Pharmaceutical preparations

Preparations of mouth wash,gargle, throat pain,ear drop,nasal drip.

1. S a n d i p i n s t i t u t e o f p h a r a m a c e u t i c a l s c i e n c e Presented By : Ashish Pathak Roll. No : 61 Sub : Pharmaceutics – I

2. Topi c f o r p r e p a r a t ion 1 ) M o u t h w a s h 2 ) G a r g l e 3 ) T h r o a t p a i n 4 ) E a r dro p e 5 ) N a s a l dro p e

3. MOUTHWASH What Is Mouthwash ? Mouthwash Is a Clear Solution Intended For External use to Deodourised the buccal cavity. Formulation Table : Zinc Sulphate and Zinc Chloride Mouthwash I.P : Sr.No Name Of Ingredient Quantity Given Quantity taken Roll Of Ingredients 1) Zncl 2gm 0.4gm Astringent 2) ZnSO 4 1gm 0.2gm Desanitizer 3) Compound Tartarizine Solution 1ml 0.2ml Colouring Agent 4) Dil.Hcl 1ml 0.2ml Remove Terbidity 5) Chloroform H 2 O 50ml 10ml Preservative

4. Procedure Dissolve Zinc Sulphate and zinc chloride in 10ml. Add Dil.Hcl to get clear solution. Add chloroform to h2o and tartrazine solution and mix well. Rinse the beaker with h20 and filter it in the same solution. Adjust final volume with remaining water .

5. Container And Storage :- Store in tightly closed glass container in cool place. Category :- Astringent. Direction :- Dilute 20 times with its volume with warm water for external using.

6. GARGLE What is gargle ? It is a clear solution used in posterior region of mouth to treat throat infection. It is usually prescribed to reduce sourness in mild throat infection. Povidone iodine is a iodine product a complex of iodine and povidone which is used as a antiseptic solution povidone. Iodine gargle is clear and red brown solution.

7. Formulation T able Povidone iodine gargle (20ml): Sr. No Name Of Ingredient Quantity Given Quantity Taken Role Of Ingredient 1) Povidone Iodine 1ml 0.2ml Antiseptic 2) Ethanol 8.38ml 1.67ml Solvent 3) Glycerin 4ml 0.80ml Viscosity Enhancing Agent 4) Methyl Salicylate 0.06ml 0.012ml Local Analgesic 5) Menthol 0.04ml 0.008ml Flavouring Agent 6) Sodium Saccharate 0.1ml 0.02gm Sweetening Agent 7) Purified H 2 O Upto 100ml 20ml Vehicle

8. Procedure 1 ) Clean all the glassweare and dry them properly. 2) Dissolve povidone in same portion of purified H2O in beaker add glycerin menthol and sodium Saccharate in it with continuous stirring. 3) Dissolve Methyl salicylate in required quantity of ethanol in separate beaker. 4) Mix both the solution and transfer into measuring cylinder. 5) Makeup volume Upto 20ml by addition of purified H2O 6) Transfer solution in a narrow mouth amber colour bottle and clothes toughly with polypropylene screw cap label properly and submit it.

9. Container and storage store in amber colour bottle and close tightly with the propylene screw cap. Store below 25 C. Protect from light Category Antiseptic in management of local infection of the mouth and oropharynx in dental surgery Direction Dilute with equal volume of warm water, for external use only and not to be swallowed in large amount

10. THROAT PAINT What is a throat paint It is viscous liquid preparation of medicament usually prescribed to relieve cough , pharyngitis, laryngitis. Application of iodine to an inflammed throat for the treatment , eliminates throat infections, kills fungus and bacteria and eradicates the underlying cause of sore throat

11. Formulation Table : Iodine throat paint ( mandls paint )1968 IP Sr. No Name of ingredients Qty Given Qty Given Role of ingredient 1) Ki 24gm 0.48gm Solubility enhancer 2) Iodine 12gm 0.24gm Anti bacterial – inflammation 3) Water 24gm 0.48ml Solvent 4) Alcohol 40ml 0.8ml Co- slvent 5) Peppermint oil 4ml 0.08ml Flavouring agent 6) Glycerine Upto 100ml 20ml vehicle

12. PROCEDURE Clean all apparatus and glass ware and dry them according to sop Weigh required quantity of iodine an dtransfer into glass mortar and triturate to get fine powder Weigh and dissolve to 20ml by adddition of glycerine required quantity of KI in water To this solution add fine powdered iodine with continuous stirring in another beaker containing alcohol (90%) V/v add required quantity of peppermint oil , add half the quantity of glycerine Add this solution to above iodine and KI solution with continuous stirring Pour content into measuring cylinder and make up the volume Transfer content to amber colour wide mouth glass bottle , close it tightly with plastic screw cap label and submit

13. CATEGORY treatment of laryngitis, pharyngitis,and follicular tonsillities Storage and direction store in tightly closed container in cool and dry place Direction apply with help of soft brush and cotton swab, food and water before and after apllication of thriat paint should be avoided for one hour

14. EAR DROP What is ear drop ? These are solution or emulsion of drug in water , glycerine and propylene glycol instilled into the ear to remove exceesive wax , to treat infection of ear to reduce inflammation or pain and for cleaning of ear. Water is not preffered vehocle for ear drop because it is aimmiscible with fatty secretions present in the ear and presence of water also make the ear canal and ideal location og of growth of bacterial fungi

15. Formulation table Sodium bicarbonate ear drop (BP) Sr no Name of ingredients Quantity taken Role of ingredients 1 Sodium bicarbonate 5g alkaline 2 3 Glycerine Freshly boiled and cooled water upto 30ml 100ml Viscosity enhancer solvent

16. PROCEDURE Weigh required amount of sodium bicarbonate added into sufficient amount of water and mix well Make up the volume upto 70 ml and add glycerine into it CATEGORY- wax softener STORAGE AND CONTAINER-plastic bottle inbuilt with with container and store in cool place DIRECTION –for external use only

17. NASAL DROP What is a nasal drop? it is aqueous or oily solution of medicament made isotonic with body fluid instilled in nasal cavity in order to relief conjation to reduce pain or inflammation and subsequently pervent further infection in nasal cavity Most commonly antibiotics , antihistamine,and symphathomonatic drug used for preparation of nasal drops

18. Formulation table Ephedrine nasal drop (BP) Name of ingredients Quantitu taken Role of ingredients 1) Ephendrine hydrochloride 0.5g symphamamonatic 2) Chlor butol 0.5g preservative 3) NaCl 0.5g Tonicity adjusting agent 4)Freshly boiled and cooled water upto 100ml vehicle

19. PROCEDURE Weigh required amount of ephedrine hydrochloride added to3/4 th volume of water Weigh require amount of NaCl added to the solution of ephedrine hydrochloride and finally make up the volume with water CATEGORY-nasal decongestent CONTANER AND STORAGE- store in coloured flutted bottle fitted with dropper DIRECTION –for external use only

20. T H A N K Y o u