Potentials of Microfluids in Life Sciences: A Lab on a Chip

Today marks the death anniversary of Mr. Werner Jacobi, the pioneering figure in microfluidics. While his initial focus was on microelectronics and semiconductor technology, he carved out a distinct path for microfluidics, diverging from his previous pursuits. His visionary approach continues to shape the trajectory of microfluidics research and its diverse applications in science and technology.

This lecture is presented by our team member and volunteer, Bushra Umer, from Volunteer Batch-V, 2023.

The lecture emphasizes the adoption of the "lab-on-a-chip" approach to ensure cost-effective and real-time experiments, underscoring the importance of developing such innovative techniques in today's modern arena.
For Video: https://youtu.be/ZF-c6k-F1RI
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#biotechnology
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#microfluidics

1. Topic: A DROP THAT HAS BROUGHT THE REVOLUTION: POTENTIALS OF MICROFLUIDICS IN LIFE SCIENCES Presenter: BUSHRA UMER BS III, Biotechnology Jinnah University for Women ‹#›

2. Table of Contents: Prelude Basics of microfluidics, working principle Types Design of microfluidic devices (MDs), Types of microfluidic devices Applications Point-of-care diagnostics, Cell culture studies, etc Conclusion ‹#›

3. ‹#›

4. Basics of microfluidics: Deal with the manipulation of very small volumes of fluids ( down to femtoliters or fL ) through microchannels. ‹#›

5. Working principle of microfluidics: ( Purpose-specific ) ‹#›

6. Design of microfluidic devices (MDs): A B PDMS Polydimethylsiloxane (PDMS) is an elastomer with excellent optical, electrical and mechanical properties, Product or MD Microchannels and Inlet/Outlet ‹#›

7. Types of MDs : ‹#› Y channel: T -junction EP (Electric potential) based MD Capillary action based MD

8. Applications: Lab-on-a-chip ‹#› Splitting microfluidic chip is used to analyze blood sample. (Point-of-care diagnostics)

9. ‹#› B. Organ -on-a-chip

10. ‹#› C . Some more applications

11. Pros and cons of microfluidics: ? ! Pros Less sample amount is required. Give results in short time. Less amount of chemicals and reagents are used. Cons Difficult to standardized. Unstable cell viability. Fluid shear stress, which can interrupt cellular interaction studies. ‹#›

12. Summary: ‹#› The present of microfluidics is really exciting! We can expect advancements in miniaturization, allowing for even smaller and more complex devices. There will likely be more integration with other technologies like sensors and artificial intelligence, enabling real-time analysis and feedback. Additionally, there's potential for personalized medicine applications, where microfluidic devices could be tailored to an individual's specific needs. The possibilities are endless! M icrofluidics is a really exciting field of study! And we can expect advancements in miniaturization, allowing for even smaller and more complex devices. There will likely be more integration with other technologies like sensors and artificial intelligence, enabling real-time analysis and feedback. Additionally, there's potential for personalized medicine applications, where microfluidic devices could be tailored to an individual's specific needs. The possibilities are endless!

13. References: ‹#› https://www.citrogene.com/microfluidic-devices-definition-and-types/ https://www.mdpi.com/1424-8220/20/20/5742 Trends_in_additively_manufactured_microfluidics_mi.pdf fsens-01-583035.pdf https://link.springer.com/book/10.1007/978-981-13-6229-3 https://link.springer.com/article/10.1007/s13206-022-00087-8 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034066/

14. Thank You! ‹#›