Pharmaceutical automation

pharmacy related

1. Pharmaceutical Automation 1

2. Contents Introduction Advantages Disadvantages Automation and compliance Benefits of automation in pharmacy Automation in tablet manufacturing Automation and robotics 2

3. Introduction Automation means the use of machines and equipments for performing physical and mental operations in a production process in place of human being. Pharmaceutical automation involves the mechanical processes of handling materials, distributing medications and manufacturing and packaging formulations in industries . 3

4. Advantages: Higher production rates and increased productivity Efficient use of materials Better product quality Improved safety Shorter workweeks for labour Reduced factory lead times Less variability Greater control and consistency of product quality. 4

5. Disadvantages High capital expenditure Higher level of maintainance Lower degree of flexibility Worker displacement- major demerit Emotional stress condition for workers Relocation of worker to find other work Workers become slaves of machines Society will become dependent on automation for its economic well being 5

6. Automation and compliance The pharmaceutical industry recognizes the value of automation. Om May 16, The International Society of Automation (ISA) invited top pharmaceutical executives to their Food and Pharmaceutical Industries Division (FPID) symposium to explore and examine solutions to automation challenges in food processing and drug manufacture and distribution. Automation improves compliance and minimizes deviations by connecting instruments to electronic systems, so users don’t have to manually enter data. 6

7. Organizations learned the importance of protecting the validity of data generated and, in a regulated environment, that deviations from processes should be investigated and removed. The Micro Therapeutic Research Labs incident in March 2017 highlighted the necessity for pharmaceutical organizations to ensure the data associated with their organization- including data produced by a third party-is compliant with industry regulations. 7

8. By automating processes and embedding rules, organizations can ensure the data produced, and associated with them, is compliant From a regulatory perspective, automation is a positive step to improving compliance . 8

9. Benefits of automation in pharmacy: Dispensing of prescriptions Filling , inspection and packaging Personalised medicines Structural protein analysis Measurement of molecular vibration and rotational energy changes of each tablet. 9

10. Automation in tablet manufacturing Benefits of automation in tablet production. 1.Improve material handling 2.Improve specific unit operations unit operations in tablet manufacturing: particle size reduction Sieving Mixing Particle size enlargement Drying Compression Sorting Coating Packaging 3. Eliminate or combine processing steps 4.Incorporated automated process control of unit operation and processes 10

11. Material handling Risks 1.Customer dissatisfication 2. Increased production rate 3. Employees safety liabilties Principles of material handling Short distance Short terminal times Two way pay load Avoid partial load Avoid manual loading Move scrap cheaply Move in straight lines Unit loads Label thoroughly 11

12. Examples of material handling improvement Granulation and tabletting sections of the computer controlled tablet manufacturing process by Merck Sharp and Dohme (MSD) and Eli lily and company. Processing step combination or elimination A] Direct compression (new process) Raw materials Weighing and measuring (automatic weigher and recording system) Gravity feeding Compression (high speed rotary press) Aqueous coating (Hi coater ) 12

13. Wet granulation: standard processing steps Load processor weigh ingredients mix, mass agglomerates, dry lubricate Transfer( store) Compress Continuous batch powder mixing and massing equipment Eg. Dionsa mixer and granulator is a high- shear powder mixer and processor 13

14. Automation and Robotics In the world of pharmaceuticals, there is a vital role for robotics to play in the complicated processes of research and development. Commonly used robots in pharmaceutical industry : Cylindrical robot for high throughput screening Pharmaceutical container replacement robots 14

15. Advantages: Tirelessness Accuracy Reliability Safety Redeployment Less chances of contamination Suitable to all environment 15

16. Disadvantages Costly Dangers and fear Safety Trained employee is needed Tough to installed 16

17. Applications of robots in pharmaceutical industry: Research and development Laboratory Robots Control systems Vision system Sterilization and clean rooms Flexible feeding Biopharma and diagnostic application 17

18. References Internet sources 18

19. Thank you 19