Role Of Lenalidomide in Multiple Myeloma Treatment

This presentation explains Multiple Myeloma, a cancer of plasma cells, and the role of Lenalidomide in its treatment. It covers causes, symptoms, diagnosis, and major therapy options like chemotherapy, stem cell transplant, and immunomodulatory drugs. The slides also highlight how Lenalidomide works, its safety considerations, and the availability of generic versions that improve access and affordability, including awareness of use in the Philippines.Learn more at www.Letsmeds.com.

1. [OM ee

MULTIPLE

UNDERSTANDING ES

and the Role of Lenalidomide i

2. Wow

TENTS

Overview of Multiple Myeloma

How the Disease Develops

Risk Factors and Diagnosis

Treatment Options

Introduction to Lenalidomide

Clinical Role of Lenalidomide

3. WHAT IS IT?

- Cancer of plasma cells found in bone
marrow

- Plasma cells normally produce
antibodies to fight infections

- In myeloma, these cells become
cancerous

- Forms tumors in multiple areas of
bone

CELL BEHAVIOR

- Abnormal plasma cells multiply
rapidly

- Crowd out healthy blood cells
- Produce abnormal antibodies
called M proteins

- Interfere with normal immune

function

COMMON SIGNS

- Bone pain, especially in spine
and chest

- Fatigue due to anemia

- Frequent infections

- Kidney problems

- Elevated calcium levels

- Unexplained weight loss

4. ABNORMAL ANTIBODY PRODUCTION

- Cancerous plasma cells produce abnormal antibodies (M proteins)
- These proteins accumulate in blood and organs

ORGAN DAMAGE

- High calcium levels from bone breakdown
- Protein buildup can damage kidneys
PROGRESSION PATTERN

- Some cases progress slowly over years
- Others advance rapidly and aggressively

5. RISK FACTORS BLOOD TESTS

- Age: Most common in people - Complete blood count
over 65 (BC)

© Gender: Siighllymöre - Blood chemistry tests
common in men
- Race: Higher rates in African

- Protein electrophoresis

- Immunofixation

‘Americans . .
e . - Free light chain assay

- Family history increases risk

- Certain genetic abnormalities

- MGUS condition (precursor)

- Urine tests for proteins

BONE TESTS

- Bone marrow aspiration
- Bone marrow biopsy

- Cytogenetic testing

- Fluorescence in situ
hybridization (FISH)

- Gene expression
profiling

IMAGING

- X-rays to detect bone
damage

- MRI scans

- CT scans

- PET scans

- Bone density tests

- Whole-body low-dose CT

6. OVERVIEW CHEMOTHERAPY STEM CELL TRANSPLANT

- No permanent cure currently exists - Traditional chemotherapy drugs - Autologous (using own stem cells)
- Treatment aims to control - Targeted therapy medications - Allogeneic (donor stem cells)
symptoms - Immunomodulatory drugs (IMiDs) - Often follows high-dose chemo
- Extend survival and quality of life like lenalidomide
RADIATION SUPPORTIVE CARE
- Used to target specific areas - Bisphosphonates for bone health
- Relieves bone pain - Medications for kidney function
- Treats bone lesions - Pain management

- May prevent fractures - Prevention of complications

7. Lenalidomide is a powerful immunomodulatory drug that plays a crucial role in modern multiple myeloma treatment protocols. It works through multiple
mechanisms to control cancer progression while supporting the body's natural defenses. Understanding how this medication functions helps patients
appreciate its importance in their treatment journey.

MEDICATION

- Used to treat multiple myeloma
- Also treats myelodysplastic
syndromes

-Oral medication taken daily

- Available in various strengths
Requires prescription

IMIDS

-Partofimmunomodulatory drugs - Directly inhibits myeloma cells Enhances T-cell activation

= Known as IMIDS or CELMoDs
-Contains an imide group

+ Related to thalidomide
More potent, fewer

effects

CANCER GROWTH IMMUNE SYSTEM INFLAMMATION

= Reduces bone marrow
Inflammation
Modifies tumor microenvironment

Disrupts cell division process -Increases natural killer cells
- Decreases pro-inflammatory

= Prevents formation of new cells -Improves immune surveilance na,

- Induces cancer cell death Helps recognize cancer cells

Improves bone marrow function
- Targets specific cellular pathways - Strengthens immune response | Supports healthy blood cell

production

8. COMBINATION THERAPY SURVIVAL BENEFITS

Most commonly paired with dexamethasone (steroid) Clinical als show significant survival advantages
= The Rt regimen sa standard treatment approach - Extends progression-free survival by months to years
May be combined with proteasome inhibitors Ike bortezomib May improve overal survival ates

- Tile combinations show improved response rates Benefits observed across diferent patient groups

- Dosage carefully adjusted based on patient factors. MAINTENANCE TREATMENT - Particularly effective in high-risk disease variants

= Treatment cycles typically run 21-28 days Quality off often maintained during treatment
Regular monitoring ensures optimal effectiveness _ Used after nal treatment to maintain emission Long term data continues to support ts use

Particularly valuable after stem cell transplantation
- Prevents or delays disease recurrence

- Lower doses than in active treatment phase

= Continued until disease progression or intolerance

= Regular follow-up appointments monitor effectiveness
- Dose adjustments made based on side effects

9. =

SIDE EFFECTS

- Fatigue and weakness are common
- Blood count reductions may occur

PREGNANCY RISKS

- Causes severe birth defects

- Absolutely contraindicated in pregnancy
MONITORING REQUIREMENTS

- Regular blood tests required
- Dose adjustments based on results

10. - Multiple manufacturers produce generic versions

- Indian pharmaceutical companies are major producers
- Contains identical active ingredient as branded drug

- Subject to strict regulatory oversight and quality control
- Bioequivalence testing ensures similar effectiveness

- Significantly lower price than branded versions

- Makes treatment accessible to more patients

- Particularly important in regions with limited resources
- Helps reduce financial burden of long-term treatment

- Available through authorized importers and pharmacies

11. AUTHENTIC MEDICINES
- Sources genuine Indian cancer medications

COMPETITIVE PRICING
- Affordable options for life-saving treatments

ACCESSIBILITY FOCUS
- Transparent sourcing and easy ordering process

PATIENT TRUST
- Thousands rely on LetsMeds for oncology drugs

12. Website: www.letsmeds.com
Email: [email protected]
Call/WhatsApp/Viber: [phone]

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