principles of auto immunity one place to start with AI diseases

initial auto immune concepts

1. Principles of Immunology
Autoimmunity
4/25/06

2. Organs Specific Autoimmune
Diseases
Hashimoto’s thyroiditis
DTH like response to thyroid Ags
Ab to thyroglobulin
Hypothyroidism
Pernicious anemia
Ab to gastric parietal cells
Interferes with vitamin update
Reduced RBCs

3. Organs Specific Autoimmune
Diseases
Goodpasture’s syndrome
Ab to Ag on basement membranes
C activation
Glomerulonephritis, pulmonary disease
Type 1 diabetes
Ab to beta cells of pancreas
DTF reaction
Cytokine induced damage

4. Organs Specific Autoimmune
Diseases
Myasthenia gravis
Ab to acetyl choline receptors
Blocks muscle activation
C activation and damage to muscle cells

5. Systemic Autoimmune Disease
SLE
Ab to certain tissue antigens
Vasculitis
Diagnosis using anti nuclear antibodies
MS
Reaction to myelin sheath
Viral component?

6. Systemic Autoimmune Disease
Rheumatoid arthritis
IgM which is anti IgG
Immune complexes
Chronic inflammation

7. Genetics vs. Environment
HLA type
Sequestered antigens

8. CD4 Cells and Autoimmune Disease
Transferable
Anti CD4 Ab protective

9. Mechanisms
Release or expression of Ags
Cross reacting Ags

10. Therapies
Cyclosporin
Interferes with T cell development
Anti-inflammatories