Preparation and properties of sulfacetamide.pptx

Preparation and properties of sulfacetamide

1. Preparation of Sulfacetamide

2. Sulfacetamide is prepared either by direct alkylation of acetamide  with 4-aminobenzenesulfonyl chloride, Or by reacting 4-aminobenzenesulfonamide with aectic anhydride and subsequent selective, reductive deacylation of the resultant acetamide using a system of zinc-sodium hydroxide. Sulfacetamide - preparation

3. Properties of sulfacetamide Irritating to eyes,Rspiratory system and skin. It causes sensitization to skin contact.

4. Sulfacetamide  stops the growth of bacteria that cause certain eye infections. It is used to treat eye infections and to prevent them after injuries. Uses of sulfacetamide

5. Sulfacetamide Sodium suspension

6. Safety precautions while handling sulfacetamide Do not swallow, Do not Inhale, Avoid contact with eyes and skin, Wear gloves and handle with caution.

7. Sulfacetamide -Testing/Analysis Testing/Analysis : Dilute the Sample with water to 25 mL, adjust with 6 N acetic acid to a pH of 4–5, and filter. Wash the precipitate with water, and dry at 105° for 2 h. Use the precipitate in Identification tests B and C. Acceptance criteria: The sulfacetamide melts at 180°– 184°C.