Suspension Formulation-Calamine lotion.pptx

To study the preparation of suspensions, specifically Calamine Lotion I.P., and understand the role of suspending and stabilizing agents in maintaining formulation stability.

1. 🌟 Calamine lotion 🌟 Prepare by: Ms. Supriya S. Bhagwat Assistant professor Pharmaceutics School of pharmaceutical Sciences, Kopargaon

2. 1. Practical Significance To study the preparation of suspensions, specifically Calamine Lotion I.P., and understand the role of suspending and stabilizing agents in maintaining formulation stability.

3. 2. Competency and Practical Skills Ability to prepare a suspension formulation. Skill to evaluate physical stability of suspension. Competence in weighing, mixing, levigation, and dispensing.

4. Definition : Suspensions are biphasic liquid dosage forms consisting of solid particles dispersed in a liquid medium with the aid of suspending agents. Calamine Lotion I.P. is a topical suspension with soothing, protective, and antipruritic action, commonly used in itching, insect bites, and mild skin irritations. Functions of Excipients: Calamine: Active ingredient (antipruritic, soothing) Zinc oxide: Astringent, protective Bentonite: Suspending agent Sodium citrate: Stabilizer Liquefied phenol: Preservative Glycerin: Humectant, dispersing agent Water: Vehicle 3. Theory

5. Chemicals : Calamine, Zinc oxide, Bentonite, Sodium citrate, Liquefied phenol, Glycerin, Purified water. Glassware & Equipment : Mortar & pestle, Beakers, Measuring cylinder, Glass rod, Volumetric flask, Amber bottle. 4. RESOURCES REQUIRED

6. Official Formula (I.P.) per 100 mL: Calamine – 15 g Zinc oxide – 5 g Bentonite – 3 g Sodium citrate – 0.5 g Liquefied phenol – 0.5 mL Glycerin – 5 mL Purified Water – q.s. to 100 mL 5. Formula (Mandl’s Throat Paint)

7. Weigh all the required ingredients accurately. Levigate calamine and zinc oxide with glycerin in a mortar until smooth. Add bentonite previously dispersed in purified water. Dissolve sodium citrate in a small quantity of water and add to the mixture. Add liquefied phenol and mix well. Transfer to a measuring cylinder and make up the volume with purified water. Mix thoroughly and transfer into a suitable labeled container. 6. Method of Preparation

8. Ensure proper levigation to prevent grittiness. Avoid excess heating as it may affect stability. Use purified water only. Shake well before use (as suspension settles on standing). 7. PRECAUTIONS

9. Why is bentonite added to Calamine Lotion? What is the role of sodium citrate in the formulation? Why should Calamine Lotion be shaken before use? Differentiate between suspension and emulsion with examples. 8.Question Bank

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