Pharmacokinetics

"عسى أن تكون علما ينتفع به
Medication journey inside the body.
Body effect on medicine

1. PHARMACOKINETICS

2. TABLE OF CONTENTS Bioavailability C max Distribution Half life T max Area under the curve

3. PHARMACOKINETICS Bioavailability

4. BIOAVAILABLITY It describes the fraction of an administered dose of a medication that reaches the systemic circulation.

5. PHARMACOKINETICS Cmax

6. TIME CONCENTRATION C MAX C MAX

7. C MAX C MAX describes the maximum concentration a drug reaches in the blood plasma. High C MAX indicates: Better absorption. Higher bioavailability. Less doses (based on HALF LIFE )

8. PHARMACOKINETICS Distribution

9. DISTRIBUTION Once in the circulation, some drugs bind non specifically and reversibly to various plasma protein; that is, to albumin or globulin. Only the free drug exerts a biological effect; the bound drug stays in the vascular space and is not metabolized or eliminated.

10. PHARMACOKINETICS T max

11. T MAX TIME CONCENTRATION C MAX T MAX

12. T MAX T MAX describes the time needed to reach the C MAX. Short T MAX indicates: Rapid onset of action. More doses (based on HALF LIFE ) Long T MAX indicates: Delayed onset of action. Less doses (based on HALF LIFE )

13. PHARMACOKINETICS T 1/2

14. HALF LIFE TIME CONCENTRATION C MAX T MAX x HALF-LIFE

15. HALF LIFE HALF-LIFE is the time required for the C MAX to decrease to half of its initial value. Long half life indicates: Less doses (based on C MAX)

16. PHARMACOKINETICS Area under the curve

17. AUC AREA UNDER THE TIME CONCENTRATION CURVE TIME CONCENTRATION C MAX T MAX x HALF-LIFE AREA UNDER THE CURVE

18. AUC AREA UNDER THE TIME CONCENTRATION CURVE AUC represents the total amount of drug absorbed by the body, irrespective of the rate of absorption. AUC becomes useful for: Knowing the average concentration over a time interval. Knowing the elimination rate.