Pulmonary interstitium

Pulmonary physiology

1. Pulmonary Interstitium Advance Physiology Aaron Paul Baliga

2. SESSION OUTCOME At the end of the session, the group must be able to: describe the physiological anatomy of pulmonary interstitium and; 2. explain the physiological mechanism of pulmonary Interstitium.

3. What is a Pulmonary Interstitium?

4. Thin portion(tight junction) – Basal lamina + adjacent capillary endothelium – Strict diffusion barrier between alveolar surface and underlying tissues

5. Thick portion Collagen : tensile strength Elastin : flexibility Proteoglycans : *Maintain hydration *Adhesive activity *Component of growth factors

6. Thick portion – Tissue fluid accumulation and exchange – Lymphatic drainage system

7. Hydrostatic and osmotic forces in mm Hg at the capillary and alveolar membrane of the lungs

8. OUTWARD FORCES Capillary pressure Interstitial fluid   colloid osmotic pressure Negative interstitial fluid pressure TOTAL OUTWARD FORCE 7 14 8 29 INWARD FORCE Plasma colloid oncotic pressure TOTAL INWARD FORCE 28 MEAN FILTRATION PRESSURE TOTAL OUTWARD FORCE TOTAL INWARD FORCE MEAN FILTRATION FORCES 28 +29 -28 +1

9. Left-sided heart failure or mitral valve disease Damage of pulmonary capillary membrane PULMONARY EDEMA

10. SESSION OUTCOME At the end of the session, the group must be able to: describe the physiological anatomy of pulmonary interstitium and; 2. explain the physiological mechanism of pulmonary Interstitium.