75
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Ranger Regiment Trauma Management Team (Tactical)
Ranger Medic Handbook
9. HETASTARCH (HEXTEND)
Class: Plasma volume expander – colloid; synthetic starch resembling human glycogen
Action: Increases colloidal osmotic pressure and expands plasma volume similar to albumin, but with less
potential for anaphylaxis or interference with cross matching or blood typing procedures; remains in the
intravascular space increasing arterial and venous pressures, heart rate, cardiac output, urine output; not a
blood or plasma substitute
Dose: 500–1000 mL IV (max rate: 20 mL/kg/h, max dose: 1500 mL/day); max rate used for acute hemorrhagic
shock, reduced rates used with burns or septic shock
Indications: For fluid replacement and plasma volume expansion when blood or plasma is not available, and
for adjunctive treatment of shock caused by hemorrhage, burns, surgery, sepsis, or other trauma
Contraindications: Severe bleeding disorders, CHF, renal failure with oliguria and anuria, treatment of shock
without hypovolemia, pregnancy category C
Adverse Effects: Peripheral edema, circulatory overload, heart failure; prolonged PT/PTT, clotting time, and
bleeding time with large doses; decreased Hb/Hct, platelets, calcium, and fibrinogen; dilution of plasma
proteins, hyperbilirubinemia, increased sedimentation rate; pruritus, anaphylactoid reactions (periorbital
edema, urticaria, wheezing), vomiting, fever, chills, flu-like symptoms, headache, muscle pains, submaxillary
and parotid gland swelling
Interactions: No clinically significant interactions established
10. IBUPROFEN (MOTRIN, ADVIL)
Class: CNS agent – NSAID (cox-1); anti-inflammatory, analgesic, antipyretic
Action: Propionic acid inhibitor prototype that blocks prostaglandin synthesis, modulates T-cell function,
inhibits inflammatory cell chemotaxis, decreases release of superoxide radicals or increases scavenging of
these compounds at inflammatory sites, inhibits platelet aggregation and prolongs bleeding time
Dose: 400–800 mg PO tid-qid (max: 3200 mg/d)
Indications: For mild to moderate pain management, symptomatic relief of arthritis, and to reduce fever
Contraindications: NSAID or aspirin induced urticaria, severe rhinitis, bronchospasm, angioedema, nasal
polyps; active peptic ulcer, bleeding abnormalities; pregnancy category B
Adverse Effects: Headache, dizziness, light-headedness, anxiety, emotional lability, fatigue, malaise,
drowsiness, anxiety, confusion, depression, aseptic meningitis; hypertension, palpitation, CHF; peripheral
edema; amblyopia (blurred vision, decreased visual acuity, scotomas, changes in color vision); nystagmus,
visual-field defects; tinnitus, impaired hearing; dry mouth, gingival ulcerations, dyspepsia, heartburn, nausea,
vomiting, anorexia, diarrhea, constipation, bloating, flatulence, epigastric or abdominal discomfort or pain, GI
ulceration, occult blood loss; thrombocytopenia, neutropenia, hemolytic or aplastic anemia, leukopenia;
decreased Hgb/Hct; acute renal failure, polyuria, azotemia, cystitis, hematuria, nephrotoxicity, decreased
creatinine clearance; maculopapular and vesicobullous skin eruptions, erythema multiforme, pruritus, acne;
fluid retention with edema, Stevens-Johnson syndrome, toxic hepatitis, hypersensitivity reactions, anaphylaxis,
bronchospasm, serum sickness, SLE, angioedema
Interactions: Oral anticoagulants and heparin may prolong bleeding time; may increase lithium and
methotrexate toxicity; herbals (feverfew, garlic, ginger, ginkgo) may increase risk of bleeding; do not take
aspirin concurrently; concurrent alcohol use may increase risk of GI ulceration and bleeding tendencies
Ranger Medic Handbook 2007 Edition
75
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Ranger Regiment, US Army Special Operations Command
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