Protein and its structure- a general description.ppt

This presentation gives a description general description on proteins amino acids and its structure.

1. Tertiary and Quaternary Protein
Structure

2. Primary and Secondary Structure
Primary protein structure- Described by the
sequence of amino acids joined by peptide
bonds.
Secondary protein structure- Common
structural motifs.
eg. Alpha helices, Beta sheets

3. So What’s Tertiary Structure
Tertiary structure is the overall shape of a
single peptide strand.

4. Example Tertiary Structure

5. Same Protein, Different View

6. Same Protein, Yet Another View

7. One Final Look

8. What Determines Tertiary
Structure?
Usually interactions between atoms in the R
groups of the peptide chain.
Typically there is not a repeating pattern of
bonding that determines the structure.

9. Common Interactions
Determining Tertiary Structure.
Image removed

10. Quaternary Structure
The overall structure of a protein made up
of more than one peptide chain.
Same interactions forming tertiary structure
are responsible for forming the quaternary
structure of a protein.

11. Image Removed

12. Factors Affecting Structure
Temperature- High temperature overcomes
hydrogen bonds
pH- protonation and deprotonation of
acidic and basic residues
Salinity- affects hydration of the protein
and bonding.

13. So what do proteins do? Your
turn
Myoglobin
Collagen
Potassium channel
Monoamine oxidase
Insulin
Immunoglobulin

14. In your lab groups
Roles
Protein Structure (1 person)
Protein Function (1 person)
Relationship of Structure to Function (1 person)
Presenter (1 person)

15. Image References
Protein Data Bank Proteins: 2a5t & 2a5s
PowerPoint Lectures Exclusively for
Adpoters of Campbell and Reece Biology,
6th Edition. 2002, Benjamin Cummings