Sustained and Controlled Release (SR/CR)

Sustained and Controlled Release drug delivery on novel drug formualtions.

1. SUSTAINED RELEASE (SR) &
CONTROLLED RELEASE (CR)
SUBMITTED BY: RAHUL PAL, PRACHI PANDEY SUBMITTED TO: ARSH CHANANA
M. PHARM (PHARMACEUTICS)
NIMS INSTITUTE OF PHARMACY, NIMS UNIVERSITY JAIPUR, RAJASTHAN IN DIA

2. SUSTAINED RELEASE (SR)
TheSustainedreleasearemajorlydesignedtoachievetheprolongedtherapeuticeffectby
continuouslyreleasingmedicationovertheextendedperiodoftimeusually8-12hr.,after
singledoseadministration.
Especiallytheyprovidethemedicationoverextendedtimeofperiod.
SRreleasefollow1
st
orderreleasekinetics,meansdependsonconcentration.
InOtherwords,“Theslowreleaseofdrugsubstancesfromadosageformtomaintain
therapeuticresponsesforextendedperiodoftime”.
Example:Aspirin,DextrinSR.

3. CONTROLLED RELEASE (CR)
Thedeliveryofthedrugmedicamentatpredeterminedrate,forlocallyandsystematically
forspecifiedperiodoftime,knownas“Controlledrelease”.
Maintaintheconstantdruglevelinthebloodaswellastissues.
CRreleasefollowZeroorderreleasekinetic,meansindependenceofconcentration.
Inshortwords,“Theformulationwhichdeliversthedrugatpredeterminedrate.”
Example:GITS(Prazosin),MorphineSulphate(RoxonalSR
®
)

4. GRAPHICAL REPRESENTATION OF SR/CR
CONTROLLED RELEASED (CR) SUSTAINED RELEASED (SR)

5. STUDY OVERVIEW OF DRUG RELEASE

6. DIFFERENCE BETWEEN SR/CR
SUSTAINED RELEASE (SR)
Dosageformthatprovidemedicationover
extendedperiodoftime.
Follow1
st
orderreleasekinetics.
Usuallydonotpromotelocalizationofthe
drugatactivesite.
Drugreleaseatprogrammedrate,
dependentonexternalenvironmental.
CONTROLLED RELEASE (CR)
Dosageformthatmaintainsconstantdruglevels
intheblood/tissue.
Followzeroorderreleasekinetics.
Usuallypromotelocalizationofthedrugat
activesite.
Drugreleaseatpredeterminedrate,
independentofexternalenvironmental.

7. ADVANTAGES OF SR/CR DRUG DELIVERY
a)ReducedGIsideeffects,anddosingfrequency.
b)Improveabsorption,enhancingthebioavailability(BA).
c)Bateerpatientsacceptanceandcompliance.
d)Decreasedthelocalandsystemicsideeffect.
e)Minimizedtheaccumulationofdrugmedicamentwithchronicdosing.

8. DISADVANTAGES OF SR/CR DRUG DELIVERY
a)Dose dumping problem occurred.
b)Stability problem.
c)Cost of single unit dosage form is higher than that of conventional dosage form.
d)Poor In-vitro & In-Vivo correction.
e)Dose adjustment sometime difficult.
f)Patient education is required for the successful therapy.

9. FACTORS AFFECTING THE SR/CR DRUG
RELEASE

10. APPROACHES IN SR/CR DDS

11. DISSOLUTION CONTROLLED RELEASE

12. DIFFUSION CONTROLLED RELEASE

14. APPLICATION OF SR/CR