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1. Diagnostic Utility of Pleural Fluid Cytology versus Cell Block Technique: A Comparative Study May 7, 2024 Plus tip: Use these slides as a starting point for customizing your presentation. Open the Plus add-on for more options. Learn more about Plus.

2. Diagnostic Utility of Pleural Fluid Cytology versus Cell Block Technique: A Comparative Study Introduction Objective Methods Results Discussion Limitations Conclusion Future Directions Agenda

3. Diagnostic Utility of Pleural Fluid Cytology versus Cell Block Technique: A Comparative Study Introduction to the diagnostic challenge of distinguishing between benign and malignant effusions. Highlighting the importance of cytological analysis in this context. Introducing the cell block technique as an adjunct for improved diagnosis. Presentation Details Plus tip: Personalize the introduction with your unique perspective or experience to engage the audience effectively.

4. This study focuses on comparing the diagnostic efficacy of pleural fluid cytology and the cell block technique, aiming to assess their performance in detecting various pleural conditions. Cytological analysis plays a crucial role in evaluating pleural effusions, aiding in the diagnosis and management of patients. The cell block technique is introduced as an adjunct to traditional cytology, offering enhanced diagnostic capabilities in identifying malignancies and other conditions. Introduction Pleural effusion is the accumulation of excess fluid in the pleural space, leading to diagnostic challenges in distinguishing between benign and malignant effusions. 3 2 1 4

5. Setting: Nepalgunj Medical College, Nepalgunj Duration: April 2020 to March 2021 To compare the diagnostic efficacy of pleural fluid cytology and cell block technique Objective 1 2 3 Plus tip: Consider adding specific goals for the comparison and any hypotheses tested to provide a clear focus.

6. Methods Hospital-based cross-sectional study to compare diagnostic efficacy of pleural fluid cytology and cell block technique Sample: Patients with pleural effusions undergoing thoracentesis at Nepalgunj Medical College, Nepalgunj Duration: April 2020 to March 2021 Study Design Sample Population Techniques Used Techniques: Routine cytology for pleural fluid analysis Cell block preparation for adjunct analysis Assessment criteria: Background blood, diagnostic material yield, architectural preservation Assessment Criteria Criteria assessed: Background blood, diagnostic material yield, architectural preservation Methods compared: Cytology and cell block technique Analysis of results: Comparative evaluation of diagnostic efficacy Plus tip: Ensure clear documentation of assessment criteria and thorough training on techniques to maintain consistency.

7. Cell block technique exhibited superior morphology in cases suspected to be malignant. Cytology findings showed 9% were negative for malignancy, while 1.4% were suspected malignant. . Majority of pleural effusions were inflammatory, with a small percentage suspected to be malignant Results 02 03 01 05 06 04 Comparative analysis revealed cell blocks provided more diagnostic material and better architectural preservation. The study's results support the use of the cell block technique for improved diagnostic outcomes in pleural fluid analysis. Advantages of cell block technique include enhanced visualization of cell characteristics and the ability to perform additional tests.

8. Age and gender distribution: The distribution of cases by age and gender aligns with the patterns observed in the literature, indicating a consistent demographic profile. Confirmation of suspicious malignancy: Cell block technique provided clarity in differentiating reactive from malignant cells, confirming the presence of suspicious malignancy. Discussion Consistency with previous research: The study confirms the predominance of inflammatory effusions and highlights the utility of cell block technique in line with existing literature. Significance of architectural preservation: Cell blocks offered superior morphology preservation in suspected malignant cases, aiding in more accurate diagnoses and treatment decisions. Advocacy for routine use of cell block method: The study advocates for the routine use of cell block technique, especially in cases of suspected malignancy, to enhance diagnostic accuracy and treatment planning. Implications for clinical practice: The study findings underscore the importance of integrating cell block technique into routine pleural fluid cytology, suggesting a shift in current practices toward a more comprehensive diagnostic approach.

9. Lack of immunohistochemistry testing for further detailed analysis of the samples. Inability to process all cases for cell block examination due to logistical constraints. Limitations . Single- center study conducted at Nepalgunj Medical College, Nepalgunj, limiting the generalizability of results

10. Medical personnel are encouraged to consider the cell block method as a routine procedure for enhanced diagnostic accuracy. Cell block technique significantly improved the confirmation of suspicious malignancy, emphasizing its crucial role in diagnosing pleural effusions. Lymphocytosis was the most frequent cytological diagnosis, underscoring the importance of cell identification in pleural fluid analysis. Conclusion Plus tip: To customize this slide, consider incorporating specific data or statistics from the study to strengthen the conclusions. Additionally, you may want to highlight any unexpected findings or challenges encountered during the research.

11. Providing training and awareness programs for clinicians on the benefits of the cell block technique Incorporating immunohistochemistry for more comprehensive analysis of pleural fluid samples Future Directions Conducting multi-center studies to validate findings and enhance generalizability of results