Robotics in pharmaceutical Industries.pptx

Robotics in pharmaceutical industries are mainly used in manufacturing and documentation works. This robots are used in transit and automation.

1. 11-10-2025 1 COMPUTER AIDED DRUG DEVELOPMENT ROBOTICS GOKULRAJ S M.PHARM SEM II DEPARTMENT OF PHARMACEUTICS

2. 11-10-2025 2 COMPUTER AIDED DRUG DEVELOPMENT ROBOTICS General overview Pharmaceutical automation Pharmaceutical application Advantages and disadvantages Current challenges Future directions

3. ROBOT – ROBOTA ( Greek word) means forced labour or work ROBOT An automatically controlled, reprogrammable, multipurpose, manipulator programmable , which may be either fixed in place or mobile for use in industrial automation applications. The word robot can refer to both physical and virtual software agents 11-10-2025 3 COMPUTER AIDED DRUG DEVELOPMENT

4. 11-10-2025 4 COMPUTER AIDED DRUG DEVELOPMENT THREE LAWS OF ROBOTICS A robot may not injure a human being or, through inaction, allow a human being to come to harm.

5. 11-10-2025 5 COMPUTER AIDED DRUG DEVELOPMENT THREE LAWS OF ROBOTICS A robot must obey orders given to it by human beings except where such orders would conflict with the First Law.

6. THREE LAWS OF ROBOTICS A robot must protect its own existence as long as such protection does not conflict with the First or Second Law. 11-10-2025 6 COMPUTER AIDED DRUG DEVELOPMENT

7. 11-10-2025 7 COMPUTER AIDED DRUG DEVELOPMENT AUTOMATION?

8. 11-10-2025 8 COMPUTER AIDED DRUG DEVELOPMENT Robotic process Automation (RPA) is more about the software containing a set of commands that communicate with digital systems which leads to perform or complete the repetitive process-oriented task more efficiently. In pharmaceutical industry, robots providing help in filling, inspection, packaging, in laboratory process and manufacturing of personalized medicines.

9. FEEDBACK CONTROL AUTOMATION SEQUENTIAL AUTOMATION COMPUTER AUTOMATION 11-10-2025 9 COMPUTER AIDED DRUG DEVELOPMENT Feedback Control Automation Sequential Automation Computer Automation TYPES OF AUTOMATION

10. FEEDBACK CONTROL AUTOMATION SEQUENTIAL AUTOMATION COMPUTER AUTOMATION 11-10-2025 10 COMPUTER AIDED DRUG DEVELOPMENT A system where the output is measured and compared with a desired setpoint, and corrections are made automatically to reduce the difference between the actual output and the desired results. Eg: temperature regulation in a chemical reactor during the drug manufacturing process.

11. FEEDBACK CONTROL AUTOMATION SEQUENTIAL AUTOMATION COMPUTER AUTOMATION 11-10-2025 11 COMPUTER AIDED DRUG DEVELOPMENT Automation that performs tasks in a specific sequence , often based in predefined logic and timing. Eg: A Laboratory robot performing a sequence of tasks such as pipetting, mixing and incubation.

12. FEEDBACK CONTROL AUTOMATION SEQUENTIAL AUTOMATION COMPUTER AUTOMATION 11-10-2025 12 COMPUTER AIDED DRUG DEVELOPMENT Automation that relies in computers to control process, makes decisions or perform repetitive tasks. These systems use software and algorithms to handle complex operations. Eg: computational models for simulating drug interactions or chemical reactions

13. 11-10-2025 13 COMPUTER AIDED DRUG DEVELOPMENT USE CASES Electronic batch record review Pharmacovigilance Trial Master Files Regulatory Submission Financial record keeping and reporting

14. 11-10-2025 14 COMPUTER AIDED DRUG DEVELOPMENT USE CASES Electronic batch record review Ensuring all documents needed is actually included and that information collected from different systems involved in the process is coherent with and within operational parameters If the bot detects any inconsistency, that requires human evolution. The robotic process automation solution can be programmed to report the issue to one or more users before proceeding with the next steps of the process. Bots can be used to perform batch record review activities.

15. 11-10-2025 15 COMPUTER AIDED DRUG DEVELOPMENT USE CASES Pharmacovigilance C urrently, companies tend to manually manage case reports because the data vary in quality, structure and format and are not easily integrated. Eudra vigilance database - tracks individual case study reports of suspected disease states. A bot can access the Eudra vigilance database and download the ICRSs on a daily basis. Pharmacovigilance is one of the main areas that benefits robotic process automation.

16. 11-10-2025 16 COMPUTER AIDED DRUG DEVELOPMENT USE CASES Trial Master Files Data entry and documents upload are manually performed, and when a trails involved multiple contract research organizations, uses bots to load and index documents with the eTMF. Optical Character Recognition technology could improve reliability and litigate risk by eliminating errors and improve accuracy. TMF or eTMF - master data used to record and integrate all activities of clinical trails.

17. 11-10-2025 17 COMPUTER AIDED DRUG DEVELOPMENT USE CASES Regulatory Submission Steps to bring value with RPA include mapping the document landscape to understand compliance requirements , walking through the as-is process to identify pain points and areas for improved user experience, development a new automated workflow enabled by RPA , and proving the technology can manage the new workflow with better compliance at a reduced cost. In regulatory submission process, RPA can speed up the process like status checking, creating record dossier, etc..

18. 11-10-2025 18 COMPUTER AIDED DRUG DEVELOPMENT USE CASES Financial record keeping and reporting It makes it easier to manage tax and legal activities . If the process and final report submission are completely automated, the time needed for the reconciliation of transaction data may be reduced from days to hours while accuracy is improved. RPA helps in streamline data workflows, data verification and scheduling during account reconciliation.

19. 11-10-2025 19 COMPUTER AIDED DRUG DEVELOPMENT ROBOTS IN PHARMA INDUSTRY

20. 11-10-2025 20 COMPUTER AIDED DRUG DEVELOPMENT ROBOTS IN PHARMA INDUSTRY First Robots are commercially viable in early 1970 for rugged and repetitive works like welding and handling in automotive manufacturing lines. The first ABB (ASEA Brown Boveri) robot, was installed in 1974 in the automotive field. Since more than 1,50,000 have been installed globally including a large proportion in the pharmaceutical field. These robots are more than liquid handlers, that provide a mechanical arm for high throughput screening system, it moves sample from one instrument to another.

21. 11-10-2025 21 COMPUTER AIDED DRUG DEVELOPMENT APPLICATION OF ROBOTS IN PHARMA INDUSTRY Research and Development Laboratory robotics Control systems Vision systems Sterilization and Clean room Flexible feeding Packaging operation Liquid handling Robotic automation of HPLC laboratories Grinding application Sterile syringe filling Biopharma and diagnostic application

22. 11-10-2025 22 COMPUTER AIDED DRUG DEVELOPMENT RESEARCH AND DEVELOPMENT In high throughput screening, millions of compounds are tested to determine which could become a new drug. This bots can test millions of compound which can speed up the process significantly and helps these repetitive process and tasks.

23. 11-10-2025 23 COMPUTER AIDED DRUG DEVELOPMENT LABOROTORY ROBOTICS Using laboratory robots, new experimental procedures are eliminating human miscalculation in washing and transferring. This includes experiment in radioactive, fluorescent and luminescent analysis. Laboratory robotics are helping to meet the needs of increased productivity, reduced cost and drug development time.

24. 11-10-2025 24 COMPUTER AIDED DRUG DEVELOPMENT LABOROTORY ROBOTICS Common geometry of laboratory robots are, Cartesian ( three mutually perpendicular axes)

25. 11-10-2025 25 COMPUTER AIDED DRUG DEVELOPMENT LABOROTORY ROBOTICS Common geometry of laboratory robots are, Cylindrical ( parallel action arm pivoted about a central point)

26. 11-10-2025 26 COMPUTER AIDED DRUG DEVELOPMENT LABOROTORY ROBOTICS Common geometry of laboratory robots are, Anthropomorphic (multijointed, human like configuration)

27. 11-10-2025 27 COMPUTER AIDED DRUG DEVELOPMENT CONTROL SYSTEMS Most robots have onboard controllers that communicate with other machines by programmable logic controller or with personal computers. These robots are connected with PCs for networking and for graphical user interfaces

28. 11-10-2025 28 COMPUTER AIDED DRUG DEVELOPMENT VISION SYSTEMS This systems is a valuable tool for determining the accuracy of text and graphics in pharmaceutical and medical packaging. And the chief benefit is the speed. It inspect in less then two minutes which could manually take about 30 to 50 mins.

29. 11-10-2025 29 COMPUTER AIDED DRUG DEVELOPMENT STERLIZATION AND CLEAN ROOMS Bots are adopted to work in aseptic environments . Clean room robots protects the sterile environment from potential contamination. These robots includes low flake coatings on robotic arm, stainless steel fasteners, special seal materials and enclosed cables.

30. 11-10-2025 30 COMPUTER AIDED DRUG DEVELOPMENT FLEXIBLE FEEDING Bots are better than hard automations in feeding and handling of multiple type of products. Traditionally high-speed automated bowl feeders that vibrate parts and feed them to fillers, labelers or product transfer mechanisms. But this bowl feeders can’t always handle a variety of products at once and their vibrations can damage fragile parts.

31. 11-10-2025 31 COMPUTER AIDED DRUG DEVELOPMENT PACKAGING OPERATION In packaging robots benefits speed and repeatability than automations. Robots perform more efficiently than dedication machine in carton loading, sealing, labelling, etc.

32. 11-10-2025 32 COMPUTER AIDED DRUG DEVELOPMENT PACKAGING OPERATION Innovative liquid handling of flexible pipetting platforms brings improved efficiency and safety in laboratory. It includes scalable sample storage and retrieval systems with unique sample tube technology, cutting edge detection instruments, microplate washers and micro array products.

33. 11-10-2025 33 COMPUTER AIDED DRUG DEVELOPMENT ROBOTIC AUTOMATION OF HPLC LABORATORIES Through the use of interchangeable hardware and an endless variety of separation media, almost any type of chromatographic separation is possible.

34. 11-10-2025 34 COMPUTER AIDED DRUG DEVELOPMENT GRINDING APPLICATION Manual grinding is tough, dirty and noisy. The metal dust produced by grinding is harmful to workers eyes and lungs. Grinding robots save manufacturing employees form having to endure hazardous work environment.

35. 11-10-2025 35 COMPUTER AIDED DRUG DEVELOPMENT STERILE SYRINGE FILLING Stericlean +, it is a collaboration product of three companies Stabuli , ATS and Sanofi-Aventis. An arm robot used for handling and filling of liquids. It replaced the manual process of filling and provides increase in productivity.

36. 11-10-2025 36 COMPUTER AIDED DRUG DEVELOPMENT BIOPHARMA AND DIAGNOSTIC APPICATION Bots provide offer high throughput and ensure reproducible, accurate results in many areas like. Genomics Cells and proton science forensics

37. 11-10-2025 37 COMPUTER AIDED DRUG DEVELOPMENT BIOPHARMA AND DIAGNOSTIC APPICATION It has a wide range of biopharma applications with automated solutions for, Cell culture Nucleic acid extraction Protein crystallography ADME screening PCR(Polymerase chain reaction) application

38. 11-10-2025 38 COMPUTER AIDED DRUG DEVELOPMENT ROBOTS USED IN PHARMACEUTICAL INDUSTRY

39. 11-10-2025 39 COMPUTER AIDED DRUG DEVELOPMENT ROBOTS USED IN PHARMACEUTICAL INDUSTRY Pharmaceutical Container Replacement Robots Cylindrical Robot for High Throughput Screening Six Axis Robot Suit Class I Clean Room Applications Space Saving Ceiling Mounted Robot Metal Detector Targets Pharmaceutical Industry

40. 11-10-2025 40 COMPUTER AIDED DRUG DEVELOPMENT PHARMACEUTICAL CONTAINER REPLACEMENT ROBOTS These robots are capable of navigating tight spaces at factories for the purpose of transporting containers used in the manufacturing process. This bots can lift up to 200Kgs of containers or packed products. It only needed to be charged once per day. These are safe and easy to use. These are freely programmed and customized for manufacturing. Now it working on the production line where they have boosted productivity by 30%.

41. 11-10-2025 41 COMPUTER AIDED DRUG DEVELOPMENT PHARMACEUTICAL CONTAINER REPLACEMENT ROBOTS

42. 11-10-2025 42 COMPUTER AIDED DRUG DEVELOPMENT CYLINDRICAL ROBOT FOR HIGH THROUGHPUT SCREENING A new 4 axis cylindrical robot for DNA screening in forensic science. Drug development, bacterial resistance and toxicology. It usually mounted on a track , which is 5 metres long. It moves the samples from one instrument to another according to the protocol decided by the user. Advanced drives create swift and smooth motion while maintaining quiet operation in the laboratory.

43. 11-10-2025 43 COMPUTER AIDED DRUG DEVELOPMENT CYLINDRICAL ROBOT FOR HIGH THROUGHPUT SCREENING KUKU KR 1000 TITAN robot is the world’s first industrial robot that can lift a payload of 1000 Kgs and gained a place in Guinness Book Of Records.

44. 11-10-2025 44 COMPUTER AIDED DRUG DEVELOPMENT SIS AXIS ROBOTS SUIT CLASS I CLEAN ROOM APPLICATION These bots move in six axis and brings precision motion to clean room assembly. With integrated vision and embedded networking , robots target the customers in solar, disk drive, LCD, semiconductor and life science markets.

45. 11-10-2025 45 COMPUTER AIDED DRUG DEVELOPMENT SIS AXIS ROBOTS SUIT CLASS I CLEAN ROOM APPLICATION

46. 11-10-2025 46 COMPUTER AIDED DRUG DEVELOPMENT SPACE SAVING CEILING MOUNTED ROBOT S 800 series Cobra Robot is a ceiling mounted version of assembly and packaging robot by ADEPT TECHNOLOGY. This inverted robot offers several advantages like high-speed packaging and assembly with a wider reach leaving much clearer working area. It also setup with vision support of four cameras helps to identify the products on the conveyer belt to pick up and pack or drop.

47. 11-10-2025 47 COMPUTER AIDED DRUG DEVELOPMENT SPACE SAVING CEILING MOUNTED ROBOT .

48. 11-10-2025 48 COMPUTER AIDED DRUG DEVELOPMENT METAL DETECTOR TARGETS PHARMACEUTICAL INSUSTRY These bots screens pills and capsules out feed of tablet presses and capsule filling machines used to detect the metal contaminations. It offers angular adjustments of 20º to 40º . It has a stainless steel finish open frame design-polished. To improve the hygiene, cables and pneumatics are contained within the stand. Mounting bars have round profile to remove risk of debris and bacteria traps.

49. 11-10-2025 49 COMPUTER AIDED DRUG DEVELOPMENT METAL DETECTOR TARGETS PHARMACEUTICAL INSUSTRY

50. 11-10-2025 50 COMPUTER AIDED DRUG DEVELOPMENT ADVANTAGES TIRELESSNESS – bots can perform 100 men hour projects in 10 hours with more consistency and quality. RETURN OF INVESTMENT – increase in quality and speed, the benefits of increased production achieves increased ROI. ACCURACY & QUALITY – robots are more accurate and consistent than humans. And thereby increase quality means of precision.

51. 11-10-2025 51 COMPUTER AIDED DRUG DEVELOPMENT ADVANTAGES SPEED – Robots work efficiently, without wasting movements or time, breaks or hesitation, robots are able to improve the productivity. SAFETY – Workers are moved to supervisory roles, so no longer they need to perform dangerous roles. FLEXIBILITY – robots can easily reprogrammable, thereby expands the application, specific abilities of packaging robots.

52. 11-10-2025 52 COMPUTER AIDED DRUG DEVELOPMENT ADVANTAGES SMALLER IS BETTER – The robots gives researchers the advantages of using tiny quantities of assay and to keep sample safe while moving in the laboratory. REDUCED CONTAMINATION – removing people from the screening process reduced the potential for contamination and dropping samples while handling. CAN WORK CONTINUOSLY IN ANY ENVIRONMENT.

53. 11-10-2025 53 COMPUTER AIDED DRUG DEVELOPMENT DISADVANTAGES DANGERS AND FEARS – the principle of ability of robot intelligence to exceed that of humans could develop a conscience and a motivation to take over or destroy human race. EXPERTIES – Employees require training in programming and interaction with the new robotic equipment's, EXPENSES SAFETY – robots protect workers form some hazards, but in meantime, their prescence can create other safety problems must taken into considerartions .

54. 11-10-2025 54 COMPUTER AIDED DRUG DEVELOPMENT CHALLENGES AND RISKS

55. 11-10-2025 55 COMPUTER AIDED DRUG DEVELOPMENT CHALLENGES AND RISKS Room for equipment Storage space Bots occupy a large space on the manufacturing area. No doubt this boost the production rate but increasing the production at considerable amount, there is need to increase the size of the facility. Not only the floor space and also the storage space of the packaging and stocking too. ROBOTS >>>>>>> LARGER INVESTMENT >>>>>>>>>> RISK OF ROI

56. 11-10-2025 56 COMPUTER AIDED DRUG DEVELOPMENT CHALLENGES AND RISKS ROBOTS >>>>>>> LARGER INVESTMENT >>>>>>>>>> RISK OF ROI

57. 11-10-2025 57 COMPUTER AIDED DRUG DEVELOPMENT CHALLENGES AND RISKS Work space adaptation and skill development Necessity of employee retraining programs to equip workers with the technical skills to manage and maintain robotic systems. LACK OF SKILLS >>>>>>>>>> UNEMPLOYEMENT

58. 11-10-2025 58 COMPUTER AIDED DRUG DEVELOPMENT CHALLENGES AND RISKS Cybersecurity consideration in automated facilities Security measures and backup systems are required to protect sensitive information and operational integrity. FIREWALL PROTECTIONS >>>>>>>>>> LARGER INVESTMENT

59. 11-10-2025 59 COMPUTER AIDED DRUG DEVELOPMENT CHALLENGES AND RISKS Addressing Job displacements and workspace evolution While automation reshapes job roles rather than eliminating them entirely, companies must invest in reskilling initiatives to ensure a smooth transition for employees into new technology driven roles. UPSKILLING >>>>> ADAPTIVE JOB POSITIONS >>>>> IMPROVES COMPANY VALUE

60. 11-10-2025 60 COMPUTER AIDED DRUG DEVELOPMENT FUTURE OF ROBOTICS

61. 11-10-2025 61 COMPUTER AIDED DRUG DEVELOPMENT FUTURE OF ROBOTICS COBOTS Next generation collaborative robots seamlessly integrate into pharmaceutical operations, working alongside human professionals. Its key role is in the development of personalized medicine . Equipped for the interactive laboratory procedures.

62. 11-10-2025 62 COMPUTER AIDED DRUG DEVELOPMENT FUTURE OF ROBOTICS COBOTS vs ROBOTS

63. 11-10-2025 63 COMPUTER AIDED DRUG DEVELOPMENT FUTURE OF ROBOTICS COBOTS ROBOTS Perform multiple tasks Easy to program and install Interact with humans Light weight Machine learning skills Easy to place in different environment Perform single specific tasks Need a specialist to install No Interaction with humans Heavy weight to perform rough tasks No Machine learning skills Placed in single environment

64. 11-10-2025 64 COMPUTER AIDED DRUG DEVELOPMENT FUTURE OF ROBOTICS ROBOTICS & PHARMA 4.0

65. 11-10-2025 65 COMPUTER AIDED DRUG DEVELOPMENT FUTURE OF ROBOTICS

66. 11-10-2025 66 COMPUTER AIDED DRUG DEVELOPMENT Big Leads Of Pharma Robot Industries

67. 11-10-2025 67 COMPUTER AIDED DRUG DEVELOPMENT REFERENCES: Subham Mukherjee, DR. Falguni Patra, et al. Robotics in Pharmaceutical Manufacturing. World Journal of Pharmaceutical and Medical Research.2021;7(6):369-375. Sandeep Suresh Khandagale , Nalawade Omkar Bappasaheb , et al. Role of Pharmaceutical Automation and Robotics in Pharmaceutical Industry: A Review. A Multifaced review journal in the field of Pharmacy.2024;15(3):131-135. Applying Robotic Process Automation in the Pharma Industry | Pharmaceutical Engineering

68. 11-10-2025 68 COMPUTER AIDED DRUG DEVELOPMENT PHARMACEUTICAL AND INDUSTRIAL APPLICATIONS OF ROBOTS IN CURRENT CLINICAL SCENARIO: A RECENT REVIEW | PharmaTutor The Rise of Pharma Robots: Transforming Drug Manufacturing and Research | RoboticsTomorrow The future of robotics in the pharmaceutical industry. Pharma 4.0 Operating Model | Industry 4.0 | ISPE | International Society for Pharmaceutical Engineering

69. 11-10-2025 69 COMPUTER AIDED DRUG DEVELOPMENT