spare receptors.pptx

Receptors

1. spare receptors

2. SPARE RECEPTOR Spare receptor also known as a “reserve receptor” or “efficacy reserve” , refers to a phenomenon in pharmacology where a maximal response can be achieved with only a fraction of the total available receptors being occupied by a drug or ligand. Spare receptors are receptors that remain unbound when an agonist is producing its maximal biologic response

3. SPARE RECEPTOR CONT … to determine the presence of spare receptors , scientists often compare the concentration of drug needed to produce 50% of the maximum effect(ec50) with the concentration of drug needed to occupy 50% of receptors( kd ). Spare receptors act as functional reserves and allows cells to economically use endogenous agonists such as hormones and neurotransmitters. The concept of spare receptors has important implications for drug development and efficacy.

4. SPARE RECEPTOR CONT… It suggests that drugs targeting receptors with spare capacity can still produce a full response even at lower concentrations or with partial receptor occupancy. The existence of spare receptors also highlights the complexity of drug-receptor interactions and the potential for multiple signaling pathways to be activated or modulated. The spare receptors may play a role in maintaining receptor sensitivity and responsiveness in certain physiological or pathological conditions. Overall, spare receptors provide a valuable concept in understanding drug-receptor interactions and have implications for drug design, dosing, and therapeutic efficacy.

5. THANK YOU

6. REFERENCE GOODMAN AND GILMAN'S PHARMACOLOGICAL BASES OF THERAPEUTICS lIPPINCOTT'S ILLUSTRATED REVIEWS WWW.SCRIBD.COM ACCESSMEDICAL.MHMEDICAL.COM