sustainable development_ jammu_half.pptx

sustainable development , atherosclerosis , gene expression

1. International Conference on Advances in Biological Sciences for Sustainable Development Central University of Jammu Department of Zoology

2. Role of the Global Transcriptomic Approaches in finding potential biomarkers for assessing the stage and risk of Atherosclerosis

3. Health in the Framework of Sustainable Development “Health is crucial for sustainable human development, both as an inalienable human right and an essential contributor to the economic growth of society. Health is also a good summative measure of the progress of nations in achieving sustainable development. It contributes to national development through productive employment, reduced expenditure on illness care and greater social cohesion (UN Development Plan 2030)”

4. Atherosclerosis Chronic inflammatory condition of the arteries Atherosclerotic vascular plaques: major pathological basis for cardiovascular diseases (CVD) - ischemic heart disease (IHD), stroke, peripheral vascular disease The annual number of deaths from CVD in India is projected to be 5 million (by 2025)  

5. Several theories of plaque development 4 stages in the development of atherosclerotic lesions

6. .. Intersection of inflammation and lipid metabolism in Atherogenesis Foam cells - produce pro- inflam mediators, ROX & pro-coagulants - local inflammation & thrombotic complications Th1 cells – IFNg - activate endothelium & macrophages Tregs – IL 10 & TGFb

7. Introduction Inflammation is involved in the majority of atherosclerosis stages . Initial phase of atherosclerosis - subendothelial accumulation of lipid molecules The expression of various chemokines and different adhesion molecules VSMCs - migrate to the lesion site and form foam cells - a characteristic feature of atherosclerotic plaques. Later stages of the development – At advanced stages, atherosclerosis is associated with prominent vascular wall thickening and calcification. R upture of the thrombotic plaque and/or blockade of vascular lumen leading to ischemic pathologies.

8. During the evolution of a plaque ; Progression from an early, lipid-rich atheroma (fatty material) to an advanced, fibro-calcified lesion Early detection of vulnerable plaque can identify patients at high risk for such events. Therefore it has become critical to develop improved molecular signature profiles for screening the plaque formation, preferably with stage specific signatures . I dentification of various key molecules and genetic pathways uniquely involved in various stages of atherosclerotic plaque formation can lead to - Development of improved prognostics biomarker(s) and thus, novel therapeutic strategies for CVD

9. BMC Medical Genomics (Springer Nature) Impact Factor: 4.5 Role of cardiologists and life scientists – complementary