Seminor on fututre biotech

Biotechnology

1. Nirmal Kumar Biotechnology Department SVNIET Safedabad Barabanki Biotechnology in India & its Application

2. Biotechnology is application of molecular and cell biology tools to solve problems of health, agricultural and the environment The discovery of DNA structure in 1955 revolutionized biology Biotechnology tools include cloning, genetic modification, genetic screening What is biotechnology? Biotechnology can provide Sustainable Growth, Healthy Lifestyle and Environment

3. Simply put, Biotechnology is set of tools that uses in cellular & and molecular process to solve problem or make product

4. Bioinformatics (Computational BT) Blue Biotechnology (Marine and aquatic application) Green Biotechnology (agricultural application) Red Biotechnology (Medical application) White Biotechnology (Industrial products) Branch of Biotechnology

5. How Biotechnology Story began in India Indian biotech story began with Biocon in 1978. Initiative in early 1980’s Agencies - DST, CSIR, ICAR, ICMR, UGC National Biotechnology Development Board – 1982 Department of Biotechnology – 1986 India is the first country in the world to create a separate Department of Biotechnology (DBT) under the Ministry of Science & Technology in 1986 Indian biotech made its presence on the world map in 1997, when Hyderabad based Shantha Biotechnics launched the indigenously developed hepatitis B vaccine, Shanvac.

6. Biotechnology Applications Life Sciences Medicine Pharmaceuticals New forms of treatment Vaccines Diagnostics Forest industry Control of biodeposits Fibre modification Bleaching of pulp Waste water treatment Bioprocesses Production of chemicals Production of enzymes Fermentation Biocatalysis Materials Biomaterials for medical applications Modification of raw materials Agriculture and environment Plant and animal breeding Treatment of biowaste Biofuels Food and feed Functional foods Food analytics Production methods Components

7. Biotechnology Applications Virus-resistant crop plants and livestock Diagnostics for detecting genetic diseases and acquired diseases Therapies that use genes to cure diseases Recombinant vaccines to prevent disease Biotechnology can also aid the environment

8. "New Drugs/Medicines/Vaccines ", "Artificial organs" "DNA analysis: be it for forensic research or for exploratory purposes", "Food Production and ways to enhance productivity ", "New Diagnostic Equipment", "Environment friendly products and services ", "Nutrient supplements", "New Apps being developed for various smart phones to probe physiological parameters“,. The future of this field is thus very bright!

9. TYPES OF BIOTECHNOLOGY Recombinant, R protein, R DNA Genetically Modified Organism (GMO) Antibody (monoclonal antibody) Transgenic Gene therapy, Immunotherapy Risks and advantages of biotech

10. PRODUCTS OF BIOTECH

11. PRODUCTS OF BIOTECH Banana Geranium Gerbera Gladiolus Jatropha

12. Shanvac-B (r-DNA Hepatitis B Vaccine) is India's first recombinant vaccine and is produced in the yeast Pichia pastoris. Hepatitis B vaccine is used for the prevention of the deadly liver infection Hepatitis B which can lead to liver failure or cancer. Shanvac-B is India’s first WHO-Geneva pre-qualified Hepatitis-B vaccine. Bharat Biotech recently launched the world’s first clinically proven typhoid conjugate vaccine, Typbar – TCV, for infants above six months and adults PRODUCTS OF BIOTECH

13. A new rice based vaccine promises effective treatment for the dreaded Cholera Other diseases targeted for rice based vaccines include the pesky influenza and the much dreaded HIV Gene-modified potato seeds would enhance the crop’s overall resistance against blight, a commonly found disease in potato. Giant Strides in crop biotechnology

14. Tomatoes, with their abundant lycopene, may defend against cancer by protecting DNA from oxidative damage Broccoli sprouts contain an abundance of the cancer-fighting phytochemical sulforaphane   Rich in flavonoids – apples may protect against lung cancer Garlic, with it’s abundant allicin , may lower blood cholesterol and protect against stomach cancer

15. A newly uncovered mechanism for clearing common brain blood clots provides a potential therapeutic target for stroke recovery and age-related cognitive disorders. C.K. Lam et al, Nature, 2010 May 27, 465(7297): 478-82. Eval by Jaime Garcia- Anoveros , Northwestern University; Ray Rodgers, University Adelaide. Brain Blood Busters

16. Super E. Coli The mother cell of E. Coli maintains a constant growth rate throughout its replicative life (hundreds of cell divisions), despite accumulating damage and an increased probability of death, suggesting that growth and aging are decoupled, unlike all other studied aging models . P. Wang et al, Current Biology, 2010 May 26, 20:1099-1103. Eval by Roy Kishony , Harvard Univ.; Thomas Meier, Max Planck Institute Biophysics.

17. First implantable artificial kidney could remove demand for dialysis and donor organs U.S researchers have just unveiled the first prototype model of the artificial kidney that would be implanted inside the body and work as well as a living organism and could eliminate the need for dialysis. The kidney is being developed in a collaborative effort by engineers, biologists and physicians led by Dr. Shuvo Roy at the University of California San Francisco. The treatment has already been proven to work for the sickest patients using a room-sized external model. The process relies on the body's blood pressure to perform filtration without needing pumps or an electrical power supply. The artificial kidney will be the size of a coffee cup. Blood will be pumped through microscopic filters using the body's own blood pressure

18. Scientists successfully grow 'mini-brains' from stem cells Scientists have successfully grown complex human brain tissue from stem cells using a new 3D culture system, according to a study published in the journal Nature. Researchers from the Institute of Molecular Biotechnology (IMBA) at the Austrian Academy of Sciences ( OeAW ) say the newly created tissue could be the start of developing model systems for the human brain

19. India among top 10 growers of biotech crops About 32 percent of the global cotton cultivation area Contributes 21 percent of the global cotton produce, second after China. Provides employment to around 42 million people directly or indirectly. Production increased more than double from 13.6 million bales in 2002-2003 to 35.5 million bales in 2011-2012. Over the past few years, India has even managed to produce at least six to nine million bales more than required for domestic consumption. An importer country became an exporter country

20. Benefits of Human Genome Project Improvements in medical prevention of disease, gene therapies, diagnosis techniques Production of useful protein products for use in medicine, agriculture, bioremediation and pharmaceutical industries. Improved bioinformatics – using computers to help in DNA sequencing …

21. Biotechnology India: The Infrastructure Advantage Institutions & Manpower Number of hospitals : 16,000 Number of doctors : 500,000 Number of research institutions : 200 Number of Scientists : 25,000 Medical graduates produced : 17,500 per yrs Science graduates produced : 500,000 per yrs Number of Agriculture Univs . : 40

22. Major Biotech Companies Biocon Serum Institute of India Panacea Biotech Nicholas Piramal Wockhardt Limited GlaxoSmithKline Bharat Serums Krebs Biochemical's & Industries Ltd Zydus Cadila Indian Immunologicals Shantha Biotechnics Chiron Behring Vaccines Eli Lilly and Company Novo Nordis Mahyco Monsanto Bharat Biotech Abbott Ranbaxy Novozymes Biological E

23. Organizations in India working for the growth of the biotechnology industry Association of Biotechnology Led Enterprises (ABLE) Association of Diagnostic Manufacturers of India (ADMI) Association of Contract Research Organizations (ACRO) Indian Society for Clinical Research (ISCR) All India Crop Biotechnology Associations (AICBA) All India Biotech Association (AIBA)

24. Funding Agencies in area of Biotechnology APIDC Venture Capital Limited Gujarat Venture Capital IDBI Venture Capital SIDBI Ventures ICICI Ventures UTI Ventures And Several Others

25. Biotech Knowledge Providers Council of Scientific and Industrial Research Indian Council of Medical Research Indian Council of Agriculture Research Indian Institute of Science, Bangalore Indian Institute of Technology Private Institutions

26. Five bioclusters are emerging in the country- Bangalore * Hyderabad * Mumbai-Pune New Delhi- Lucknow * Chennai Three of these clusters have already found a place in a recent global listing of bioclusters by a US-based agency. Source : Biospectrum

27. Why did a Biocluster arise in Lucknow ? Expertise of over 400 Scientists, 700 Technicians and 500 Research Students

28. Park holding hands of 15 biotech units Biopharma - TWO Lifecare Innovation Pvt. Ltd. Chandan Healthcare Pvt. Ltd. Bio- Agri (PPP mode) - TWO Sheel Biotech Pvt. Ltd. Hindustan Bioenergy Ltd. - Expanded its activities in 28 acres of land at Kundanganj District, Raebareli Bioinformatics & Bioservices – Five Institute of Biological Sciences ACS Informatics Pvt. Ltd. Software Technology Parks of India Acadia Research Lab. Pvt. Ltd. Genetech BioLabs Private Limited Health area (diagnostics, herbal cosmetics, nutraceuticals) – Six India Pesticides Limited: ABC Genomics (India) Pvt. Ltd Amor Herbals Pvt. Ltd. CIMAP – Point of Presence Super Biofresh Pvt. Ltd . SKiES Life Technologies Pvt. Ltd.- has 2 acres of land at UPSIDC Food Park

29. TOP 10 biotech companies (in revenues)

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