Development:is considered the area of
differentiation and maturation that leads to increase in
skill, more comprehensive function and sexual
dimorphism in progress towards maturity.
Remodeling:is shaping of the outline of a bone by
selective resorption in some areas and apposition in
others.
Ossification:formation and development of bone is
termed ossification
Endochondral ossification:bone formation taking
place on a cartilage matrix, the cartilage immediately
preceding bone in development.
Intramembranous ossification:bone formation
directly within a connective tissue membrane
without any intermediate formation of cartilage.
Displacement:movement away from a certain
position or place.
Primary displacement:occurring in conjunction
with a bone’s own growth.
Secondary displacement:bone displacement
caused by enlargement of adjacent or remote
bones or tissues but not of bone itself.
Theories of growth
The Remodeling Theory Of Craniofacial
Growth
J.C.Brash (1930’s)
TheresearchbyBrashonboneprovidedthe
foundationforthedevelopmentofthefirst
generaltheoryofcraniofacialgrowth.
Genetic theory
•Growthiscontrolled
bygeneticinfluence
and is pre-
determined.
Sichers’ sutural theory
•Craniofacialgrowthoccursatsutures.
•Pairedparallelsuturesthatattachfacial
areastotheskullandcranialbaseregion
pushthenaso-maxillarycomplaex
forwardstoplaceitsgrowthwiththatof
mandible.
E.g. Coronoid –temporalis
Angular –Masseter and
medial pterygoid
Alveolar –Presence and
position of teeth.
Skeletal Units:
1. The Neurocranial
capsule
2. The Orofacial
capsule
Van Limborgh theory
•Multifactorialtheory
•5factorscontrollinggrowth
•Intrinsicgeneticfactors
•Localepigeneticfactors
•Generalepigeneticfactors
•Localenvironmentalfactors
•Generalenvironmentalfactors.
Trajectories of bone
GivenbyBenninghoff.
Localandepigeneticfactorsresponsible
forfinalbonestructure.
Verticalpillarsinmaxilla:canine,
zygomaticandpterygoid
Mandible:coronoid,ramusandbody.
Types of ossification
Chondrogenesis
Chondroblasts produce matrix
Cells become encased in matrix
Chondrocytes enlarge, divide, and produce matrix
Matrix remains uncalcified
Membrane covers the surface but is not essential
Endochondral bone formation
Hypertrophy of chondrocytes and matrix calicifies
Invasion of blood vessels and connective tissue
cells
Osteoblast differentiate and produce osteoid tissue
Osteoid tissue calcifies
Membrane covers bone and is essential
INTRAMEMBRANOUS BONE
FORMATION
Osteoblast produce osteoid tissue
Cells and blood vessels are encased
Osteoid tissue is produced by membrane cells
Osteoid calcifies
Essential membrane covers bone
Theundifferentiatedmesenchymalcellsofthe
membranousconnectivetissuechangeto
osteoblastsandelaborateosteoidmatrix.The
matrixorintercelluarsubstancebecomescalcified
andboneresults.
Bone tissue laid down by
periosteum, endosteum, sutures,
and the periodontal membrane
are intramembranous in origin.
Herein, the formation of
bone is not preceded by
the formation of a
cartilaginous model.
Instead, bone is directly
laid down into a fibrous
membrane.
Intramembranousboneformationisthe
predominantwayofformationofboneintheskull.
MAXILLA
•Orbital
•Alveolar
•BasalBody
•Nasal
•Pneumatic
Developing elements of maxilla:
Maxillaarisesfromasinglecentreofossificationinthe
mesenchymeofthemaxillaryprocessofthe1
st
arch.
Noprimarycartilageexistsinthemaxillaryprocess.
The centre of ossification appears in theangle between the
division ofan nerve (i.e. where theanteriosuperior dental
nerveis given off from theinferior orbital nerve)just above
the canine tooth.
Pre-natal development of maxilla
Center of ossification
Spread of ossification
POST NATAL DEVELOPMENT OF
MAXILLA
Growthatthenaso-maxillarycomplexis
complex.
Mechanisminvolvedinplacingthemaxilla
forward
Growthatthesutures
Displacement
Surfaceremodelling
Growth at the sutures
Maxillaconnectedtocraniumbyfollowingsutures:
1.Frontonasal
2.Frontomaxillary
3.Zygomatico-temporal
4.Zygomatico-maxillary
5.Pteryopalatine
–Allthesesuturesareobliqueandparalleltoeachother.
–Growthatthesesuturesisgreatestuntilageof4
years.
Development of mandible
•Largestandstrongestboneofface.
•Undergoesconsiderableamountofchanges
amongthefacialbones.
•Itissecondbonetoossifyafterclavicle.
•Appearsasasingleboneinadult.
•Oneoftheunpairedbonesoffacialskeleton.
Prenatal Development of Mandible
•Derivedfromossificationofan
osteogenicmembraneat36to38days
ofdevelopment.
•At6
th
week,asingleossificationcenter
foreachhalfofmandiblearisesat
bifurcationofinferioralveolarnerve.
Thus, mandible is membrane bone developed in
relation to the nerve of the 1
st
arch& almost
independent of Meckel’s cartilage. The mandible has
neural, alveolar & muscular elements & its growth is
assisted by the development of secondary cartilages
Postnatal development of Mandible
•Mandibleundergoesthelargestamountofgrowth
post-natallyandalsoexhibitsthelargestvariability.
•Atbirth:Obtuseshape,Rudimentarycondyles
Ascendingramus–Low&wide
Coronoid–Large& projectsabove
thecondyle.
Body–OpenShell
MandibularCanal–Runslow.
Postnatal development of Mandible
The functional parts include-
Ramus
Corpus
Angle of mandible
Lingual tuberosity
The alveolar process
The chin
Corpus
•Asanteriorborderoframusresorbs–posterior
drift.
•Conversionofearlierramusintoposteriorpartof
thebody.
•Thusbodyofthemandiblelengthens.
•Growthofalveolarprocessincreasestheheight.
Developmental relation of maxilla & mandible
Fetal life:
•Initial–mandible>maxilla
•8
th
weeks–maxilla overlaps mandible
•11
th
weeks–approximately equal size
•13
th
–20
th
weeks–mandible lags behind
At birth:
•Mandible–Retrognathic, corrected early in post
natal life.
Similarities in maxilla and
mandible
Derivativesoffirstpharyngealarch.
Innervatedbyfifthcranialnerve.
Bothremodelpredominantlyinposterior
mannerandhencebecomedisplacedin
anantero-inferiormode
Differences between maxilla and
mandible
Mandibleisasinglebone,whereasnaso
maxillarycomplexisanelaborategrouping
ofmanyseparatebones.
Mandibleisamovablearticulationwithbasi
cranium,whilemaxillaisfixedwithcranial
floor.
Maxilla develops entirelyby
intramembranousossificationwhereas
mandibularcondyleexihibitsendochondral
ossification.