Pyridine

Mumbai University T Y B Pharm Sem V

1. Heterocycles:Heterocycles:
Pyridine Pyridine
Dr. Taj Khan
Dept. of Pharmaceutical Chemistry, Oriental
college of pharmacy Sanpada, New Mumbai.

3. Electron density

4. Used in synthetic chemistry as Weak base and solvent

7. Synthesis of Pyridine:

8. Hantzsch pyridine synthesis:
Condensation of aldehyde, dicarbonyl compound X 2 and NH
3

10. Reaction with Hydrazine:
Chichibabin reaction:

12. E
+

13. Pyridine itself act as Nu

14. Reaction at P position of substituents

16. Reduction of pyridine:
Oxidation: Leads to formation of pyridine N-Oxide

17. Nucleophilic Reactions:

18. Other reaction at C atom: