pharmacology Answers CVS cardio system.pptx

cvs pharma

1. Answers CVS

2. FILL-UPS spironolactone- K sparring diuretic, aldosterone antagonist,reduces mortality in severe HF patients by reducing harmful effects of aldosterone on heart Ligocaine - IB anti- arrythmic . Weak fast Na channel blockers. Good for ischaemic tissue Sacuitril - neprilysin inhibitor. Combined with valsartan k/a angiotensin receptot -neprilysin inhibitor. Degrades ANP, BNP,CNP, Bradykinin and adrenomedullin Acute decompensated HF- negative inotropic effect reduce contractility. Give i /v inotropes and vasopressors Minoxidil- directly acting arteriolar vasodilator- k channel opener Other arteriolar dilators- hydralazine, diazoxide, fenoldapam , sodium nitroprusside

3. Bradykinin Captopril, lisinipril Na nitroprusside Guanylyl cyclase ET1 receptor antagonist Bosentan - dual action Other ERA- Ambrisentan , Macitentan Other PAH drugs- Sildenafil, Eprostenol , Riociguat

4. Labetalol/ alpha- methydopa CCBs- Beta blockers- masking in diabetic patients ; ACEIs- C/I in renal artery stenosis patients ACE inhibitors Na-K-ATPase pump Nifedipine

5. NIMODIPINE Dipyridamole- others adenosine, hydralazine High first pass metabolism Nicorandil Amyl nitrate- cyanide poisoning Bonus point- Nitrate- indiced methemoglobulinemia treatement - methylene blue-1-2 mg/kg IV

6. TRUE/FALSE True False False True False ( phenylalkyl amine) True True True False False 11. True 12. True 13. False 14. False- rho kinase Is- netarsudil,fasudil ; ranolazine inhibits late phase na current INAC 15. True- blocks L-type cal channels in SAN 16. True 17. False 18. False 19. False 20. True