personalized medicine its uses , application etc

for biotechnology students

1. What if there was a single size for shoes and clothes? Isn’t this unacceptable?

2. Then why do we accept this when it comes to our health?

3. Personalized Medicine Personalized medicine is an emerging practice of medicine that uses an individual’s genetic profile to guide decisions made in regard to the prevention, diagnosis, and treatment of disease. Knowledge of a patient’s genetic profile can help doctors select the proper medication or therapy and administer it using the proper dose or regimen.

4. It allows the possibility of picking the right drug at the right dose for the right person instead of the “one size fits all” approach to drug therapy. ultimately it will be hard to see how any kind of medicine will not be affected by this as we learn more and more about the individual, and as many of us find our complete genomes being sequenced and placed into our medical records to empower that kind of personalized approach It is the biggest revolution in medicine in a very long time. Personalized Medicine

5. Development of personalized medicine Since the discovery of DNA’s overall structure in 1953, the world’s scientific community has rapidly gained a detailed knowledge of the genetic information encoded by the DNA of a cell or organism so that today we are beginning to “personalize” this information. In the 1980s and 1990s, biotechnology techniques produced novel therapeutics and a wealth of information about the mechanisms of various diseases such as cancer at the genetic and molecular level, yet the aetiologies of other complex diseases such as obesity and heart disease remained poorly understood. Researchers utilizing exciting and groundbreaking “ omic ” technologies and working closely with clinicians have begun to make serious progress not only toward a molecular-level understanding of the aetiology of complex diseases but to clearly identify that there are actually many genetically different diseases called by the single name of cancer, diabetes, depression, etc.

6. Traditional medicine vs personalized medicine

7. Process ; how it’s done : The ability to provide precision medicine to patients in routine clinical settings depends on the availability of molecular profiling tests, e.g. Individual germline DNA sequencing. While precision medicine currently individualizes treatment mainly on the basis of genomic tests (clinical Exome ), several promising technology modalities are being developed, from techniques combining spectrometry and computational power to real-time imaging of drug effects in the body. On the treatment side, PM can involve the use of customized medical products such drug cocktails produced by pharmacy compounding or customized devices It can also prevent harmful drug interactions, increase overall efficiency when prescribing medications, and reduce costs associated with healthcare.

8. AI in personal medicine Artificial intelligence is a providing paradigm shift toward precision medicine Machine learning algorithms are used for genomic sequence and to analyse and draw inferences from the vast amounts of data patients and healthcare institutions recorded in every moment. AI techniques are used in precision cardiovascular medicine to understand genotypes and phenotypes in existing diseases, improve the quality of patient care, enable cost-effectiveness, and reduce readmission and mortality rates.

9. A 2021 paper reported that machine learning was able to predict the outcomes of Phase III clinical trials (for treatment of prostate cancer) with 76% accuracy. 2020 paper showed that training machine learning models in a population-specific fashion (i.e. Training models specifically for Black cancer patients) can yield significantly superior performance than population-agnostic models AI in personal medicine

10. Advantages of personalized medicine Precision medicine helps health care providers better understand the many things—including environment, lifestyle, and heredity—that play a role in a patient’s health, disease, or condition. This information lets them more accurately predict which treatments will be most effective and safe, or possibly how to prevent the illness from starting in the first place.

11. Shift the emphasis in medicine from reaction to prevention
predict susceptibility to disease
improve disease detection
pre-empt disease progression
customize disease-prevention strategies
prescribe more effective drugs
avoid prescribing drugs with predictable negative side effects
reduce the time, cost, and failure rate of pharmaceutical clinical trials Advantages of personalized medicine

12. Disadvantages of personalized Medicine High technology demand High initial cost of production and development Data biases that may occur along the way Time for treatment increases in some cases Patient privacy and confidentiality

13. Application and recent developments in PM •The detailed account of genetic information from the individual allows for appropriate dosages, For instance, warfarin is the FDA approved oral anticoagulant commonly prescribed to patients with blood clots. Due to warfarin’s significant inter individual variability in pharmacokinetics and pharmacodynamics, its rate of adverse events is among the highest of all commonly prescribed drugs. •However, with the discovery of polymorphic variants in CYP2C9 and VKORC1 genotypes, two genes that encode the individual anticoagulant response, physicians can use patients’ gene profile to prescribe optimum doses of warfarin to prevent side effects such as major bleeding and to allow sooner and better therapeutic efficacy

14. Microarrays: •The biochips known as DNA microarrays and oligonucleotide microarrays are a surface collection of hundreds to thousands of immobilized nucleic acid sequences or oligonucleotides in a grid created with specialized equipment that can be simultaneously examined to conduct expression analysis . •Biochips may contain representatives of a particular set of gene sequences (i.e., sequences coding for all human cytochrome P450 isozymes) or may contain sequences representing all genes of an organism. They can produce massive amounts of genetic information . •Roche CYP 450 is a FDA-approved diagnostic tool able to determine a patient’s genotype with respect to two genes that govern drug metabolism. This information obtained may be useful by a physician to select the appropriate drug and/or dosage for a given patient in the areas of cardiovascular disease, high blood pressure, depression, and others (according to the company). Application and recent developments in PM

15. oncogenomics Oncogenomics is a sub-field of genomics that characterizes cancer-associated genes. It focuses on genomic, epigenomic and transcript alterations in cancer. The genome of a cancer cell can also be used to stratify cancer cells identifying one type of cancer from another or identifying a subtype of cancer within that type, such as HER2+ breast cancer. Understanding the cancer genome is a step toward personalized oncology. Numerous projects are underway around the world. Two such projects include the US NIH Cancer Genome Atlas Project (U.S. NIH 2012) and the Sanger Institute Cancer Genome Project (Sanger Institute 2012). B Application and recent developments in PM

16. Thankyou Group 1 : Chakshu Deepansh Aryavarman Pranav