O rganogenesis   Folds: form in the germinal sheet of cells and usually form an enclosed tube which we can see in the development of vertebrates neural tube . Splits : or pockets may form in the germinal sheet of cells forming vesicles or elongations. The lungs and glands of the organism may develop this way.  Organogenesis occur after gastrulation or between forth to eighth week, we can say that Organogenesis followed by gastrulation

6. Gastrulation: The term gastrulation states that: “The dramatic rearrangement (movement) of cells in the blastula to create the embryonic tissue layers. These tissue layers will go on to produce the tissues and organs of the adult animal.” The purpose of gastrulation is to position the three embryonic germ layers, the endoderm, ectoderm and mesoderm. These layers later develop into certain bodily systems . . 6

7. Morphogenesis 7 Morphogenesis: Morphogenesis stated that: The origin and development of morphological characteristics. Gastrulation and organogenesis together contribute to morphogenesis: the biological processes that results in an organism’s shape and body organization

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9. . Organs form from the germ layers through the differentiation: the process by which a less-specialized cell becomes a more-specialized cell type. This must occur many times as a zygote becomes a fully-developed organ ism. 9

10. Ectoderm In vertebrates, one of the primary steps during organogenesis is the formation of the neural system. The ectoderm forms epithelial cells and tissues, as well as neuronal tissues. During the formation of the neural system, special signaling molecules called growth factors signal some cells at the edge of the ectoderm to become epidermis cells. 10

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12. The remaining cells in the center form the neural plate. If the signaling by growth factors were disrupted, then the entire ectoderm would differentiate into neural tissue. The neural plate undergoes a series of cell movements where it rolls up and forms a tube called the neural tube. In further development, the neural tube will give rise to the brain and the spinal cord. 12

13. Mesoderm The mesoderm that lies on either side of the vertebrate neural tube will develop into the various connective tissues of the animal body. A spatial pattern of gene expression reorganizes the mesoderm into groups of cells called smites, with spaces between them. The smites will further develop into the ribs, lungs, and segmental (spine) muscle. The mesoderm also forms a structure called the notochord, which is rod-shaped and forms the central axis of the animal body. 13

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15. Endoderm The endoderm consists, at first, of flattened cells, which subsequently become columnar. It forms the epithelial lining of the whole of the digestive tube (except part of the mouth and pharynx) and the terminal part of the rectum (which is lined by involutions of the ectoderm). It also forms the lining cells of all the glands which open into the digestive tube, including those of the liver and pancreas; the epithelium of the auditory tube and tympanic cavity; ; the trachea, bronchi, and air cells of the lungs; the urinary bladder and part of the urethra; and the follicle lining of the thyroid gland and thymus. 15 s .

16. Endoderm (Cont.) Additionally , the endoderm forms internal organs including the stomach, the colon, the liver, the pancreas, the urinary bladder, the epithelial parts of trachea, the lungs, the pharynx, the thyroid, the parathyroid, and the intestines. 16

17. Organogenesis of Frog   The primary organ rudiments from ectoderm, mesoderm and endoderm get well established during the processes of gastrulation and neurulation . In the next stage the primary organ rudiments subdivide into  secondary   organ rudiments . These rudiments get differentiated into various organs and   organ systems. The development of ectodermal organs   The neurula of frog has three kinds of ectodermal tissues namely, epidermal ectoderm, neural ectoderm and neural crest cells. 17

18. 18   Epidermal ectoderm  The epidermal derivatives are the skin, olfactory sense organs, ear, lateral line sense organs, median fins, external gills and lining of mouth and anus Neural ectoderm   This layer of cells form the central nervous system and peripheral nervous systems.   The development of mesodermal organs   The mesodermal derivatives are the limbs, endoskeleton, heart, blood vessels, kidney, coelom and reproductive organs. .

19. 19   The development of endodermal organs  The predominant endodermal organs are the organs of the alimentary canal, lungs, pancreas and urinary bladder Development of heart in Frog   The heart is a mesodermal derivative. It develops on the ventral side of pharynx. It is formed from the lateral plate mesoderm. Initially the heart is formed as a straight tube. Later it gets folded to form the chambered heart.

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21. 21 In humans this process takes place between about week 3 to the end of week 8. At the end of this period the embryo is referred to as a fetus . The development of the limbs is a good example of the types of processes that are involved in organogenesis.

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25. Diagrams and infographics 25