MILLION HEALTH PHARMACEUTICALS prolia 60mg,prolia 60mg injection , prolia 60mg price in India Prolia 60mg injection | Denosumab | MHP
Prolia 60mg is a human monoclonal antibody for the treatment of osteoporosis, treatment-persuaded bone loss, metastases to bone, and giant cell tumor of bone. Prolia 60mg contraindicated in people with low blood calcium levels. Prolia 60mg injection is prescription drug which is used under the guidance of medical oncologist. DESCRIPTION
• Prolia 60mg injection Indicated for treatment of osteoporosis at high risk postmenopausal women with (end of menopause/ change of life), whose have serious problem of fractures raised or who failed to other medication of osteoporosis. • Prolia 60mg Indicated for treatment of Breast cancer in women whose taking certain treatment which make severe their risk of fractures and bone loss in men with prostate cancer. • Indicated for treatment in adults and some adolescents with giant cell tumor of bone which cannot treat with surgery / surgery is not possible is treated with Prolia 60mg injection . INDICATION
Denosumab ( Prolia 60mg injection )mechanism by aiming a protein called RANKL, which is required for new osteoclasts to be made and to function. This promote to inhibit further breakdown of bone and reduces the risk of problems caused by secondary bone cancer, such as fractures. It can also promote to decreased pain caused by secondary bone cancer. MECHANISM OF ACTION
PRODUCT DETAILS Brand : Prolia Ingredients : Denosumab Strength : 60mg Manufactured : Dr. Reddy’s laboratories Package : 1 injection in a prefilled syringe Price : prolia 60mg price in India
• Peak plasma concentration: 6.75mcg/mL • Tmax : 10days • Without aggregation in Prolia 60mg injection pharmacokinetics with duration was noticed upon multiple dosing of 60 mg SC administered once every 6 months. • Pharmacokinetics of Prolia 60mg will not affected by the binding antibodies formation. • Half-life is 25.4 days. ADME
For adult : The prescribed dose for Osteoporosis is Prolia 60mg injection SC (subcutaneously) once every 6 months Administer injection in upper arm, upper thigh or abdomen The prescribed dose for Androgen Deprivation induced bone loss is Prolia 60mg SC q6months. The prescribed dose is Glucocorticoid induced osteoporosis Prolia 60mg injection q6months . The prescribed dose is Aromatase inhibitor induced bone loss Prolia 60mg SC q6months For pediatric : The prescribed dose is 13 years and older and 45kg or more for Giant Cell Tumor of bone: The recommended dose is of 120mg Prolia 60mg injection tablet given SC, with additional 120mg doses on days 8 and 15 of the 1st month treatment every 4 weeks DOSAGE MANAGEMENT
No experienced with Prolia 60mg injection overdose. If occurs take the patient to emergency department and call poison control OVERDOSE
• Before starting denosumab should be corrected. Hypocalcemia may worsen, specifically in patients with renal impairment. Sufficiently supplement patients with calcium and vitamin D. • Prolia 60mg injection has negative effects of immuno -suppressants may improve. Especially the harm for severe infections may be raised. Discuss with your doctor of any immuno -suppressive drugs you early consume . • While treatment with Prolia 60mg have Osteonecrosis of the jaw (ONJ) has been reported with denosumab – check for symptoms. • Prolia 60mg injection Planning to become pregnant before to starting this therapy, consult with doctor before the treatment because use in pregnancy only if benefit to mother outweighs risk to fetus). PRECAUTIONS
Common side effects for the patient taking Prolia 60mg injection : • Nausea • Fatigue • Muscle weakness • Hypophosphatemia. SIDE EFFECTS
Less common side effects for patients taking Prolia 60mg : • Diarrhae • Shortness of breath • Hypocalcemia • Joint pain • Hypocalcemia • Cough • Arthralgia • Limb pain • Eczema • Headache • Eczema • Rash SIDE EFFECTS
No formal drug-drug interaction with denosumab ( Prolia 60mg injection )during trials. When concomitant use with some anticancer drug, orthopedic drugs, vaccines will lead to risk of adverse effects can be increased CONTRAINDICATION Prolia 60mg injection is contraindicated in Hypocalcemia Pregnancy Hypersensitivity DRUG INTERACTION
Pregnancy category C The Prolia 60mg which has no enough data in pregnant women to convey any drug analog risk for adverse development outcomes the drug in pregnant women is contraindicated for use because it may cause serious risk to the fetus. LACTATION Prolia 60mg injection is excreted into human milk is not known. Since possible for severe side effects occurs in nursing infants from Prolia 60mg injection. Avoid breastfeeding during treatment of Denosumab . PREGNANCY
Store at 2°C to 8°C in the original container. Avoid freeze. Before to administration keep at room temperature. Prolia 60mg injection protect from direct light and heat. MISSED DOSE If Prolia 60mg dose is missed then have the dose immediately before next dose duration. Next dose time reaches then left off the missed dose and follows regular schedule. Avoid taking double dose at same time. Please consult the doctor for further information. STORAGE
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