Pilot-plant Scale-up Consideration Of Solids by monalisha nayak

PILOT PLANT SCALE-UP TECHNIQUE.
BY MONA.
introduction, lab. scale-up, stages of producing tablets, instrumantation, types, complication, and basic things about it.

1. Pilot-plant Scale-up Consideration Of Solids Name – Monalisa Nayak Class – b.pharm 7 th sem Regd no – 1803268050 Subject – Industrial pharmacy College– JEYPORE College of pharmacy 1

2. Introduction Plant :- It is a place were the 5M’s like Money, Material,Man, Method and Machine are brought together for manufacturing of the product. Pilot-plant :- It is defined as a part of pharmaceutical Industry where a free comercial production system which include new production Technology. Scale-up :- “The art of designing of protype using the data obtained from the pilot plant material. 2

3. Laboratory scale-up Once a formulation scientist develop a laboratory scale product . The first step towards commercialization is to scale it up at a pilot plant level . Purpose of this Scale-up is to assure that the data , information and finding observed for small scale batches are reproducible during comparatively larger pilot scale manufacturing. 3

4. Stages of production Tablet Material handling Dry blending Granulation Drying Reduction of particle size Slugging Compression 4

5. Material handling :- In the laboratory , material are simply poured by hand,but in large scale operation , handling of this material often become necessary. Dry blending :- Powdered to be used for encapsulation are to be granulated and must be well blended to ensure good drug distribution. Miling of the Ingredients usually makes the process more reliable and reproducible. Equipment required for blending :- V-blender,Double cone blender 5

6. V-blender Double-Cone blender 6

7. 3. Granulation :- In this process in which the primary powder particles are made to adhere to form large, multiparticle entities called granules. Granulation process is a form of particle designing. Types Of Granulation Wet Granulation Method - Tray dryer Dry Granulation Method – Slugging mill 7

8. 4 .Drying :- Most common conventional method of drying a granulation Continuous to be the circulating hot air oven ,which is heated by either steam or electricity. Drying time at specified temperature and air flow rates must be established for each product ,and for each particular oven load . 5. Reduction of particle size :- Compression factors that may be affected by the particle size distribution are flow ability, compressibility,uniformity of the tablet weight, tablet hardness and colour uniformity. Equipment:- Oscillating granulator, Screening device 8

9. 9 Oscilating Granulator Screening Device

10. 6. Slugging :- The process is utilised to produce granules for moisture and and heat –sensitive API and when APIS exhibit sufficient binding. The method of slugging is also known as dry Granulation. 10 Roll Compactor

11. 7. Compression :- The ultimate test of a tablet formulation and granulation Process is weather the granulation can be compressed on a high-speed tablet press . Steps involved during compressed on a high-speed tablet press. Filling of empty die cavity with granulation Press compression of granulation Compress of granulation 11

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