SMEDDS (Self Micro Emulsifying Drug Delivery System) ->by Mohit kumar

Self micro emulsifying drug delivery system (SMEDDS) is defined as isotropic mixture of oil and surfactants or alternatively one or more hydrophilic solvents and co-solvents.

1. SMEDDS- Self Micro Emulsifying Drug Delivery System PRESENTED BY: MOHIT KUMAR M. PHARMACY (PHARMACEUTICS) 3 rd SEMESTER SETH G. L. BIHANI S. D. COLLEGE OF TECHNICAl EDUCATION (INSTITUTE OF PHARMACEUTICAL SCIENCES & DRUG RESEARCH) GAGAN PATH, SRI GANGANAGAR (RAJ.) 335001, INDIA.   GUIDED BY: DR. MAHESH KUMAR KATARIA DESIGNATION: HEAD, DEPT. OF PHARMACEUTI PHARMACEUTICS

2. Introduction Composition Preparation of SMEDDS Evaluation of SMEDDS Advantages of SMEDDS Applications of SMEDDS Dosage form development Factors affecting SMEDDS Future aspects Contents

3. Self micro emulsifying drug delivery system (SMEDDS) is defined as isotropic mixture of oil and surfactants or alternatively one or more hydrophilic solvents and co-solvents. Oral route is one of the most patient widely used routes for the most of the pharmacologically chronic treatment disease. Up to 40% of new chemical entities discovered by the pharmaceutical industry are poorly soluble or lipophilic compounds, which lead to poor oral bioavailability, high intra and inter subject variability and lack of dose proportionality INTRODUCTION-

4. Lipids (Oils) Surfactants Co-surfactants COMPOSITION-

5. Step 1 – Screening of excipients - (using orbital shaker). Step 2 – To find out correct combination- (using ternary phase diagram). Step 3 – Addition of drug. Step 4 – Solidification- (using adsorption substances). Preparation of SMEDDS -

6. Differential Scanning Calorimetry Fourier transform-infrared spectroscopy Macroscopic evaluation Visual assessment Determination of self-emulsification time Solubility studies Transmittance test Droplet size determination Stability- Temperature Stability , Centrifugation EVALUATION OF SMEDDS-

7. Improvement in oral bioavailability. Ease of manufacture and scale-up. Reduction in inter-subject and intra-subject variability and food effects. Ability to deliver peptides that are prone to enzymatic hydrolysis in GIT. No influence of lipid digestion process. Increased drug loading capacity. ADVANTAGES OF SMEDDS -

8. APPLICATION OF SMEDDS- Super Saturable SMEDDS. Solid SMEDDS. Improvement in solubility and bioavailability. Protection against Biodegradation.

9. Dry emulsions Self-emulsifying Capsules Self-emulsifying Sustained/Controlled-Release Tablets Self-emulsifying Sustained/Controlled-Release Pellets Self-emulsifying Solid Dispersions Self-emulsifying Beads Self-emulsifying Sustained-Release Microspheres Self-emulsifying Nanoparticles Self-emulsifying Suppositories Self-emulsifying Implant DOSAGE FORM DEVELOPMENT-

10. Paclitaxel - Anticancer Fenofibrate , Fluvastatin - Antihyperlipidemic Rapamycin , Cyclosporin - Immunosuppresive Nifedipine - Antihypertensive Ibuprofen, Naproxen- Analgesic Tipranavir - Anti- HIV Progesterone- Hormones Vitamins (A,D,E,K)- Nutritional supplement Acyclovir- Antiviral Melatonin- Immunomodulatory Bioavailability enhancement of some drugs using micron emulsion technology

11. Nature and dose of the drug. Polarity of the lipophillic phase. FUTURE ASPECTS: Supersaturable SMEDDS (S-SMEDDS) Solid SMEDDS FACTORS AFFECTING SMEDDS:

12. Maurya , S.D., et al. (2017) Self-micro emulsifying drug delivery systems ( smedds ): A review on physico -chemical and biopharmaceutical aspect. Journal of drug delivery & therapeutics. 7(3),55-6 Sharma V.K., et al. (2016) Self-micro emulsifying drug delivery systems: A strategy to improve oral bioavailability. Ars pharmaceutica Kyatanwar A.U., et al.(2010) Self micro-emulsifying drug delivery system (SMEDDS) : Review. Journal of pharmacy research 3(1),75-83 Kalamkar P.,et al. (2016) A Review on “Self Micro Emulsifying Drug Delivery System (SMEDDS). IJPPR 6(3) < ijppr.humanjournals.com > [Accessed 1 July 2020] Swarbrick J. (2006) Encyclopedia of Pharmaceutical Technology, Third Edition, Taylor & Francis Self-Micro Emulsifying Drug Delivery Systems: a Strategy to Improve Oral Bioavailability - Scientific Figure on ResearchGate . [Online image]. < https://www.researchgate.net/figure/Flow-chart-for-preparation-of-SMEDDS_fig1_313723924/actions#reference > [Accessed 1 July 2020] Barakoti H. Self-Micro Emulsifying Drug Delivery Systems, 17 february 2018 (2018) .[Online image]. < https://www.slideshare.net/HimalBarakoti/self-microemulsifying-drug-delivery-system-smedds >[Accessed 1 July 2020] REFERENCES

13. THANK YOU & ALL THE BEST