Predmet Tablets (Generic Methylprednisolone Tablets)

Predmet (Generic Methylprednisolone tablets) is used to treat many different inflammatory conditions such as arthritis, lupus, psoriasis, ulcerative colitis, allergic disorders, gland (endocrine) disorders, and conditions that affect the skin, eyes, lungs, stomach, nervous system, or blood cells. Methylprednisolone is a corticosteroid medicine that prevents the release of substances in the body that cause inflammation.

1. Predmet Tablets (Generic Methylprednisolone Tablets)
© The Swiss Pharmacy

2. Predmet Tablets (Generic Methylprednisolone Tablets)
© The Swiss Pharmacy
Predmet (Generic Methylprednisolone tablets) is used to
treat many different inflammatory conditions such as
arthritis, lupus, psoriasis, ulcerative colitis, allergic disorders,
gland (endocrine) disorders, and conditions that affect the
skin, eyes, lungs, stomach, nervous system, or blood cells.
Methylprednisolone is a corticosteroid medicine that
prevents the release of substances in the body that cause
inflammation.

3. Predmet Tablets (Generic Methylprednisolone Tablets)
© The Swiss Pharmacy
Predmet Tablets are manufactured by Sun Pharmaceutical
Industries Limited, India in the strengths of 4mg, 8mg and 16mg.

4. Predmet Tablets (Generic Methylprednisolone Tablets)
© The Swiss Pharmacy
Chemical Structure

5. Predmet Tablets (Generic Methylprednisolone Tablets)
© The Swiss Pharmacy
The active ingredient contained in Predmet tablets is
Methylprednisolone. Each Predmet tablet contains 4
mg, 8 mg or 16 mg of Methylprednisolone.

6. Predmet Tablets (Generic Methylprednisolone Tablets)
© The Swiss Pharmacy
Uses of Predmet 4mg, 8mg and 16mg Tablets:
Predmet (Generic Methylprednisolone Tablets) provides relief for
inflamed areas of the body. It is used to treat a number of different
conditions, such as inflammation (swelling), severe allergies,
adrenal problems, arthritis, asthma, blood or bone marrow
problems, eye or vision problems, lupus, skin conditions, kidney
problems, ulcerative colitis, and flare-ups of multiple sclerosis.
Methylprednisolone is a corticosteroid (cortisone-like medicine or
steroid). It works on the immune system to help relieve swelling,
redness, itching, and allergic reactions.
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7. Predmet Tablets (Generic Methylprednisolone Tablets)
© The Swiss Pharmacy
Uses of Predmet 4mg, 8mg and 16mg Tablets:
Predmet (Generic Methylprednisolone Tablets) is used to treat the
following conditions:
1. Endocrine Disorders: Primary or secondary adrenocortical insufficiency,
Congenital adrenal hyperplasia, Nonsuppurative thyroiditis, Hypercalcemia
associated with cancer.
2. Rheumatic Disorders: As adjunctive therapy for short-term administration
(to tide the patient over an acute episode or exacerbation) in: Rheumatoid
arthritis, including juvenile rheumatoid arthritis (selected cases may require
low-dose maintenance therapy), Ankylosing spondylitis, Acute and
subacute bursitis, Synovitis of osteoarthritis, Acute nonspecific
tenosynovitis, Post-traumatic osteoarthritis, Psoriatic arthritis, Epicondylitis,
Acute gouty arthritis.
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8. Predmet Tablets (Generic Methylprednisolone Tablets)
© The Swiss Pharmacy
Uses of Predmet 4mg, 8mg and 16mg Tablets:
3. Collagen Diseases: During an exacerbation or as maintenance therapy in selected cases
of: Systemic lupus erythematosus, Systemic dermatomyositis (polymyositis), Acute
rheumatic carditis
4.Dermatologic Diseases: Bullous dermatitis herpetiformis, Severe erythema multiforme
(Stevens-Johnson syndrome), Severe seborrheic dermatitis, Exfoliative dermatitis, Mycosis
fungoides, Pemphigus, Severe psoriasis
5.Allergic States: Control of severe or incapacitating allergic conditions intractable to
adequate trials of conventional treatment: Seasonal or perennial allergic rhinitis, Drug
hypersensitivity reactions, Serum sickness, Contact dermatitis, Bronchial asthma, Atopic
dermatitis
6.Ophthalmic Diseases: Severe acute and chronic allergic and inflammatory processes
involving the eye and its adnexa such as: Allergic corneal marginal ulcers, Herpes zoster
ophthalmicus, Anterior segment inflammation, Diffuse posterior uveitis and choroiditis,
Sympathetic ophthalmia, Keratitis, Optic neuritis, Allergic conjunctivitis, Chorioretinitis, Iritis
and iridocyclitis
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9. Predmet Tablets (Generic Methylprednisolone Tablets)
© The Swiss Pharmacy
Uses of Predmet 4mg, 8mg and 16mg Tablets:
7.Respiratory Diseases: Symptomatic sarcoidosis, Berylliosis, Loeffler’s
syndrome not manageable by other means, Fulminating or disseminated
pulmonary tuberculosis when used concurrently with appropriate
antituberculous chemotherapy, Aspiration pneumonitis.
8.Hematologic Disorders: Idiopathic thrombocytopenic purpura in adults,
Secondary thrombocytopenia in adults, Acquired (autoimmune) hemolytic
anemia, Erythroblastopenia (RBC anemia), Congenital (erythroid) hypoplastic
anemia.
9.Neoplastic Diseases: For palliative management of: Leukemias and
lymphomas in adults, Acute leukemia of childhood
10.Edematous States: To induce a diuresis or remission of proteinuria in the
nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus
erythematosus.
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10. Predmet Tablets (Generic Methylprednisolone Tablets)
© The Swiss Pharmacy
Uses of Predmet 4mg, 8mg and 16mg Tablets:
11.Gastrointestinal Diseases: To tide the patient over a critical period of
the disease in: Ulcerative colitis, Regional enteritis
12.Nervous System: Acute exacerbations of multiple sclerosis
13.Miscellaneous: Tuberculous meningitis with subarachnoid block or
impending block when used concurrently with appropriate
antituberculous chemotherapy. Trichinosis with neurologic or
myocardial involvement.
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11. Predmet Tablets (Generic Methylprednisolone Tablets)
© The Swiss Pharmacy
Recommended Adult Dosage
For most patients, the starting dose of Predmet Tablets (Generic
Methylprednisolone Tablets) may vary from 4 mg to 48 mg of
Methylprednisolone per day depending on the specific disease
entity being treated. In situations of less severity lower doses will
generally suffice while in selected patients higher initial doses may
be required.
Multiple Sclerosis: In treatment of acute exacerbations of multiple
sclerosis daily doses of 200 mg of Prednisolone for a week followed
by 80 mg every other day for 1 month have been shown to be
effective (4 mg of Methylprednisolone is equivalent to 5 mg of
Prednisolone).
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12. Predmet Tablets (Generic Methylprednisolone Tablets)
© The Swiss Pharmacy
Contraindications
➔Predmet is contraindicated in patients with a known
hypersensitivity to Methylprednisolone or any component of the
tablet.
➔Administration of Predmet (Generic Methylprednisolone
Tablets) is contraindicated in patients with Systemic fungal
infections.
➔Administration of live or live attenuated vaccines is
contraindicated in patients receiving immunosuppressive
doses of corticosteroids.
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13. Predmet Tablets (Generic Methylprednisolone Tablets)
© The Swiss Pharmacy
Storage Instructions
Predmet Tablets (Generic Methylprednisolone Tablets) have to
be stored at controlled room temperature i.e. from 20°C to 25°C
(68°F to 77°F) with excursions permitted between 15° to 30°C (59°
to 86°F). Keep this as well as all other medicines away from
children and pets.
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14. Predmet Tablets (Generic Methylprednisolone Tablets)
© The Swiss Pharmacy
Warnings
In patients on corticosteroid therapy subjected to unusual stress,
increased dosage of rapidly acting corticosteroids before, during, and
after the stressful situation is indicated.
Corticosteroids may mask some signs of infection, and new infections
may appear during their use. There may be decreased resistance and
inability to localize infection when corticosteroids are used.
Prolonged use of corticosteroids may produce posterior subcapsular
cataracts, glaucoma with possible damage to the optic nerves, and
may enhance the establishment of secondary ocular infections due to
fungi or viruses.
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15. Predmet Tablets (Generic Methylprednisolone Tablets)
© The Swiss Pharmacy
Warnings
While on corticosteroid therapy patients should not be vaccinated against
smallpox. Other immunization procedures should not be undertaken in
patients who are on corticosteroids, especially on high dose, because of
possible hazards of neurological complications and a lack of antibody
response.
The use of Methylprednisolone Tablets (Predmet Tablets) in active
tuberculosis should be restricted to those cases of fulminating or
disseminated tuberculosis in which the corticosteroid is used for the
management of the disease in conjunction with an appropriate anti-
tuberculous regimen.
Children who are on immunosuppressant drugs are more susceptible to
infections than healthy children.
Chickenpox and measles, for example, can have a more serious or even fatal
course in children on immunosuppressant corticosteroids.

16. Predmet Tablets (Generic Methylprednisolone Tablets)
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Possible Side Effects
Possible Predmet (Generic Methylprednisolone Tablets) side effects
include the following:
Fluid and Electrolyte Disturbances: Sodium retention, Congestive heart
failure in susceptible patients, Hypertension, Fluid retention,
Potassium loss, Hypokalemic alkalosis. .
Musculoskeletal: Muscle weakness, Loss of muscle mass, Steroid
myopathy, Osteoporosis, Vertebral compression fractures, Aseptic
necrosis of femoral and humeral heads, Pathologic fracture of long
bones..
Gastrointestinal: Peptic ulcer with possible perforation and
hemorrhage, Pancreatitis, Abdominal distention, Ulcerative esophagitis.
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17. Predmet Tablets (Generic Methylprednisolone Tablets)
© The Swiss Pharmacy
Possible Side Effects
Dermatologic: Impaired wound healing, Petechiae and ecchymoses,
May suppress reactions to skin tests, Thin fragile skin, Facial erythema,
Increased sweating.
Neurological: Increased intracranial pressure with papilledema (pseudo-
tumor cerebri) usually after treatment, Convulsions, Vertigo, Headache.
Endocrine: Development of Cushingoid state, Suppression of growth in
children, Secondary adrenocortical and pituitary unresponsiveness,
particularly in times of stress, as in trauma, surgery or illness, Menstrual
irregularities, Decreased carbohydrate tolerance, Manifestations of
latent diabetes mellitus, Increased requirements for insulin or oral
hypoglycemic agents in diabetics.
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18. Predmet Tablets (Generic Methylprednisolone Tablets)
© The Swiss Pharmacy
Possible Side Effects
Ophthalmic: Posterior subcapsular cataracts, Increased
intraocular pressure, Glaucoma, Exophthalmos
Metabolic: Negative nitrogen balance due to protein
catabolism
The following additional reactions have been reported
following oral as well as parenteral therapy: Urticaria and other
allergic, anaphylactic or hypersensitivity reactions.

19. Predmet Tablets (Generic Methylprednisolone Tablets)
© The Swiss Pharmacy
Predmet Tablets Overdosage
Administration of Methylprednisolone (Predmet tablets) should not be
discontinued abruptly but tailed off over a period of time. Appropriate
action should be taken to alleviate the symptoms produced by any side-
effect that may become apparent. It may be necessary to support the
patient with corticosteroids during any further period of trauma occurring
within two years of overdosage.
There is no clinical syndrome of acute overdose with Methylprednisolone
(Predmet tablets). Reports of acute toxicity and/or death following
overdosage of glucocorticoids are rare. In the event of overdosage, no
specific antidote is available. Treatment is supportive and symptomatic.
Methylprednisolone is haemodialysable.
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20. Predmet Tablets (Generic Methylprednisolone Tablets)
© The Swiss Pharmacy
Predmet Tablets During Pregnancy
Methylprednisolone (Predmet tablets) has been classified by the US
FDA as Pregnancy Category C. Some animal studies have shown that
corticosteroids (such as Methylprednisolone) have been shown to
increase the incidence of fetal malformations of various kinds
(cleft palate, skeletal malformations), embryo-fetal lethality (e.g.,
increase in resorptions), intra-uterine growth retardation and
abortion.
However, corticosteroids do not appear to cause congenital
anomalies when given to pregnant women. Since adequate human
reproductive studies have not been done with Methylprednisolone, this
medicine should be used during pregnancy only after a careful
assessment of the benefit-risk ratio to the mother and fetus.
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21. Predmet Tablets (Generic Methylprednisolone Tablets)
© The Swiss Pharmacy
Predmet Tablets During Pregnancy
Corticosteroids readily cross the placenta. An increased incidence
of low-birth weights in infants born of mothers receiving
corticosteroids has been reported.
In humans, the risk of low birth weight appears to be dose
related and may be minimized by administering lower
corticosteroid doses.
Infants born to mothers who have received substantial doses of
corticosteroids during pregnancy must be carefully observed and
evaluated for signs of adrenal insufficiency, although neonatal
adrenal insufficiency is rarely reported in infants exposed in utero
to corticosteroids.
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22. Predmet Tablets (Generic Methylprednisolone Tablets)
© The Swiss Pharmacy
Predmet Tablets (Generic Methylprednisolone
Tablets) are manufactured by Sun Pharmaceutical
Industries Limited, India.
URL: https://www.theswisspharmacy.com/product_info.php?info=p9789_Methylprednisolone-Tablets.html