Practical Phagocytosis and REPAIR AREGENERATION PROCESSES.pptx

Lecture

1. Phagocytosis and REPAIR AREGENERATION PROCESSES 1

2. Phagocytosis Recognition Attachment Engulfment Killing 2

3. 3 Microbial endotoxin Activate T-cell Release cytokine IFN-γ Bind with Toll-like receptors ( TLRs) Macrophages activation – M1 NO , ROS, up regulate lysozymes Killing Secrete cytokines – inflammation (IL-1 , TNF, IL-12, IL-6) Classical Pathway

4. 4 Microbial endotoxin Activate T-cell Release cytokines IL-4, 13 Bind with TLRs Activate macrophages – M2 IL-10, TGF- β Not microbicidal – anti-inflammatory Tissue repair Angiogenesis, collagen synthesis, fibrosis Alternative Pathway

5. Granulomatous Inflammation 5

6. 6 Mechanism of Formation Offending agent Activate T-cells Lymphokines Attract and activate macrophages Epitheloid cells Giant cell Granuloma

7. 7

8. Process of Proliferation Signals by GF – Produced locally or circulating in serum Non specific (TGF-ά), specific (PDGF ) Bind with ECM protein – Displayed at site of injury Changes in gene expression – drive cells to S phase, synthesis of substances needed for division 8 Growth Factors Epidermal GF Platelets derived GF Fibroblast GF Vascular endothelial GF Cytokine (IL-1, TNF) TGF-alpha

9. Proliferative Phase (2) 9

10. 10

11. Healing by 1st Intension/Primary Union 11

12. Healing by 2nd Intension/Secondary Union 12

13. Complication of Wound Healing 13

14. Thank you 14