PLGA-An Biodegradable Polymer

Poly(lactic-co-glycolic acid) (PLGA) is one of the most successfully developed biodegradable polymers.
Among the different polymers developed to formulate polymeric nanoparticles, PLGA has attracted considerable attention due to its attractive properties: (i) biodegradability and biocompatibility, (ii) FDA and European
Medicine Agency approval in drug delivery systems for parenteral administration, (iii) well-described formulations and methods of production adapted to various types of drugs e.g. hydrophilic or hydrophobic small
molecules or macromolecules, (iv) protection of the drug from degradation, (v) possibility of sustained release,
(vi) possibility to modify surface properties to provide stealthiness and/or better interaction with biological
materials and (vii) the possibility to target nanoparticles to specific organs or cells.

1. Department of
Pharmaceutics
Presented by :
Manu Singhai
(M.Pharm-1
st
semester)
19/10/2022
1

3. •Polymerisderivationof
ancientGreekword‘Polus’
which means many, much and
‘Meros’ meansparts
•The term was coined in 1833
by Jons JacobBerzelius.
Introduction

4. •Theyarebrokendownintobiologicallyacceptablemoleculesthatare
metabolizedandremovedfromthebodyvianormalmetabolic
pathways.
Example:-PolylacticAcid
PolyglycolicAcid
•BiodegradablePolymersarenaturalorsyntheticinoriginandare
degradedinvivo,eitherenzymaticallyornon-enzymaticallyorboth.
Biodegradable Polymer

5. Classification

6. Poly(lactic-co-glycolic-acid)
•PLGAisasyntheticpolymermade
frommonomersoflactideand
glycolide.
1960:PGAwasusedinthefirsttotally
biodegradableSuturesdeveloped.
1970:marketedunderthenameDexon.
1970:PLGA(10:90)Sutures,were
marketedasVicryl.

7. Poly(lactic-co-glycolicacid)
•PLGAareafamilyofFDA-approvedbiodegradablepolymer
thathavebeenextensivelystudiesasdeliveryvehiclesfordrugs,
proteinsandvariousothermacromoleculesasDNA,RNAand
Peptides.
•Polyesterpoly(lactic-co-glycolide)(PLGA)isacopolymerofPLA
andpolyglycolicacid(PGA).
•PLGAisthemostwellknownandwidelyappliedpolymerin
controlledreleasesystems.Thissyntheticpolymerhasfoundgreat
successduetoitsbiocompatibility,biodegradability,andfavorable
releasekinetics.
•PLGAnanoparticlescanbeusedsafelyfororal,nasal,pulmonary,
parenteral,transdermalandintra-ocularroutesofadministrationthe.

8. Synthesis and degradation of PLGA

10. Methods of synthesis of PLGA

11. •Solubility:-
➢(HighLacticacid)
SolubleinorganicsolventsuchasChloroformand
Dichloromethane,Ethylacetate,Acetone.
➢(HighGlycolicacid)
Itisinsolubleinmostorganicsolvents.
SolubleinHighlyfluorinatedsolvents,suchas
hexafluoroisopropanol.
•GlassTransitionTemp.(Tg):44-55
0
C
Properties

12. Experimental condition
pH, temperature, ionic
strength of medium
Intrinsic property of Polymer
Molecular weight, chemical
structure, hydrophobicity,
crystallinity, glass transition
temperatures
Preparation method
Miscellaneous Factors
Site of implantation,
mechanism of hydrolysis,
presence of low molecular
weight units

13. Applications

16. •PLGApolymershavebeenshowntobeexcellentdeliverycarriers
forcontrolledadministrationofdrugs,peptidesandproteinsdueto
theirbiocompatibilityandbiodegradability.
•Thesepolymersareincreasinglybecomingfeasiblecandidatesfor
drugdeliverysystems,anticanceragentsandvaccine
immunotherapy.
•ModifiedPLGAhelpstoenhancedthepermeabilityofDrugs.
Conclusion

17. References
1.RehmanA.,et.al.,”RecentapplicationsofPLGAbasednano-structuresindrug
delivery”,ColloidsandSurfacesBiointerfaces,2017.
2.Gupta,A.andV.Kumar,Newemergingtrendsinsyntheticbiodegradable
polymers–Polylactide:Acritique.Europeanpolymerjournal,2007.43(10):p.
4053-4074.
3.JainRA.Themanufacturingtechniquesofvariousdrugloadedbiodegradable
poly(lactide-co-glycolide)(PLGA)devices.Biomaterials.2000;21:2475–2490.
[PubMed:11055295]
4.https://www.researchgate.net/publication/50373741_Engineered_PLGA_Nanop
articles_An_Emerging_Delivery_Tool_in_Cancer_Therapeutics
5.https://www.Slideshare.Net/dralooky/plga-role-inbiopharmaceutic.
6.https://www.Slideshare.Net/princerohit1995/plga-anbiodegradable-polymer-