Quinolones

The brief summary about the Quinolones and their MOA and Uses.

1. Quinolones/ Fluroquinolones Sindhoora D Assistant Professor Dept.of.Pharmacology

2. Quinolones Synthetic Quinolone structure Primarily against gram negative bacteria Newer fluorinated are gram positive also First member are Nalidixic acid Adverse effect: G.i upset and rashes frequent Headache, drowsiness, vertigo, visula disturbance Contraindicated in childrens

3. Fluroquinolones Containing fluorine in their structure. Classification:

4. Ciprofloxacin: Aerobic gram negative bacilli Rapidly absorbed in orally Adverse effect: Tendinitis and tendon rupture Headache, dizziness and restlessness Skin hypersensitivity G.i disturbances Uses: Gonorrhoea, conjunctivitis, bone,soft tissue and wound infection, Gynaecological infection, respiratory infection, typhoid and Bacterial gastroenteritis.

5. Norfloxacin : Primarily used for urinary and genital infection. Effective in bacterial diarrhoea. Ofloxacin : Active against chlamydia and mycoplasma. Effective against Tuberculosis and M.leprae Chronic bronchitis, respiratory and ENT infection Levofloxacin: levo isomer 100% bioavailibility Both oral and IV Acquired community pneumonia and exacerbation of chronic bronchitis Gatifloxacin : Strep.penumoniae Moxifloxacin : M.tuberculosis Bronchitis,sinusitis and ENT infection .