Radiopharmaceuticals HCP.pptx

Radiopharmaceuticals are the radioactive substances or radioactive drugs for diagnostic or therapeutic interventions.
Radiopharmaceuticals are composed of 2 parts: Radionuclide + Pharmaceutical
Radiopharmacy/Radionuclide laboratory is a controlled area & access will be restricted.
Only properly trained staff should be allowed to work in radionuclide laboratory.
Protective equipments should be used to reduce staff dose.

1. Course: Hospital & Clinical Pharmacy Course Code: 20225/ ER20-25T Chapter No: 06 HSBPVT’s Parikrama Diploma in Pharmaceutical Sciences, Kashti . Topic- Radiopharmaceuticals Ms . Sathe Komal P.   Lecturer ,   HSBPVT's, Parikrama Diploma in Pharmaceutical Sciences, Kashti . Vision : To develop as a center for pharmaceutical education by providing knowledge, skills & attitude in our students to make them proficient in pharmaceutical sciences.   

2. Radiopharmaceuticals Radiopharmaceuticals are the radioactive substances or radioactive drugs for diagnostic or therapeutic interventions. OR Radiopharmaceuticals are medicinal formulations containing radioisotopes which are safe for administration in humans for diagnosis or for therapy. Examples- Ga-67 citrate, Tl-201 chloride, Xe-133 gas, 51Cr-sodium chromate

3. Radiopharmaceuticals are composed of 2 parts: Radionuclide + Pharmaceutical A  radionuclide  (radioactive nuclide, radioisotope or radioactive isotope) is a nuclide that has excess nuclear energy, making it unstable. A radionuclide may decay by emitting different types of ionizing radiation: Alpha ( α ), beta ( β ) & gamma ( γ ) radiations . The basic unit for measurement of radioactivity is Curie .

4. Preparing & Dispensing of radiopharmaceuticals Radiopharmacy /Radionuclide laboratory is a controlled area & access will be restricted. Only properly trained staff should be allowed to work in radionuclide laboratory . Personnel monitoring Operator should wear personal dosimeter (TLD- Thermoluminescent Dosimeter, film badge, electronic dosimeter. ) 2. Protective clothing Before beginning the work the staff should wash the hands thoroughly.

5. They should wear gloves, protective coats & gowns After handling the radioactive materials, the gloves should be removed & disposed of before touching any other material in the laboratory. Hands should be washed after removing the gloves. After removal, the disposable gowns should be stored as radioactive waste.

6. 3. Protective equipments Protective equipments should be used to reduce staff dose. Equipments Long handed tongs & forceps Syringe shields Vial shields Shielded syringe carriers Decontamination kit Long handed tongs & forceps

7. Syringe & Vial shields Decontamination kit

8. 4. Work Procedure

9. 5. Reconstitution of pharmaceuticals

10. Labeling of Radiopharmaceuticals

11. Collection & Disposal of Radioactive waste A standard waste management procedure should be followed. Non-radioactive waste should be separated from radioactive waste. Shielded waste bins should be lined with plastic liners that can be easily removed when full. The waste bin at workstation be emptied before starting work when the waste has decayed overnight. The waste bins should be closed, marked as radioactive, dated & removed to radioactive waste store. All waste bins should be securely stored & monitored regularly. Once the radioactivity decayed, it should be disposed off.