SWAPNIL HANGE PRESENTATION .1.pptx useful

Presentation

1. Shri Dattakrupa Foundation’s Saikrupa Institute Of Pharmacy , Ghargaon Affiliated to Dr. Babasaheb Ambedkar Technology University , Lonere , Raigad GUIDE Prof . Neha Garud PRESENTED BY Mr. Swapnil S. Hange Final year B. pharmacy SEM – VII PRN: 2054713823061 Academic year 2023-24 Review on subject Presentation on practice School- Training Report.

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3. Laboratory training at aster analytics research institute ( pune )

4. PROFILE OF ORGANISATION Aster Analytics Research Institute Pune is a 2 years 6 months old Proprietorship Firm incorporated on 06-May-2021, having its registered office located at 227, Ananya , Pandavnagar , Wadachwadi , Srp Road, Wadachi Wadi , Maharashtra- 411060 . The major activity of Aster Analytics Research Institute Pune is Services, Sub-classified into Other professional scientific and technical activities and is primarily engaged in the Other professional scientific and technical activities. Aster Analytics Research Institute Pune is classified as Micro enterprise in the financial year 2022-23. It has its unit situated at Wadachi Wadi , Maharashtra. Aster Analytics Research Institute has one director – Dr. Amit kasbe & managing director – Miss. Grishma patil Aster Analytics Research Institute Pune – NABL Accredited Laboratory as per ISO/IEC 17025:2017.

5. Training experience The aster analytics research give the chance to learn new skills or improve the new skills and handling of the instrument the workings of the laboratory is provided by lab training. gives us information and a general understanding of the current situation. Staff provided us with their role in the laboratory and gives us knowledge regarding UV -spectroscopy, HPLC, Dissolution tester, Diffusion cell apparatus, Magnetic stirrer, pH meter . We had the experience of handling the instruments and the software related to the each instruments and they gives us idea of how it work . Also, we do overview of instrument to know the working of it we had the survey of the hole laboratory instrument which gave us idea for distribution and working of laboratory instruments.

6. DISSOLUTION TESTER(USP) [ELECTROLAB TDT-08L] AIM: To assess the rate and extent of drug release from a pharmaceutical dosage form. Dissolution testing measures the extent and rate of solution formation from a dosage form, such as tablet, capsule, ointment, etc. 

7. PRINCIPLE: It works on principle that describes the overall rate of all the processes involved in the % drug release into a bioavailable form. APPARATUS: Dissolution Vessel Paddles or Baskets Temperature Control Agitator Sampling Port Filtration System WORKING: A dissolution tester assesses how quickly solid drug forms dissolve. The process involves placing a dosage form in a vessel with a simulated fluid, stirring for uniformity, withdrawing samples at intervals, and analyzing them. The results create a dissolution profile, crucial for ensuring consistent drug release and quality in pharmaceuticals.

8. DIFFUSION CELL APPARATUS [DBK] AIM: to simulate and study the diffusion of substances across membranes, providing insights into drug absorption and permeability.

9. PRINCIPLE: The diffusion cell works like a tiny model to see how things move through barriers, like how drugs get absorbed in our bodies. It helps scientists understand this process better. APPARATUS: Donor compartment Membrane Receptor Compartment Stirring System Temperature Control Sampling ports Clamps or Seals WORKING: The diffusion cell apparatus is used to study the permeability of substances through biological membranes. It typically consists of two compartments separated by a membrane. A substance is applied to one side, and its diffusion through the membrane is measured over time. This helps in understanding drug absorption, skin permeation, and other related processes in pharmaceutical and biological research.

10. UV- SPECTROSCOPY [ jasco V-630] AIM: UV spectroscopy aims to analyze how molecules absorb ultraviolet light, providing insights into their electronic structure and aiding identification in fields like chemistry and biochemistry.

11. PRINCIPLE: Principle of UV-Visible Spectroscopy is based on the absorption of ultraviolet light or visible light by chemical compounds, which results in the production of distinct spectra. APPARATUS: UV Light Source Monochromator Sample Compartment Detector Data Display/Recorder Reference Cell WORKING: UV spectroscopy works by passing UV and visible light through a sample. A UV lamp emits light, a monochromator selects a specific wavelength, and the sample absorbs some light. The remaining light is detected, and the instrument measures the absorbance, providing information about the sample's composition and concentration.

12. HPLC (HIGH PERFORMANCE LIQUID CHROMATOGRAPHY ) [ jasco .UV-4075] AIM: to separate, identify, and quantify components in a mixture. This analytical technique is widely used in various fields, including chemistry, biochemistry, and pharmaceuticals, for precise analysis of compounds with high sensitivity and efficiency.

13. PRINCIPLE: The principle of High-Performance Liquid Chromatography (HPLC) involves the separation of components in a liquid mixture based on their interaction with a stationary phase and a flowing mobile phase. Key aspects include the sample injection, column chromatography, and detection: Sample Injection Column chromatography Mobile phase Detetction APPARATUS: Pump Injectors Column Detector

14. WORKING: The working of High-Performance Liquid Chromatography (HPLC) involves several sequential steps: Sample Injection Mobile Phase Flow Column Interaction Elution Detection Data Analysis Quantification Results output

15. Shri Dattakrupa Foundation’s Saikrupa Institute Of Pharmacy , Ghargaon Affiliated to Dr. Babasaheb Ambedkar Technology University , Lonere , Raigad Academic year 2023-24 Review on subject Presentation on practice School- Review paper

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17. AIM: AN OVERVIEW OF HERBAL DRUGS ON SKIN SKIN DISEASE (ACNE) OBJECTIVE: Explore the historical context of herbal drugs in traditional medicine for treating acne vulgaris . Assess the anti-inflammatory properties of herbal drugs and their role in reducing acne-related inflammation. Examine the antimicrobial effects of herbal compounds, targeting acne-causing bacteria, and evaluate their impact on acne vulgaris . Evaluate the safety profile of herbal drugs compared to conventional acne treatments.

18. Acne, a common dermatological condition, continues to pose challenges in effective management due to its multifactorial etiology and varying severity. While conventional treatments often target specific symptoms, the increasing recognition of herbal drugs as complementary or alternative therapies has sparked interest in their potential for acne management. This abstract reviews the current research on the utilization of herbal drugs, highlighting their anti-inflammatory, antimicrobial, and sebum-regulating properties, which play pivotal roles in the treatment of acne. Additionally, it discusses the emerging evidence supporting the safety and efficacy of herbal drugs, underscoring their promise as adjunctive or standalone treatments for acne, thus paving the way for the development of novel therapeutic interventions. INTRODUCTION

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20. HERBAL DRUG USED TO TREAT ACNE Aloe vera : It can soften and moisturize the skin while also having a healing effect on skin wounds. The antimicrobial and moisturizing qualities of aloe vera guard against microbial deterioration and prevent dryness and abrasiveness in skin Neem : Neem has anti-acne, anti-wrinkles, anti-ageing, and anti-microbial effects in addition to being moisturizing and decreasing pimples. Neem has skin hydrating and skin-nourishing properties. Honey: honey possesses potent antibacterial activities against a minimum of sixty different kinds of bacteria. Unlike antibiotics, which are frequently ineffective against specific types of bacteria, honey exhibits potent antibacterial qualities without being hazardous

21. REVIEW OF LITERATURE: Sara Moradi Tuchayi et.al 2015: Acne vulgaris is a chronic inflammatory disease — rather than a natural part of the life cycle as colloquially viewed — of the pilosebaceous unit (comprising the hair follicle, hair shaft and sebaceous gland) and is among the most common dermatological conditions worldwide. Manoj A. Suva et.al 2014: Acne vulgaris is one of the most common dermatological disorders that afflict people in their adolescence. Acne vulgaris or simply known as acne is a human skin disease characterized by skin with scaly red skin (seborrhea), blackheads and whiteheads ( comedones ), pinheads (papules), large papules (nodules), pimples and scarring. Gudade Gayatri Ashok et.al 2022: The herbal cosmetics are those when natural herbs and their products used for their aromatic value in cosmetic preparation among consumers for herbal products triggered the demand for natural products and natural extracts in cosmetics preparations.

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