Semisolid dosage form

Semisolid dosage Form:- Defination & Classification

1. Semisolid Dosage Form Definition & Classification Submitted By:- Suyash Jain B Pharm (1 st sem ) Department of Pharmaceutical Sciences Dr. HariSingh Gour University Sagar(M.P.)

2. SEMISOLID DOSAGE FORMS

3. Semisolid Dosage Form DEFINATION:- Semisolid dosage forms are dermatological preparations intended to apply externally on the skin to produce local or systematic effect . They contain one or more active ingredients dissolved or uniformly dispersed in a suitable base and any suitable excepients.

4. Site of Application Intended for tropical applications Treatment of Dermal disorders Applied as following:- To the skin Placed on eye surface Used nassaly Introduced into body cavities

5. Ideal properties Semisolid dosage forms Physical Properties Smooth texture Elegant in apperance Non dehydrating Non gritty Non greasy and non staining Non hydroscopic Physiological Properties Non irritating Do not alter membrane/skin functioning Miscible with skin secretion Have low sensitization index Application Properties Easily applicable with efficient drug release Have aqueous wash ability

6. Used externally. •Probability of side effect can be reduce. •Local action and Site specific action of drug on affected area. •Convenient for unconscious patient or patient having difficulty on oral administration. •Suitable dosage form for bitter drugs. •More stable than liquid dosage form. No dosage accuracy in this type of dosage form •Base used can be easily oxidized. •May cause staining. •Bulky to handle. •Application with finger may cause contamination. •Less stable than solid dosage form. •May cause irritation or allergy to some patients Advantages Disadvantages

7. 1. Ointments Ointments are homogenous, translucent, viscous , semi solid preparation intended for external application . They may or may not be medicated . They are used as:- - Emollients - Protective - Therapeutic - Prophylactic purpose

8. A- Epidermic ointments :- intended to produce their action on the surface of the skin. They are not absorbed and produce local effect and acts as protectives , antiseptics and parasiticides . B- Endodermic ointments :- intended to release the medicaments that penetrate into the skin . They are partially absorbed and acts as emollients, stimulants and local irritants . C- Diadermic ointments :- intended to release the medicaments that pass through the skin and produce systemic effects . On the basis of penetration

9. On the basis of Therapeutic use Anti-biotic ointments Anti-fungal ointments Anti-inflammatory ointments Anti- pruritic ointments Counter Irritant ointments Anti-dandruff ointments

10. 2. Creams Creams are homogeneous , semi-solid preparations consisting of opaque emulsion, lipophilic emulsifying agent . Their consistency depend on the type of emulsion, either water-in-oil(w/o) or oil-in–water(o/w) , and on the nature of the solids in the internal phase. Creams are intended for the application to the skin or certain mucous membranes. Examples :- Vanishing cream, Cold cream.

11. 3. Jellies A semisolid dispersion systems containing a gelling agent in sufficient quantities to impart a 3-dimensional polymeric matrix •Provides a cooling sensation when applied to the skin •Usually translucent and non-greasy . •They are used for medication and lubrication .

12. 4. Pastes Pastes are basically ointments into which a high percentage of insoluble solid dispersed in an aqueous or fatty vehicle . Pastes are less greasy and less penetrating than ointments and do not flow at body temperature. Like ointments, pastes forms an unbroken, relatively water– impermeable film , but unlike ointments the film is opaque and therefore, an effective sun block accordingly. Skiers apply pastes around the nose and lips to gain a dual protection. Examples: -Fatty pastes: e.g , zinc oxide paste -toothpaste, mustard.

13. 5. Suppositories Suppositories are semi-solid dosage forms intended for insertion into body orifices (rectum, vagina, urethra) where they melt, soften, or dissolve and exert a local or systemic effect. Local action : Rectal suppositories intended for localized action are most frequently used to relieve constipation or pain , irritation, itching, and inflammation associated with hemorrhoids . Systemic action : e.g., Antiasthmatic , antirheumatic & analgesic drugs).

14. THANK YOU

15. Made by- Mr. Suyash Jain B Pharm (1 st sem) Department of Pharmaceutical Sciences Dr. HariSingh Gour Vishwavidyala Sagar(M.P.)

16. References Jain NK,Sharma SK,“A Textbook of Professional Pharmacy”,Vallabh prakashan,Delhi,2016,edition-6 th ,292-318. Jones D “ FASTtrack Pharmaceutics – Dosage Form and Design ”, Pharmaceutical Press London , 2008 ,edition- 1 st ,75-88.