SUBARNA 010_ADV ORG synthesis of heterocycles .pptx

It is helpful for masters student. It is a synthesis of heterocycles.

1. Synthesis of Antipyrin and Promazine Advanced Organic Chemistry Presented By : SUBARNA KANTI MAL M.PHARM(CHEMISTRY) BHARAT THECHNOLOGY ULUBERIYA,HOWRAH

2. CONTENTS : Introduction of Antipyrin . Synthesis and uses of Antipyrin . Introduction of Promazine . Synthesis and usese of Promazine .

3. Antipyrine Antipyrin is an antipyretic agent . Molecular Formula of Antipyrin is – C 11 H 12 N 2 O. It’s most commonly in combination with benzokaine . (1-phenyl-2,3-dimethyl-5-pyrazolne)

4. Synthesis of Antipyrin : Part -1 : (Aniline) ( Diazonium Salt) ( Phenylhydrazine ) Part – 2 :

5. Method of Synthesis From part 1 ,The Aniline are react with NaNo2 and HCl at 273-278 K and give Diazonium salt. The Diazonium salt react with SnCl2 and give Phenylhydrazine . From part 2, The EAA react with Phenylhydrazine heat at 110-120 °C,and give 1-phenyl-3methyl-5-pyrazolone. After that, by the Methylation of 1-phenyl-3methyl-5-pyrazolone give the Antipyrin . Uses : It is used in the ear to help relieve the pain , and swealling . And also used in build up of ear wax in the ear.

6. Promazine Promazine is the phenothiazine derivative. It’s highly sedative H1-Antihistaminic Agent. Molecular Formula of Promazine is C17H20N2S [ N,N-dimethyl-3-(10H-phenothiazine-10-yl)-propan-1-amine ]

7. Synthesis of Promazine : Synthesis of promazine :

8. Method of Synthesis : Diphenylamine reacts with sulfur to give phenothiazine . Promazine can be synthesized from phenothiazine by alkylation with 3-dimethylaminopropylchloride in the presence of sodium amide. USES : Treatment of Schizophrenia. Side Effects : Anticholinergic side effects. Extrapyramidal side effects.

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