Syllabus b pharm

bachelor of pharmacy syllabus according to PCI

1. PharmacyCouncilofIndia
NewDelhi
Rules&SyllabusfortheBachelor
ofPharmacy(B.Pharm)Course
[FramedunderRegulation6,7&8 oftheBachelorof
Pharmacy(B. Pharm)courseregulations2014]

2. CHAPTER-I:REGULATIONS
1.Short Title andCommencement
Theseregulationsshall becalledas“TheRevisedRegulationsfor theB.Pharm.Degree
Program(CBCS)ofthePharmacy CouncilofIndia,NewDelhi”.Theyshallcomeinto
effectfromtheAcademicYear2016-17.Theregulationsframedare subjectto
modifications from timeto timebyPharmacyCouncil ofIndia.
2.Minimumqualificationforadmission
2.1FirstyearB.Pharm:
Candidateshallhavepassed10+2examinationconductedbytherespective
state/centralgovernmentauthorities recognizedasequivalent to 10+2examination
by theAssociationofIndianUniversities(AIU)withEnglishasoneofthe
subjectsandPhysics,Chemistry,Mathematics(P.C.M)andorBiology (P.C.B/
P.C.M.B.)asoptionalsubjectsindividually.Any otherqualificationapprovedby
the PharmacyCouncil ofIndiaas equivalent toanyoftheabove examinations.
2.2. B.Pharmlateralentry(tothird semester):
ApassinD.Pharm.coursefromaninstitutionapprovedbythePharmacyCouncil
ofIndia undersection 12ofthePharmacyAct.
3. Durationoftheprogram
Thecourseofstudy forB.Pharmshallextendoveraperiodofeightsemesters(four
academicyears)andsixsemesters(threeacademicyears)forlateralentry students.The
curriculaandsyllabifortheprogramshallbeprescribedfromtimetotimebyPharmacy
Council ofIndia,NewDelhi.
4.Mediumofinstructionandexaminations
Medium of instructionandexamination shall beinEnglish.
5. Workingdaysineachsemester
Eachsemestershallconsistofnotlessthan100workingdays.Theoddsemestersshallbe
conductedfromthemonthofJune/July toNovember/Decemberandtheevensemesters
shall be conductedfromDecember/JanuarytoMay/Junein everycalendaryear.
6. Attendance and progress
Acandidate isrequiredtoputinatleast80%attendanceinindividualcourses
consideringtheoryandpracticalseparately.Thecandidateshallcompletetheprescribed
coursesatisfactorilytobe eligibletoappear forthe respective examinations.
2

3. 7.Program/Course credit structure
AsperthephilosophyofCreditBasedSemesterSystem,certainquantumofacademic
workviz.theoryclasses,tutorialhours,practicalclasses,etc.aremeasuredintermsof
credits.Onsatisfactorycompletionofthecourses,acandidateearnscredits.Theamount
ofcreditassociatedwithacourseisdependentuponthenumberofhoursofinstruction
perweekinthatcourse.Similarly,thecreditassociatedwithanyoftheotheracademic,
co/extra-curricularactivitiesisdependentuponthequantumofworkexpectedtobeput
in for each of theseactivities perweek.
7.1. Credit assignment
7.1.1.Theory and Laboratorycourses
CoursesarebroadlyclassifiedasTheoryandPractical.Theorycoursesconsistof
lecture(L)and/or tutorial(T) hours,andPractical(P)coursesconsistofhours
spentinthelaboratory.Credits(C) foracourseisdependentonthe number of
hoursofinstructionperweekinthatcourse,andisobtainedbyusingamultiplier
of one(1)forlectureandtutorialhours,anda multiplier ofhalf(1/2)for practical
(laboratory)hours.Thus,forexample,atheorycoursehavingthreelecturesand
one tutorialper weekthroughoutthe semestercarriesacreditof 4.Similarly,a
practicalhavingfourlaboratoryhoursperweekthroughoutsemestercarriesa
creditof2.
7.2.Minimumcreditrequirements
TheminimumcreditpointsrequiredforawardofaB.Pharm.degreeis208.
ThesecreditsaredividedintoTheorycourses,Tutorials,Practical,Practice
SchoolandProjectoverthedurationofeightsemesters.Thecreditsare distributed
semester-wiseasshowninTableIX.Coursesgenerallyprogressinsequences,
buildingcompetenciesandtheirpositioningindicatescertainacademicmaturity
onthepartofthelearners.Learnersareexpectedtofollowthe semester-wise
schedule of coursesgiven in thesyllabus.
Thelateralentrystudents shallget52creditpointstransferredfromtheirD.
Pharmprogram.Suchstudentsshalltakeupadditionalremedialcoursesof
‘CommunicationSkills’(TheoryandPractical)and‘ComputerApplicationsin
Pharmacy’(TheoryandPractical)equivalentto3and4creditpointsrespectively,
atotalof7creditpointstoattain59creditpoints,themaximumofIandII
semesters.
8. Academicwork
AregularrecordofattendancebothinTheoryandPracticalshallbemaintainedbythe
teachingstaffof respective courses.
3

4. Course code Nameofthe course
No. of
hours
Tuto
rial
Credit
points
BP101T
Human AnatomyandPhysiologyI–
Theory
3 1 4
BP102T Pharmaceutical AnalysisI– Theory 3 1 4
BP103T PharmaceuticsI–Theory 3 1 4
BP104T
PharmaceuticalInorganicChemistry–
Theory
3 1 4
BP105T Communication skills–Theory* 2 - 2
BP106RBT
BP106RMT
RemedialBiology/
Remedial Mathematics–Theory*
2 - 2
BP107P
Human AnatomyandPhysiology–
Practical
4 - 2
BP108P Pharmaceutical AnalysisI–Practical 4 - 2
BP109P PharmaceuticsI–Practical 4 - 2
BP110P
PharmaceuticalInorganicChemistry–
Practical
4 - 2
BP111P Communication skills–Practical* 2 - 1
BP112RBPRemedialBiology–Practical* 2 - 1
Total32/34
$
/36
#
427/29
$
/30
#
9. Courseofstudy
ThecourseofstudyforB.PharmshallincludeSemesterWiseTheory&Practicalas
giveninTable–ItoVIII.Thenumberofhourstobedevotedtoeachtheory,tutorialand
practicalcoursein anysemester shall not be less than that shown inTable–ItoVIII.
Table-I: Courseofstudyforsemester I
#
ApplicableONLYforthestudentswhohavestudiedMathematics/Physics/Chemistry atHSCand
appearingfor RemedialBiology(RB)course.
$
ApplicableONLYforthestudentswhohavestudiedPhysics/Chemistry/Botany/ZoologyatHSCand
appearingfor RemedialMathematics(RM)course.
*NonUniversityExamination(NUE)
4

5. Table-II: Courseofstudyforsemester II
Course
Code
Nameofthecourse
No. of
hours
Tutorial
Credit
points
BP201THuman AnatomyandPhysiologyII– Theory 3 1 4
BP202TPharmaceuticalOrganicChemistryI– Theory 3 1 4
BP203TBiochemistry–Theory 3 1 4
BP204TPathophysiology–Theory 3 1 4
BP205TComputerApplications inPharmacy– Theory* 3 - 3
BP206TEnvironmental sciences– Theory* 3 - 3
BP207PHuman AnatomyandPhysiologyII–Practical 4 - 2
BP208PPharmaceuticalOrganicChemistryI–Practical 4 - 2
BP209PBiochemistry–Practical 4 - 2
BP210PComputerApplicationsinPharmacy–Practical*2 - 1
Total32 4 29
*NonUniversityExamination(NUE)
Table-III: Courseofstudyforsemester III
Course
code
Nameofthecourse
No. of
hours
Tutorial
Credit
points
BP301TPharmaceuticalOrganicChemistryII– Theory 3 1 4
BP302TPhysicalPharmaceuticsI– Theory 3 1 4
BP303TPharmaceuticalMicrobiology– Theory 3 1 4
BP304TPharmaceutical Engineering– Theory 3 1 4
BP305PPharmaceuticalOrganicChemistryII–Practical 4 - 2
BP306PPhysicalPharmaceuticsI–Practical 4 - 2
BP307PPharmaceuticalMicrobiology–Practical 4 - 2
BP308PPharmaceutical Engineering–Practical 4 - 2
Total28 4 24
5

6. Table-IV:Courseofstudyforsemester IV
Course
code
Nameofthecourse
No. of
hours
Tutorial
Credit
points
BP401TPharmaceuticalOrganicChemistryIII–Theory 3 1 4
BP402TMedicinal ChemistryI–Theory 3 1 4
BP403TPhysicalPharmaceuticsII–Theory 3 1 4
BP404TPharmacologyI– Theory 3 1 4
BP405TPharmacognosyandPhytochemistry I– Theory 3 1 4
BP406PMedicinal ChemistryI–Practical 4 - 2
BP407PPhysicalPharmaceuticsII–Practical 4 2
BP408PPharmacologyI–Practical 4 - 2
BP409PPharmacognosyandPhytochemistryI–Practical4 - 2
Total31 5 28
Table-V:CourseofstudyforsemesterV
Course
code
Nameofthecourse
No. of
hours
Tutorial
Credit
points
BP501TMedicinal ChemistryII–Theory 3 1 4
BP502TIndustrial PharmacyI–Theory 3 1 4
BP503TPharmacologyII–Theory 3 1 4
BP504TPharmacognosyandPhytochemistryII– Theory 3 1 4
BP505TPharmaceuticalJurisprudence– Theory 3 1 4
BP506PIndustrial PharmacyI–Practical 4 - 2
BP507PPharmacologyII–Practical 4 - 2
BP508PPharmacognosyandPhytochemistryII–
Practical
4 - 2
Total27 5 26
6

7. Table-VI:Courseofstudyforsemester VI
Course
code
Nameofthecourse
No. of
hours
Tutorial
Credit
points
BP601TMedicinal ChemistryIII– Theory 3 1 4
BP602TPharmacologyIII– Theory 3 1 4
BP603THerbalDrugTechnology– Theory 3 1 4
BP604T
Biopharmaceutics andPharmacokinetics–
Theory
3 1 4
BP605TPharmaceuticalBiotechnology– Theory 3 1 4
BP606TQualityAssurance–Theory 3 1 4
BP607PMedicinalchemistryIII–Practical 4 - 2
BP608PPharmacologyIII–Practical 4 - 2
BP609PHerbalDrugTechnology–Practical 4 - 2
Total30 6 30
Table-VII:Courseofstudyforsemester VII
Course
code
Nameofthecourse
No. of
hours
Tutorial
Credit
points
BP701TInstrumental Methods ofAnalysis– Theory 3 1 4
BP702TIndustrialPharmacyII–Theory 3 1 4
BP703TPharmacyPractice– Theory 3 1 4
BP704TNovel DrugDeliverySystem– Theory 3 1 4
BP705PInstrumental Methods ofAnalysis–Practical 4 - 2
BP706PSPracticeSchool* 12 - 6
Total28 5 24
*NonUniversityExamination(NUE)
7

8. Table-VIII:Courseofstudyforsemester VIII
Course
code
Nameofthe course
No. of
hours
Tutorial
Credit
points
BP801TBiostatistics andResearchMethodology 3 1 4
BP802TSocialandPreventivePharmacy 3 1 4
BP803ETPharmaMarketingManagement
BP804ETPharmaceuticalRegulatoryScience
BP805ETPharmacovigilance
BP806ET
QualityControl andStandardization of
Herbals
BP807ETComputerAided DrugDesign
BP808ETCelland MolecularBiology
BP809ETCosmeticScience
BP810ETExperimentalPharmacology
BP811ETAdvancedInstrumentation Techniques
3 + 3 =
6
1 +1 =2
4 +4 =
8
BP812ETDietarySupplements andNutraceuticals
BP813PWProjectWork 12 - 6
Total24 4 22
Table-IX:Semesterwise creditsdistribution
Semester CreditPoints
I 27/29
$
/30
#
II 29
III 26
IV 28
V 26
VI 26
VII 24
VIII 22
Extracurricular/Cocurricular activities 01*
Total credit pointsfor theprogram 209/211
$
/212
#
*Thecreditpointsassignedforextracurricularandorco-curricularactivitiesshallbegivenbythe
PrincipalsofthecollegesandthesameshallbesubmittedtotheUniversity.Thecriteriatoacquirethis
creditpointshallbedefinedbythecollegesfromtimeto time.
$
ApplicableONLYforthestudentsstudiedPhysics/Chemistry/Botany/ZoologyatHSC andappearing
for RemedialMathematicscourse.
#
ApplicableONLYforthestudentsstudiedMathematics/Physics/ChemistryatHSCandappearingfor
RemedialBiologycourse.
8

9. 10.ProgramCommittee
1. TheB.Pharm.programshallhaveaProgramCommitteeconstitutedbytheHead
ofthe institution in consultation with all theHeads of the departments.
2. The composition of theProgram Committeeshall beas follows:
A seniorteacher shallbe the Chairperson;OneTeacherfromeachdepartment
handlingB.Pharmcourses;andfour studentrepresentativesoftheprogram(one
fromeachacademicyear), nominatedbytheHeadofthe institution.
3. Duties of the ProgramCommittee:
i.Periodicallyreviewingtheprogressof the classes.
ii.Discussingtheproblemsconcerningcurriculum,syllabusandtheconductof
classes.
iii.Discussing withthecourseteachersonthenatureandscopeofassessmentfor
thecourseandthesameshallbeannouncedtothestudentsatthebeginningof
respectivesemesters.
iv. CommunicatingitsrecommendationtotheHeadoftheinstitutionon
academicmatters.
v.TheProgramCommitteeshallmeetatleastthriceinasemesterpreferablyat
theendofeachSessionalexam(Internal Assessment)andbeforetheend
semesterexam.
11. Examinations/Assessments
Theschemefor internalassessmentandend semester examinationsisgiveninTable– X.
11.1.Endsemester examinations
TheEndSemesterExaminationsforeachtheoryandpracticalcoursethroughsemestersI
toVIIIshallbeconducted bytheuniversityexceptforthesubjectswithasterixsymbol(*)
intableIandIIforwhichexaminationsshallbeconductedbythesubjectexpertsat
collegelevel andthemarks/grades shall be submitted to theuniversity.
9

10. InternalAssessment EndSemesterExams
SessionalExams
Course
code
Nameofthecourse Continuous
Mode Marks Duration
Total Marks Duration
Total
Marks
BP101T
HumanAnatomyand
PhysiologyI–Theory
10 15 1 Hr 25 75 3Hrs 100
BP102T
PharmaceuticalAnalysisI–
Theory
10 15 1 Hr 25 75 3Hrs 100
BP103TPharmaceuticsI–Theory 10 15 1 Hr 25 75 3Hrs 100
BP104T
PharmaceuticalInorganic
Chemistry–Theory
10 15 1 Hr 25 75 3Hrs 100
BP105T
Communicationskills–
Theory*
5 10 1 Hr 15 35 1.5Hrs 50
BP106RBT
BP106RMT
RemedialBiology/
Mathematics–Theory*
5 10 1 Hr 15 35 1.5Hrs 50
BP107P
HumanAnatomyand
Physiology–Practical
5 10 4Hrs 15 35 4Hrs 50
BP108P
PharmaceuticalAnalysisI–
Practical
5 10 4Hrs 15 35 4Hrs 50
BP109PPharmaceuticsI–Practical 5 10 4Hrs 15 35 4Hrs 50
BP110P
PharmaceuticalInorganic
Chemistry–Practical
5 10 4Hrs 15 35 4Hrs 50
BP111P
Communicationskills–
Practical*
5 5 2Hrs 10 15 2Hrs 25
BP112RBP
RemedialBiology–
Practical*
5 5 2Hrs 10 15 2Hrs 25
Total70/75
$
/80
#
115/125
$
/130
#
23/24
$
/26
#
Hrs
185/200
$
/210
#
490/525
$
/
540
#
31.5/33
$
/
35
#
Hrs
675/725
$
/
750
#
SemesterI
Tables-X:Schemesforinternal assessments andendsemesterexaminations semesterwise
#
ApplicableONLYforthe studentsstudiedMathematics/Physics/ChemistryatHSCandappearingfor RemedialBiology(RB)course.
$
ApplicableONLYforthe studentsstudiedPhysics/Chemistry/Botany/ZoologyatHSCandappearingfor RemedialMathematics(RM)course.
*NonUniversityExamination(NUE)
10

11. SemesterII
Internal Assessment End SemesterExams
SessionalExams
Course
code
Nameofthe course Continuous
Mode MarksDuration
Total MarksDuration
Total
Marks
BP201T
Human AnatomyandPhysiology
II– Theory
10 15 1 Hr 25 75 3 Hrs 100
BP202T
PharmaceuticalOrganic
ChemistryI– Theory
10 15 1 Hr 25 75 3 Hrs 100
BP203TBiochemistry–Theory 10 15 1 Hr 25 75 3 Hrs 100
BP204TPathophysiology– Theory 10 15 1 Hr 25 75 3 Hrs 100
BP205T
ComputerApplicationsin
Pharmacy–Theory*
10 15 1 Hr 25 50 2 Hrs 75
BP206TEnvironmental sciences– Theory* 10 15 1 Hr 25 50 2 Hrs 75
BP207P
Human AnatomyandPhysiology
II–Practical
5 10 4 Hrs 15 35 4 Hrs 50
BP208P
PharmaceuticalOrganic
ChemistryI–Practical
5 10 4 Hrs 15 35 4 Hrs 50
BP209PBiochemistry–Practical 5 10 4 Hrs 15 35 4 Hrs 50
BP210P
ComputerApplicationsin
Pharmacy–Practical*
5 5 2 Hrs 10 15 2 Hrs 25
Total 80 125 20 Hrs 205 520 30 Hrs 725
*Thesubject expertsatcollegelevel shallconductexaminations
11

12. SemesterIII
Internal Assessment End SemesterExams
SessionalExams
Course
code
Nameofthe course Continuous
Mode MarksDuration
Total MarksDuration
Total
Marks
BP301T
PharmaceuticalOrganic
ChemistryII– Theory
10 15 1 Hr 25 75 3 Hrs 100
BP302TPhysicalPharmaceuticsI–Theory 10 15 1 Hr 25 75 3 Hrs 100
BP303T
Pharmaceutical Microbiology–
Theory
10 15 1 Hr 25 75 3 Hrs 100
BP304T
Pharmaceutical Engineering–
Theory
10 15 1 Hr 25 75 3 Hrs 100
BP305P
PharmaceuticalOrganic
ChemistryII–Practical
5 10 4 Hr 15 35 4 Hrs 50
BP306P
PhysicalPharmaceuticsI–
Practical
5 10 4 Hr 15 35 4 Hrs 50
BP307P
Pharmaceutical Microbiology–
Practical
5 10 4 Hr 15 35 4 Hrs 50
BP308P
Pharmaceutical Engineering–
Practical
5 10 4 Hr 15 35 4 Hrs 50
Total 60 100 20 160 440 28Hrs 600
12

13. SemesterIV
Internal Assessment End SemesterExams
SessionalExams
Course
code
Nameofthe course Continuous
Mode MarksDuration
Total MarksDuration
Total
Marks
BP401T
PharmaceuticalOrganic
ChemistryIII–Theory
10 15 1 Hr 25 75 3 Hrs 100
BP402TMedicinal ChemistryI–Theory 10 15 1 Hr 25 75 3 Hrs 100
BP403T
PhysicalPharmaceuticsII–
Theory
10 15 1 Hr 25 75 3 Hrs 100
BP404TPharmacologyI– Theory 10 15 1 Hr 25 75 3 Hrs 100
BP405TPharmacognosyI– Theory 10 15 1 Hr 25 75 3 Hrs 100
BP406PMedicinal ChemistryI–Practical 5 10 4 Hr 15 35 4 Hrs 50
BP407P
PhysicalPharmaceuticsII–
Practical
5 10 4 Hrs 15 35 4 Hrs 50
BP408PPharmacologyI–Practical 5 10 4 Hrs 15 35 4 Hrs 50
BP409PPharmacognosyI–Practical 5 10 4 Hrs 15 35 4 Hrs 50
Total 70 115 21 Hrs 185 515 31 Hrs 700
13

14. SemesterV
Internal Assessment End SemesterExams
SessionalExams
Course
code
Nameofthe course Continuous
Mode MarksDuration
Total MarksDuration
Total
Marks
BP501TMedicinal ChemistryII–Theory 10 15 1 Hr 25 75 3 Hrs 100
BP502TIndustrial PharmacyI–Theory 10 15 1 Hr 25 75 3 Hrs 100
BP503TPharmacologyII– Theory 10 15 1 Hr 25 75 3 Hrs 100
BP504TPharmacognosyII–Theory 10 15 1 Hr 25 75 3 Hrs 100
BP505T
PharmaceuticalJurisprudence–
Theory
10 15 1 Hr 25 75 3 Hrs 100
BP506PIndustrialPharmacyI– Practical 5 10 4 Hr 15 35 4 Hrs 50
BP507PPharmacologyII–Practical 5 10 4 Hr 15 35 4 Hrs 50
BP508PPharmacognosyII–Practical 5 10 4 Hr 15 35 4 Hrs 50
Total 65 105 17 Hr 170 480 27 Hrs 650
14

15. SemesterVI
Internal Assessment End SemesterExams
SessionalExams
Course
code
Nameofthe course Continuous
Mode MarksDuration
Total MarksDuration
Total
Marks
BP601TMedicinal ChemistryIII– Theory 10 15 1 Hr 25 75 3 Hrs 100
BP602TPharmacologyIII– Theory 10 15 1 Hr 25 75 3 Hrs 100
BP603T
HerbalDrugTechnology–
Theory
10 15 1 Hr 25 75 3 Hrs 100
BP604T
Biopharmaceutics and
Pharmacokinetics– Theory
10 15 1 Hr 25 75 3 Hrs 100
BP605T
PharmaceuticalBiotechnology–
Theory
10 15 1 Hr 25 75 3 Hrs 100
BP606TQualityAssurance– Theory 10 15 1 Hr 25 75 3 Hrs 100
BP607P
MedicinalchemistryIII–
Practical
5 10 4 Hrs 15 35 4 Hrs 50
BP608PPharmacologyIII–Practical 5 10 4 Hrs 15 35 4 Hrs 50
BP609P
HerbalDrugTechnology–
Practical
5 10 4 Hrs 15 35 4 Hrs 50
Total 75 120 18 Hrs 195 555 30 Hrs 750
15

16. SemesterVII
Internal Assessment
End Semester
Exams
SessionalExams
Course
code
Nameofthecourse
Continuous
Mode MarksDuration
TotalMarksDuration
Total
Marks
BP701T
Instrumental Methods ofAnalysis
– Theory
10 15 1 Hr 25 75 3 Hrs 100
BP702TIndustrial Pharmacy–Theory 10 15 1 Hr 25 75 3 Hrs 100
BP703TPharmacyPractice–Theory 10 15 1 Hr 25 75 3 Hrs 100
BP704T
Novel DrugDeliverySystem–
Theory
10 15 1 Hr 25 75 3 Hrs 100
BP705 P
Instrumental Methods ofAnalysis
–Practical
5 10 4 Hrs 15 35 4 Hrs 50
BP706PSPracticeSchool* 25 - - 25 125 5 Hrs 150
Total 70 70 8Hrs 140 460 21 Hrs 600
*Thesubject expertsatcollegelevel shallconductexaminations
16

17. SemesterVIII
Internal Assessment End SemesterExams
SessionalExams
Course
code
Nameofthecourse Continuous
Mode MarksDuration
Total MarksDuration
Total
Marks
BP801T
Biostatistics andResearch
Methodology– Theory
10 15 1 Hr 25 75 3 Hrs 100
BP802T
SocialandPreventivePharmacy
– Theory
10 15 1 Hr 25 75 3 Hrs 100
BP803ET
Pharmaceutical Marketing–
Theory
BP804ET
PharmaceuticalRegulatory
Science– Theory
BP805ETPharmacovigilance–Theory
BP806ET
QualityControl and
Standardization ofHerbals–
Theory
BP807ET
ComputerAided DrugDesign–
Theory
BP808ET
Celland MolecularBiology–
Theory
BP809ETCosmeticScience–Theory
BP810ET
ExperimentalPharmacology–
Theory
BP811ET
AdvancedInstrumentation
Techniques– Theory
10 +10
=20
15 + 15 =
30
1 +1 =
2 Hrs
25 +25 =
50
75 +75
=150
3 +3 =6
Hrs
100 +
100 =
200
BP812PWProjectWork - - - - 150 4 Hrs 150
Total 40 60 4 Hrs 100 450 16 Hrs 550
17

18. 18

19. 11.2. Internal assessment:Continuousmode
ThemarksallocatedforContinuousmodeofInternalAssessmentshallbe
awardedasper theschemegivenbelow.
Table-XI:Schemeforawardinginternal assessment:Continuousmode
Theory
Criteria Maximum
Marks
Attendance (Refer Table–XII) 4 2
Academicactivities(Averageofany3activitiese.g.quiz,assignment,
open book test, field work,groupdiscussionandseminar)
3 1.5
Student– Teacher interaction 3 1.5
Total 10 5
Practical
Attendance (Refer Table–XII) 2
Based onPracticalRecords,Regular vivavoce,etc. 3
Total 5
Table- XII:Guidelinesfor the allotment ofmarksfor attendance
PercentageofAttendance Theory Practical
95–100 4 2
90–94 3 1.5
85–89 2 1
80–84 1 0.5
Less than80 0 0
11.2.1.SessionalExams
TwoSessionalexamsshallbeconductedforeachtheory /practicalcourseasperthe
schedulefixedby thecollege(s).Theschemeofquestionpaperfortheoryandpractical
Sessionalexaminationsisgivenbelow.TheaveragemarksoftwoSessionalexamsshall
be computed forinternalassessmentas perthe requirementsgiven in tables– X.
Sessionalexamshallbeconductedfor30marksfortheoryandshallbecomputed
for15marks.SimilarlySessionalexamforpracticalshallbeconductedfor40marksand
shall be computed for10marks.
Question paperpatternfor theorySessionalexaminations
Forsubjects having Universityexamination
I. Multiple ChoiceQuestions (MCQs) = 10 x1 =10
OR OR
Objective Type Questions (5 x 2) = 05 x 2 = 10
(Answer all thequestions)
I.LongAnswers(Answer 1out of 2) = 1 x10 =10
II.Short Answers(Answer 2out of 3) = 2 x5 =10
-----------------
Total= 30 marks
19

20. Forsubjects having NonUniversity Examination
I.LongAnswers(Answer 1out of 2) = 1 x10=10
II.Short Answers(Answer 4 out of 6) = 4 x5=20
------------------
Total =30 marks
------------------
Question paperpatternforpractical sessional examinations
I.Synopsis = 10
II.Experiments = 25
III.Viva voce = 05
Total=
------------------
40 marks
------------------
12.Promotionandawardofgrades
AstudentshallbedeclaredPASSandeligibleforgettinggradeinacourseof
B.Pharm.programifhe/shesecuresatleast50%marksinthatparticularcourse including
internalassessment.Forexample,tobedeclaredasPASSandtogetgrade,the student has
tosecureaminimumof50marksforthetotalof100includingcontinuousmodeof
assessmentandendsemestertheoryexaminationandhastosecureaminimumof25
marksforthetotal50including internalassessmentandendsemesterpractical
examination.
13. Carryforwardofmarks
Incaseastudentfailstosecuretheminimum50%inany TheoryorPracticalcourseas
specified in12,thenhe/sheshallreappearfortheendsemesterexaminationof thatcourse.
However his/hermarksof theInternalAssessmentshallbecarriedoverandhe/sheshallbe
entitled forgradeobtainedbyhim/heron passing.
14. Improvementofinternal assessment
Astudentshallhavetheopportunitytoimprovehis/herperformanceonly onceinthe
Sessionalexamcomponentoftheinternalassessment.The re-conductoftheSessional
examshallbecompletedbefore thecommencementofnextendsemestertheory
examinations.
15. Re-examinationofendsemesterexaminations
Reexaminationofendsemesterexaminationshallbeconductedaspertheschedulegiven
in tableXIII. The exactdates of examinations shallbenotified from timeto time.
20

21. Table-XIII: Tentativeschedule ofendsemesterexaminations
Semester ForRegularCandidates ForFailedCandidates
I,III,VandVII November/December May/June
II,IV,VIandVIII May/June November/December
Question paperpatternfor endsemestertheoryexaminations
For75marks paper
I. Multiple ChoiceQuestions(MCQs) = 20 x 1 = 20
OR OR
Objective Type Questions (10 x 2) = 10 x 2 = 20
(Answer all the questions)
II.LongAnswers(Answer 2 out of 3) = 2 x10=20
III.Short Answers(Answer 7 out of 9) = 7 x5=35
------------------
Total =75 marks
------------------
For50marks paper
I.LongAnswers(Answer 2out of 3) = 2 x10 =20
II.Short Answers(Answer 6 out of 8)= 6 x5=30
------------------
Total =50 marks
------------------
For35marks paper
I.LongAnswers(Answer 1 out of 2) = 1 x10=10
II.Short Answers(Answer 5 out of 7)= 5 x5=25
------------------
Total =35 marks
------------------
Question paperpatternfor endsemesterpractical examinations
I.Synopsis = 5
II.Experiments = 25
III.Viva voce = 5
------------------
Total =35 marks
------------------
21

22. 16. AcademicProgression:
Nostudentshallbeadmittedtoanyexaminationunlesshe/shefulfillsthenormsgivenin
6. Academicprogressionrulesare applicableasfollows:
AstudentshallbeeligibletocarryforwardallthecoursesofI,II andIIIsemesterstillthe
IVsemesterexaminations.However,he/sheshallnotbeeligibletoattendthecoursesof
V semester untilall thecourses ofIandIIsemestersaresuccessfullycompleted.
AstudentshallbeeligibletocarryforwardallthecoursesofIII,IVandVsemesterstill
theVIsemesterexaminations.However,he/sheshallnotbeeligibletoattendthecourses
ofVIIsemesteruntilall thecoursesofI,II,IIIandIVsemestersaresuccessfully
completed.
Astudentshallbeeligibletocarry forwardallthecoursesofV,VIandVIIsemesterstill
theVIIIsemesterexaminations.However,he/sheshallnotbeeligibletogetthecourse
completioncertificateuntilallthecoursesofI,II,III,IV,VandVIsemestersare
successfullycompleted.
Astudentshallbeeligible togethis/herCGPAuponsuccessfulcompletionofthecourses
ofItoVIIIsemesterswithin the stipulated time periodas perthe norms specifiedin 26.
Alateralentry studentshallbeeligibletocarryforwardallthecoursesofIII,IVandV
semesterstilltheVIsemesterexaminations.However,he/sheshallnotbeeligibleto
attendthecoursesofVIIsemesteruntilallthecoursesofIIIandIVsemestersare
successfullycompleted.
Alateralentry studentshallbeeligibletocarry forwardallthecoursesofV,VIandVII
semesterstilltheVIIIsemesterexaminations.However,he/sheshallnotbeeligibletoget
thecoursecompletioncertificateuntilallthecoursesofIII,IV,VandVI semestersare
successfullycompleted.
Alateralentrystudentshallbeeligibletogethis/herCGPAuponsuccessfulcompletion
ofthecoursesofIII toVIIIsemesterswithinthestipulatedtimeperiodasperthenorms
specifiedin 26.
Any studentwhohasgivenmorethan4chancesforsuccessfulcompletionofI/III
semestercoursesandmore than3chancesforsuccessfulcompletionofII/IVsemester
coursesshallbepermittedtoattendV/VIIsemesterclassesONLYduring the
subsequentacademicyearasthecasemay be.InsimplertermsthereshallNOTbeany
ODDBATCHforanysemester.
22

23. Note:GradeABshouldbeconsideredasfailedandtreatedasoneheadfordeciding
academic progression.Suchrulesarealsoapplicableforthosestudentswhofailto
register forexamination(s)ofanycourseinanysemester.
17.Grading ofperformances
17.1.Lettergrades andgradepoints allocations:
Basedontheperformances,eachstudentshallbeawardedafinallettergradeattheend
of thesemesterforeachcourse.The lettergradesandtheircorrespondinggrade pointsare
given in Table–XII.
Table– XII:Lettergrades andgradepointsequivalent to
Percentageofmarks and performances
Percentageof
MarksObtained
LetterGrade GradePoint Performance
90.00– 100 O 10 Outstanding
80.00– 89.99 A 9 Excellent
70.00– 79.99 B 8 Good
60.00– 69.99 C 7 Fair
50.00– 59.99 D 6 Average
Less than50 F 0 Fail
Absent AB 0 Fail
Alearnerwhoremainsabsentforanyendsemesterexaminationshallbeassignedaletter
gradeofABandacorrespondinggradepointofzero.He/she shouldreappearforthesaid
evaluation/examinationin due course.
18.TheSemestergrade point average(SGPA)
Theperformanceofastudentinasemesterisindicated by anumbercalled‘Semester
GradePointAverage’(SGPA).TheSGPAis the weightedaverage ofthegrade points
obtainedinallthecoursesby thestudentduring thesemester.Forexample,ifastudent
takesfivecourses(Theory/Practical)inasemesterwithcreditsC1,C2,C3,C4andC5
andthe student’sgradepointsinthesecoursesare G1,G2,G3,G4andG5,respectively,
and then students’ SGPA isequal to:
C1G1+ C2G2+ C3G3+C4G4+ C5G5
SGPA=--------------------------------------------------
C1+ C2+C3+ C4+C5
TheSGPAiscalculatedtotwodecimalpoints.Itshouldbenotedthat,theSGPAforany
semestershalltake intoconsiderationtheFandABSgradeawardedinthatsemester.For
exampleifalearnerhasaForABSgradeincourse4,theSGPAshallthenbecomputed
as:
23

24. C1G1+ C2G2+ C3G3+C4*ZERO + C5G5
SGPA=------------------------------------------------------
C1+ C2+C3+ C4+C5
19. CumulativeGradePointAverage(CGPA)
TheCGPAiscalculatedwiththeSGPAofalltheVIIIsemesterstotwodecimalpoints
andisindicatedinfinalgradereportcard/finaltranscriptshowingthegradesofallVIII
semestersandtheircourses.The CGPAshallreflectthefailedstatusincaseofF
grade(s),tillthecourse(s)is/arepassed.Whenthecourse(s)is/arepassedbyobtaininga
passgradeonsubsequentexamination(s)theCGPAshallonlyreflectthenewgradeand
not the failgradesearnedearlier.TheCGPA iscalculatedas:
C1S1+C2S2+C3S3+C4S4+ C5S5+ C6S6+C7S7+C8S8
CGPA=-------------------------------------------------------------------------
C1+ C2+C3+ C4+C5+C6+ C7+ C8
whereC1,C2,C3,….isthe totalnumberofcreditsforsemesterI,II,III,….andS1,S2,S3,….is
the SGPA ofsemesterI,II,III,…. .
20. Declarationofclass
The class shallbe awarded on the basisofCGPAas follows:
FirstClass with Distinction= CGPA of. 7.50andabove
FirstClass = CGPA of 6.00 to 7.49
Second Class = CGPA of 5.00 to5.99
21.Projectwork
Allthestudentsshall undertakeaprojectunderthesupervisionofateacherandsubmita
report.The areaoftheprojectshalldirectlyrelateanyoneoftheelectivesubjectoptedby
thestudentinsemesterVIII.Theprojectshallbecarriedoutingroupnotexceeding 5in
number.Theprojectreportshallbesubmittedintriplicate(typed&boundcopy notless
than 25 pages).
TheinternalandexternalexaminerappointedbytheUniversityshallevaluatetheproject
atthetimeofthePracticalexaminationsofother semester(s). Studentsshallbeevaluated
ingroupsforfourhours(i.e.,abouthalfanhourforagroupoffivestudents).The
projectsshall beevaluatedas perthecriteriagivenbelow.
24

25. Evaluationof DissertationBook:
Objective(s)ofthe workdone 15 Marks
Methodologyadopted 20Marks
Results and Discussions 20 Marks
Conclusionsand Outcomes 20 Marks
Total 75Marks
Evaluationof Presentation:
Presentation of work 25 Marks
Communication skills 20 Marks
Questionandanswer skills 30 Marks
Total 75Marks
Explanation:The 75marksassignedtothe dissertationbookshallbe sameforallthe
studentsinagroup.However,the75marksassignedforpresentationshallbeawarded
based on the performanceofindividualstudentsin thegivencriteria.
22. Industrialtraining(Desirable)
Everycandidateshall berequiredtoworkforat least150hoursspreadoverfourweeksin
aPharmaceuticalIndustry/Hospital.ItincludesProductionunit,Quality Control
department,Quality Assurance department,Analyticallaboratory,Chemical
manufacturing unit,PharmaceuticalR&D,Hospital(ClinicalPharmacy),Clinical
ResearchOrganization,CommunityPharmacy,etc.AftertheSemester–VIandbefore
thecommencementofSemester–VII,andshallsubmitsatisfactoryreportofsuchwork
andcertificateduly signedbytheauthorityoftrainingorganizationtotheheadofthe
institute.
23.PracticeSchool
IntheVIIsemester,everycandidateshallundergopracticeschoolforaperiodof150
hoursevenly distributedthroughoutthesemester.Thestudentshalloptany oneofthe
domains forpracticeschool declaredbytheprogram committeefrom time totime.
Attheendofthepracticeschool,everystudentshallsubmitaprintedreport(intriplicate)
onthepracticeschoolhe/sheattended(notmorethan25pages).Along withtheexamsof
semesterVII,thereportsubmittedby thestudent,knowledgeandskillsacquiredbythe
student throughpracticeschoolshallbeevaluatedbythesubjectexpertsatcollege
levelandgrade pointshall beawarded.
25

26. 24. AwardofRanks
RanksandMedalsshallbeawardedonthebasisoffinalCGPA.However,candidates
whofailinoneormorecoursesduringtheB.Pharmprogramshallnotbeeligiblefor
awardofranks.Moreover,thecandidatesshouldhavecompletedtheB.Pharmprogramin
minimum prescribed numberofyears, (fouryears)fortheawardof Ranks.
25. Awardofdegree
Candidateswhofulfilltherequirementsmentionedaboveshallbeeligible foraward of
degreeduringtheensuingconvocation.
26. Durationfor completion oftheprogramofstudy
Thedurationforthecompletionoftheprogramshallbefixedasdoubletheactual
durationof theprogramandthestudentshavetopasswithinthesaidperiod,otherwise
theyhavetogetfreshRegistration.
27. Re-admissionafterbreakofstudy
Candidatewhoseeksre-admissiontotheprogramafterbreakofstudy hastogetthe
approval fromtheuniversitybypayinga condonationfee.
Nocondonationisallowedforthecandidatewhohasmorethan2yearsofbreakup
periodand he/shehas to rejoin the programbypayingtherequiredfees.
26

27. CHAPTER-II:SYLLABUS
27

28. SemesterI
28

29. BP101T. HUMANANATOMY ANDPHYSIOLOGY-I (Theory)
45 Hours
Scope:Thissubjectisdesignedtoimpartfundamentalknowledge onthestructureand
functionsofthevarioussystemsofthehumanbody.Italsohelpsinunderstanding both
homeostaticmechanisms.The subjectprovidesthebasicknowledgerequiredto
understand the various disciplines ofpharmacy.
Objectives: Uponcompletion ofthis coursethe student should beable to
1.Explainthegrossmorphology,structureandfunctionsofvariousorgansofthehuman
body.
2.Describethe various homeostaticmechanismsand theirimbalances.
3.Identifythe various tissues andorgansof differentsystems of human body.
4.Perform the variousexperiments related to special sensesandnervoussystem.
5.Appreciatecoordinatedworkingpattern ofdifferent organsofeachsystem
CourseContent:
Unit I 10hours
Introduction tohuman body
Definitionandscopeofanatomyandphysiology,levelsofstructural
organizationandbodysystems,basiclifeprocesses,homeostasis,basic
anatomical terminology.
Cellularlevel oforganization
Structureandfunctionsofcell,transportacrosscellmembrane,cell
division,celljunctions. Generalprinciples ofcellcommunication,
intracellularsignalingpathwayactivationby extracellularsignal
molecule,Formsof intracellularsignaling:a)Contact-dependentb)
Paracrine c)Synapticd)Endocrine
Tissue level oforganization
Classificationoftissues,structure,locationand functionsofepithelial,
muscularandnervousandconnectivetissues.
Unit II
Integumentary system
Structure andfunctions of skin
Skeletal system
Divisions of skeletalsystem,typesof bone, salientfeatures and functions
ofbones ofaxialandappendicular skeletalsystem
Organization ofskeletalmuscle, physiologyofmuscle contraction,
neuromuscularjunction
10hours
29

30. Joints
Structural andfunctionalclassification,types of joints movementsand its
articulation
Unit III 10hours
Bodyfluids andblood
Bodyfluids,compositionandfunctionsofblood,hemopoeisis,formationof
hemoglobin,anemia,mechanismsofcoagulation,bloodgrouping,Rhfactors,
transfusion, itssignificance and disorders ofblood, Reticulo endothelialsystem.
Lymphatic system
Lymphaticorgansandtissues,lymphaticvessels,lymphcirculationandfunctions of
lymphaticsystem
Unit IV 08hours
Peripheralnervous system:
Classification ofperipheral nervoussystem:Structureandfunctions of
sympathetic and parasympathetic nervoussystem.
Origin and functions ofspinalandcranial nerves.
Specialsenses
Structure andfunctions ofeye,ear, noseand tongue and their disorders.
Unit V 07hours
Cardiovascular system
Heart–anatomyofheart, blood circulation, blood vessels,structureandfunctions of
artery,vein andcapillaries,elements ofconductionsystem ofheartandheart beat, its
regulationbyautonomicnervoussystem, cardiacoutput,cardiaccycle.Regulation of
bloodpressure, pulse,electrocardiogram and disorders ofheart.
30

31. BP107P. HUMAN ANATOMY ANDPHYSIOLOGY (Practical)
4 Hours/week
Practicalphysiologyiscomplimentary tothetheoreticaldiscussionsin
physiology.Practicalsallowtheverificationofphysiologicalprocessesdiscussed
intheoryclassesthroughexperimentsonlivingtissue,intactanimalsornormal
human beings. This ishelpful fordevelopingan insight onthesubject.
1.Studyofcompound microscope.
2. Microscopic studyofepithelialandconnectivetissue
3. Microscopic studyofmuscular andnervous tissue
4.Identification ofaxial bones
5.Identification ofappendicularbones
6.Introduction to hemocytometry.
7. Enumeration of white bloodcell(WBC)count
8. Enumeration of total redblood corpuscles (RBC)count
9. Determination ofbleedingtime
10. Determination of clotting time
11. Estimation of hemoglobincontent
12. Determination ofbloodgroup.
13. Determination of erythrocytesedimentation rate(ESR).
14. Determination ofheart rateand pulserate.
15.Recordingofbloodpressure.
RecommendedBooks(LatestEditions)
1. EssentialsofMedicalPhysiologybyK.SembulingamandP.Sembulingam.Jaypee
brothers medical publishers, NewDelhi.
2. Anatomyand Physiologyin HealthandIllnessbyKathleenJ.W.Wilson,Churchill
Livingstone,New York
3.PhysiologicalbasisofMedicalPractice-BestandTailor.Williams&Wilkins
Co,Riverview,MIUSA
4. TextbookofMedicalPhysiology-ArthurC,GuytonandJohn.E.Hall.Miamisburg,OH,
U.S.A.
5.Principles of AnatomyandPhysiologybyTortoraGrabowski.Palmetto,GA, U.S.A.
31

32. 6. TextbookofHumanHistologybyInderbirSingh,Jaypeebrother’smedicalpublishers,
New Delhi.
7. TextbookofPracticalPhysiologybyC.L.Ghai,Jaypeebrother’smedicalpublishers,
New Delhi.
8.PracticalworkbookofHumanPhysiologybyK.SrinageswariandRajeevSharma,
Jaypeebrother’s medicalpublishers, New Delhi.
ReferenceBooks (Latest Editions)
1.PhysiologicalbasisofMedicalPractice-BestandTailor.Williams&WilkinsCo,
Riverview,MIUSA
2. TextbookofMedicalPhysiology-ArthurC, GuytonandJohn.E.Hall. Miamisburg,OH,
U.S.A.
3. HumanPhysiology(vol1and 2)byDr. C.C.Chatterrje ,AcademicPublishers Kolkata
32

33. BP102T.PHARMACEUTICAL ANALYSIS(Theory)
45 Hours
Scope:Thiscoursedealswiththefundamentalsofanalyticalchemistryandprinciplesof
electrochemical analysisofdrugs
Objectives:Uponcompletion ofthecoursestudent shall be able to
understand the principles of volumetric andelectrochemical analysis
carryoutvarious volumetricandelectrochemical titrations
develop analytical skills
CourseContent:
UNIT-I 10 Hours
(a)Pharmaceutical analysis-Definitionand scope
i)Differenttechniquesofanalysis
ii) Methods ofexpressingconcentration
iii)Primaryandsecondarystandards.
iv) Preparationandstandardizationofvariousmolarandnormalsolutions-
Oxalicacid,sodiumhydroxide,hydrochloricacid,sodiumthiosulphate,
sulphuricacid, potassium permanganateandcericammoniumsulphate
(b)Errors:Sourcesoferrors,typesoferrors,methodsofminimizingerrors,
accuracy,precisionandsignificantfigures
(c)Pharmacopoeia, Sources of impurities in medicinalagents,limittests.
UNIT-II 10 Hours
Acid basetitration: Theories of acidbaseindicators, classification of
acid basetitrationsand theoryinvolved in titrations of strong,weak,and
veryweakacidsand bases, neutralizationcurves
Non aqueous titration:Solvents,acidimetryandalkalimetrytitrationand
estimation of Sodium benzoateand Ephedrine HCl
UNIT-III 10 Hours
Precipitationtitrations:Mohr’smethod,Volhard’s,Modified
Volhard’s,Fajans method,estimation of sodium chloride.
Complexometrictitration:Classification,metalionindicators,masking
anddemaskingreagents,estimationofMagnesiumsulphate,andcalcium
gluconate.
Gravimetry:Principleandstepsinvolvedingravimetricanalysis.Purity
oftheprecipitate:co-precipitationandpostprecipitation,Estimation of
barium sulphate.
BasicPrinciples,methodsandapplication ofdiazotisationtitration.
33

34. UNIT-IV 08 Hours
Redox titrations
(a)Concepts ofoxidationandreduction
(b)Typesof redoxtitrations (Principles andapplications)
Cerimetry,Iodimetry,Iodometry,Bromatometry,Dichrometry,Titrationwith
potassiumiodate
UNIT-V 07 Hours
Electrochemicalmethods ofanalysis
Conductometry-Introduction,Conductivitycell,Conductometric
titrations,applications.
Potentiometry-Electrochemicalcell,constructionandworking
of reference(Standard hydrogen,silverchloride electrodeand
calomelelectrode)andindicatorelectrodes(metal electrodesand
glasselectrode), methodstodetermineendpointof potentiometric
titrationandapplications.
Polarography-Principle,Ilkovicequation,constructionand
workingofdroppingmercuryelectrodeandrotatingplatinum
electrode,applications
34

35. BP108P.PHARMACEUTICAL ANALYSIS(Practical)
4 Hours /Week
ILimitTestofthe following
(1)Chloride
(2)Sulphate
(3)Iron
(4)Arsenic
IIPreparationandstandardizationof
(1)Sodiumhydroxide
(2)Sulphuricacid
(3)Sodiumthiosulfate
(4)Potassiumpermanganate
(5)Ceric ammoniumsulphate
IIIAssay ofthefollowingcompounds alongwithStandardizationofTitrant
(1)Ammonium chloridebyacid basetitration
(2) Ferrous sulphatebyCerimetry
(3)Copper sulphatebyIodometry
(4)Calciumgluconatebycomplexometry
(5)Hydrogen peroxidebyPermanganometry
(6)Sodiumbenzoatebynon-aqueous titration
(7)SodiumChloridebyprecipitation titration
IVDeterminationofNormality byelectro-analyticalmethods
(1)Conductometric titrationof strongacidagainststrongbase
(2)Conductometric titration of strongacid and weakacidagainststrongbase
(3)Potentiometric titration of strongacidagainststrongbase
RecommendedBooks:(Latest Editions)
1. A.H.Beckett&J.B.Stenlake's,PracticalPharmaceuticalChemistryVolI& II,Stahlone
Press of UniversityofLondon
2.A.I. Vogel,TextBook ofQuantitativeInorganic analysis
3.P. Gundu Rao,InorganicPharmaceuticalChemistry
4.BentleyandDriver'sTextbook ofPharmaceuticalChemistry
5.John H. Kennedy, Analytical chemistryprinciples
6.Indian Pharmacopoeia.
35

36. BP103T.PHARMACEUTICS-I (Theory)
45 Hours
Scope:Thiscourseisdesignedtoimpartafundamentalknowledgeonthepreparatory
pharmacywith artsandscienceofpreparingthe different conventional dosage forms.
Objectives:Uponcompletion ofthis coursethe student should beable to:
Knowthe historyofprofession ofpharmacy
Understandthebasicsofdifferentdosageforms,pharmaceuticalincompatibilitiesand
pharmaceuticalcalculations
Understand theprofessional wayofhandlingtheprescription
Preparation ofvariousconventional dosageforms
CourseContent:
UNIT– I 10 Hours
Historicalbackgroundanddevelopmentofprofessionofpharmacy:History
ofprofessionofPharmacyinIndiainrelationtopharmacyeducation,industry
andorganization,Pharmacyasacareer,Pharmacopoeias:IntroductiontoIP,BP,
USPand ExtraPharmacopoeia.
Dosageforms:Introduction to dosageforms, classificationand definitions
Prescription:Definition,Parts of prescription, handlingofPrescriptionand
Errors in prescription.
Posology:Definition,Factorsaffectingposology.Pediatricdose calculations
based on age,bodyweight and bodysurfacearea.
UNIT– II 10 Hours
Pharmaceuticalcalculations:Weightsandmeasures–Imperial&Metric
system,Calculationsinvolvingpercentagesolutions,alligation,proofspiritand
isotonic solutionsbasedonfreezingpointand molecularweight.
Powders:Definition,classification,advantagesanddisadvantages,Simple&
compoundpowders–officialpreparations,dusting powders,effervescent,
efflorescent andhygroscopic powders,eutecticmixtures. Geometric dilutions.
Liquiddosageforms:Advantagesanddisadvantagesofliquiddosageforms.
Excipientsusedinformulationofliquiddosageforms.Solubilityenhancement
techniques
36

37. UNIT– III 08 Hours
Monophasicliquids:DefinitionsandpreparationsofGargles,Mouthwashes,
ThroatPaint,Eardrops,Nasaldrops,Enemas,Syrups, Elixirs,Linimentsand
Lotions.
Biphasicliquids:
Suspensions:Definition,advantagesanddisadvantages,classifications,
Preparationof suspensions;FlocculatedandDeflocculatedsuspension&stability
problemsand methods to overcome.
Emulsions:Definition,classification,emulsifyingagent,testfortheidentification
oftypeofEmulsion,Methodsofpreparation&stabilityproblemsandmethodsto
overcome.
UNIT– IV 08 Hours
Suppositories:Definition,types,advantagesanddisadvantages,typesofbases,
methodsof preparations.Displacementvalue&itscalculations,evaluationof
suppositories.
Pharmaceuticalincompatibilities:Definition,classification,physical,chemical
and therapeuticincompatibilities withexamples.
UNIV– V 07 Hours
Semisoliddosageforms:Definitions,classification,mechanismsandfactors
influencing dermal penetrationofdrugs.Preparationofointments,pastes,creams
andgels.Excipientsused insemisoliddosageforms.Evaluationof semisolid
dosages forms
37

38. BP109P.PHARMACEUTICSI(Practical)
1 .Syrups
a)SyrupIP’66
b)Compoundsyrupof FerrousPhosphateBPC’68
3 Hours /week
2.Elixirs a) Piperazinecitrate elixir
b)Paracetamol pediatricelixir
3.Linctusa)TerpinHydrateLinctusIP’66
4.Solutions
b)IodineThroatPaint(MandlesPaint)
a) Strongsolution of ammonium acetate
b)Cresol with soap solution
c)Lugol’s solution
5.Suspensions
a) Calamine lotion
b)MagnesiumHydroxide mixture
c)AluminimumHydroxidegel
6.Emulsionsa)TurpentineLiniment
b)Liquidparaffinemulsion
7.Powders andGranules
a) ORSpowder(WHO)
b) Effervescentgranules
c)Dustingpowder
d)Divdedpowders
8.Suppositories
a)Glycerogelatin suppository
b)Cocabutter suppository
c)ZincOxidesuppository
8.Semisolids
a) Sulphur ointment
b)Non staining-iodineointment with methylsalicylate
c) Carbopalgel
9.Gargles andMouthwashes
a)Iodinegargle
b)Chlorhexidinemouthwash
RecommendedBooks:(Latest Editions)
38

39. 1. H.C.Anseletal.,PharmaceuticalDosageFormandDrugDeliverySystem,Lippincott
Williams andWalkins, New Delhi.
2.CarterS.J.,CooperandGunn’s-DispensingforPharmaceuticalStudents,CBSpublishers,
New Delhi.
3. M.E.Aulton,Pharmaceutics,The Science&DosageFormDesign,ChurchillLivingstone,
Edinburgh.
4.Indian pharmacopoeia.
5.British pharmacopoeia.
6.Lachmann.TheoryandPracticeofIndustrialPharmacy,Lea&FebigerPublisher,The
Universityof Michigan.
7. AlfonsoR. GennaroRemington.TheScienceandPracticeofPharmacy,Lippincott
Williams, New Delhi.
8.Carter S.J., Cooperand Gunn’s. TutorialPharmacy,CBS Publications,New Delhi.
9. E.A.Rawlins,Bentley’sTextBookofPharmaceutics,EnglishLanguageBookSociety,
ElsevierHealth Sciences,USA.
10.IsaacGhebreSellassie:PharmaceuticalPelletizationTechnology,MarcelDekker,INC,
New York.
11. DilipM.Parikh:HandbookofPharmaceuticalGranulationTechnology,MarcelDekker,
INC,New York.
12.FrancoiseNieloudandGilberteMarti-Mestres:PharmaceuticalEmulsionsand
Suspensions, Marcel Dekker,INC,New York.
39

40. BP104T.PHARMACEUTICAL INORGANICCHEMISTRY (Theory)
45 Hours
Scope: This subject deals withthemonographsofinorganicdrugs andpharmaceuticals.
Objectives:Uponcompletion of coursestudent shall be able to
know thesourcesof impurities andmethods todeterminethe impurities in inorganic
drugsand pharmaceuticals
understand themedicinal and pharmaceutical importanceof inorganiccompounds
CourseContent:
UNITI 10 Hours
Impuritiesinpharmaceuticalsubstances:HistoryofPharmacopoeia,
Sourcesandtypesofimpurities,principle involved inthelimittestfor
Chloride,Sulphate,Iron,Arsenic,LeadandHeavy metals,modifiedlimittest
forChlorideandSulphate
Generalmethodsofpreparation,assayforthecompoundssuperscripted
withasterisk(*),propertiesandmedicinalusesof inorganiccompounds
belongingtothe followingclasses
UNITII 10 Hours
Acids,BasesandBuffers:Bufferequationsandbuffercapacityingeneral,
buffersinpharmaceuticalsystems,preparation,stability, buffered isotonic
solutions,measurementsof tonicity,calculationsandmethodsofadjusting
isotonicity.
Majorextraandintracellularelectrolytes:Functionsofmajor
physiologicalions,Electrolytes usedin thereplacementtherapy:Sodium
chloride*,Potassiumchloride,Calciumgluconate*and OralRehydrationSalt
(ORS), Physiological acid basebalance.
Dentalproducts:Dentifrices,role offluorideinthetreatmentof dental
caries,Desensitizingagents,Calciumcarbonate,Sodiumfluoride,andZinc
eugenol cement.
UNITIII 10 Hours
Gastrointestinal agents
Acidifiers:Ammoniumchloride*and Dil. HCl
Antacid:Idealpropertiesofantacids,combinationsofantacids,Sodium
40

41. Bicarbonate*, Aluminumhydroxidegel,Magnesiumhydroxide mixture
Cathartics:Magnesiumsulphate,Sodiumorthophosphate, Kaolinand
Bentonite
Antimicrobials: Mechanism,classification,Potassiumpermanganate,Boric
acid,Hydrogen peroxide*, Chlorinated lime*,Iodineand its preparations
UNITIV 08 Hours
Miscellaneouscompounds
Expectorants:Potassiumiodide, Ammonium chloride*.
Emetics:Copper sulphate*,Sodiumpotassiumtartarate
Haematinics:Ferrous sulphate*,Ferrousgluconate
PoisonandAntidote:Sodiumthiosulphate*, Activatedcharcoal,Sodium
nitrite333
Astringents:ZincSulphate,Potash Alum
UNITV 07 Hours
Radiopharmaceuticals:Radioactivity,Measurementofradioactivity,
Propertiesofα,β,γradiations,Halflife,radioisotopesandstudy ofradio
isotopes-SodiumiodideI
131
,Storageconditions,precautions&
pharmaceutical application of radioactivesubstances.
41

42. BP110P.PHARMACEUTICAL INORGANICCHEMISTRY(Practical)
4 Hours /Week
ILimittestsforfollowing ions
Limit test forChloridesandSulphates
Modified limit test forChlorides andSulphates
Limit test forIron
Limit test forHeavymetals
Limit test forLead
Limit test forArsenic
IIIdentificationtest
Magnesiumhydroxide
Ferrous sulphate
Sodiumbicarbonate
Calciumgluconate
Copper sulphate
IIITestforpurity
Swellingpower ofBentonite
Neutralizingcapacityofaluminumhydroxidegel
Determination ofpotassiumiodateand iodinein potassiumIodide
IVPreparationofinorganicpharmaceuticals
Boricacid
Potashalum
Ferrous sulphate
RecommendedBooks(Latest Editions)
1.A.H.Beckett&J.B.Stenlake's, PracticalPharmaceutical ChemistryVolI& II,
StahlonePress of UniversityofLondon,4
th
edition.
2.A.I. Vogel, TextBook ofQuantitativeInorganic analysis
3.P. GunduRao,InorganicPharmaceuticalChemistry,3
rd
Edition
4.M.LSchroff,InorganicPharmaceuticalChemistry
5.BentleyandDriver'sTextbook of PharmaceuticalChemistry
6.Anand &Chatwal,Inorganic PharmaceuticalChemistry
7.Indian Pharmacopoeia
42

43. BP105T.COMMUNICATION SKILLS(Theory)
30 Hours
Scope:Thiscoursewillpreparetheyoungpharmacy studenttointeracteffectively with
doctors,nurses,dentists,physiotherapistsandother healthworkers.Attheendof this
coursethestudentwillgetthesoftskillssettoworkcohesively withtheteamasateam
playerand willaddvalueto thepharmaceutical business.
Objectives:
Uponcompletion ofthecoursethe student shall be able to
1. Understand thebehavioral needs foraPharmacistto functioneffectivelyin the
areasof pharmaceuticaloperation
2. Communicateeffectively(Verbal and NonVerbal)
3. Effectivelymanagetheteam as ateam player
4. Developinterviewskills
5. DevelopLeadershipqualitiesandessentials
Course content:
UNIT– I 07 Hours
CommunicationSkills:Introduction,Definition,TheImportanceofCommunication,
The Communication Process–Source,Message,Encoding,Channel,Decoding,
Receiver,Feedback, Context
Barrierstocommunication:PhysiologicalBarriers,PhysicalBarriers,Cultural
Barriers,LanguageBarriers, GenderBarriers,InterpersonalBarriers,Psychological
Barriers, Emotional barriers
PerspectivesinCommunication:Introduction,VisualPerception,Language,Other
factorsaffectingourperspective-Past Experiences,Prejudices,Feelings,Environment
UNIT– II 07 Hours
ElementsofCommunication:Introduction,FacetoFaceCommunication-Toneof
Voice,BodyLanguage(Non-verbalcommunication),VerbalCommunication,Physical
Communication
CommunicationStyles:Introduction,TheCommunicationStylesMatrixwithexample
foreach-DirectCommunicationStyle,SpiritedCommunicationStyle,Systematic
CommunicationStyle,Considerate CommunicationStyle
43

44. UNIT– III 07 Hours
BasicListeningSkills:Introduction,Self-Awareness,ActiveListening,Becomingan
ActiveListener,Listeningin Difficult Situations
EffectiveWrittenCommunication:Introduction,WhenandWhenNottoUseWritten
Communication-Complexity oftheTopic,AmountofDiscussion’Required,Shadesof
Meaning,FormalCommunication
WritingEffectively:SubjectLines,PuttheMainPointFirst,KnowYourAudience,
Organization ofthe Message
UNIT– IV 05 Hours
InterviewSkills:Purposeof an interview, Do’sand Dont’s ofan interview
GivingPresentations:Dealing withFears,PlanningyourPresentation, StructuringYour
Presentation,Delivering YourPresentation,Techniques of Delivery
UNIT– V 04 Hours
GroupDiscussion:Introduction,Communicationskillsingroupdiscussion,Do’sand
Dont’s ofgroupdiscussion
44

45. BP111P.COMMUNICATION SKILLS(Practical)
2 Hours /week
Thefollowinglearningmodulesareto beconducted usingwordsworth
®
Englishlanguage
lab software
Basiccommunicationcovering thefollowingtopics
MeetingPeople
AskingQuestions
MakingFriends
What didyou do?
Do’s andDont’s
Pronunciationscovering thefollowing topics
Pronunciation (Consonant Sounds)
Pronunciation and Nouns
Pronunciation(VowelSounds)
Advanced Learning
ListeningComprehension / Direct andIndirectSpeech
Figures of Speech
EffectiveCommunication
WritingSkills
EffectiveWriting
InterviewHandlingSkills
E-Mailetiquette
PresentationSkills
45

46. RecommendedBooks:(Latest Edition)
1.BasiccommunicationskillsforTechnology,Andreja.J.RutherFord,2
nd
Edition,
Pearson Education, 2011
2.Communication skills,SanjayKumar, Pushpalata,1
st
Edition,OxfordPress, 2011
3.OrganizationalBehaviour, Stephen .P. Robbins,1
st
Edition, Pearson, 2013
4.Brilliant-Communication skills, GillHasson,1
st
Edition,PearsonLife,2011
5.TheAce ofSoftSkills:Attitude,CommunicationandEtiquetteforsuccess,Gopala
SwamyRamesh, 5
th
Edition,Pearson, 2013
6.Developingyourinfluencing skills,DeborahDalley,LoisBurton,Margaret,Green
hall, 1st Edition UniverseofLearningLTD, 2010
7.Communicationskillsforprofessionals,Konarnira,2
nd
Edition,Newarrivals–
PHI, 2011
8.Personalitydevelopmentandsoftskills,BarunKMitra,1
st
Edition,OxfordPress,
2011
9.Softskillforeveryone,ButterField,1stEdition,CengageLearningindiapvt.ltd,
2011
10.Soft skills andprofessional communication,Francis PetersSJ,1
st
Edition,McGraw
HillEducation, 2011
11.Effectivecommunication,John Adair,4
th
Edition,Pan MacMillan,2009
12.Bringingout thebestin people, AubreyDaniels,2
nd
Edition, Mc GrawHill, 1999
46

47. BP106RBT.REMEDIAL BIOLOGY(Theory)
30 Hours
Scope:To learnand understand thecomponents of livingworld,structure andfunctional
system of plant andanimal kingdom.
Objectives:Uponcompletion ofthecourse, thestudent shall beable to
know theclassificationand salient features offivekingdoms of life
understand the basiccomponents ofanatomy&physiologyofplant
know understand thebasiccomponents ofanatomy& physiologyanimalwith
specialreferenceto human
UNITI 07 Hours
Livingworld:
Definitionandcharactersoflivingorganisms
Diversityin thelivingworld
Binomial nomenclature
Fivekingdomsoflifeandbasisofclassification.SalientfeaturesofMonera,
Potista,Fungi, AnimaliaandPlantae, Virus,
Morphology ofFloweringplants
Morphologyofdifferentparts offloweringplants– Root, stem, inflorescence,
flower, leaf, fruit, seed.
General AnatomyofRoot,stem,leaf ofmonocotyledons &Dicotylidones.
UNITII 07 Hours
Bodyfluids andcirculation
Composition of blood, bloodgroups,coagulationofblood
Composition andfunctions oflymph
Humancirculatorysystem
Structureofhuman heartand blood vessels
Cardiaccycle,cardiacoutputand ECG
DigestionandAbsorption
Humanalimentarycanaland digestiveglands
Role of digestiveenzymes
Digestion,absorptionandassimilation of digested food
Breathing andrespiration
Human respiratorysystem
Mechanismofbreathingand itsregulation
Exchangeofgases,transport ofgases andregulation of respiration
Respiratoryvolumes
47

48. UNITIII 07 Hours
Excretoryproducts andtheirelimination
Modes of excretion
Humanexcretorysystem-structure andfunction
Urine formation
Rennin angiotensinsystem
Neural controlandcoordination
Definitionandclassification of nervoussystem
Structureofaneuron
Generationandconduction ofnerveimpulse
Structureofbrainand spinal cord
Functions ofcerebrum,cerebellum,hypothalamusand medulla oblongata
Chemicalcoordinationandregulation
Endocrineglandsandtheir secretions
Functions of hormonessecretedbyendocrineglands
Humanreproduction
Parts offemalereproductivesystem
Parts of male reproductivesystem
SpermatogenesisandOogenesis
Menstrualcycle
UNITIV 05 Hours
Plants andmineralnutrition:
Essential mineral, macroand micronutrients
Nitrogenmetabolism, Nitrogencycle, biological nitrogenfixation
Photosynthesis
Autotrophicnutrition,photosynthesis,Photosyntheticpigments,Factorsaffecting
photosynthesis.
UNITV 04 Hours
Plantrespiration:Respiration,glycolysis,fermentation(anaerobic).
Plantgrowthand development
Phasesandrateofplantgrowth,Conditionofgrowth,Introductiontoplantgrowth
regulators
Cell-Theunit oflife
Structure andfunctions ofcellandcellorganelles.Cell division
Tissues
Definition,types of tissues, locationandfunctions.
48

49. TextBooks
a. Text book ofBiologybyS.B.Gokhale
b. A Text book ofBiologybyDr. ThulajappaandDr.Seetaram.
ReferenceBooks
a. A Text book ofBiologybyB.V. SreenivasaNaidu
b. A Text book ofBiologybyNaidu and Murthy
c.BotanyforDegreestudentsByA.C.Dutta.
d.Outlines ofZoologybyM. Ekambaranathaayyerand T. N. Ananthakrishnan.
e. A manual for pharmaceutical biologypracticalbyS.B.Gokhaleand C.K. Kokate
49

50. BP112RBP.REMEDIAL BIOLOGY(Practical)
1.Introduction to experimentsin biology
a)Studyof Microscope
b)Sectioncuttingtechniques
c)Mountingand staining
d)Permanentslide preparation
2.Studyofcelland its inclusions
3.Studyof Stem,Root,Leaf, seed, fruit,flowerand theirmodifications
4. Detailed studyoffrogbyusingcomputer models
5. Microscopic studyandidentification of tissues pertinenttoStem,Root
Leaf, seed, fruitandflower
6.Identification of bones
7. Determination of bloodgroup
8. Determination of blood pressure
9. Determination of tidalvolume
30 Hours
ReferenceBooks
1.Practical humananatomyand physiology.byS.R.Kaleand R.R.Kale.
2. A Manual of pharmaceutical biologypracticalbyS.B.Gokhale,C.K.Kokateand
S.P.Shriwastava.
3.Biologypractical manualaccordingtoNational corecurriculum.Biologyforum of
Karnataka.Prof .M.J.H.Shafi
50

51. BP106RMT.REMEDIALMATHEMATICS(Theory)
30 Hours
Scope:Thisisanintroductorycourseinmathematics.Thissubjectdealswiththe
introductiontoPartialfraction,Logarithm,matricesandDeterminant,Analytical
geometry,Calculus, differentialequationandLaplacetransform.
Objectives:Uponcompletion ofthecoursethestudent shall be able to:-
1.Knowthe theoryandtheirapplication inPharmacy
2.Solve the differenttypesofproblemsbyapplyingtheory
3.Appreciatethe importantapplication ofmathematics inPharmacy
CourseContent:
UNIT– I 06 Hours
Partialfraction
Introduction,Polynomial,Rationalfractions,ProperandImproperfractions,
Partialfraction,ResolvingintoPartialfraction,ApplicationofPartial
Fraction inChemical Kinetics andPharmacokinetics
Logarithms
Introduction,Definition,Theorems/Propertiesoflogarithms,Common
logarithms,CharacteristicandMantissa,workedexamples,applicationof
logarithm to solve pharmaceutical problems.
Function:
Real Valuedfunction, Classification of real valued functions,
Limits andcontinuity:
Introduction,Limitofafunction,Definitionoflimitofafunction(-
n n 

definition) ,lim
xa
na
n1
,lim
sin

1,
xaxa
0
UNIT–II 06 Hours
Matrices andDeterminant:
Introductionmatrices,Typesofmatrices,Operationonmatrices,
Transposeofamatrix,MatrixMultiplication,Determinants,Propertiesof
determinants,Productofdeterminants,Minorsandco-Factors,Adjoint
oradjugateofasquarematrix,Singular andnon-singularmatrices,
Inverseofamatrix,Solution ofsystem oflinearofequations usingmatrix
method,Cramer’srule,Characteristicequationandrootsofa square
matrix, Cayley–Hamilton theorem,Applicationof Matricesinsolving
Pharmacokineticequations
51

52. UNIT– III 06 Hours
Calculus
Differentiation:Introductions,Derivativeofafunction,Derivativeofa
constant,Derivativeofaproductofaconstantandafunction,Derivative
of the sumor differenceoftwofunctions,Derivative of theproductoftwo
functions(productformula),Derivativeofthequotientoftwofunctions
(Quotientformula)–WithoutProof,Derivative ofx
n
w.r.tx,wherenisany
rationalnumber,Derivative ofe
x
,,Derivativeoflogex,Derivativeof
a
x
,Derivative of trigonometric functionsfromfirstprinciples(without
Proof),Successive Differentiation,Conditionsfor afunctiontobea
maximum or aminimumat a point. Application
UNIT– IV 06 Hours
AnalyticalGeometry
Introduction:Signsof theCoordinates, Distanceformula,
StraightLine:Slopeorgradientofastraightline,Conditionsfor
parallelismandperpendicularity oftwolines,Slopeofalinejoiningtwo
points,Slope– interceptform of astraight line
Integration:
Introduction,Definition, Standardformulae,Rulesof integration,Methodof
substitution,MethodofPartialfractions,Integrationbyparts,definite
integrals, application
UNIT-V 06 Hours
DifferentialEquations:Somebasicdefinitions,Orderanddegree,
Equations in separableform,Homogeneousequations,Linear
Differentialequations,Exactequations,Applicationinsolving
Pharmacokinetic equations
LaplaceTransform:Introduction,Definition,PropertiesofLaplace
transform,LaplaceTransformsofelementary functions,Inverse
Laplacetransforms,Laplacetransformofderivatives,Applicationto
solveLineardifferentialequations,ApplicationinsolvingChemical
kinetics andPharmacokinetics equations
RecommendedBooks(Latest Edition)
1. DifferentialCalculusbyShanthinarayan
2.Pharmaceutical Mathematics withapplicationto PharmacybyPanchaksharappa
Gowda D.H.
3.IntegralCalculusbyShanthinarayan
4. Higher EngineeringMathematicsbyDr.B.S.Grewal
52

53. SemesterII
53

54. BP201T. HUMANANATOMY ANDPHYSIOLOGY-II (Theory)
45 Hours
Scope:Thissubjectisdesignedtoimpartfundamentalknowledge onthestructureand
functionsofthevarioussystemsofthehumanbody.Italsohelpsinunderstanding both
homeostatic mechanisms.The subjectprovidesthebasicknowledgerequiredto
understand the various disciplines ofpharmacy.
Objectives: Uponcompletion ofthis coursethe student should beable to:
1.Explainthegrossmorphology,structureandfunctionsofvariousorgansofthe
human body.
2.Describethevarious homeostatic mechanismsand their imbalances.
3.Identifythe varioustissues and organsof differentsystems of humanbody.
4.Performthehematologicaltestslikebloodcellcounts,haemoglobinestimation,
bleeding/clottingtimeetcandalsorecordbloodpressure,heartrate,pulseand
respiratoryvolume.
5.Appreciate coordinatedworkingpattern ofdifferent organs ofeachsystem
6.Appreciatetheinterlinkedmechanismsinthemaintenanceofnormalfunctioning
(homeostasis) ofhumanbody.
CourseContent:
Unit I 10hours
Nervous system
Organizationof nervoussystem,neuron,neuroglia,classificationand
propertiesofnervefibre,electrophysiology,actionpotential,
nerveimpulse, receptors,synapse, neurotransmitters.
Centralnervoussystem:Meninges,ventriclesofbrainand
cerebrospinalfluid.structureandfunctionsof brain(cerebrum,brain
stem,cerebellum),spinalcord(grossstructure,functionsofafferent
andefferentnervetracts,reflexactivity)
Unit II 06hours
Digestive system
Anatomyof GITractwithspecialreferencetoanatomyandfunctionsofstomach,
(Acidproductioninthestomach,regulationofacidproductionthrough
parasympatheticnervoussystem,pepsinroleinproteindigestion)smallintestine
54

55. andlargeintestine,anatomyandfunctionsofsalivaryglands,pancreasandliver,
movements ofGIT, digestionandabsorption of nutrients and disorders ofGIT.
Energetics
Formation androleofATP,Creatinine PhosphateandBMR.
Unit III
Respiratory system 10hours
Anatomyofrespiratory systemwithspecialreferencetoanatomyoflungs,
mechanismof respiration, regulation ofrespiration
LungVolumesandcapacitiestransportofrespiratorygases,artificialrespiration,
andresuscitationmethods.
Urinary system
Anatomyofurinarytractwithspecialreferencetoanatomyofkidneyand
nephrons,functionsofkidneyandurinarytract,physiologyofurineformation,
micturitionreflexandroleofkidneysinacidbasebalance,roleofRASinkidney
and disorders ofkidney.

Unit IV 10hours

Endocrinesystem
Classification ofhormones, mechanismofhormone action, structure
and functions of pituitary gland,thyroidgland,parathyroidgland,
adrenal
gland,pancreas, pinealgland,thymus and their disorders.
UnitV 09hours
Reproductivesystem
Anatomyofmaleandfemalereproductivesystem,Functionsofmaleandfemale
reproductivesystem,sexhormones,physiology ofmenstruation,fertilization,
spermatogenesis, oogenesis, pregnancyand parturition
Introduction to genetics
Chromosomes,genesand DNA, proteinsynthesis,geneticpatternof inheritance
55

56. BP207P. HUMAN ANATOMY ANDPHYSIOLOGY (Practical)
4 Hours/week
Practicalphysiologyiscomplimentary tothetheoreticaldiscussionsin
physiology.Practicalsallowtheverificationofphysiologicalprocessesdiscussed
intheoryclassesthroughexperimentsonlivingtissue,intactanimalsornormal
human beings. This ishelpful fordevelopingan insight onthesubject.
1. To studythe integumentaryand special senses usingspecimen, models,etc.,
2. To studythenervoussystem usingspecimen, models, etc.,
3. To studytheendocrinesystem usingspecimen,models, etc
4. To demonstrate thegeneral neurologicalexamination
5. To demonstrate the function of olfactorynerve
6. Toexamine the differenttypes oftaste.
7. To demonstrate thevisual acuity
8. To demonstrate the reflexactivity
9.Recordingofbodytemperature
10. To demonstrate positiveand negativefeedbackmechanism.
11. Determination of tidal volume and vital capacity.
12.Studyofdigestive,respiratory,cardiovascularsystems,urinaryandreproductive
systems with the help ofmodels,chartsand specimens.
13.Recordingofbasal mass index .
14.Studyof familyplanningdevices andpregnancydiagnosis test.
15. Demonstration oftotal bloodcountbycellanalyser
16.Permanentslides ofvitalorgans andgonads.
RecommendedBooks(Latest Editions)
1. EssentialsofMedicalPhysiologybyK.SembulingamandP.Sembulingam.Jaypee
brothers medical publishers, NewDelhi.
2. Anatomyand Physiologyin HealthandIllnessbyKathleenJ.W.Wilson,Churchill
Livingstone,New York
3.PhysiologicalbasisofMedicalPractice-BestandTailor.Williams&Wilkins
Co,Riverview,MIUSA
56

57. 4. TextbookofMedicalPhysiology-ArthurC,GuytonandJohn.E.Hall.Miamisburg,OH,
U.S.A.
5.Principles of AnatomyandPhysiologybyTortoraGrabowski.Palmetto,GA, U.S.A.
6. TextbookofHumanHistologybyInderbirSingh,Jaypeebrothersmedicalpublishers,
New Delhi.
7. TextbookofPracticalPhysiologybyC.L.Ghai, Jaypeebrothersmedicalpublishers,New
Delhi.
8.PracticalworkbookofHumanPhysiologybyK.SrinageswariandRajeevSharma,
Jaypeebrother’s medicalpublishers, New Delhi.
ReferenceBooks:
1.PhysiologicalbasisofMedicalPractice-BestandTailor.Williams&WilkinsCo,
Riverview,MIUSA
2. TextbookofMedicalPhysiology-ArthurC, GuytonandJohn.E.Hall. Miamisburg,OH,
U.S.A.
3. HumanPhysiology(vol1and 2)byDr. C.C.Chatterrje ,AcademicPublishers Kolkata
57

58. BP202T.PHARMACEUTICAL ORGANICCHEMISTRY–I (Theory)
45 Hours
Scope:Thissubjectdealswithclassificationandnomenclatureofsimpleorganic
compounds,structuralisomerism,intermediatesforming inreactions,importantphysical
properties,reactionsandmethodsof preparationof thesecompounds.Thesyllabusalso
emphasizes onmechanisms and orientation of reactions.
Objectives:Uponcompletion ofthecoursethestudent shall beable to
1. writethe structure, nameand thetypeofisomerism of the organiccompound
2. writethereaction, namethereactionand orientation ofreactions
3.account for reactivity/stabilityof compounds,
4. identify/confirm theidentification oforganiccompound
CourseContent:
Generalmethodsofpreparationandreactionsofcompoundssuperscriptedwithasterisk(*)tobe
explained
Toemphasizeondefinition,types,classification,principles/mechanisms,applications,examples
and differences
UNIT-I 07 Hours
Classification,nomenclatureandisomerism
Classification of OrganicCompounds
CommonandIUPACsystems of nomenclatureoforganiccompounds
(up to 10 Carbons openchain andcarbocycliccompounds)
Structural isomerisms in organiccompounds
UNIT-II10Hours
Alkanes*, Alkenes* andConjugated dienes*
SP
3
hybridization in alkanes, Halogenationofalkanes, uses ofparaffins.
Stabilities ofalkenes,SP
2
hybridization in alkenes
E1andE2reactions–kinetics,orderofreactivityofalkylhalides,rearrangementof
carbocations,Saytzeffs orientationandevidences.E1versesE2reactions,FactorsaffectingE1
andE2reactions.Ozonolysis,electrophilicadditionreactionsofalkenes, Markownikoff’s
orientation,freeradicaladdition reactions ofalkenes, Anti Markownikoff’sorientation.
Stabilityofconjugateddienes,Diel-Alder,electrophilicaddition,freeradicaladdition
reactions ofconjugateddienes, allylicrearrangement
UNIT-III10 Hours
58

59. Alkylhalides*
SN1andSN2reactions-kinetics,orderofreactivityofalkylhalides,stereochemistryand
rearrangement ofcarbocations.
SN1versus SN2reactions,FactorsaffectingSN1andSN2reactions
Structureanduses ofethylchloride, Chloroform,trichloroethylene,tetrachloroethylene,
dichloromethane, tetrachloromethane and iodoform.
Alcohols*-Qualitativetests,StructureandusesofEthylalcohol, Methylalcohol,
chlorobutanol,Cetosterylalcohol,Benzylalcohol,Glycerol, Propyleneglycol
UNIT-IV10 Hours
Carbonyl compounds* (Aldehydes and ketones)
Nucleophilicaddition,Electromericeffect,aldolcondensation,CrossedAldolcondensation,
Cannizzaroreaction,CrossedCannizzaro reaction,Benzoincondensation,Perkin
condensation,qualitativetests, StructureandusesofFormaldehyde, Paraldehyde,Acetone,
Chloralhydrate, Hexamine,Benzaldehyde, Vanilin,Cinnamaldehyde.
UNIT-V 08 Hours
Carboxylicacids*
Acidityofcarboxylicacids,effectofsubstituentsonacidity,inductiveeffectandqualitative
tests forcarboxylicacids,amide andester
StructureandUsesofAceticacid,Lacticacid, Tartaricacid,Citricacid,Succinicacid.Oxalic
acid,Salicylicacid,Benzoicacid,Benzylbenzoate,Dimethylphthalate,Methylsalicylateand
Acetyl salicylicacid
Aliphaticamines*-Basicity,effectofsubstituentonBasicity.Qualitativetest,Structureand
uses ofEthanolamine, Ethylenediamine, Amphetamine
59

60. BP208P.PHARMACEUTICAL ORGANICCHEMISTRY-I (Practical)
4 Hours /week
1.Systematicqualitativeanalysisofunknown organic compoundslike
1.Preliminary test:Color,odour,aliphatic/aromaticcompounds,saturation
and unsaturation,etc.
2.DetectionofelementslikeNitrogen,SulphurandHalogenby
Lassaigne’s test
3. Solubilitytest
4.FunctionalgrouptestlikePhenols,Amides/Urea,Carbohydrates,
Amines,Carboxylicacids, Aldehydesand Ketones, Alcohols, Esters,
Aromaticand HalogenatedHydrocarbons,Nitrocompoundsand
Anilides.
5.Meltingpoint/Boilingpointoforganiccompounds
6.Identificationoftheunknowncompoundfromtheliteratureusing
meltingpoint/ boilingpoint.
7.Preparationofthederivativesandconfirmationoftheunknown
compoundbymeltingpoint/ boilingpoint.
8.Minimum 5 unknown organic compounds tobeanalysedsystematically.
2.Preparation ofsuitable solid derivatives from organiccompounds
3.Construction ofmolecular models
RecommendedBooks(Latest Editions)
1.Organic ChemistrybyMorrisonandBoyd
2.Organic ChemistrybyI.L.Finar, Volume-I
3. Textbook of Organic ChemistrybyB.S.Bahl&ArunBahl.
4.Organic ChemistrybyP.L.Soni
5.PracticalOrganic ChemistrybyMannandSaunders.
6. Vogel’s text book of Practical OrganicChemistry
7. AdvancedPracticalorganicchemistrybyN.K.Vishnoi.
8.Introduction toOrganicLaboratorytechniquesbyPavia,Lampmanand Kriz.
9.Reactionand reaction mechanismbyAhluwaliah/Chatwal.
60

61. BP203 T.BIOCHEMISTRY (Theory)
45 Hours
Scope:Biochemistrydealswithcompleteunderstandingofthemolecularlevelsofthe
chemicalprocessassociatedwithlivingcells.Thescopeof thesubjectis providing
biochemicalfactsandthe principlestounderstandmetabolismof nutrientmoleculesin
physiologicalandpathologicalconditions.Itisalsoemphasizingongeneticorganization
ofmammaliangenomeand hetero&autocatalyticfunctions of DNA.
Objectives:Uponcompletion of coursestudent shellable to
1. Understandthecatalyticroleofenzymes,importanceofenzymeinhibitorsin
design ofnewdrugs, therapeuticand diagnosticapplications ofenzymes.
2. Understandthemetabolismofnutrientmoleculesinphysiologicaland
pathological conditions.
3. Understandthegeneticorganizationofmammaliangenomeandfunctionsof
DNA in thesynthesisofRNAs and proteins.
CourseContent:
UNITI 08 Hours
Biomolecules
Introduction,classification,chemicalnatureand biologicalroleof
carbohydrate, lipids, nucleic acids, aminoacids and proteins.
Bioenergetics
Conceptoffreeenergy,endergonicandexergonicreaction,Relationship
betweenfreeenergy,enthalpyandentropy;Redoxpotential.
Energyrichcompounds;classification;biologicalsignificancesofATP
andcyclicAMP
UNITII 10 Hours
Carbohydratemetabolism
Glycolysis–Pathway,energetics and significance
Citric acidcycle-Pathway,energeticsand significance
HMPshuntanditssignificance;Glucose-6-Phosphatedehydrogenase
(G6PD)deficiency
Glycogen metabolism Pathwaysandglycogenstoragediseases (GSD)
Gluconeogenesis-Pathwayand itssignificance
Hormonal regulation ofbloodglucoselevel and Diabetes mellitus
Biological oxidation
Electron transportchain(ETC)andits mechanism.

62. Oxidativephosphorylation&itsmechanismandsubstrate
phosphorylation
Inhibitors ETC and oxidativephosphorylation/Uncouplers
level
UNITIII 10 Hours
Lipidmetabolism
β-Oxidation ofsaturatedfattyacid (Palmiticacid)
61

63. Formation and utilizationofketone bodies; ketoacidosis
Denovosynthesisof fattyacids (Palmiticacid)
Biologicalsignificanceofcholesterolandconversionofcholesterolinto
bile acids, steroid hormone and vitamin D
Disordersoflipidmetabolism:Hypercholesterolemia,atherosclerosis,
fattyliverand obesity.
Amino acidmetabolism
Generalreactionsofaminoacidmetabolism:Transamination,
deamination &decarboxylation, ureacycle and its disorders
Catabolismofphenylalanineandtyrosineandtheirmetabolicdisorders
(Phenyketonuria, Albinism, alkeptonuria,tyrosinemia)
Synthesisandsignificanceofbiologicalsubstances;5-HT,melatonin,
dopamine, noradrenaline,adrenaline
Catabolism ofheme;hyperbilirubinemiaand jaundice
UNITIV 10 Hours
Nucleic acidmetabolismandgeneticinformationtransfer
Biosynthesisofpurineandpyrimidine nucleotides
Catabolism of purine nucleotidesandHyperuricemia and Gout disease
Organization of mammaliangenome
Structureof DNAandRNAand theirfunctions
DNAreplication (semiconservative model)
Transcription or RNAsynthesis
Genetic code, Translation orProteinsynthesis and inhibitors
62

64. UNITV 07 Hours
Enzymes
Introduction,properties,nomenclature andIUBclassification ofenzymes
Enzymekinetics(Michaelis plot,LineWeaverBurkeplot)
Enzymeinhibitors withexamples
Regulationofenzymes:enzymeinductionandrepression,allosteric
enzymesregulation
Therapeuticand diagnosticapplications ofenzymes andisoenzymes
Coenzymes–Structure and biochemical functions
BP209P.BIOCHEMISTRY (Practical)
4 Hours /Week
1.Qualitativeanalysisofcarbohydrates(Glucose,Fructose,Lactose,Maltose,
Sucrose and starch)
2.Identification testsforProteins (albumin andCasein)
3.Quantitativeanalysisof reducingsugars(DNSAmethod)andProteins
(Biuret method)
4.Qualitativeanalysis ofurinefor abnormal constituents
5.Determination ofbloodcreatinine
6.Determination ofbloodsugar
7.Determination of serum total cholesterol
8.Preparation ofbuffer solutionand measurementof pH
9.Studyofenzymatichydrolysisof starch
10.Determination ofSalivaryamylase activity
11.Studytheeffect ofTemperatureonSalivaryamylase activity.
12.Studytheeffect ofsubstrateconcentrationon salivaryamylaseactivity.
63

65. RecommendedBooks(Latest Editions)
1.Principles ofBiochemistrybyLehninger.
2.Harper’sBiochemistrybyRobert K.Murry,Daryl K. Grannerand VictorW. Rodwell.
3.BiochemistrybyStryer.
4.BiochemistrybyD.Satyanarayanand U.Chakrapani
5. Textbook ofBiochemistrybyRama Rao.
6. TextbookofBiochemistrybyDeb.
7. Outlines ofBiochemistrybyConnandStumpf
8.PracticalBiochemistrybyR.C. GuptaandS.Bhargavan.
9.Introduction ofPracticalBiochemistrybyDavidT.Plummer.(3rd Edition)
10.PracticalBiochemistryfor MedicalstudentsbyRajagopal andRamakrishna.
11.PracticalBiochemistrybyHarold Varley.
BP204T.PATHOPHYSIOLOGY(THEORY)
45Hours
Scope:Pathophysiologyisthestudyofcausesofdiseasesandreactionsofthebody to
suchdiseaseproducingcauses.Thiscourseisdesignedtoimpartathoroughknowledgeof
therelevantaspectsofpathologyofvariousconditionswithreferencetoits
pharmacologicalapplications,andunderstanding ofbasicpathophysiological
mechanisms.Henceitwillnotonlyhelptostudythesyllabusofpathology,butalsoto
getbaselineknowledgerequiredtopracticemedicinesafely,confidently,rationallyand
effectively.
Objectives:Uponcompletion ofthesubjectstudent shallbeableto–
1.Describetheetiologyandpathogenesisoftheselecteddiseasestates;
2.Name the signsandsymptoms ofthediseases;and
3.Mentionthecomplicationsof thediseases.
Course content:
UnitI 10Hours
BasicprinciplesofCell injury andAdaptation:
Introduction,definitions,Homeostasis,ComponentsandTypesofFeedbacksystems,
Causesof cellularinjury,Pathogenesis(Cellmembranedamage, Mitochondrialdamage,
Ribosomedamage,Nucleardamage),Morphology ofcellinjury–Adaptivechanges
(Atrophy,Hypertrophy,hyperplasia,Metaplasia,Dysplasia),Cellswelling,Intracellular
accumulation,Calcification,EnzymeleakageandCellDeathAcidosis
&Alkalosis,Electrolyteimbalance
64

66. Basicmechanism involved inthe processofinflammationandrepair:
Introduction,Clinicalsigns of inflammation,Different typesofInflammation,Mechanism
ofInflammation–Alterationinvascularpermeabilityandbloodflow,migrationof
WBC’s,Mediatorsofinflammation,Basicprinciplesofwoundhealinginthe
skin,PathophysiologyofAtherosclerosis
UnitII 10Hours
CardiovascularSystem:
Hypertension,congestiveheartfailure,ischemicheartdisease(angina,myocardial
infarction,atherosclerosis and arteriosclerosis)
Respiratory system:Asthma, Chronic obstructiveairwaysdiseases.
Renal system:Acuteand chronicrenalfailure.
UnitII 10Hours
Haematological Diseases:
Irondeficiency,megaloblasticanemia(VitB12andfolicacid),sicklecellanemia,
thalasemia, hereditaryacquiredanemia,hemophilia
Endocrinesystem:Diabetes, thyroid diseases, disorders ofsexhormones
Nervous system:Epilepsy,Parkinson’s disease,stroke,psychiatricdisorders:
depression, schizophrenia and Alzheimer’s disease.
Gastrointestinal system:PepticUlcer

UnitIV 8Hours
Inflammatorybowel diseases, jaundice,hepatitis(A,B,C,D,E,F)alcoholicliver
disease.
Disease ofbones andjoints:Rheumatoid arthritis, osteoporosisandgout
Principles ofcancer:classification,etiologyandpathogenesis ofcancer
Diseasesofbones andjoints:RheumatoidArthritis,Osteoporosis,Gout
PrinciplesofCancer:Classification,etiologyand pathogenesisofCancer
UnitV 7Hours
Infectiousdiseases:Meningitis,Typhoid,Leprosy,Tuberculosis
Urinarytractinfections
Sexually transmitteddiseases:AIDS,Syphilis,Gonorrhea
RecommendedBooks(LatestEditions)
65

67. 1.VinayKumar,AbulK.Abas,JonC.Aster;Robbins&CotranPathologicBasisof
Disease;SouthAsiaedition;India;Elsevier;2014.
2.HarshMohan;TextbookofPathology;6
th
edition;India;JaypeePublications;2010.
3.LaurenceB,BruceC,BjornK.;GoodmanGilman’sThePharmacologicalBasisof
Therapeutics;12
th
edition; NewYork; McGraw-Hill;2011.
4.Best,CharlesHerbert1899-1978; Taylor,NormanBurke1885-1972;West,JohnB
(JohnBurnard);BestandTaylor’sPhysiologicalbasis ofmedicalpractice;12thed;
unitedstates;
5.WilliamandWilkins, Baltimore;1991[1990printing].
6.NickiR.Colledge,BrianR. Walker,StuartH.Ralston;Davidson’sPrinciplesandPractice
ofMedicine;21
st
edition;London;ELBS/ChurchillLivingstone;2010.
7.GuytonA,John.EHall;TextbookofMedicalPhysiology;12
th
edition;WBSaunders
Company;2010.
8.JosephDiPiro,RobertL.Talbert,GaryYee,BarbaraWells,L.MichaelPosey;
Pharmacotherapy:APathophysiologicalApproach;9
th
edition;London;McGraw-Hill
Medical;2014.
9.V.Kumar,R.S.CotranandS.L.Robbins;BasicPathology;6
th
edition;Philadelphia;
WB Saunders Company;1997.
10.RogerWalker,CliveEdwards;ClinicalPharmacyandTherapeutics;3
rd
edition;London;
ChurchillLivingstone publication;2003.
Recommended Journals
1.TheJournalofPathology.ISSN:1096-9896 (Online)
2.TheAmericanJournalofPathology.ISSN:0002-9440
3. Pathology. 1465-3931(Online)
4.InternationalJournalofPhysiology,PathophysiologyandPharmacology.ISSN:1944-8171
(Online)
5.IndianJournalofPathologyand Microbiology.ISSN-0377-4929.
66

68. BP205 T.COMPUTERAPPLICATIONSINPHARMACY (Theory)
30 Hrs(2 Hrs/Week)
Scope:ThissubjectdealswiththeintroductionDatabase,DatabaseManagement system,
computerapplication inclinicalstudiesand useofdatabases.
Objectives:Uponcompletion ofthecoursethestudent shall beable to
1. know the varioustypesof application of computers in pharmacy
2. know the varioustypesof databases
3. know the variousapplications of databases in pharmacy
Course content:
UNIT– I 06hours
Numbersystem:Binarynumbersystem, Decimalnumbersystem, Octal
numbersystem, Hexadecimal numbersystems,conversion decimal to
binary, binaryto decimal, octal to binaryetc, binaryaddition,binary
subtraction–One’scomplement ,Two’s complement method, binary
multiplication, binarydivision
Concept ofInformationSystems andSoftware:Informationgathering,
requirementand feasibilityanalysis, data flow diagrams, process
specifications, input/outputdesign, process lifecycle, planningand
managingthe project
UNIT–II
06hours
Webtechnologies:Introduction to HTML, XML,CSSand
Programminglanguages,introduction to web serversandServer
Products
Introduction to databases, MYSQL, MSACCESS,PharmacyDrugdatabase
UNIT– III 06hours
ApplicationofcomputersinPharmacy–Druginformationstorageand
retrieval,Pharmacokinetics,MathematicalmodelinDrug design,Hospital
andClinicalPharmacy,ElectronicPrescribinganddischarge(EP)systems,
barcodemedicineidentificationandautomateddispensing ofdrugs,mobile
technologyandadherencemonitoring
DiagnosticSystem,Lab-diagnosticSystem, Patient MonitoringSystem,
PharmaInformationSystem
67

69. UNIT– IV 06hours
Bioinformatics:Introduction,Objective ofBioinformatics,Bioinformatics
Databases, Concept ofBioinformatics,Impact ofBioinformatics inVaccine
Discovery
UNIT-V 06hours
Computers as data analysis inPreclinicaldevelopment:
Chromatographic dada analysis(CDS),LaboratoryInformationmanagement
System(LIMS)andTextInformationManagementSystem(TIMS)
68

70. BP210P.COMPUTER APPLICATIONSINPHARMACY (Practical)
1.Designaquestionnaireusingawordprocessingpackage togatherinformation
about a particular disease.
2.Create aHTMLwebpageto show personalinformation.
3 Retrievethe information ofadrugand itsadverseeffectsusingonlinetools
4 CreatingmailinglabelsUsingLabelWizard ,generatinglabel in MS WORD
5 Create adatabasein MSAccessto storethepatient information with therequired
fields Usingaccess
6.Designa form in MSAccess to view,add,deleteand modifythepatient record in
the database
7.Generatingreportandprintingthereportfrompatient database
8.Creatinginvoicetableusing– MSAccess
9.Druginformationstorageandretrieval usingMSAccess
10.Creatingand workingwith queriesin MS Access
11.ExportingTables, Queries,Forms and Reportstoweb pages
12.ExportingTables,Queries,Forms and ReportstoXMLpages
Recommendedbooks(Latestedition):
1.Computer Application inPharmacy–William E.Fassett–Lea andFebiger,600
SouthWashingtonSquare, USA,[phone].
2.Computer Application inPharmaceuticalResearchand Development–Sean Ekins–
Wiley-Interscience, AJohnWilleyandSons,INC.,Publication, USA
3.Bioinformatics(Concept,Skills and Applications)–S.C.Rastogi-CBS Publishers and
Distributors, 4596/1-A, 11 DaryaGani, New Delhi– 110 002(INDIA)
4.MicrosoftofficeAccess-2003, Application Development UsingVBA, SQLServer,
DAPandInfopath–CaryN.Prague–WileyDreamtechIndia(P)Ltd.,4435/7,
Ansari Road, Daryagani,New Delhi-110002
69

71. BP206 T. ENVIRONMENTAL SCIENCES(Theory)
30hours
Scope:EnvironmentalSciencesisthescientificstudyoftheenvironmentalsystemand
thestatusofitsinherentorinducedchangesonorganisms.Itincludesnotonlythestudy
of physicalandbiologicalcharacters of theenvironmentbutalsothe socialandcultural
factorsand the impact ofman onenvironment.
Objectives:Uponcompletion ofthecoursethestudent shall beable to:
1. Create theawarenessabout environmental problems amonglearners.
2.Impart basic knowledgeabout the environment and its alliedproblems.
3. Develop anattitudeofconcern for the environment.
4. Motivatelearner toparticipatein environment protectionandenvironment
improvement.
5. Acquireskills tohelpthe concerned individuals inidentifyingand solving
environmental problems.
6.Strivetoattain harmonywith Nature.
Course content:
Unit-I 10hours
TheMultidisciplinarynatureofenvironmental studies
NaturalResources
Renewableand non-renewableresources:
Naturalresources and associated problems
a)Forestresources;b)Waterresources;c)Mineralresources;d)Food
resources;e)Energyresources;f)Landresources:Roleofanindividualin
conservation ofnaturalresources.
Unit-II 10hours
Ecosystems
Concept ofanecosystem.
Structure andfunction of anecosystem.
Introduction,types,characteristicfeatures,structureandfunctionof
theecosystems:Forestecosystem;Grasslandecosystem;Desert
ecosystem;Aquaticecosystems(ponds,streams,lakes,rivers,oceans,
estuaries)
Unit-III 10hours
Environmental Pollution: Airpollution;Waterpollution;Soilpollution
70

72. RecommendedBooks(Latestedition):
1.Y.K.Sing,EnvironmentalScience,NewAgeInternationalPvt,Publishers,
Bangalore
2. Agarwal, K.C. 2001 EnvironmentalBiology, NidiPubl.Ltd.Bikaner.
3.BharuchaErach,TheBiodiversityofIndia, MapinPublishingPvt.Ltd.,
Ahmedabad– 380 013,India,
4.Brunner R.C., 1989,HazardousWasteIncineration, McGrawHillInc. 480p
5. Clark R.S., MarinePollution,Clanderson Press Oxford
6.Cunningham,W.P.Cooper,T.H.Gorhani,E&Hepworth,M.T.2001,
Environmental Encyclopedia,Jaico Publ. House,Mumbai, 1196p
7. DeA.K., EnvironmentalChemistry,WileyEasternLtd.
8. Down of Earth, Centre for Science and Environment
71

73. SEMESTERIII
72

74. BP301T.PHARMACEUTICAL ORGANICCHEMISTRY–II (Theory)
45 Hours
Scope:Thissubjectdealswithgeneralmethodsof preparationandreactionsof some
organiccompounds.Reactivityoforganiccompoundsarealsostudiedhere.Thesyllabus
emphasizesonmechanismsandorientationofreactions.Chemistryoffatsandoilsare
alsoincluded in thesyllabus.
Objectives:Uponcompletion ofthecoursethestudent shall beable to
1. writethe structure, nameand thetypeofisomerism of theorganiccompound
2. writethereaction, namethe reactionandorientation of reactions
3.account forreactivity/stabilityof compounds,
4. prepareorganic compounds
CourseContent:
General methodsofpreparationandreactionsof compounds superscriptedwith asterisk (*) tobe
explained
Toemphasizeondefinition, types,classification,principles/mechanisms,applications,examples
and differences
UNITI 10 Hours
Benzeneanditsderivatives
A.Analytical,syntheticandotherevidencesinthe derivationof structure
of benzene,Orbitalpicture,resonanceinbenzene,aromatic
characters, Huckel’srule
B.Reactionsofbenzene-nitration,sulphonation,halogenation-
reactivity,Friedelcraftsalkylation-reactivity,limitations,
Friedelcraftsacylation.
C.Substituents,effectofsubstituentsonreactivityandorientationof
monosubstitutedbenzenecompoundstowardselectrophilic
substitutionreaction
D.Structure and usesofDDT, Saccharin,BHCandChloramine
UNITII 10 Hours
Phenols*-Acidityofphenols,effectofsubstituentsonacidity,qualitative
tests,Structureand usesofphenol, cresols,resorcinol, naphthols
AromaticAmines*-Basicity ofamines,effectofsubstituentsonbasicity,
andsynthetic uses ofaryldiazoniumsalts
AromaticAcids*–Acidity,effectofsubstituentsonacidityand
importantreactionsofbenzoicacid.
UNITIII
10 Hours
Fats andOils
a.Fattyacids–reactions.
73

75. b.Hydrolysis,Hydrogenation,SaponificationandRancidityofoils,Drying
oils.
c.Analyticalconstants–Acidvalue, Saponificationvalue,Ester value,
Iodinevalue,Acetylvalue,ReichertMeissl(RM) value–significanceand
principle involved in their determination.
UNITIV 08 Hours
Polynuclearhydrocarbons:
a.Synthesis,reactions
b.Structure and medicinal uses ofNaphthalene,Phenanthrene, Anthracene,
Diphenylmethane, Triphenylmethaneand theirderivatives
UNITV 07 Hours
Cyclo alkanes*
Stabilities–Baeyer’s strain theory, limitation ofBaeyer’s strain theory,
Coulsonand Moffitt’smodification,Sachse Mohr’s theory(Theoryof
strainless rings),reactions ofcyclopropane andcyclobutaneonly
74

76. BP305P.PHARMACEUTICAL ORGANICCHEMISTRY-II (Practical)
4 Hrs/week
IExperimentsinvolvinglaboratorytechniques
Recrystallization
Steam distillation
IIDeterminationoffollowingoilvalues(includingstandardizationof
reagents)
Acid value
Saponification value
Iodinevalue
IIIPreparationofcompounds
Benzanilide/Phenylbenzoate/AcetanilidefromAniline/Phenol
/Anilinebyacylationreaction.
2,4,6-Tribromoaniline/Parabromoacetanilidefrom Aniline/
Acetanilidebyhalogenation (Bromination)reaction.
5-Nitrosalicylicacid/Meta dinitrobenzenefromSalicylicacid/
Nitro benzenebynitrationreaction.
BenzoicacidfromBenzyl chloridebyoxidation reaction.
Benzoicacid/Salicylicacidfromalkylbenzoate/alkylsalicylateby
hydrolysisreaction.
1-Phenylazo-2-naptholfromAnilinebydiazotizationandcoupling
reactions.
BenzilfromBenzoinbyoxidation reaction.
Dibenzal acetonefromBenzaldehydebyClaison Schmidt reaction
Cinnammic acid fromBenzaldehydebyPerkinreaction
P-Iodo benzoicacidfromP-amino benzoicacid
RecommendedBooks(Latest Editions)
1. Organic ChemistrybyMorrisonandBoyd
2. Organic ChemistrybyI.L.Finar, Volume-I
3. Textbook of Organic ChemistrybyB.S.Bahl&ArunBahl.
4. Organic ChemistrybyP.L.Soni
5.PracticalOrganic ChemistrybyMannandSaunders.
6. Vogel’s text book of Practical OrganicChemistry
7. Advanced PracticalorganicchemistrybyN.K.Vishnoi.
75

77. 8.Introduction toOrganicLaboratorytechniquesbyPavia,Lampmanand Kriz.
BP302T.PHYSICALPHARMACEUTICS-I(Theory)
45Hours
Scope:Thecoursedealswiththevariousphysicaandphysicochemicalproperties,and
principlesinvolvedindosageforms/formulations.Theoryandpractical
componentsofthesubjecthelpthestudenttogetabetterinsightintovarious
areasofformulationresearchanddevelopment,andstability studiesof
pharmaceutical dosageforms.
Objectives:Uponthe completionof the coursestudent shall beable to
1. Understandvarious physicochemical properties of drugmoleculesinthe
designingthe dosage forms
2. Knowtheprinciplesofchemicalkinetics&tousethemforstabilitytestingnad
determinationof expirydate of formulations
3. Demonstrate useofphysicochemical properties in theformulation
developmentandevaluation of dosage forms.
CourseContent:
UNIT-I 10 Hours
Solubilityofdrugs:Solubilityexpressions,mechanismsofsolutesolventinteractions,
idealsolubilityparameters,solvation&association,quantitativeapproachtothefactors
influencingsolubilityofdrugs,diffusionprinciplesin biologicalsystems.Solubility
ofgasinliquids,solubilityofliquidsinliquids,(Binarysolutions,idealsolutions)
Raoult’slaw,realsolutions.Partiallymiscibleliquids, Critical solution temperatureand
applications. Distributionlaw, itslimitationsandapplications
UNIT-II 10Hours
StatesofMatterand propertiesofmatter:Stateofmatter,changesinthestateofmatter,
latentheats,vapourpressure,sublimationcriticalpoint,eutecticmixtures,gases,aerosols
–inhalers,relativehumidity,liquidcomplexes,liquidcrystals,glassystates,solid-
crystalline,amorphous& polymorphism.
Physicochemicalpropertiesofdrugmolecules:Refractiveindex,opticalrotation,
dielectricconstant, dipolemoment, dissociationconstant,determinationsandapplications
UNIT-III 08 Hours
Surfaceandinterfacialphenomenon:Liquidinterface,surface&interfacialtensions,
surfacefreeenergy,measurementofsurface&interfacialtensions,spreadingcoefficient,
adsorptionatliquidinterfaces, surfaceactiveagents,HLBScale,solubilisation,
detergency,adsorption atsolid interface.
76

78. UNIT-IV 08Hours
Complexationand proteinbinding:Introduction, Classification ofComplexation,
Applications,methodsofanalysis, proteinbinding,Complexationanddrugaction,
crystallinestructuresofcomplexesandthermodynamictreatment of stabilityconstants.
UNIT-V 07 Hours
pH,buffersandIsotonic solutions:Sorensen’spH scale,pHdetermination
(electrometricandcalorimetric),applicationsof buffers, bufferequation,buffercapacity,
buffers in pharmaceuticaland biologicalsystems,buffered isotonic solutions.
77

79. BP306P.PHYSICALPHARMACEUTICS– I (Practical)
1.Determination the solubilityofdrugat roomtemperature
4 Hrs/week
2. Determination ofpKavaluebyHalfNeutralization/ Henderson Hasselbalch
equation.
3. Determination ofPartitionco- efficient ofbenzoicacidin benzene andwater
4. Determination ofPartitionco- efficient ofIodineinCCl4and water
5. Determination of% composition of NaClin asolution usingphenol-watersystemby
CST method
6. Determination ofsurfacetensionofgiven liquidsbydropcount and dropweight
method
7. Determination ofHLBnumberofasurfactantbysaponification method
8. Determination of FreundlichandLangmuirconstantsusingactivatedcharcoal
9. Determination of criticalmicellarconcentration ofsurfactants
10. Determination ofstabilityconstantand donor acceptor ratio ofPABA-Caffeine
complex bysolubilitymethod
11. Determination ofstabilityconstantand donor acceptorratio of Cupric-Glycine
complex bypH titrationmethod
RecommendedBooks:(Latest Editions)
1.PhysicalPharmacybyAlfredMartin
2. ExperimentalPharmaceuticsbyEugene,Parott.
3. TutorialPharmacybyCooperand Gunn.
4.StocklosamJ.PharmaceuticalCalculations,Lea&Febiger, Philadelphia.
5.Liberman H.A,LachmanC.,PharmaceuticalDosageforms, Tablets,Volume-1 to
3, MarcelDekkarInc.
6.Liberman H.A,LachmanC,PharmaceuticalDosage forms.Disperse
systems, volume1, 2, 3.MarcelDekkarInc.
7.PhysicalPharmaceuticsbyRamasamyCandManavalanR.
8.LaboratoryManual ofPhysicalPharmaceutics,C.V.S.Subramanyam,J.
Thimmasettee
9.PhysicalPharmaceuticsbyC.V.S.Subramanyam
10. Test book of PhysicalPhramacy,byGauravJain &Roop K.Khar
78

80. BP303 T.PHARMACEUTICALMICROBIOLOGY(Theory)
Scope:
45Hours
Studyofallcategoriesofmicroorganisimsespeciallyfortheproductionofalchol
antibiotics,vaccines, vitaminsenzymesetc..
Objectives:Uponcompletion ofthe subjectstudent shall be able to;
1. Understandmethodsofidentification,cultivationandpreservationof
variousmicroorganisms
2. To understand the importanceand implementation ofsterlizationin
pharmaceutical processingandindustry
3.Learn sterilitytestingofpharmaceutical products.
4. Carried out microbiologicalstandardization ofPharmaceuticals.
5. Understandthecellculturetechnologyanditsapplicationsinpharmaceutical
industries.
Course content:
Unit I 10 Hours
Introduction,historyofmicrobiology,itsbranches,scopeandits
importance.
Introduction to Prokaryotes andEukaryotes
Study ofultra-structureandmorphologicalclassificationofbacteria,
nutritionalrequirements,rawmaterialsusedforculture mediaandphysical
parametersforgrowth,growthcurve,isolationandpreservationmethods
forpurecultures,cultivation ofanaerobes, quantitative measurementof
bacterialgrowth(total &viable count).
Studyofdifferenttypesofphaseconstrastmicroscopy,darkfield
microscopyandelectronmicroscopy.
Unit II 10 Hours
Identificationofbacteriausingstainingtechniques(simple,Gram’s&Acid
faststaining)and biochemical tests(IMViC).
Studyofprinciple, procedure, merits,demeritsandapplications of physical,
chemicalgaseous,radiationandmechanicalmethod of sterilization.
Evaluation of theefficiencyof sterilization methods.
79

81. Equipments employed inlargescale sterilization.
Sterilityindicators.
Unit III 10 Hours
Studyofmorphology,classification,reproduction/replicationand
cultivation ofFungi andViruses.
Classification and modeof action ofdisinfectants
Factorsinfluencingdisinfection,antisepticsandtheirevaluation.For
bacteriostaticandbactericidalactions
Evaluation of bactericidal &Bacteriostatic.
Sterilitytestingofproducts(solids,liquids,ophthalmicandothersterile
products)accordingtoIP,BPandUSP.
Unit IV 08 Hours
Designingofasepticarea,laminarflowequipments;studyofdifferent
sourcesofcontaminationinanasepticareaandmethodsofprevention,
cleanareaclassification.
Principlesandmethodsofdifferentmicrobiologicalassay.Methodsfor
standardization ofantibiotics, vitamins andaminoacids.
Assessmentofanewantibiotic.
Unit V 07Hours
Typesofspoilage,factorsaffecting themicrobialspoilageof
pharmaceuticalproducts,sourcesandtypesofmicrobialcontaminants,
assessment ofmicrobialcontamination and spoilage.
Preservationofpharmaceuticalproductsusingantimicrobialagents,
evaluation of microbialstabilityofformulations.
Growthofanimalcellsinculture,generalprocedureforcellculture,
Primary,establishedandtransformedcellcultures.
Application ofcellculturesin pharmaceutical industryandresearch.
80

82. BP307P.PHARMACEUTICAL MICROBIOLOGY (Practical)
4 Hrs/week
1.Introductionandstudyofdifferentequipmentsandprocessing,e.g.,B.O.D.incubator,
laminar flow,aseptichood,autoclave,hotairsterilizer,deepfreezer,refrigerator,
microscopes used inexperimental microbiology.
2.Sterilization ofglassware, preparationand sterilization ofmedia.
3.Subculturingofbacteriaandfungus. Nutrientstabs andslants preparations.
4.Stainingmethods-Simple,Gramsstainingandacidfaststaining(Demonstrationwith
practical).
5.Isolationofpurecultureofmicro-organismsbymultiplestreakplatetechniqueandother
techniques.
6. Microbiological assayof antibioticsbycup plate methodand other methods
7. MotilitydeterminationbyHangingdrop method.
8.Sterilitytestingofpharmaceuticals.
9.Bacteriological analysisofwater
10.Biochemical test.
RecommendedBooks(Latestedition)
1.W.B. Hugoand A.D.Russel: PharmaceuticalMicrobiology,BlackwellScientific
publications, OxfordLondon.
2.Prescottand Dunn.,Industrial Microbiology,4
th
edition,CBS Publishers &Distributors,
Delhi.
3.Pelczar, Chan Kreig,Microbiology,TataMcGrawHilledn.
4. MalcolmHarris,BalliereTindalland Cox:PharmaceuticalMicrobiology.
5. Rose:IndustrialMicrobiology.
6.Probisher,Hinsdillet al:Fundamentals of Microbiology, 9th ed.Japan
7. Cooperand Gunn’s: TutorialPharmacy,CBSPublisher and Distribution.
8.Peppler:Microbial Technology.
9.I.P.,B.P., U.S.P.-latest editions.
10. Ananthnarayan :TextBook ofMicrobiology,Orient-Longman, Chennai
11. Edward:Fundamentalsof Microbiology.
12. N.K.Jain:PharmaceuticalMicrobiology,VallabhPrakashan,Delhi
13.Bergeysmanual ofsystematic bacteriology,Williams andWilkins-AWaverlycompany
81

83. BP304 T.PHARMACEUTICAL ENGINEERING(Theory)
45 Hours
Scope:Thiscourseisdesignedtoimpartafundamentalknowledgeontheartandscience
ofvarious unitoperations used in pharmaceuticalindustry.
Objectives:Uponcompletion ofthecoursestudent shall be able:
1. To know various unitoperations used inPharmaceuticalindustries.
2. To understand the material handlingtechniques.
3. To performvarious processes involved in pharmaceutical manufacturingprocess.
4. Tocarryoutvarioustestto prevent environmental pollution.
5. Toappreciateandcomprehendsignificanceofplantlayoutdesignforoptimum
useof resources.
6. Toappreciatethevariouspreventivemethodsusedforcorrosioncontrolin
Pharmaceutical industries.
Course content:
UNIT-I 10 Hours
Flow offluids:Types ofmanometers,Reynoldsnumberanditssignificance,
Bernoulli’stheoremanditsapplications,Energy losses,Orificemeter,
Venturimeter,Pitot tube and Rotometer.
SizeReduction:Objectives,Mechanisms&Lawsgoverningsizereduction,
factorsaffecting sizereduction,principles,construction,working,uses,meritsand
demeritsofHammermill,ballmill,fluidenergymill,Edgerunnermill&end
runner mill.
SizeSeparation:Objectives,applications&mechanismofsizeseparation,
officialstandardsof powders,sieves,size separationPrinciples,construction,
working, uses,meritsand demerits ofSieveshaker,cycloneseparator, Air
separator,Bagfilter&elutriation tank.
UNIT-II 10Hours

HeatTransfer:Objectives,applications&Heattransfermechanisms.Fourier’s
law,Heattransferbyconduction,convection&radiation.Heatinterchangers&
heat exchangers.
82

84. Evaporation:Objectives,applicationsandfactorsinfluencingevaporation,
differencesbetweenevaporationandother heatprocess.principles,construction,
working,uses,meritsanddemeritsofSteamjacketedkettle,horizontaltube
evaporator,climbing filmevaporator,forcedcirculationevaporator,multiple
effect evaporator&Economyofmultiple effect evaporator.

Distillation:BasicPrinciplesandmethodologyofsimpledistillation,flash
distillation,fractionaldistillation,distillationunderreducedpressure,steam
distillation &moleculardistillation
UNIT-III 08Hours
Drying:Objectives,applications&mechanismofdryingprocess,measurements
&applicationsofEquilibriumMoisturecontent,rateofdryingcurve.principles,
construction,working,uses,meritsanddemeritsofTray dryer,drumdryerspray
dryer,fluidized bed dryer, vacuumdryer, freezedryer.
Mixing:Objectives,applications&factorsaffectingmixing,Differencebetween
solidandliquidmixing,mechanismofsolidmixing,liquidsmixingand
semisolidsmixing.Principles,Construction,Working,uses,MeritsandDemerits
of Doubleconeblender,twinshellblender,ribbonblender,Sigmablademixer,
planetarymixers, Propellers,Turbines,Paddles&Silverson Emulsifier,
UNIT-IV 08Hours
Filtration:Objectives,applications,Theories&Factorsinfluencingfiltration,
filter aids,filter medias. Principle,Construction, Working,Uses,Meritsand
demeritsofplate&framefilter, filterleaf, rotarydrum filter, Meta filter &
Cartridgefilter, membrane filtersandSeidtzfilter.
Centrifugation:Objectives,principle&applicationsofCentrifugation,
principles,construction,working,uses, meritsanddemeritsofPerforated basket
centrifuge,Non-perforatedbasketcentrifuge,semicontinuouscentrifuge& super
centrifuge.
UNIT-V 07 Hours
Materialsofpharmaceuticalplantconstruction,Corrosionandits
prevention:Factorsaffecting duringmaterialsselectedforPharmaceuticalplant
construction,Theoriesofcorrosion,typesofcorrosionandthere prevention.
Ferrousandnonferrousmetals,inorganicandorganic nonmetals,basicof
material handlingsystems.
83

85. RecommendedBooks:(Latest Editions)
1.Introductiontochemicalengineering–WalterLBadger&JuliusBanchero,Latest
edition.
2.Solidphaseextraction,Principles,techniquesandapplicationsbyNigelJ.K.Simpson-
Latest edition.
3. Unit operation ofchemical engineering–McabeSmith,Latest edition.
4.Pharmaceuticalengineeringprinciplesandpractices–C.V.SSubrahmanyametal.,Latest
edition.
5.Remington practiceof pharmacy-Martin,Latestedition.
6. Theoryandpracticeofindustrial pharmacybyLachmann.,Latestedition.
7.Physical pharmaceutics-C.V.S Subrahmanyamet al.,Latestedition.
8. Cooperand Gunn’sTutorial pharmacy,S.J. Carter,Latest edition.
84

86. BP308P-PHARMACEUTICAL ENGINEERING(Practical)
4 Hours/week
I.Determinationofradiation constant of brass,iron,unpaintedand paintedglass.
II.Steamdistillation– Tocalculate theefficiencyofsteamdistillation.
III.To determinetheoverallheat transfercoefficientbyheat exchanger.
IV.Constructionof dryingcurves (forcalciumcarbonateand starch).
V.Determination ofmoisture contentand loss on drying.
VI.Determinationofhumidityofair–i)Fromwetanddrybulbtemperatures–useof
Dew pointmethod.
VII. DescriptionofConstructionworkingandapplicationofPharmaceutical
Machinerysuchasrotarytabletmachine,fluidizedbedcoater,fluidenergymill,
dehumidifier.
VIII.Size analysisbysieving– Toevaluatesizedistribution of tabletgranulations–
Constructionofvarioussizefrequencycurvesincludingarithmetic
andlogarithmicprobabilityplots.
IX.Sizereduction:Toverifythelawsofsizereductionusingballmilland
determining Kicks,Rittinger’s,Bond’scoefficients,powerrequirementand
critical speedofBall Mill.
X.Demonstrationofcolloidmill,planetarymixer,fluidizedbeddryer,freezedryer
and such othermajorequipment.
XI.FactorsaffectingRateofFiltrationandEvaporation (Surfacearea,Concentration
and Thickness/viscosity
XII. To studytheeffect of time on theRate ofCrystallization.
XIII. TocalculatetheuniformityIndexforgiven samplebyusingDoubleCone
Blender.
85

87. SEMESTERIV
86

88. BP401T.PHARMACEUTICAL ORGANICCHEMISTRY–III (Theory)
45 Hours
Scope:Thissubjectimpartsknowledgeonstereo-chemicalaspectsoforganiccompounds
andorganicreactions,importantnamedreactions,chemistryofimportantheterocyclic
compounds.Italso emphasizes onmedicinal andotheruses oforganiccompounds.
Objectives:At theend ofthecourse, the studentshall be able to
1. understand the methodsofpreparationand properties of organiccompounds
2.explainthestereochemicalaspectsoforganiccompoundsandstereochemical
reactions
3. know the medicinal usesand other applications of organiccompounds
CourseContent:
Note: Toemphasizeondefinition,types,mechanisms,examples, uses/applications
UNIT-I 10 Hours
Stereo isomerism
Optical isomerism–
Optical activity,enantiomerism, diastereoisomerism,mesocompounds
Elements ofsymmetry,chiral andachiral molecules
DLsystemofnomenclatureofopticalisomers,sequencerules,RSsystemof
nomenclatureof opticalisomers
Reactions of chiral molecules
Racemicmodificationandresolution ofracemicmixture.
Asymmetricsynthesis:partialandabsolute
UNIT-II 10Hours
Geometricalisomerism
Nomenclatureofgeometrical isomers (Cis Trans,EZ,Syn Antisystems)
Methods ofdetermination ofconfiguration ofgeometrical isomers.
Conformational isomerism in Ethane,n-Butane andCyclohexane.
Stereoisomerisminbiphenylcompounds(Atropisomerism)andconditionsforoptical
activity.
Stereospecificand stereoselective reactions
UNIT-III 10 Hours
87

89. Heterocycliccompounds:
Nomenclatureandclassification
Synthesis,reactionsandmedicinal uses offollowingcompounds/derivatives
Pyrrole,Furan,and Thiophene
RelativearomaticityandreactivityofPyrrole,Furanand Thiophene
UNIT-IV 8 Hours
Synthesis,reactionsandmedicinal uses offollowingcompounds/derivatives
Pyrazole,Imidazole, Oxazoleand Thiazole.
Pyridine, Quinoline,Isoquinoline, Acridine andIndole.Basicityofpyridine
Synthesis andmedicinaluses ofPyrimidine, Purine,azepinesand theirderivatives
UNIT-V 07 Hours
Reactionsofsynthetic importance
Metalhydridereduction(NaBH4andLiAlH4),Clemmensenreduction,Birch
reduction,Wolff Kishnerreduction.
Oppenauer-oxidation and Dakin reaction.
Beckmannsrearrangement and Schmidtrearrangement.
Claisen-Schmidt condensation
RecommendedBooks(Latest Editions)
1.OrganicchemistrybyI.L.Finar, Volume-I& II.
2.A text book of organicchemistry–ArunBahl,B.S.Bahl.
3.HeterocyclicChemistrybyRaj K.Bansal
4.Organic ChemistrybyMorrisonandBoyd
5.HeterocyclicChemistrybyT.L. Gilchrist
88

90. BP402T.MEDICINALCHEMISTRY– I (Theory)
45 Hours
Scope:Thissubjectis designedtoimpartfundamentalknowledgeonthestructure,
chemistryandtherapeuticvalueofdrugs.Thesubjectemphasizesonstructureactivity
relationshipsofdrugs,importance ofphysicochemicalpropertiesandmetabolismof
drugs.Thesyllabusalsoemphasizesonchemicalsynthesisofimportantdrugsundereach
class.
Objectives:Uponcompletion ofthecoursethestudent shall beable to
1. understand thechemistryofdrugs withrespect to theirpharmacologicalactivity
2. understandthedrugmetabolicpathways,adverseeffectandtherapeuticvalueof
drugs
3. know theStructural ActivityRelationship(SAR) ofdifferent class of drugs
4. writethechemicalsynthesis of some drugs
CourseContent:
Studyofthe development ofthefollowingclassesofdrugs,Classification,mechanismof
action,usesofdrugsmentionedinthecourse, Structureactivityrelationshipofselective
classofdrugs asspecifiedinthe courseandsynthesis ofdrugssuperscripted(*)
UNIT-I 10 Hours
Introduction toMedicinal Chemistry
Historyand development ofmedicinal chemistry
Physicochemicalproperties inrelationtobiological action
Ionization, Solubility,Partition Coefficient,Hydrogen bonding,Protein
binding, Chelation,Bioisosterism, Optical and Geometrical isomerism.
Drugmetabolism
Drugmetabolism principles-PhaseIandPhaseII.
Factorsaffectingdrugmetabolismincludingstereochemical aspects.
UNIT-II 10 Hours
Drugs acting onAutonomicNervousSystem
Adrenergic Neurotransmitters:
Biosynthesisandcatabolism ofcatecholamine.
Adrenergicreceptors(Alpha&Beta)and their distribution.
Sympathomimeticagents:SAR ofSympathomimeticagents
Directacting:Nor-epinephrine,Epinephrine,Phenylephrine*,Dopamine,
89

91. Methyldopa,Clonidine, Dobutamine,Isoproterenol,Terbutaline,
Salbutamol*,Bitolterol,Naphazoline,Oxymetazoline andXylometazoline.
Indirectactingagents:Hydroxyamphetamine,Pseudoephedrine,
Propylhexedrine.
Agents withmixed mechanism: Ephedrine, Metaraminol.
Adrenergic Antagonists:
Alpha adrenergic blockers: Tolazoline*, Phentolamine,
Phenoxybenzamine,Prazosin, Dihydroergotamine, Methysergide.
Beta adrenergic blockers:SARofbetablockers,Propranolol*,
Metibranolol, Atenolol,Betazolol,Bisoprolol, Esmolol,Metoprolol,
Labetolol, Carvedilol.
UNIT-III 10 Hours
Cholinergic neurotransmitters:
Biosynthesisandcatabolism ofacetylcholine.
Cholinergicreceptors(Muscarinic&Nicotinic) and theirdistribution.
Parasympathomimeticagents:SAR ofParasympathomimeticagents
Direct actingagents:Acetylcholine,Carbachol*,Bethanechol,
Methacholine,Pilocarpine.
Indirectacting/Cholinesteraseinhibitors(Reversible&Irreversible):
Physostigmine,Neostigmine*,Pyridostigmine,Edrophoniumchloride,
Tacrinehydrochloride,Ambenoniumchloride,Isofluorphate,Echothiophate
iodide,Parathione, Malathion.
Cholinesterasereactivator:Pralidoxime chloride.
Cholinergic Blockingagents:SAR ofcholinolyticagents
Solanaceousalkaloidsandanalogues:Atropine sulphate,Hyoscyamine
sulphate, Scopolaminehydrobromide,Homatropinehydrobromide,
Ipratropium bromide*.
Syntheticcholinergicblockingagents:Tropicamide,Cyclopentolate
hydrochloride,Clidinium bromide, Dicyclominehydrochloride*,
Glycopyrrolate,Methantheline bromide,Propantheline bromide,
Benztropinemesylate,Orphenadrinecitrate,Biperidinehydrochloride,
Procyclidinehydrochloride*,Tridihexethylchloride,Isopropamide iodide,
Ethopropazinehydrochloride.
UNIT-IV 08 Hours
Drugs acting onCentral NervousSystem
90

92. A. Sedatives andHypnotics:
Benzodiazepines:SARofBenzodiazepines,Chlordiazepoxide,Diazepam*,
Oxazepam, Chlorazepate,Lorazepam, Alprazolam,Zolpidem
Barbiturtes:SARofbarbiturates,Barbital*,Phenobarbital,Mephobarbital,
Amobarbital,Butabarbital,Pentobarbital,Secobarbital
Miscelleneous:
Amides &imides: Glutethmide.
Alcohol &their carbamate derivatives:Meprobomate, Ethchlorvynol.
Aldehyde&their derivatives: Triclofos sodium,Paraldehyde.
B. Antipsychotics
Phenothiazeines:SARofPhenothiazeines-Promazinehydrochloride,
Chlorpromazinehydrochloride*,Triflupromazine, Thioridazine
hydrochloride,Piperacetazinehydrochloride,Prochlorperazine maleate,
Trifluoperazinehydrochloride.
RingAnaloguesofPhenothiazeines:Chlorprothixene,Thiothixene,
Loxapine succinate, Clozapine.
Flurobuterophenones:Haloperidol, Droperidol,Risperidone.
Betaaminoketones:Molindonehydrochloride.
Benzamides:Sulpieride.
C.Anticonvulsants:SAR of Anticonvulsants,mechanismofanticonvulsant
action
Barbiturates:Phenobarbitone, Methabarbital.Hydantoins:
Phenytoin*, Mephenytoin, EthotoinOxazolidinediones:
Trimethadione,ParamethadioneSuccinimides:
Phensuximide, Methsuximide, Ethosuximide*Urea and
monoacylureas:Phenacemide, Carbamazepine*
Benzodiazepines:Clonazepam
Miscellaneous:Primidone, Valproicacid , Gabapentin,Felbamate
UNIT– V 07 Hours
Drugs acting onCentral NervousSystem
91

93. Generalanesthetics:
Inhalationanesthetics:Halothane*, Methoxyflurane,Enflurane,
Sevoflurane,Isoflurane,Desflurane.
Ultrashortactingbarbitutrates:Methohexitalsodium*,Thiamylal
sodium, Thiopental sodium.
Dissociative anesthetics:Ketaminehydrochloride.*
Narcotic andnon-narcoticanalgesics
Morphine andrelateddrugs:SARof Morphineanalogues,Morphine
sulphate, Codeine, Meperidinehydrochloride,Anilerdinehydrochloride,
Diphenoxylatehydrochloride,Loperamidehydrochloride,Fentanylcitrate*,
Methadonehydrochloride*,Propoxyphenehydrochloride,Pentazocine,
Levorphanol tartarate.
Narcoticantagonists:Nalorphinehydrochloride,Levallorphantartarate,
Naloxonehydrochloride.
Anti-inflammatoryagents:Sodiumsalicylate,Aspirin,Mefenamicacid*,
Meclofenamate,Indomethacin, Sulindac, Tolmetin,Zomepriac,Diclofenac,
Ketorolac,Ibuprofen*,Naproxen,Piroxicam,Phenacetin,Acetaminophen,
Antipyrine,Phenylbutazone.
92

94. BP406P.MEDICINALCHEMISTRY– I(Practical)
4 Hours/Week
IPreparationofdrugs/ intermediates
1 1,3-pyrazole
2 1,3-oxazole
3 Benzimidazole
4 Benztriazole
5 2,3-diphenyl quinoxaline
6 Benzocaine
7 Phenytoin
8 Phenothiazine
9 Barbiturate
IIAssay ofdrugs
1 Chlorpromazine
2 Phenobarbitone
3 Atropine
4 Ibuprofen
5 Aspirin
6 Furosemide
IIIDeterminationofPartitioncoefficientforanytwodrugs
RecommendedBooks(Latest Editions)
1.Wilsonand Giswold’sOrganic medicinal andPharmaceuticalChemistry.
2.Foye’s Principlesof MedicinalChemistry.
3.Burger’s MedicinalChemistry, VolItoIV.
4.Introduction to principles of drugdesign-Smith andWilliams.
5. Remington’s PharmaceuticalSciences.
6. Martindale’sextrapharmacopoeia.
93

95. 7. Organic ChemistrybyI.L.Finar, Vol.II.
8. TheOrganicChemistryofDrugSynthesisbyLednicer,Vol.1-5.
9.Indian Pharmacopoeia.
10. Text book of practical organic chemistry-A.I.Vogel.
94

96. BP403 T.PHYSICALPHARMACEUTICS-II(Theory)
45Hours
Scope:Thecoursedealswiththevariousphysicaandphysicochemicalproperties,and
principlesinvolvedindosageforms/formulations.Theoryandpractical
componentsofthesubjecthelpthestudenttogetabetterinsightintovarious
areasofformulationresearchanddevelopment,andstability studiesof
pharmaceutical dosageforms.
Objectives:Uponthe completionof the coursestudent shall beable to
1. Understandvarious physicochemical properties of drugmoleculesinthe
designingthe dosage forms
2. Knowtheprinciplesofchemicalkinetics&tousethemforstabilitytestingnad
determinationof expirydate of formulations
3. Demonstrate useofphysicochemical properties in theformulation
developmentandevaluation of dosage forms.
CourseContent:
UNIT-I 07 Hours
Colloidaldispersions:Classificationofdispersedsystems&theirgeneral
characteristics,size &shapesofcolloidalparticles,classificationofcolloids&
comparativeaccountof theirgeneralproperties.Optical,kinetic&electricalproperties.
Effectofelectrolytes,coacervation, peptization& protective action.
UNIT-II 10Hours
Rheology:Newtoniansystems,law of flow,kinematic viscosity,effectof temperature,
non-Newtoniansystems,pseudoplastic,dilatant,plastic,thixotropy,thixotropy in
formulation, determination ofviscosity,capillary,fallingSphere,rotationalviscometers
Deformationofsolids:Plasticandelasticdeformation,Heckelequation, Stress,Strain,
Elastic Modulus
UNIT-III 10 Hours
Coarsedispersion:Suspension,interfacialpropertiesofsuspendedparticles,settling in
suspensions,formulationofflocculatedanddeflocculated suspensions.Emulsionsand
theoriesofemulsification,microemulsionandmultipleemulsions;Stability ofemulsions,
preservationofemulsions,rheologicalpropertiesof emulsionsandemulsion
formulationbyHLB method.
95

97. UNIT-IV 10Hours
Micromeretics:Particlesizeanddistribution,meanparticle size,numberandweight
distribution,particlenumber,methodsfordeterminingparticlesizeby different
methods,countingandseparationmethod,particleshape,specificsurface,methodsfor
determining surfacearea,permeability,adsorption,derivedpropertiesofpowders,
porosity, packingarrangement, densities, bulkiness & flow properties.
UNIT-V 10 Hours
Drugstability:Reactionkinetics:zero,pseudo-zero,first&secondorder,unitsofbasic
rateconstants,determinationofreactionorder.Physicalandchemicalfactorsinfluencing
thechemicaldegradationofpharmaceuticalproduct:temperature,solvent,ionic strength,
dielectricconstant,specific&generalacidbasecatalysis, Simple numericalproblems.
Stabilizationofmedicinalagentsagainstcommonreactionslikehydrolysis& oxidation.
Acceleratedstabilitytestinginexpirationdatingofpharmaceuticaldosageforms.
Photolyticdegradationand its prevention
96

98. BP407P.PHYSICALPHARMACEUTICS-II(Practical)
3 Hrs/week
1. Determination of particlesize, particlesizedistribution usingsievingmethod
2. Determination of particlesize, particlesizedistribution usingMicroscopicmethod
3. Determination of bulk density,truedensityand porosity
4. Determinetheangleofrepose and influenceoflubricant on angleof repose
5. Determination ofviscosityofliquid usingOstwald’s viscometer
6. Determinationsedimentation volume with effectof different suspendingagent
7. Determinationsedimentationvolumewitheffectofdifferentconcentrationof
single suspendingagent
8. Determination of viscosityofsemisolidbyusing Brookfield viscometer
9. Determination ofreactionrateconstant first order.
10. Determination ofreactionrateconstantsecond order
11. Accelerated stabilitystudies
RecommendedBooks:(Latest Editions)
1.PhysicalPharmacybyAlfredMartin,Sixthedition
2.Experimental pharmaceuticsbyEugene,Parott.
3.Tutorial pharmacybyCooperandGunn.
4.StocklosamJ.Pharmaceutical calculations,Lea&Febiger, Philadelphia.
5.Liberman H.A,LachmanC.,Pharmaceutical Dosage forms, Tablets, Volume-1 to 3,
MarcelDekkarInc.
6.Liberman H.A,LachmanC,Pharmaceuticaldosage forms. Dispersesystems, volume1,
2, 3. MarcelDekkarInc.
7.PhysicalPharmaceuticsbyRamasamyC,andManavalan R.
97

99. BP404 T.PHARMACOLOGY-I (Theory)
45 Hrs
Scope:Themainpurposeofthesubjectistounderstandwhatdrugsdototheliving
organismsandhow theireffectscanbeappliedtotherapeutics.The subjectcoversthe
informationaboutthedrugslike,mechanismofaction,physiologicalandbiochemical
effects(pharmacodynamics)aswellasabsorption,distribution,metabolismandexcretion
(pharmacokinetics)along withtheadverseeffects,clinicaluses,interactions,doses,
contraindicationsandroutes of administration ofdifferentclasses ofdrugs.
Objectives:Uponcompletion ofthiscoursethe student should beable to
1. Understand the pharmacologicalactions of different categories of drugs
2. Explain themechanism ofdrugactionat organsystem/subcellular/
macromolecular levels.
3. Applythebasic pharmacological knowledgein thepreventionandtreatment of
various diseases.
4. Observetheeffect of drugs onanimalsbysimulatedexperiments
5. Appreciate correlation ofpharmacologywithother bio medical sciences
CourseContent:
UNIT-I 08hours
1.GeneralPharmacology
a.Introductionto Pharmacology-Definition,historicallandmarksandscope of
pharmacology,natureandsourceofdrugs,essentialdrugsconceptandroutesof
drugadministration,Agonists,antagonists(competitiveandnoncompetitive),spare
receptors,addiction, tolerance,dependence, tachyphylaxis,idiosyncrasy,allergy.
b.Pharmacokinetics-Membranetransport,absorption,distribution,metabolismand
excretion of drugs .Enzyme induction,enzyme inhibition, kinetics ofelimination
UNIT-II 12 Hours
GeneralPharmacology
a.Pharmacodynamics-Principles and mechanisms of drugaction.Receptortheories
andclassification of receptors,regulation ofreceptors. drugreceptors interactions
signal transduction mechanisms,G-protein–coupledreceptors, ion channelreceptor,
transmembrane enzymelinkedreceptors, transmembraneJAK-STATbinding
receptorandreceptors that regulate transcriptionfactors, doseresponse
relationship,therapeuticindex,combinedeffectsofdrugsandfactors modifying
drugaction.
b.Adversedrugreactions.
c.Druginteractions (pharmacokineticand pharmacodynamic)
d.Drugdiscoveryandclinical evaluation ofnew drugs-Drugdiscoveryphase,
preclinical evaluation phase,clinical trial phase,phases ofclinical trials and
pharmacovigilance.
98

100. UNIT-III 10 Hours
2.Pharmacology ofdrugsacting onperipheralnervous system
a. Organizationandfunction ofANS.
b.Neurohumoral transmission,co-transmissionandclassification ofneurotransmitters.
c.Parasympathomimetics,Parasympatholytics,Sympathomimetics,sympatholytics.
d. Neuromuscular blockingagents and skeletalmuscle relaxants (peripheral).
e.Local anestheticagents.
f.Drugs used inmyastheniagravis andglaucoma
UNIT-IV 08 Hours
3.Pharmacology ofdrugsactingoncentralnervous system
a. Neurohumoral transmission in theC.N.S.specialemphasis onimportanceofvarious
neurotransmitters like with GABA, Glutamate, Glycine, serotonin, dopamine.
b. General anestheticsand pre-anesthetics.
c.Sedatives,hypnoticsandcentrallyactingmuscle relaxants.
d. Anti-epileptics
e. Alcoholsand disulfiram
UNIT-V 07 Hours
3.Pharmacology ofdrugsacting oncentralnervous system
a.Psychopharmacological agents:Antipsychotics,antidepressants,anti-anxietyagents,
anti-manics and hallucinogens.
b. Drugs used inParkinsons disease and Alzheimer’s disease.
c. CNSstimulants and nootropics.
d. Opioid analgesics andantagonists
e. Drugaddiction, drugabuse,toleranceanddependence.
99

101. BP408P.PHARMACOLOGY-I(Practical)
4Hrs/Week
1.Introduction to experimental pharmacology.
2. Commonlyused instrumentsinexperimental pharmacology.
3.Studyofcommon laboratoryanimals.
4. Maintenanceof laboratoryanimals asper CPCSEAguidelines.
5. Commonlaboratorytechniques.Bloodwithdrawal,serumandplasmaseparation,
anesthetics andeuthanasiaused for animalstudies.
6.Studyof different routesofdrugs administration in mice/rats.
7.Studyofeffectofhepaticmicrosomalenzymeinducersonthephenobarbitonesleeping
time in mice.
8. Effectofdrugs onciliarymotilityoffrogoesophagus
9. Effectofdrugs onrabbiteye.
10. Effects of skeletal muscle relaxants usingrota-rod apparatus.
11. Effectofdrugs on locomotoractivityusingactophotometer.
12. AnticonvulsanteffectofdrugsbyMESandPTZmethod.
13.Studyof stereotype andanti-catatonicactivityofdrugs onrats/mice.
14.Studyof anxiolyticactivityofdrugs usingrats/mice.
15.Studyof local anestheticsbydifferentmethods
Note:Alllaboratorytechniques and animal experimentsaredemonstratedbysimulated
experimentsbysoftwares andvideos
RecommendedBooks(Latest Editions)
1. RangH. P.,DaleM. M.,RitterJ. M.,Flower R.J.,Rangand Dale’s
Pharmacology,.ChurchilLivingstoneElsevier
2. KatzungB. G.,MastersS.B., TrevorA.J.,Basicandclinical pharmacology, TataMc
Graw-Hill
3. Goodman and Gilman’s,ThePharmacologicalBasisofTherapeutics
4. MarryAnneK. K.,Lloyd YeeY.,BrianK.A.,RobbinL.C.,JosephG.B.,WayneA.
K.,BradleyR.W., Applied Therapeutics, TheClinical use ofDrugs, ThePointLippincott
Williams &Wilkins
5. Mycek M.J, GelnetS.BandPerperM.M.Lippincott’sIllustrated Reviews-
Pharmacology
100

102. 6. K.D.Tripathi. EssentialsofMedical Pharmacology,JAYPEEBrothersMedical
Publishers (P)Ltd,NewDelhi.
7. SharmaH.L.,SharmaK.K., Principles ofPharmacology,Paras medical publisher
8. ModernPharmacologywithclinical Applications,byCharlesR.Craig&Robert,
9. GhoshMN.FundamentalsofExperimentalPharmacology.Hilton&Company,
Kolkata.
10. Kulkarni SK. Handbookof experimentalpharmacology. VallabhPrakashan,
101

103. BP 405 T.PHARMACOGNOSYANDPHYTOCHEMISTRYI(Theory)
45 Hours
Scope:ThesubjectinvolvesthefundamentalsofPharmacognosylikescope,classificationof
crudedrugs,theiridentificationandevaluation,phytochemicalspresentinthemandtheir
medicinal properties.
Objectives:Uponcompletion ofthecourse, thestudentshallbe able
1.to know thetechniquesinthe cultivationand production ofcrudedrugs
2.to know thecrudedrugs, their uses andchemical nature
3.knowtheevaluationtechniquesfortheherbaldrugs
4.tocarryout themicroscopic andmorphologicalevaluationofcrudedrugs
CourseContent:
UNIT-I 10 Hours
Introductionto Pharmacognosy:
(a) Definition,history,scope anddevelopment ofPharmacognosy
(b)SourcesofDrugs–Plants,Animals, Marine&Tissue culture
(c)Organizeddrugs,unorganizeddrugs(driedlatex,driedjuices,driedextracts,gumsand
mucilages, oleoresinsandoleo-gum-resins).
Classificationofdrugs:
Alphabetical,morphological,taxonomical,chemical,pharmacological,chemoandsero
taxonomicalclassificationofdrugs
QualitycontrolofDrugsofNaturalOrigin:
Adulterationofdrugsofnaturalorigin.Evaluationbyorganoleptic,microscopic,physical,
chemicaland biologicalmethodsandproperties.
Quantitativemicroscopyofcrudedrugsincludinglycopodiumsporemethod,leafconstants,
cameralucidaand diagramsofmicroscopicobjectstoscalewithcameralucida.
UNIT-II 10 Hours
Cultivation, Collection,Processingandstorageofdrugsofnaturalorigin:
CultivationandCollectionofdrugsofnaturalorigin
Factorsinfluencingcultivation ofmedicinalplants.
Plant hormonesandtheirapplications.
Polyploidy, mutationandhybridizationwith reference tomedicinalplants
Conservationofmedicinalplants
UNIT-III 07 Hours
Plant tissue culture:
Historicaldevelopmentofplanttissueculture,typesofcultures,Nutritionalrequirements,
growthand theirmaintenance.
Applicationsofplant tissue culturein pharmacognosy.
Ediblevaccines
102

104. UNITIV 10 Hours
Pharmacognosy in various systemsofmedicine:
RoleofPharmacognosyinallopathyandtraditionalsystemsofmedicinenamely,Ayurveda,
Unani,Siddha,Homeopathyand Chinesesystemsofmedicine.
Introductiontosecondarymetabolites:
Definition,classification, propertiesandtestforidentificationofAlkaloids,Glycosides,
Flavonoids,Tannins,VolatileoilandResins
UNIT V 08 Hours
Studyofbiologicalsource,chemicalnatureandusesofdrugsofnaturalorigincontaining
followingdrugs
PlantProducts:
Fibers- Cotton,Jute,Hemp
Hallucinogens, Teratogens,Naturalallergens
Primarymetabolites:
Generalintroduction,detailedstudywithrespecttochemistry,sources,preparation,
evaluation,preservation,storage,therapeuticusedandcommercialutilityasPharmaceutical
Aidsand/orMedicinesforthefollowingPrimarymetabolites:
Carbohydrates:Acacia,Agar,Tragacanth,Honey
Proteins and Enzymes:Gelatin, casein,proteolyticenzymes (Papain,bromelain,
serratiopeptidase, urokinase,streptokinase, pepsin).
Lipids(Waxes,fats,fixedoils):Castoroil, Chaulmoograoil,WoolFat, BeesWax
MarineDrugs:
Novelmedicinal agentsfrom marinesources
103

105. 104

106. BP408 P.PHARMACOGNOSYANDPHYTOCHEMISTRYI(Practical)
4 Hours/Week
1.Analysisofcrudedrugsbychemicaltests:(i)Tragaccanth(ii)Acacia(iii)Agar(iv)
Gelatin(v)starch(vi) Honey(vii)Castor oil
2.Determinationofstomatalnumberandindex
3.Determinationof veinislet number,veinisletterminationandpalisideratio.
4.Determinationofsizeofstarchgrains,calciumoxalatecrystalsbyeyepiece
micrometer
5.DeterminationofFiberlengthandwidth
6.DeterminationofnumberofstarchgrainsbyLycopodiumspore method
7.DeterminationofAshvalue
8.DeterminationofExtractivevaluesofcrudedrugs
9.Determinationofmoisturecontent ofcrudedrugs
10.Determinationofswellingindexandfoaming
Recommended Books:(Latest Editions)
1.W.C.Evans,TreaseandEvans Pharmacognosy,16thedition,W.B.Sounders&Co.,
London, 2009.
2.Tyler, V.E., Brady,L.R.and Robbers,J.E.,Pharmacognosy, 9thEdn.,Lea and
Febiger,Philadelphia,1988.
3.TextBook ofPharmacognosybyT.E.Wallis
4.MohammadAli.PharmacognosyandPhytochemistry, CBSPublishers&
Distribution,NewDelhi.
5.Textbook ofPharmacognosybyC.K.Kokate,Purohit,Gokhlae(2007),37thEdition,
NiraliPrakashan,NewDelhi.
6.HerbaldrugindustrybyR.D. Choudhary(1996),IstEdn,EasternPublisher,New
Delhi.
7.EssentialsofPharmacognosy,Dr.SH.Ansari, IIndedition,Birlapublications,New
Delhi, 2007
8.PracticalPharmacognosy:C.K. Kokate,Purohit,Gokhlae
9.AnatomyofCrudeDrugsbyM.A.Iyengar
105

107. SEMESTERV
106

108. BP501T.MEDICINALCHEMISTRY– II (Theory)
45 Hours
Scope:Thissubjectis designedtoimpartfundamentalknowledgeonthestructure,
chemistryandtherapeuticvalueofdrugs.Thesubjectemphasizesonstructureactivity
relationshipsofdrugs,importance ofphysicochemicalpropertiesandmetabolismof
drugs.Thesyllabusalsoemphasizesonchemicalsynthesisofimportantdrugsundereach
class.
Objectives:Uponcompletion ofthecoursethestudent shall beable to
1. Understand thechemistryofdrugswithrespect to theirpharmacological activity
2. Understandthedrugmetabolicpathways,adverseeffectandtherapeuticvalueof
drugs
3. KnowtheStructuralActivityRelationship of different class ofdrugs
4.Studythechemicalsynthesisofselecteddrugs
CourseContent:
Studyofthedevelopmentofthefollowingclassesofdrugs, Classification,
mechanismof action,usesofdrugsmentionedinthecourse,Structureactivity
relationshipofselectiveclassofdrugsasspecifiedinthecourse andsynthesisof
drugs superscripted(*)
UNIT-I 10 Hours
Antihistaminicagents:Histamine,receptorsandtheirdistributioninthe
humanbody
H1–antagonists: Diphenhydraminehydrochloride*,Dimenhydrinate,
Doxylaminescuccinate,Clemastinefumarate,Diphenylphyralinehydrochloride,
Tripelenaminehydrochloride,Chlorcyclizinehydrochloride, Meclizine
hydrochloride,Buclizinehydrochloride,Chlorpheniramine maleate,Triprolidine
hydrochloride*, Phenidamine tartarate, Promethazinehydrochloride*,
Trimeprazine tartrate,Cyproheptadinehydrochloride,Azatidinemaleate,
Astemizole,Loratadine,Cetirizine,LevocetrazineCromolyn sodium
H2-antagonists:Cimetidine*,Famotidine, Ranitidin.
GastricProton pumpinhibitors:Omeprazole,Lansoprazole,Rabeprazole,
Pantoprazole
Anti-neoplastic agents:
Alkylatingagents:Meclorethamine*,Cyclophosphamide,Melphalan,
107

109. Chlorambucil,Busulfan,Thiotepa
Antimetabolites:Mercaptopurine*,Thioguanine,Fluorouracil,Floxuridine,
Cytarabine, Methotrexate*, Azathioprine
Antibiotics:Dactinomycin, Daunorubicin,Doxorubicin,Bleomycin
Plantproducts:Etoposide,Vinblastinsulphate,Vincristinsulphate
Miscellaneous:Cisplatin, Mitotane.
UNIT– II 10 Hours
Anti-anginal:
Vasodilators:Amylnitrite,Nitroglycerin*,Pentaerythritoltetranitrate,Isosorbide
dinitrite*, Dipyridamole.
Calciumchannelblockers:Verapamil,Bepridilhydrochloride,Diltiazem
hydrochloride, Nifedipine, Amlodipine,Felodipine, Nicardipine,Nimodipine.
Diuretics:
Carbonicanhydrase inhibitors:Acetazolamide*,Methazolamide,
Dichlorphenamide.
Thiazides:Chlorthiazide*,Hydrochlorothiazide,Hydroflumethiazide,
Cyclothiazide,
Loop diuretics:Furosemide*,Bumetanide, Ethacrynicacid.
PotassiumsparingDiuretics:Spironolactone, Triamterene, Amiloride.
Osmotic Diuretics:Mannitol
Anti-hypertensive Agents:Timolol, Captopril,Lisinopril,Enalapril,Benazepril
hydrochloride,Quinaprilhydrochloride,Methyldopatehydrochloride,*Clonidine
hydrochloride,Guanethidine monosulphate,Guanabenzacetate,Sodium
nitroprusside, Diazoxide,Minoxidil, Reserpine, Hydralazinehydrochloride.
UNIT-III 10 Hours
Anti-arrhythmicDrugs:Quinidine sulphate,Procainamidehydrochloride,
Disopyramide phosphate*, Phenytoinsodium,Lidocainehydrochloride,
Tocainidehydrochloride,Mexiletinehydrochloride,Lorcainidehydrochloride,
Amiodarone,Sotalol.
Anti-hyperlipidemicagents:Clofibrate,Lovastatin,Cholesteramineand
Cholestipol
Coagulant & Anticoagulants:Menadione,Acetomenadione,Warfarin*,
Anisindione,clopidogrel
Drugsusedin CongestiveHeartFailure:Digoxin,Digitoxin,Nesiritide,
Bosentan,Tezosentan.
108

110. 109

111. UNIT-IV 08 Hours
Drugs acting onEndocrinesystem
Nomenclature,Stereochemistryand metabolismof steroids
Sexhormones:Testosterone,Nandralone,Progestrones,Oestriol,Oestradiol,
Oestrione, Diethylstilbestrol.
Drugsfor erectile dysfunction:Sildenafil, Tadalafil.
Oralcontraceptives:Mifepristone, Norgestril,Levonorgestrol
Corticosteroids:Cortisone,Hydrocortisone,Prednisolone,Betamethasone,
Dexamethasone
Thyroidandantithyroiddrugs:L-Thyroxine,L-Thyronine,Propylthiouracil,
Methimazole.
UNIT– V 07 Hours
Antidiabeticagents:
Insulin and its preparations
Sulfonyl ureas: Tolbutamide*, Chlorpropamide,Glipizide, Glimepiride.
Biguanides: Metformin.
Thiazolidinediones: Pioglitazone, Rosiglitazone.
Meglitinides: Repaglinide, Nateglinide.
Glucosidase inhibitors: Acrabose,Voglibose.
Local Anesthetics:SARofLocalanesthetics
BenzoicAcidderivatives;Cocaine,Hexylcaine,Meprylcaine,Cyclomethycaine,
Piperocaine.
AminoBenzoicacidderivatives:Benzocaine*,Butamben,Procaine*,Butacaine,
Propoxycaine, Tetracaine,Benoxinate.
Lidocaine/Anilidederivatives:Lignocaine, Mepivacaine, Prilocaine, Etidocaine.
Miscellaneous:Phenacaine, Diperodon, Dibucaine.*
RecommendedBooks(Latest Editions)
1.Wilsonand Giswold’sOrganic medicinal andPharmaceutical Chemistry.
2.Foye’s Principlesof MedicinalChemistry.
3.Burger’s MedicinalChemistry, VolItoIV.
4.Introduction to principles of drugdesign-Smith andWilliams.
5. Remington’s PharmaceuticalSciences.
6. Martindale’s extrapharmacopoeia.
7. Organic ChemistrybyI.L.Finar, Vol.II.
8. TheOrganicChemistryofDrugSynthesisbyLednicer,Vol.1to 5.
9.Indian Pharmacopoeia.
10. Text book of practical organic chemistry-A.I.Vogel.
110

112. 111

113. BP502 T.IndustrialPharmacyI(Theory)
45 Hours
Scope:Courseenablesthestudenttounderstandandappreciate the influenceof
pharmaceuticaladditivesandvariouspharmaceuticaldosageformsontheperformanceof
the drugproduct.
Objectives:Uponcompletion ofthecoursethe student shall beable to
1. Know thevariouspharmaceuticaldosageformsandtheirmanufacturing
techniques.
2. Knowvariousconsiderationsin development of pharmaceutical dosageforms
3.Formulate solid,liquid and semisolid dosage forms and evaluatethemfortheir
quality
Course content:
3hours/week
UNIT-I 07 Hours
PreformulationStudies:Introductiontopreformulation,goalsandobjectives,studyof
physicochemical characteristics of drugsubstances.
a.Physicalproperties:Physicalform(crystal&amorphous),particlesize,shape,flow
properties, solubilityprofile (pKa, pH,partitioncoefficient), polymorphism
b.Chemical Properties:Hydrolysis, oxidation, reduction,racemisation, polymerization
BCSclassification ofdrugs&its significant
Applicationofpreformulationconsiderationsinthedevelopmentofsolid,liquidoraland
parenteral dosageformsand itsimpact on stabilityofdosage forms.
UNIT-II 10 Hours
Tablets:
a.Introduction,idealcharacteristicsoftablets,classificationoftablets.Excipients,
Formulationof tablets,granulationmethods,compressionandprocessingproblems.
Equipments and tablet tooling.
b.Tabletcoating:Typesofcoating,coatingmaterials,formulationofcoating
composition, methods ofcoating,equipmentemployedanddefectsincoating.
c.Qualitycontroltests:Inprocess andfinishedproduct tests
Liquidorals:Formulationandmanufacturingconsiderationofsyrupsandelixirs
suspensionsandemulsions;Fillingandpackaging;evaluationofliquidorals
officialin pharmacopoeia
112

114. UNIT-III 08 Hours
Capsules:
a.Hardgelatincapsules:Introduction,Productionofhardgelatincapsuleshells.size
ofcapsules,Filling,finishingandspecialtechniquesofformulation ofhardgelatin
capsules,manufacturingdefects.Inprocessandfinalproductqualitycontroltests
for capsules.
b.Softgelatincapsules:Natureofshellandcapsulecontent,size of
capsules,importance ofbaseadsorptionandminim/gramfactors,production,in
processandfinalproductqualitycontroltests.Packing,storageandstabilitytesting
ofsoftgelatin capsulesand their applications.
Pellets:Introduction,formulationrequirements,pelletizationprocess,equipmentsfor
manufactureofpellets
UNIT-IV 10 Hours
ParenteralProducts:
a.Definition,types,advantagesandlimitations.Preformulationfactorsandessential
requirements,vehicles,additives, importanceofisotonicity
b.Productionprocedure,productionfacilitiesandcontrols,
asepticprocessing
c.Formulationofinjections,sterilepowders,largevolumeparenterals and
lyophilized products.
d.Containersandclosuresselection,fillingandsealingofampoules,vialsandinfusion
fluids. Qualitycontroltests of parenteral products.
OphthalmicPreparations:Introduction,formulationconsiderations;formulationofeye
drops,eye ointmentsandeye lotions;methodsof preparation;labeling,containers;
evaluation of ophthalmicpreparations
UNIT-V 10 Hours
Cosmetics:Formulationandpreparationofthefollowingcosmeticpreparations:
lipsticks,shampoos,coldcreamand vanishingcream,toothpastes,hairdyesand
sunscreens.
PharmaceuticalAerosols:Definition,propellants,containers,valves,types ofaerosol
systems;formulationandmanufactureofaerosols;Evaluationofaerosols;Quality
controland stabilitystudies.
PackagingMaterialsScience:Materialsusedforpackaging ofpharmaceuticalproducts,
factorsinfluencingchoiceofcontainers,legalandofficialrequirementsforcontainers,
stabilityaspects ofpackagingmaterials, qualitycontrol tests.
113

115. BP506P.IndustrialPharmacyI(Practical)
1.Preformulation studies on paracetamol/asparin/oranyotherdrug
2.Preparationandevaluation of Paracetamol tablets
3.Preparationandevaluation ofAspirin tablets
4.Coatingoftablets-filmcoatingoftables/granules
5.Preparationandevaluation ofTetracycline capsules
6.Preparation ofCalciumGluconate injection
7.Preparation ofAscorbicAcid injection
8.Qulaitycontroltestof (as perIP)marketedtabletsandcapsules
9.Preparation ofEyedrops/ andEyeointments
10.Preparation ofCreams (cold /vanishingcream)
11.Evaluation of Glasscontainers (asperIP)
4 Hours/week
RecommendedBooks:(Latest Editions)
1.Pharmaceutical dosageforms-Tablets, volume1-3byH.A.Liberman,LeonLachman
&J.B.Schwartz
2.Pharmaceuticaldosageform-Parenteralmedicationvol-1&2byLiberman&
Lachman
3.Pharmaceutical dosageform dispersesystemVOL-1byLiberman&Lachman
4. Modern PharmaceuticsbyGilbertS.Banker& C.T. Rhodes,3rd Edition
5.Remington:TheScienceandPracticeofPharmacy,20theditionPharmaceutical
Science (RPS)
6. TheoryandPracticeofIndustrialPharmacyby Liberman&Lachman
7.Pharmaceutics-ThescienceofdosageformdesignbyM.E.Aulton,Churchill
livingstone,Latestedition
8.IntroductiontoPharmaceuticalDosageFormsbyH.C.Ansel,Lea&Febiger,
Philadelphia, 5
th
edition,2005
9.Drugstability-PrinciplesandpracticebyCartensen&C.J.Rhodes,3rdEdition,
MarcelDekker Series,Vol 107.
114

116. BP503.T.PHARMACOLOGY-II (Theory)
45 Hours
Scope:Thissubjectis intended to impart thefundamentalknowledgeonvariousaspects
(classification,mechanismofaction,therapeuticeffects,clinicaluses,sideeffectsand
contraindications)ofdrugsactingondifferentsystemsofbodyandinaddition,emphasis
on the basicconcepts ofbioassay.
Objectives:Uponcompletion ofthis coursethe student should beable to
1. Understand the mechanism of drugactionanditsrelevancein thetreatment of
differentdiseases
2. Demonstrate isolation ofdifferentorgans/tissues fromthelaboratoryanimalsby
simulatedexperiments
3. Demonstrate thevariousreceptoractions usingisolated tissue preparation
4. Appreciate correlation ofpharmacologywithrelated medical sciences
CourseContent:
UNIT-I 10hours
1.Pharmacology ofdrugs acting oncardio vascularsystem
a.Introduction to hemodynamicandelectrophysiologyofheart.
b. Drugs used incongestiveheartfailure
c. Anti-hypertensivedrugs.
d. Anti-anginal drugs.
e. Anti-arrhythmicdrugs.
f.Anti-hyperlipidemicdrugs.
UNIT-II 10hours
1.Pharmacology ofdrugs acting oncardio vascular system
a. Drugusedin thetherapyofshock.
b. Hematinics, coagulants and anticoagulants.
c.Fibrinolytics and anti-platelet drugs
d.Plasma volume expanders
2.Pharmacology ofdrugs acting on urinarysystem
a. Diuretics
b. Anti-diuretics.
UNIT-III 10hours
3. Autocoidsandrelated drugs
a.Introduction to autacoids andclassification
b. Histamine, 5-HTandtheirantagonists.
c.Prostaglandins, Thromboxanes andLeukotrienes.
d. Angiotensin,Bradykinin and SubstanceP.
e. Non-steroidal anti-inflammatoryagents
f.Anti-goutdrugs
g. Antirheumatic drugs
115

117. UNIT-IV 08hours
5.Pharmacology ofdrugs acting onendocrinesystem
a.Basicconceptsinendocrinepharmacology.
b. AnteriorPituitaryhormones-analoguesand their inhibitors.
c. Thyroid hormones-analogues and theirinhibitors.
d. Hormonesregulatingplasmacalcium level-Parathormone, Calcitonin and
Vitamin-D.
d.Insulin,OralHypoglycemicagents andglucagon.
e. ACTHandcorticosteroids.
UNIT-V 07hours
5.Pharmacology ofdrugs acting onendocrinesystem
a. Androgensand Anabolic steroids.
b. Estrogens, progesterone and oralcontraceptives.
c. Drugsactingon the uterus.
6.Bioassay
a.Principles andapplications of bioassay.
b.Typesof bioassay
c.Bioassayofinsulin, oxytocin, vasopressin, ACTH,d-tubocurarine,digitalis, histamine
and 5-HT
116

118. BP507P.PHARMACOLOGY-II(Practical)
4Hrs/Week
1.Introduction toin-vitropharmacologyand physiological salt solutions.
2.Effectof drugs on isolatedfrogheart.
3.Effectof drugs on bloodpressure and heartrateofdog.
4.Studyof diureticactivityofdrugs using rats/mice.
5.DRCofacetylcholineusingfrogrectus abdominismuscle.
6.Effectof physostigmine andatropine on DRCof acetylcholineusingfrog rectus
abdominismuscle and ratileumrespectively.
7.Bioassayofhistamine usingguineapigileumbymatchingmethod.
8.Bioassayofoxytocinusingrat uterinehornbyinterpolation method.
9.Bioassayofserotonin usingrat fundus stripbythreepointbioassay.
10.Bioassayofacetylcholineusing rat ileum/colonbyfour point bioassay.
11.Determination ofPA2value ofprazosin usingratanococcygeus muscle (by
Schilds plotmethod).
12.Determination ofPD2value usingguineapigileum.
13.Effectof spasmogens and spasmolytics using rabbitjejunum.
14.Anti-inflammatoryactivityofdrugsusingcarrageenaninducedpaw-edema
model.
15.Analgesicactivityofdrugusingcentralandperipheralmethods
Note:Alllaboratorytechniques and animal experimentsaredemonstratedbysimulated
experimentsbysoftwares andvideos
RecommendedBooks(Latest Editions)
1.RangH. P.,Dale M.M.,RitterJ. M.,Flower R.J.,Rangand Dale’s Pharmacology,
ChurchilLivingstoneElsevier
2. KatzungB. G., MastersS.B., Trevor A.J.,Basicandclinical pharmacology, TataMc
Graw-Hill.
3. Goodman and Gilman’s,ThePharmacologicalBasisofTherapeutics
4. MarryAnneK. K.,Lloyd YeeY.,BrianK. A.,RobbinL.C.,JosephG.B.,WayneA.
K.,BradleyR.W., Applied Therapeutics, TheClinical use ofDrugs, ThePoint
LippincottWilliams & Wilkins.
5.Mycek M.J, GelnetS.BandPerper M.M.Lippincott’sIllustrated Reviews-
Pharmacology.
6. K.D.Tripathi. EssentialsofMedical Pharmacology,,JAYPEEBrothersMedical
Publishers (P)Ltd,NewDelhi.
7.SharmaH.L.,SharmaK.K., Principles of Pharmacology,Paras medical publisher
8. ModernPharmacologywithclinical Applications,byCharlesR.Craig& Robert.
9. Ghosh MN.Fundamentals of ExperimentalPharmacology. Hilton&Company,
Kolkata.
10. Kulkarni SK. Handbookof experimental pharmacology.VallabhPrakashan.
117

119. 118

120. BP504 T.PHARMACOGNOSYANDPHYTOCHEMISTRYII(Theory)
45Hours
Scope:Themainpurposeofsubjectistoimpartthestudentstheknowledgeofhowthe
secondarymetabolitesareproducedinthecrudedrugs,howtoisolateandidentifyand
producethemindustrially.Alsothissubjectinvolvesthestudyofproducingtheplantsand
phytochemicalsthroughplanttissueculture,druginteractionsandbasicprinciplesof
traditionalsystem ofmedicine
Objectives:Uponcompletion ofthecourse, thestudentshallbe able
1.toknowthemodernextractiontechniques,characterizationandidentificationofthe
herbal drugsand phytoconstituents
2.to understandthepreparationanddevelopmentofherbalformulation.
3.to understandtheherbaldruginteractions
4.tocarryoutisolationandidentification ofphytoconstituents
CourseContent:
UNIT-I 7 Hours
Metabolicpathwaysin higherplantsandtheirdetermination
a)Briefstudy ofbasicmetabolicpathwaysandformationofdifferentsecondarymetabolites
through thesepathways-Shikimicacid pathway,AcetatepathwaysandAminoacidpathway.
b)Studyofutilization ofradioactive isotopesintheinvestigation ofBiogenetic studies.
UNIT-II 14 Hours
Generalintroduction,composition,chemistry&chemicalclasses,biosources,therapeutic
uses andcommercial applicationsoffollowing
secondarymetabolites:
Alkaloids:Vinca, Rauwolfia, Belladonna,Opium,
PhenylpropanoidsandFlavonoids:Lignans,Tea,Ruta
Steroids,CardiacGlycosides& Triterpenoids:Liquorice,Dioscorea,Digitalis
Volatileoils:Mentha, Clove, Cinnamon,Fennel, Coriander,
Tannins:Catechu,Pterocarpus
Resins:Benzoin,Guggul,Ginger,Asafoetida,Myrrh, Colophony
Glycosides:Senna,Aloes,Bitter Almond
Iridoids,Otherterpenoids& Naphthaquinones:Gentian,Artemisia,taxus,carotenoids
UNIT-III 06 Hours
Isolation, IdentificationandAnalysisofPhytoconstituents
a)Terpenoids:Menthol, Citral,Artemisin
b)Glycosides:Glycyrhetinicacid &Rutin
c)Alkaloids:Atropine,Quinine,Reserpine,Caffeine
d)Resins:Podophyllotoxin,Curcumin
UNIT-IV 10 Hours
Industrial production,estimationand utilization ofthefollowingphytoconstituents:
Forskolin,Sennoside,Artemisinin,Diosgenin,Digoxin,Atropine,Podophyllotoxin,Caffeine,
Taxol,Vincristine andVinblastine
UNIT V 8Hours
BasicsofPhytochemistry
Modernmethods ofextraction,application oflatesttechniqueslikeSpectroscopy,
chromatographyandelectrophoresisintheisolation,purificationandidentification ofcrude
drugs.
119

121. BP 508P.PHARMACOGNOSYANDPHYTOCHEMISTRYII(Practical)
4 Hours/Week
1.Morphology, histologyand powdercharacteristics& extraction &detectionof:
Cinchona, Cinnamon,Senna, Clove,Ephedra,Fennel and Coriander
2.Exerciseinvolvingisolation &detectionofactiveprinciples
a.Caffeine-from teadust.
b.DiosgeninfromDioscorea
c.AtropinefromBelladonna
d.SennosidesfromSenna
3.Separation ofsugarsbyPaperchromatography
4.TLCofherbal extract
5.Distillation ofvolatileoilsand detectionofphytoconstitutents byTLC
6.Analysisofcrudedrugsbychemicaltests:(i) Asafoetida(ii) Benzoin(iii)
Colophony(iv)Aloes(v)Myrrh
Recommended Books:(Latest Editions)
1.W.C.Evans,TreaseandEvans Pharmacognosy,16thedition,W.B.Sounders&Co.,
London, 2009.
2.MohammadAli.PharmacognosyandPhytochemistry, CBSPublishers&
Distribution,NewDelhi.
3.Textbook ofPharmacognosybyC.K.Kokate,Purohit,Gokhlae(2007),37thEdition,
NiraliPrakashan,NewDelhi.
4.HerbaldrugindustrybyR.D. Choudhary(1996),IstEdn,EasternPublisher,New
Delhi.
5.EssentialsofPharmacognosy,Dr.SH.Ansari, IIndedition,Birlapublications,New
Delhi,2007
6.Herbal CosmeticsbyH.Pande,AsiaPacificBusinesspress,Inc,New Delhi.
7.A.N. Kalia,Textbookof IndustrialPharmacognosy, CBSPublishers,NewDelhi,
2005.
8.R Endress,PlantcellBiotechnology,Springer-Verlag, Berlin, 1994.
9.Pharmacognosy&Pharmacobiotechnology.JamesBobbers,MarilynKS,VE Tylor.
10.Theformulationandpreparation ofcosmetic,fragrancesandflavours.
11.Remington’sPharmaceuticalsciences.
12.TextBook ofBiotechnologybyVyasandDixit.
13.TextBook ofBiotechnologybyR.C.Dubey.
120

122. 121

123. BP505 T.PHARMACEUTICAL JURISPRUDENCE(Theory)
Scope:This courseis designed to impart basicknowledgeon important
legislations related to theprofession of pharmacyinIndia.
45 Hours
Objectives: Uponcompletion ofthecourse, thestudent shallbeable to understand:
1. ThePharmaceuticallegislationsand theirimplications in the development and
marketingof pharmaceuticals.
2. VariousIndian pharmaceutical Acts andLaws
3. The regulatoryauthorities and agenciesgoverningthemanufactureandsaleof
pharmaceuticals
4. The codeofethics duringthe pharmaceuticalpractice
CourseContent:
UNIT-I 10 Hours
Drugs andCosmeticsAct, 1940 anditsrules 1945:
Objectives,Definitions,LegaldefinitionsofschedulestotheActand
Rules
Importofdrugs–Classesofdrugsandcosmeticsprohibitedfromimport,Importunder
licenseor permit. Offences andpenalties.
Manufactureofdrugs–Prohibition ofmanufacture and saleofcertain drugs,
Conditionsforgrantoflicenseandconditionsof licensefor manufacture ofdrugs,
Manufacture ofdrugsfor test,examinationandanalysis,manufacture ofnew drug,loan
licenseandrepackinglicense.
UNIT-II 10 Hours
Drugs andCosmeticsAct, 1940 anditsrules 1945.
DetailedstudyofScheduleG,H,M,N,P,T,U, V,X,Y,PartXIIB,SchF&DMR(OA)
Sale ofDrugs– Wholesale, Retail saleand Restricted license.Offences andpenalties
Labeling&Packingofdrugs-Generallabelingrequirementsandspecimenlabelsfor
drugsandcosmetics,Listofpermittedcolors.Offences andpenalties.
AdministrationoftheActandRules–DrugsTechnicalAdvisoryBoard,Centraldrugs
Laboratory,DrugsConsultativeCommittee,Governmentdruganalysts,Licensing
authorities,controllingauthorities, DrugsInspectors
UNIT-III 10 Hours
PharmacyAct–1948:Objectives,Definitions,PharmacyCouncilofIndia;its
constitutionandfunctions,EducationRegulations,StateandJointstate pharmacy
councils;constitutionandfunctions,RegistrationofPharmacists,Offencesand
122

124. Penalties
MedicinalandToiletPreparationAct–1955:Objectives,Definitions,Licensing,
ManufactureInbondandOutside bond,Export ofalcoholicpreparations,
ManufactureofAyurvedic,Homeopathic,Patent&ProprietaryPreparations.
Offences andPenalties.
NarcoticDrugs andPsychotropicsubstances Act-1985andRules:Objectives,
Definitions,AuthoritiesandOfficers, ConstitutionandFunctionsofnarcotic&
Psychotropic Consultative Committee,NationalFundforControllingtheDrug
Abuse,Prohibition,ControlandRegulation,opiumpoppycultivationandproduction
ofpoppystraw, manufacture, sale andexport ofopium, Offences andPenalties
UNIT-IV 08 Hours
StudyofSalientFeaturesofDrugsandMagicRemediesActandits
rules:Objectives,Definitions, Prohibitionofcertainadvertisements,Classesof
Exemptedadvertisements, OffencesandPenalties
PreventionofCrueltytoanimalsAct-1960:Objectives,Definitions,Institutional
AnimalEthicsCommittee,CPCSEAguidelinesforBreedingandStockingof
Animals,Performanceof Experiments,Transferandacquisitionofanimalsfor
experiment, Records,Power to suspend orrevokeregistration, Offences andPenalties
NationalPharmaceuticalPricingAuthority:DrugsPriceControlOrder(DPCO)-
2013.Objectives,Definitions,Sale pricesof bulkdrugs,Retailpriceofformulations,
Retailpriceandceilingprice ofscheduledformulations,NationalListofEssential
Medicines(NLEM)
UNIT-V 07 Hours
PharmaceuticalLegislations–Abriefreview,Introduction,Study ofdrugsenquiry
committee,Healthsurveyand developmentcommittee,Hathicommitteeand
Mudaliarcommittee
CodeofPharmaceuticalethicsDefinition,Pharmacistinrelationtohisjob,trade,
medical professionandhis profession,Pharmacist’s oath
MedicalTerminationofPregnancy Act
Right to InformationAct
Introduction toIntellectualPropertyRights(IPR)
Recommendedbooks:(Latest Edition)
1.Forensic PharmacybyB.Suresh
123

125. 2. Text book ofForensicPharmacybyB.M. Mithal
3. Hand book of druglaw-byM.L. Mehra
4. A text book ofForensicPharmacybyN.K.Jain
5. Drugs andCosmeticsAct/RulesbyGovt. ofIndia publications.
6. Medicinal and Toiletpreparationsact 1955byGovt. ofIndia publications.
7. Narcoticdrugs andpsychotropicsubstancesactbyGovt. ofIndia publications
8. Drugs andMagic RemediesactbyGovt. ofIndiapublication
9.BareActs ofthesaidlaws publishedbyGovernment.Referencebooks(Theory)
124

126. SEMESTERVI
125

127. BP601T.MEDICINALCHEMISTRY– III (Theory)
45 Hours
Scope:Thissubjectisdesignedtoimpartfundamentalknowledge onthestructure,
chemistryandtherapeuticvalueofdrugs.Thesubjectemphasisonmoderntechniquesof
rationaldrugdesign likequantitativestructureactivityrelationship(QSAR),Prodrug
concept,combinatorialchemistryandComputeraideddrugdesign(CADD).Thesubject
alsoemphasizesonthechemistry,mechanismofaction,metabolism,adverseeffects,
StructureActivityRelationships(SAR),therapeuticusesandsynthesisofimportant
drugs.
Objectives:Uponcompletion ofthecoursestudent shall be able to
1. Understand the importanceofdrugdesignanddifferent techniques of drug
design.
2. Understand thechemistryofdrugswithrespect to theirbiologicalactivity.
3. Knowthe metabolism, adverse effects and therapeuticvalue ofdrugs.
4.Knowthe importanceofSAR of drugs.
CourseContent:
Studyofthedevelopmentofthefollowingclassesofdrugs,Classification,mechanism of
action,usesofdrugsmentionedinthecourse, Structureactivityrelationshipofselective
classofdrugs asspecifiedinthe courseandsynthesis ofdrugssuperscripted by (*)
UNIT– I 10 Hours
Antibiotics
Historicalbackground,Nomenclature, Stereochemistry, Structureactivity
relationship,Chemicaldegradationclassificationandimportantproductsof
thefollowingclasses.
β-Lactamantibiotics:Penicillin,Cepholosporins,β-Lactamaseinhibitors,
Monobactams
Aminoglycosides:Streptomycin,Neomycin,Kanamycin
Tetracyclines:Tetracycline,Oxytetracycline,Chlortetracycline,
Minocycline,Doxycycline
UNIT– II 10 Hours
Antibiotics
Historicalbackground,Nomenclature,Stereochemistry, Structureactivity
relationship,Chemicaldegradationclassificationandimportantproductsof
thefollowingclasses.
126

128. Macrolide:ErythromycinClarithromycin, Azithromycin.
Miscellaneous:Chloramphenicol*, Clindamycin.
Prodrugs:Basic concepts andapplication ofprodrugsdesign.
Antimalarials:Etiologyofmalaria.
Quinolines:SAR,Quininesulphate,Chloroquine*,Amodiaquine,
Primaquine phosphate,Pamaquine*, Quinacrinehydrochloride, Mefloquine.
Biguanides anddihydrotriazines:Cycloguanilpamoate,Proguanil.
Miscellaneous:Pyrimethamine, Artesunete, Artemether,Atovoquone.
UNIT– III 10 Hours
Anti-tubercular Agents
Syntheticantitubercularagents:Isoniozid*,Ethionamide,Ethambutol,
Pyrazinamide, Para amino salicylic acid.*
Antitubercularantibiotics:Rifampicin,Rifabutin,Cycloserine
Streptomycine, Capreomycinsulphate.
Urinary tract anti-infectiveagents
Quinolones:SARofquinolones,Nalidixic Acid,Norfloxacin,Enoxacin,
Ciprofloxacin*, Ofloxacin,Lomefloxacin, Sparfloxacin, Gatifloxacin,
Moxifloxacin
Miscellaneous:Furazolidine, Nitrofurantoin*,Methanamine.
Antiviral agents:
Amantadinehydrochloride,Rimantadinehydrochloride,Idoxuridine
trifluoride, Acyclovir*, Gancyclovir,Zidovudine,Didanosine,Zalcitabine,
Lamivudine,Loviride,Delavirding, Ribavirin, Saquinavir,Indinavir,
Ritonavir.
UNIT– IV 08 Hours
Antifungal agents:
Antifungalantibiotics:Amphotericin-B,Nystatin, Natamycin, Griseofulvin.
SyntheticAntifungalagents:Clotrimazole, Econazole,Butoconazole,
Oxiconazole Tioconozole, Miconazole*,Ketoconazole, Terconazole,
Itraconazole,Fluconazole, Naftifinehydrochloride, Tolnaftate*.
Anti-protozoalAgents:Metronidazole*,Tinidazole,Ornidazole,Diloxanide,
Iodoquinol,PentamidineIsethionate, Atovaquone,Eflornithine.
Anthelmintics:Diethylcarbamazinecitrate*,Thiabendazole,Mebendazole*,
Albendazole, Niclosamide, Oxamniquine,Praziquantal,Ivermectin.
127

129. Sulphonamides and Sulfones
Historicaldevelopment,chemistry,classificationandSARofSulfonamides:
Sulphamethizole,Sulfisoxazole,Sulphamethizine, Sulfacetamide*,
Sulphapyridine, Sulfamethoxaole*, Sulphadiazine, Mefenideacetate,
Sulfasalazine.
Folate reductaseinhibitors:Trimethoprim*, Cotrimoxazole.
Sulfones:Dapsone*.
UNIT– V 07 Hours
Introduction to DrugDesign
Various approaches usedin drugdesign.
Physicochemicalparametersusedinquantitativestructureactivity
relationship(QSAR)suchaspartitioncoefficient, Hammet’selectronic
parameter,Tafts stericparameterand Hanschanalysis.
Pharmacophoremodelingand dockingtechniques.
CombinatorialChemistry:Conceptandapplications
chemistry: solid phaseand solution phasesynthesis.
ofcombinatorial
128

130. BP607P.MEDICINALCHEMISTRY-III(Practical)
4 Hours /week
IPreparationofdrugsandintermediates
1Sulphanilamide
27-Hydroxy, 4-methylcoumarin
3Chlorobutanol
4Triphenyl imidazole
5Tolbutamide
6Hexamine
IIAssay ofdrugs
1Isonicotinicacidhydrazide
2Chloroquine
3Metronidazole
4Dapsone
5Chlorpheniraminemaleate
6Benzylpenicillin
IIIPreparation ofmedicinallyimportant compoundsorintermediatesbyMicrowave
irradiation technique
IVDrawingstructuresandreactions usingchem draw®
VDeterminationofphysicochemicalpropertiessuchaslogP,clogP,MR,Molecular
weight,Hydrogenbonddonorsandacceptorsforclassofdrugscoursecontent
usingdrugdesign softwareDruglikelinessscreening(LipinskiesRO5)
RecommendedBooks(Latest Editions)
1.Wilsonand Giswold’sOrganic medicinalandPharmaceuticalChemistry.
2.Foye’s PrinciplesofMedicinalChemistry.
3.Burger’s MedicinalChemistry, VolItoIV.
4.Introduction to principlesofdrugdesign-Smith andWilliams.
5.Remington’sPharmaceuticalSciences.
6. Martindale’s extrapharmacopoeia.
129

131. 7.Organic ChemistrybyI.L.Finar, Vol.II.
8. TheOrganicChemistryofDrugSynthesisbyLednicer,Vol.1-5.
9.Indian Pharmacopoeia.
10. Text book ofpractical organic chemistry-A.I.Vogel.
130

132. BP602 T.PHARMACOLOGY-III (Theory)
45 Hours
Scope:Thissubjectisintendedtoimpartthefundamentalknowledge onvariousaspects
(classification,mechanismofaction,therapeuticeffects,clinicaluses,sideeffectsand
contraindications)ofdrugsactingonrespiratoryandgastrointestinal system,infectious
diseases,immuno-pharmacologyandinaddition,emphasisontheprinciplesof
toxicologyandchronopharmacology.
Objectives:Uponcompletion ofthiscoursethe student should beable to:
1. understand the mechanism of drugactionanditsrelevancein thetreatment of
differentinfectious diseases
2.comprehend theprinciples of toxicologyand treatment of various poisoningsand
3.appreciatecorrelationofpharmacologywithrelated medical sciences.
CourseContent:
UNIT-I 10hours
1.Pharmacology ofdrugs acting onRespiratory system
a.Anti-asthmaticdrugs
b. Drugs used in the management of COPD
c.Expectorants andantitussives
d. Nasal decongestants
e.Respiratorystimulants
2.Pharmacology ofdrugs acting ontheGastrointestinalTract
a. Antiulcer agents.
b.Drugsforconstipationanddiarrhoea.
c.Appetitestimulantsandsuppressants.
d. Digestants andcarminatives.
e. Emetics and anti-emetics.
UNIT-II 10hours
3. Chemotherapy
a. General principlesof chemotherapy.
b.Sulfonamides and cotrimoxazole.
c. Antibiotics-Penicillins,cephalosporins,chloramphenicol, macrolides,
quinolones and fluoroquinolins,tetracyclineandaminoglycosides
UNIT-III 10hours
3. Chemotherapy
a. Antitubercularagents
b. Antileproticagents
131

133. c. Antifungalagents
d. Antiviral drugs
e.Anthelmintics
f. Antimalarial drugs
g. Antiamoebicagents
UNIT-IV 08hours
3. Chemotherapy
l. Urinarytract infectionsand sexuallytransmitteddiseases.
m.Chemotherapyof malignancy.
4. Immunopharmacology
a.Immunostimulants
b.Immunosuppressant
Protein drugs, monoclonal antibodies, target drugs toantigen, biosimilars
UNIT-V 07hours
5.Principles oftoxicology
a.Definitionand basic knowledge ofacute, subacute and chronictoxicity.
b.Definitionand basic knowledge ofgenotoxicity,carcinogenicity, teratogenicity
and mutagenicity
c.General principles oftreatment of poisoning
d.Clinicalsymptoms andmanagement ofbarbiturates, morphine,
organophosphosphoruscompound and lead, mercuryand arsenic poisoning.
6. Chronopharmacology
a.Definition of rhythmandcycles.
b.Biological clockandtheir significanceleadingtochronotherapy.
132

134. BP608P.PHARMACOLOGY-III(Practical)
4Hrs/Week
1. Dose calculation in pharmacological experiments
2. Antiallergic activitybymastcellstabilizationassay
3.Studyofanti-ulceractivityofadrugusingpylorusligand (SHAY) ratmodel and
NSAIDSinduced ulcermodel.
4.Studyofeffectofdrugsongastrointestinal motility
5. Effectofagonistandantagonists onguineapigileum
6. Estimation ofserum biochemical parametersbyusingsemi- autoanalyser
7. Effectof salinepurgativeonfrogintestine
8.Insulinhypoglycemiceffectin rabbit
9. Test forpyrogens (rabbitmethod)
10. Determination of acuteoral toxicity(LD50) ofadrugfrom agivendata
11. Determination of acuteskin irritation / corrosion ofatest substance
12. Determination of acuteeyeirritation /corrosionof atest substance
13.Calculation ofpharmacokinetic parametersfromagivendata
14.Biostatistics methods inexperimental pharmacology( student’s t test,ANOVA)
15.Biostatistics methods inexperimental pharmacology(Chi squaretest,Wilcoxon
Signed Rank test)
*Experimentsaredemonstrated bysimulatedexperiments/videos
RecommendedBooks(Latest Editions)
1. RangH. P.,DaleM. M.,RitterJ. M.,Flower R.J.,Rangand Dale’s Pharmacology,
ChurchilLivingstoneElsevier
2. KatzungB. G.,MastersS.B., TrevorA.J.,Basicandclinicalpharmacology, TataMc
Graw-Hill
3. Goodman and Gilman’s,ThePharmacologicalBasisofTherapeutics
4. MarryAnneK. K.,Lloyd YeeY.,BrianK.A.,RobbinL.C.,JosephG.B.,WayneA.
K.,BradleyR.W., Applied Therapeutics, TheClinical use ofDrugs. ThePointLippincott
Williams &Wilkins
5. Mycek M.J, GelnetS.BandPerper M.M.Lippincott’sIllustrated Reviews-
Pharmacology
6. K.D.Tripathi. EssentialsofMedical Pharmacology,,JAYPEEBrothersMedical
Publishers (P)Ltd,NewDelhi.
7. SharmaH.L.,SharmaK.K.,PrinciplesofPharmacology,Parasmedicalpublisher
ModernPharmacologywithclinical Applications,byCharlesR.Craig&Robert,
8. GhoshMN.FundamentalsofExperimentalPharmacology.Hilton&Company,
Kolkata,
9. Kulkarni SK. Handbookof experimentalpharmacology.VallabhPrakashan,
10. N.UdupaandP.D. Gupta, Conceptsin Chronopharmacology.
133

135. BP 603 T.HERBALDRUGTECHNOLOGY(Theory)
45hours
Scope:Thissubjectgivesthestudenttheknowledgeofbasicunderstandingofherbaldrug
industry,thequalityofrawmaterial,guidelinesforqualityofherbaldrugs,herbalcosmetics,
naturalsweeteners,nutraceuticaletc.ThesubjectalsoemphasizesonGoodManufacturing
Practices(GMP),patentingand regulatoryissuesofherbal drugs
Objectives:Uponcompletion ofthiscourse thestudentshouldbeableto:
1.understandrawmaterialassourceofherbaldrugsfromcultivationtoherbaldrug
product
2.knowtheWHOandICHguidelinesforevaluationofherbal drugs
3.knowtheherbalcosmetics, naturalsweeteners,nutraceuticals
4.appreciatepatentingofherbal drugs,GMP.
Course content:
UNIT-I 11 Hours
Herbsasrawmaterials
Definition ofherb,herbalmedicine, herbalmedicinal product, herbal drugpreparation
SourceofHerbs
Selection,identification andauthentication ofherbalmaterials
Processingofherbal rawmaterial
BiodynamicAgriculture
Goodagriculturalpracticesincultivation ofmedicinal plantsincludingOrganicfarming.
Pest andPestmanagementinmedicinalplants: Biopesticides/Bioinsecticides.
IndianSystemsof Medicine
a) Basicprinciplesinvolved inAyurveda,Siddha,UnaniandHomeopathy
b)Preparationandstandardization ofAyurvedicformulationsvizAristasandAsawas,
Ghutika,Churna,Lehya and Bhasma.
UNIT-II 7 Hours
Nutraceuticals
Generalaspects,Market,growth,scopeandtypesofproductsavailableinthemarket.Health
benefitsandroleofNutraceuticalsinailmentslikeDiabetes,CVSdiseases,Cancer,Irritable
bowelsyndrome andvarious Gastrointestinal diseases.
Studyoffollowing herbsashealthfood:Alfaalfa,Chicory,Ginger,Fenugreek,Garlic,
Honey,Amla, Ginseng,Ashwagandha,Spirulina
Herbal-Drugand Herb-FoodInteractions:Generalintroductionto interactionand
classification.Studyoffollowing drugsandtheirpossiblesideeffectsandinteractions:
Hypercium,kava-kava,Ginkobiloba,Ginseng,Garlic,Pepper &Ephedra.
UNIT-III 10 Hours
HerbalCosmetics
134

136. Sourcesanddescriptionofrawmaterialsof herbaloriginusedvia,fixedoils,waxes,gums
colours,perfumes,protectiveagents,bleachingagents,antioxidants inproductssuchasskin
care, haircareand oral hygieneproducts.
Herbalexcipients:
HerbalExcipients–Significanceofsubstancesofnaturaloriginasexcipients–colorants,
sweeteners,binders, diluents,viscositybuilders, disintegrants,flavors&perfumes.
Herbalformulations:
Conventionalherbalformulationslikesyrups,mixturesandtabletsandNoveldosageforms
likephytosomes
UNIT-IV 10 Hours
EvaluationofDrugsWHO&ICHguidelinesforthe assessmentofherbaldrugs
Stabilitytestingofherbal drugs.
Patenting andRegulatoryrequirementsofnaturalproducts:
a)Definitionoftheterms:Patent,IPR,Farmersright,Breeder’sright,Bioprospectingand
Biopiracy
b)PatentingaspectsofTraditionalKnowledgeandNaturalProducts.CasestudyofCurcuma
&Neem.
RegulatoryIssues-RegulationsinIndia(ASUDTAB,ASUDCC),Regulationof
manufactureofASUdrugs-ScheduleZofDrugs&Cosmetics ActforASUdrugs.
UNIT-V 07 Hours
GeneralIntroductiontoHerbalIndustry
Herbal drugsindustry:Presentscopeandfutureprospects.
Abriefaccountofplantbasedindustriesandinstitutionsinvolvedinworkonmedicinaland
aromaticplantsinIndia.
ScheduleT– GoodManufacturingPracticeofIndiansystemsofmedicine
ComponentsofGMP(Schedule–T)anditsobjectives
Infrastructuralrequirements,workingspace,storagearea,machineryandequipments,
standardoperatingprocedures, healthand hygiene, documentationandrecords.
135

137. BP609P. HERBALDRUGTECHNOLOGY(Practical)
4hours/week
1.Toperformpreliminaryphytochemicalscreeningofcrudedrugs.
2.Determinationof thealcoholcontentofAsavaandArista
3.Evaluationof excipients ofnaturalorigin
4.Incorporationofprepared andstandardizedextractincosmeticformulationslikecreams,
lotionsandshampoosandtheir evaluation.
5.Incorporationofprepared andstandardizedextractinformulationslikesyrups, mixtures
and tabletsand their evaluation asperPharmacopoeialrequirements.
6.Monograph analysis ofherbal drugsfromrecentPharmacopoeias
7.DeterminationofAldehydecontent
8.DeterminationofPhenolcontent
9.Determinationoftotal alkaloids
RecommendedBooks:(Latest Editions)
1.Textbook of PharmacognosybyTrease&Evans.
2.Textbook of PharmacognosybyTyler, Brady&Robber.
3.PharmacognosybyKokate, Purohitand Gokhale
4.Essential of PharmacognosybyDr.S.H.Ansari
5.Pharmacognosy&PhytochemistrybyV.D.Rangari
6.PharmacopoealstandardsforAyurvedicFormulation(CouncilofResearchin
IndianMedicine&Homeopathy)
7.Mukherjee,P.W.QualityControlofHerbalDrugs:AnApproachtoEvaluationof
Botanicals.Business HorizonsPublishers, New Delhi,India, 2002.
136

138. BP604 T.BIOPHARMACEUTICSANDPHARMACOKINETICS
(Theory)
45 Hours
Scope:ThissubjectisdesignedtoimpartknowledgeandskillsofBiopharmaceutics
andpharmacokineticsand theirapplicationsin pharmaceuticaldevelopment,design of
doseanddosage regimenandin solving theproblemsarised therein.
Objectives:Uponcompletionofthecoursestudentshallbeable
to:
1. Understand thebasicconcepts in biopharmaceutics and pharmacokineticsand
theirsignificance.
2. Useofplasmadrugconcentration-timedata tocalculate thepharmacokinetic
parameterstodescribethekinetics ofdrugabsorption, distribution,
metabolism,excretion,elimination.
3. To understand theconcepts of bioavailabilityand bioequivalenceof drug
products and theirsignificance.
4. Understand various pharmacokineticparameters, their significance&
applications.
Course
Content:
UNIT-I 10
Hours
Introduction
Biopharmaceutics
to
Absorption;MechanismsofdrugabsorptionthroughGIT,factorsinfluencingdrug
absorptionthoughGIT,absorptionof drugfromNonperoralextra-vascular
routes,DistributionTissuepermeabilityofdrugs,bindingofdrugs,apparent,volume
of drugdistribution,plasmaandtissueproteinbindingofdrugs,factorsaffecting
protein-drugbinding.Kineticsofproteinbinding,Clinicalsignificance of protein
bindingofdrugs
UNIT-II 10
Hours
Elimination:Drug metabolismandbasicunderstanding metabolicpathwaysrenal
excretionofdrugs,factorsaffectingrenalexcretionofdrugs,renalclearance,Nonrenal
routes of drugexcretionofdrugs
BioavailabilityandBioequivalence:DefinitionandObjectivesofbioavailability,
absoluteandrelative bioavailability,measurement of bioavailability,in-vitrodrug
dissolutionmodels,in-vitro-in-vivocorrelations,bioequivalencestudies,methodsto
enhancethe dissolution ratesand bioavailabilityof poorlysolubledrugs.
UNIT-III 10 Hours
Pharmacokinetics:DefinitionandintroductiontoPharmacokinetics,Compartment
models, Noncompartmentmodels,physiologicalmodels,Onecompartmentopen
model. (a).IntravenousInjection(Bolus)(b).Intravenousinfusionand (c) Extra
vascularadministrations.Pharmacokinetics parameters-KE,t1/2,Vd,AUC,Ka, Clt and
CLR-definitions methods ofeliminations, understandingof their significance and
application

139. 137
UNIT-IV 08 Hours
Multicompartmentmodels:Two compartment open model.IV bolus
Kinetics of multipledosing, steadystate druglevels, calculation ofloadingand
mainetnancedoses andtheir significancein clinical settins.
UNIT-V 07 Hours
NonlinearPharmacokinetics:a.Introduction, b.FactorscausingNon-linearity.
c. Michaelis-menton method of estimatingparameters,Explanationwithexampleof
drugs.
RecommendedBooks:(Latest Editions)
1.Biopharmaceutics andClinicalPharmacokineticsby, Milo Gibaldi.
2.Biopharmaceutics andPharmacokinetics; ByRobertFNotari
3.Applied biopharmaceutics andpharmacokinetics,LeonShargel andAndrew
B.C.YU 4th edition,Prentice-HallInernationaledition.USA
4.Bio pharmaceutics andPharmacokinetics-ATreatise,ByD. M.Brahmankarand
SunilB.Jaiswal,VallabhPrakashanPitampura,Delhi
5.Pharmacokinetics:ByMilo Glbaldi Donald,R. Mercel DekkerInc.
6.HandBookof ClinicalPharmacokinetics,ByMiloGibaldiandLauriePrescottby
ADISHealthSciencePress.
7.Biopharmaceutics;BySwarbrick
8.Clinical Pharmacokinetics,Concepts and Applications:ByMalcolmRowlandand
9.Thomas, N. Tozen,LeaandFebrger, Philadelphia,1995.
10.Dissolution,BioavailabilityandBioequivalence,ByAbdou H.M, Mack,
PublishingCompany,Pennsylvania 1989.
11.Biopharmaceutics andClinicalPharmacokinetics-An introduction 4thedition
RevisedandexpandedbyRebortFNotariMarcelDekkerInn, NewYorkand
Basel, 1987.
12.Remington’sPharmaceuticalSciences,ByMackPublishingCompany,
Pennsylvnia

140. 138

141. Scope:
BP605 T.PHARMACEUTICAL BIOTECHNOLOGY(Theory)
45 Hours
Biotechnologyhasalongpromisetorevolutionizethebiologicalsciencesand
technology.
Scientificapplicationofbiotechnologyinthefieldofgeneticengineering,
medicineandfermentation technologymakes thesubject interesting.
Biotechnologyisleadingtonewbiologicalrevolutionsindiagnosis,prevention
andcureof diseases, new andcheaperpharmaceutical drugs.
Biotechnologyhasalreadyproducedtransgeniccropsandanimalsandthefuture
promises lotmore.
It isbasicallya research-based subject.
Objectives:Uponcompletion ofthe subjectstudent shall be able to;
1. UnderstandingtheimportanceofImmobilizedenzymes in Pharmaceutical
Industries
2. Geneticengineeringapplications in relation toproduction of pharmaceuticals
3.Importanceof Monoclonal antibodies inIndustries
4. Appreciatethe useofmicroorganisms in fermentation technology
Unit I 10 Hours
a)Brief introduction toBiotechnologywith referencetoPharmaceuticalSciences.
b)EnzymeBiotechnology-Methods ofenzymeimmobilizationandapplications.
c)Biosensors-Workingandapplications of biosensors inPharmaceuticalIndustries.
d)Brief introduction toProtein Engineering.
e)Useofmicrobesinindustry.ProductionofEnzymes-Generalconsideration-
Amylase,Catalase,Peroxidase,Lipase,Protease,Penicillinase.
f)Basic principles ofgenetic engineering.
Unit II 10 Hours
a)Studyofcloningvectors,restriction endonucleases andDNA ligase.
b)Recombinant DNAtechnology. Application ofgenetic engineeringinmedicine.
c)Application of rDNAtechnologyandgenetic engineeringintheproduction of:
i)Interferon ii)Vaccines-hepatitis-Biii)Hormones-Insulin.
d)Brief introduction toPCR
139

142. Unit III 10 Hours
Typesof immunity-humoral immunity,cellularimmunity
a)StructureofImmunoglobulins
b)StructureandFunctionof MHC
c)Hypersensitivityreactions,Immune stimulationandImmune suppressions.
d)Generalmethodofthepreparationofbacterialvaccines,toxoids,viralvaccine,
antitoxins, serum-immuneblood derivatives andotherproductsrelative to immunity.
e)Storage conditions and stabilityofofficial vaccines
f)Hybridoma technology-Production,Purificationand Applications
g)BloodproductsandPlasmaSubstituties.
Unit IV 08Hours
a)Immuno blottingtechniques-ELISA,Western blotting,Southern blotting.
b)Genetic organization ofEukaryotes andProkaryotes
c)Microbialgeneticsincludingtransformation,transduction,conjugation,plasmidsand
transposons.
d)Introduction to Microbialbiotransformation andapplications.
e)Mutation:Typesofmutation/mutants.
Unit V 07 Hours
a)Fermentationmethodsandgeneralrequirements,studyofmedia,equipments,
sterilization methods,aeration process,stirring.
b)Largescale production fermenterdesignandits variouscontrols.
c)Studyoftheproductionof-penicillins,citricacid,VitaminB12,Glutamicacid,
Griseofulvin,
d)BloodProducts:Collection,ProcessingandStorageofwhole human blood, dried
human plasma, plasmaSubstituties.
RecommendedBooks(Latestedition):
1.B.R.GlickandJ.J.Pasternak:MolecularBiotechnology:PrinciplesandApplications
ofRecombinantDNA: ASMPressWashington D.C.
2.RA Goldshyet. al., : KubyImmunology.
3.J.W. Goding: Monoclonal Antibodies.
4.J.M.WalkerandE.B.Gingold:MolecularBiologyandBiotechnologybyRoyal

143. SocietyofChemistry.
5.Zaborsky:Immobilized Enzymes,CRC Press,Degraland, Ohio.
6.S.B.Primrose:MolecularBiotechnology(SecondEdition)BlackwellScientific
Publication.
7.StanburyF.,P.,WhitakarA.,andHallJ.,S.,Principlesoffermentationtechnology,
2ndedition, AdityabooksLtd.,New Delhi
140

144. BP606TPHARMACEUTICAL QUALITY ASSURANCE (Theory)
45 Hours
Scope:Thiscoursedealswiththevariousaspectsofqualitycontrolandquality
assuranceaspectsofpharmaceuticalindustries.Itdeals withthe importantaspectslike
cGMP, QCtests, documentation, qualitycertificationsand regulatoryaffairs.
Objectives:Uponcompletion ofthecoursestudent shall be able to:
understandthe cGMP aspectsin a pharmaceutical industry
appreciate the importanceofdocumentation
understand the scopeofqualitycertificationsapplicable to pharmaceutical
industries
understand theresponsibilities of QA &QC departments
Course content:
UNIT– I 10 Hours
QualityAssuranceandQualityManagementconcepts:DefinitionandconceptofQuality
control, Qualityassurance and GMP
Total QualityManagement (TQM):Definition,elements, philosophies
ICHGuidelines:purpose,participants,processofharmonization,BriefoverviewofQSEM,
with specialemphasis onQ-seriesguidelines,ICHstabilitytestingguidelines
Quality bydesign(QbD): Definition, overview,elements of QbD program, tools
ISO 9000 & ISO14000:Overview,Benefits, Elements, steps for registration
NABL accreditation:Principles andprocedures
UNIT-II 10Hours
Organization and personnel:Personnel responsibilities, training,hygieneand personalrecords.
Premises:Design,constructionandplantlayout,maintenance,sanitation,environmental
control, utilitiesand maintenanceof sterileareas,control ofcontamination.
Equipmentsandrawmaterials:Equipmentselection,purchasespecifications,maintenance,
purchasespecificationsand maintenanceof storesfor raw materials.
UNIT– III 10 Hours
QualityControl:Qualitycontroltestforcontainers,rubberclosuresandsecondarypacking
141

145. materials.
Good LaboratoryPractices:General Provisions, OrganizationandPersonnel,Facilities,
Equipment,TestingFacilitiesOperation,TestandControlArticles,ProtocolforConductof a
NonclinicalLaboratoryStudy, Recordsand Reports, DisqualificationofTestingFacilities
UNIT– IV 08Hours
Complaints:Complaintsandevaluationofcomplaints,Handlingofreturngood,recallingand
waste disposal.
Documentmaintenancein pharmaceutical industry:BatchFormulaRecord, Master Formula
Record,SOP, Qualityaudit, QualityReviewandQualitydocumentation,Reportsand
documents, distribution records.
UNIT– V 07 Hours
CalibrationandValidation:Introduction,definitionandgeneralprinciplesofcalibration,
qualificationandvalidation,importanceandscope ofvalidation,typesofvalidation,validation
master plan. CalibrationofpHmeter, Qualificationof UV-Visiblespectrophotometer,General
principles ofAnalyticalmethod Validation.
Warehousing:Good warehousingpractice, materialsmanagement
RecommendedBooks:(Latest Edition)
1. QualityAssuranceGuidebyorganization ofPharmaceuticalProducts ofIndia.
2. GoodLaboratoryPracticeRegulations,2
nd
Edition,SandyWeinbergVol. 69.
3.QualityAssuranceofPharmaceuticals-AcompendiumofGuidelinesandRelated
materials VolIWHOPublications.
4. Aguide to TotalQualityManagement-Kushik Maitra and SedhanK Ghosh
5. Howto PracticeGMP’s– PP Sharma.
6.ISO 9000and TotalQualityManagement–Sadhank G Ghosh
7.TheInternational Pharmacopoeia–VolI,II,III,IV- GeneralMethodsofAnalysis
andQuality specificationforPharmaceuticalSubstances,ExcipientsandDosage
forms
8. Good laboratoryPractices– MarcelDeckker Series
9.ICHguidelines,ISO9000and 14000guidelines
142

146. SEMESTERVII
143

147. BP701T. INSTRUMENTALMETHODS OFANALYSIS(Theory)
45 Hours
Scope:Thissubjectdealswiththeapplicationofinstrumentalmethodsinqualitativeand
quantitativeanalysis ofdrugs.Thissubjectisdesignedtoimparta fundamental
knowledgeontheprinciplesandinstrumentationof spectroscopicandchromatographic
technique. Thisalsoemphasizesontheoreticalandpracticalknowledgeonmodern
analytical instruments that areused fordrugtesting.
Objectives:Uponcompletion ofthecoursethestudent shall beableto
1. Understandtheinteractionofmatterwithelectromagneticradiationsandits
applications in druganalysis
2. Understand thechromatographic separationandanalysisofdrugs.
3.Performquantitative&qualitativeanalysisofdrugsusingvariousanalytical
instruments.
CourseContent:
UNIT–I 10 Hours
UV Visible spectroscopy
Electronictransitions,chromophores,auxochromes,spectralshifts,solventeffecton
absorption spectra,BeerandLambert’slaw,Derivationand deviations.
Instrumentation-Sourcesofradiation,wavelengthselectors,samplecells,detectors-
Photo tube,Photomultipliertube, Photo voltaiccell,Silicon Photodiode.
Applications-Spectrophotometrictitrations,Singlecomponentandmulticomponent
analysis
Fluorimetry
Theory,Conceptsofsinglet,doubletandtripletelectronicstates,internalandexternal
conversions,factorsaffecting fluorescence,quenching,instrumentationand
applications
UNIT–II 10 Hours
IR spectroscopy
Introduction,fundamentalmodesofvibrations inpolyatomicmolecules,sample
handling,factorsaffectingvibrations
Instrumentation-Sourcesofradiation,wavelengthselectors,detectors-Golaycell,
Bolometer, Thermocouple, Thermister,Pyroelectricdetectorandapplications
FlamePhotometry-Principle, interferences, instrumentationandapplications
144

148. Atomicabsorptionspectroscopy-Principle,interferences,instrumentationand
applications
Nepheloturbidometry-Principle, instrumentationandapplications
UNIT–III 10 Hours
Introduction tochromatography
Adsorptionandpartitioncolumnchromatography-Methodology,advantages,
disadvantagesand applications.
Thinlayerchromatography-Introduction,Principle,Methodology,Rfvalues,
advantages, disadvantages and applications.
Paperchromatography-Introduction,methodology,development techniques,
advantages, disadvantages and applications
Electrophoresis–Introduction,factorsaffectingelectrophoreticmobility,Techniques
ofpaper,gel, capillaryelectrophoresis,applications
UNIT–IV 08 Hours
Gaschromatography-Introduction,theory,instrumentation,derivatization,
temperatureprogramming,advantages, disadvantagesandapplications
Highperformanceliquidchromatography(HPLC)-Introduction,theory,
instrumentation, advantagesandapplications.
UNIT–V 07 Hours
Ionexchangechromatography-Introduction,classification,ionexchangeresins,
properties,mechanismofionexchangeprocess,factorsaffecting ionexchange,
methodologyandapplications
Gel chromatography-Introduction, theory, instrumentationandapplications
Affinitychromatography-Introduction, theory,instrumentation andapplications
145

149. BP705P.INSTRUMENTALMETHODS OFANALYSIS(Practical)
4 Hours/Week
1Determinationofabsorptionmaximaandeffectofsolventsonabsorption
maxima oforganiccompounds
2 Estimation of dextrosebycolorimetry
3 Estimation of sulfanilamidebycolorimetry
4 SimultaneousestimationofibuprofenandparacetamolbyUV spectroscopy
5 AssayofparacetamolbyUV-Spectrophotometry
6 Estimation of quinine sulfatebyfluorimetry
7 Studyof quenchingof fluorescence
8 Determination ofsodiumbyflamephotometry
9 Determination ofpotassiumbyflame photometry
10Determination of chlorides andsulphatesbynephelo turbidometry
11Separation ofaminoacidsbypaperchromatography
12Separation of sugarsbythin layerchromatography
13Separation of plantpigmentsbycolumnchromatography
14Demonstrationexperiment on HPLC
15Demonstrationexperiment on GasChromatography
RecommendedBooks(Latest Editions)
1.Instrumental Methods ofChemical AnalysisbyB.K Sharma
2.Organic spectroscopybyY.RSharma
3. Text book ofPharmaceutical AnalysisbyKennethA. Connors
4. Vogel’s Text book of QuantitativeChemicalAnalysisbyA.I. Vogel
5.PracticalPharmaceuticalChemistrybyA.H.BeckettandJ.B.Stenlake
6.Organic ChemistrybyI.L.Finar
7.Organic spectroscopybyWilliam Kemp
8. Quantitative AnalysisofDrugsbyD. C. Garrett
9. Quantitative AnalysisofDrugs in PharmaceuticalFormulationsbyP.D.Sethi
10.Spectrophotometric identificationof OrganicCompoundsbySilverstein
146

150. BP702 T. INDUSTRIALPHARMACYII(Theory)
45 Hours
Scope:This courseis designed to impart fundamental knowledge on pharmaceutical
product development andtranslationfromlaboratorytomarket
Objectives:Uponcompletion ofthecourse, thestudent shall beable to:
1. Knowthe process ofpilotplant and scale up ofpharmaceutical dosageforms
2. Understand theprocessof technologytransferfrom labscale tocommercial batch
3. KnowdifferentLawsandActsthatregulatepharmaceuticalindustry
4. Understand theapprovalprocess andregulatoryrequirements fordrugproducts
CourseContent:
UNIT-I 10 Hours
Pilotplant scaleuptechniques:Generalconsiderations-includingsignificanceof
personnelrequirements,spacerequirements,raw materials,Pilotplant scale up
considerationsfor solids,liquidorals,semisolidsandrelevantdocumentation, SUPAC
guidelines,Introductionto platform technology
UNIT-II 10 Hours
Technologydevelopmentandtransfer:WHOguidelinesfor Technology Transfer(TT):
Terminology,Technologytransferprotocol,Qualityriskmanagement,TransferfromR
&Dtoproduction(Process,packagingandcleaning),Granularity ofTTProcess(API,
excipients,finishedproducts,packaging materials)Documentation,Premisesand
equipments,qualificationandvalidation,qualitycontrol,analyticalmethodtransfer,
Approvedregulatorybodiesandagencies, Commercialization- practicalaspectsand
problems(case studies),TT agenciesinIndia-APCTD, NRDC,TIFAC,BCIL,TBSE/
SIDBI;TT relateddocumentation-confidentialityagreement,licensing,MoUs,
legal issues
UNIT-III 10 Hours
Regulatoryaffairs:Introduction,HistoricaloverviewofRegulatoryAffairs,Regulatory
authorities,RoleofRegulatoryaffairsdepartment,ResponsibilityofRegulatoryAffairs
Professionals
Regulatoryrequirementsfordrugapproval:Drug DevelopmentTeams,Non-Clinical
DrugDevelopment,Pharmacology,DrugMetabolismandToxicology,General
considerationsofInvestigationalNewDrug(IND)Application,Investigator’sBrochure
(IB)andNewDrug Application(NDA),Clinicalresearch/BEstudies,ClinicalResearch
Protocols,Biostatisticsin Pharmaceutical ProductDevelopment,DataPresentationfor
FDASubmissions, Management of ClinicalStudies.
147

151. UNIT-IV 08 Hours
Qualitymanagementsystems:Qualitymanagement&Certifications:Conceptof
Quality,TotalQualityManagement,QualitybyDesign(QbD),SixSigmaconcept,Out
ofSpecifications(OOS),Changecontrol,IntroductiontoISO9000seriesofquality
systems standards,ISO14000, NABL,GLP
UNIT-V 07 Hours
IndianRegulatoryRequirements:CentralDrugStandardControlOrganization
(CDSCO)andStateLicensing Authority:Organization,Responsibilities,Certificateof
PharmaceuticalProduct(COPP),Regulatoryrequirementsandapprovalproceduresfor
NewDrugs.
RecommendedBooks:(Latest Editions)
1.RegulatoryAffairsfromWikipedia, thefree encyclopediamodified on 7
th
Aprilavailable
at http,//en.wikipedia.org/wiki/Regulatory_Affairs.
2.InternationalRegulatoryAffairs Updates, 2005.availableat
http://www.iraup.com/about.php
3. Douglas JPisanoand DavidS. Mantus. Text bookofFDARegulatoryAffairs A Guide
forPrescription Drugs,Medical Devices, andBiologics’Second Edition.
4.RegulatoryAffairs broughtbylearningplus, inc.availableat
http.//www.cgmp.com/ra.htm.
148

152. BP703T.PHARMACYPRACTICE(Theory)
45 Hours
Scope:Inthechanging scenarioofpharmacypracticeinIndia,forsuccessfulpracticeof
HospitalPharmacy,the studentsarerequiredtolearnvariousskillslikedrug distribution,
drug information,andtherapeuticdrug monitoring forimprovedpatientcare.In
communitypharmacy,studentswill belearning various skillssuchasdispensingof
drugs,respondingtominorailmentsby providingsuitablesafemedication,patient
counsellingfor improvedpatient careinthe communityset up.
Objectives:Uponcompletion ofthecourse, thestudent shallbeable to
1. know various drugdistribution methodsin a hospital
2.appreciate thepharmacystores managementand inventorycontrol
3. monitordrugtherapyofpatientthroughmedicationchartreviewandclinical
review
4. obtain medication historyinterviewandcounsel thepatients
5. identifydrugrelatedproblems
6. detect andassessadversedrugreactions
7. interpretselectedlaboratoryresults(asmonitoringparametersintherapeutics)of
specific diseasestates
8. know pharmaceuticalcareservices
9. do patientcounselingincommunitypharmacy;
10.appreciate the concept ofRational drugtherapy.
Unit I: 10 Hours
a)Hospital andit’s organization
Definition,Classificationofhospital-Primary,SecondaryandTertiaryhospitals,
Classificationbasedonclinicalandnon-clinicalbasis,OrganizationStructure ofa
Hospital, and Medicalstaffs involved in the hospital and theirfunctions.
b) Hospitalpharmacyandits organization
Definition,functionsofhospitalpharmacy,Organizationstructure,Location,Layout
and staff requirements,andResponsibilitiesandfunctions of hospital pharmacists.
c)Adversedrugreaction
Classifications-Excessive pharmacologicaleffects,secondarypharmacological
effects,idiosyncrasy,allergicdrugreactions,genetically determinedtoxicity,toxicity
following suddenwithdrawalofdrugs,Druginteraction-beneficialinteractions,
adverseinteractions,andpharmacokineticdruginteractions,Methodsfordetecting
149

153. drug interactions,spontaneouscasereportsandrecordlinkagestudies,andAdverse
drugreaction reportingandmanagement.
d)CommunityPharmacy
Organizationandstructureof retailandwholesaledrug store,typesanddesign,Legal
requirementsforestablishmentandmaintenanceofadrug store,Dispensingof
proprietaryproducts,maintenanceofrecords of retailand wholesaledrugstore.
Unit II: 10 Hours
a)Drugdistributionsysteminahospital
Dispensingofdrugstoinpatients,typesofdrugdistributionsystems,chargingpolicy
andlabelling,Dispensingofdrugstoambulatorypatients,andDispensingof
controlled drugs.
b)Hospitalformulary
Definition,contentsofhospitalformulary,Differentiationofhospitalformularyand
Druglist,preparationandrevision,andadditionanddeletionofdrugfromhospital
formulary.
c)Therapeuticdrugmonitoring
NeedforTherapeuticDrugMonitoring,Factorstobeconsideredduringthe
Therapeutic DrugMonitoring,andIndian scenario forTherapeuticDrug Monitoring.
d)Medicationadherence
Causesofmedicationnon-adherence,pharmacistroleinthemedicationadherence,
and monitoringofpatient medicationadherence.
e)Patientmedication history interview
Needfor thepatient medication historyinterview,medication interviewforms.
f)Communitypharmacymanagement
Financial, materials,staff,and infrastructure requirements.
Unit III: 10 Hours
a)Pharmacyandtherapeutic committee
Organization,functions,Policiesofthepharmacyandtherapeuticcommitteein
includingdrugsintoformulary,inpatientandoutpatientprescription,automaticstop
order,andemergencydruglist preparation.
b) Drug
informationservices
150

154. DrugandPoisoninformationcentre,Sourcesofdrug information,Computerised
services, and storage andretrieval ofinformation.
c) Patient
counseling
Definitionofpatientcounseling;stepsinvolvedinpatientcounseling,andSpecial
cases thatrequirethe pharmacist
d)Educationandtrainingprograminthehospital
Roleofpharmacistintheeducationandtraining program,Internalandexternal
trainingprogram,Servicestothenursing homes/clinics,Codeofethicsforcommunity
pharmacy,andRoleofpharmacistintheinterdepartmentalcommunicationand
communityhealtheducation.
e)Prescribedmedicationorderandcommunicationskills
Prescribedmedicationorder-interpretationandlegalrequirements,and
Communication skills-communication with prescribersandpatients.
Unit IV 8 Hours
a) Budget
preparationandimplementation
Budget preparationandimplementation
b)ClinicalPharmacy
IntroductiontoClinicalPharmacy, Conceptofclinicalpharmacy,functionsand
responsibilitiesofclinicalpharmacist,Drugtherapy monitoring-medicationchart
review,clinicalreview,pharmacistintervention, Wardroundparticipation,Medication
historyand Pharmaceutical care.
Dosingpatternand drugtherapybased onPharmacokinetic&diseasepattern.
c)Over the counter (OTC) sales
Introductionand saleofoverthecounter,andRationaluseofcommon overthe
countermedications.
Unit V 7 Hours
a)Drug storemanagement andinventorycontrol
Organisationofdrug store, typesofmaterialsstockedandstorageconditions,Purchase
andinventorycontrol:principles,purchaseprocedure,purchaseorder,procurement
andstocking,Economicorderquantity,Reorderquantitylevel,andMethodsusedfor
theanalysisofthe drugexpenditure
b)Investigationaluseofdrugs
151

155. Description,principlesinvolved,classification,control,identification,roleofhospital
pharmacist,advisorycommittee.
c)Interpretation ofClinicalLaboratory Tests
Blood chemistry, hematology,andurinalysis
RecommendedBooks(Latest Edition):
1. MerchantS.H.andDr.J.S.Quadry.A textbookofhospitalpharmacy, 4th ed.
Ahmadabad:B.S.ShahPrakakshan; 2001.
2.ParthasarathiG,KarinNyfort-Hansen, MilapC Nahata.A textbook ofClinical
PharmacyPractice- essential concepts and skills,1
st
ed. Chennai: Orient
Longman PrivateLimited; 2004.
3.William E. Hassan.Hospital pharmacy, 5th ed.Philadelphia:Lea&Febiger;
1986.
4. TipnisBajaj.Hospital Pharmacy, 1
st
ed. Maharashtra:Career Publications; 2008.
5.ScottLT.Basicskillsin interpretinglaboratory data, 4thed.AmericanSocietyof
HealthSystemPharmacistsInc; 2009.
6.Parmar N.S.HealthEducation and CommunityPharmacy,18th ed.India:CBS
Publishers &Distributers; 2008.
Journals:
1. Therapeuticdrugmonitoring.ISSN: 0163-4356
2.Journal of pharmacypractice.ISSN : 0974-8326
3. American journal of healthsystem pharmacy.ISSN: 1535-2900(online)
4.Pharmacytimes(Monthlymagazine)
152

156. BP704T:NOVELDRUGDELIVERY SYSTEMS(Theory)
45 Hours
Scope:This subject is designed to impart basicknowledgeon theareaofnovel drug
deliverysystems.
Objectives:Uponcompletion ofthecoursestudent shall be able
1. To understand variousapproachesfordevelopment of novel drugdeliverysystems.
2. To understand thecriteria forselectionofdrugsand polymersforthe development of
Novel drugdeliverysystems,their formulationandevaluation
Course content:
Unit-I 10 Hours
Controlleddrugdelivery systems:Introduction, terminology/definitionsand rationale,
advantages,disadvantages,selectionofdrugcandidates.Approachestodesigncontrolled
releaseformulationsbasedondiffusion,dissolutionandionexchange principles.
Physicochemicalandbiologicalproperties ofdrugsrelevanttocontrolledrelease
formulations
Polymers:Introduction,classification,properties,advantagesandapplication of
polymers in formulationofcontrolled releasedrugdeliverysystems.
Unit-II 10 Hours
Microencapsulation:Definition,advantagesanddisadvantages,microspheres
/microcapsules,microparticles, methods of microencapsulation,applications
MucosalDrugDeliverysystem:Introduction,Principlesofbioadhesion/
mucoadhesion,concepts,advantagesanddisadvantages,transmucosalpermeabilityand
formulationconsiderations of buccaldeliverysystems
ImplantableDrugDelivery Systems:Introduction,advantagesanddisadvantages,
concept of implantsandosmotic pump
Unit-III 10 Hours
TransdermalDrug DeliverySystems:Introduction,Permeation through skin,factors
affectingpermeation,permeationenhancers,basiccomponentsofTDDS,formulation
approaches
Gastroretentivedrugdeliverysystems:Introduction,advantages,disadvantages,
approachesforGRDDS–Floating,highdensitysystems,inflatableandgastroadhesive
systems and theirapplications
Nasopulmonarydrugdeliverysystem:IntroductiontoNasalandPulmonary routesof
drugdelivery,FormulationofInhalers(dry powderandmetereddose),nasalsprays,
nebulizers
Unit-IV 08 Hours
153

157. Targeted drugDelivery:Conceptsandapproachesadvantagesanddisadvantages,
introductiontoliposomes, niosomes,nanoparticles, monoclonalantibodiesandtheir
applications
Unit-V 07 Hours
OcularDrugDeliverySystems:Introduction,intraocularbarriersandmethodsto
overcome–Preliminarystudy, ocular formulationsand ocuserts
IntrauterineDrugDeliverySystems:Introduction,advantagesanddisadvantages,
development of intrauterine devices(IUDs)andapplications
RecommendedBooks:(Latest Editions)
1. YW.Chien,NovelDrugDeliverySystems,2
nd
edition,revisedandexpanded,
MarcelDekker,Inc.,New York, 1992.
2. Robinson,J.R.,LeeV.H.L,ControlledDrugDeliverySystems,MarcelDekker,
Inc.,New York, 1992.
3. EncyclopediaofControlledDelivery.EdithMathiowitz,PublishedbyWiley
IntersciencePublication,JohnWileyandSons,Inc, New York. Chichester/Weinheim
4. N.K.Jain,ControlledandNovelDrugDelivery,CBSPublishers&Distributors,
New Delhi,First edition 1997(reprintin 2001).
5. S.P.VyasandR.K.Khar,ControlledDrugDelivery-conceptsandadvances,
VallabhPrakashan, NewDelhi,First edition 2002.
Journals
1. IndianJournal of PharmaceuticalSciences(IPA)
2. IndianDrugs(IDMA)
3. Journal of Controlled Release (ElsevierSciences)
4. DrugDevelopment andIndustrialPharmacy(Marcel&Decker)
5. InternationalJournal of Pharmaceutics (ElsevierSciences)
154

158. SEMESTERVIII
155

159. BP801T. BIOSTATISITCS AND RESEARCHMETHODOLOGY(Theory)
45 Hours
Scope:TounderstandtheapplicationsofBiostatics in Pharmacy.Thissubjectdealswith
descriptive statistics,Graphics, Correlation,Regression,logisticregression Probability
theory,Sampling technique,Parametrictests,NonParametric tests,ANOVA,
IntroductiontoDesignof Experiments,Phasesof ClinicaltrialsandObservationaland
Experimentalstudies,SPSS, Rand MINITABstatisticalsoftware’s,analyzingthe
statistical data usingExcel.
Objectives:Uponcompletion ofthecoursethestudent shall beable to
• Knowthe operation ofM.S. Excel,SPSS,RandMINITAB
®
,DoE (Design of
Experiment)
• Knowthe various statistical techniques to solvestatistical problems
• Appreciate statistical techniques in solvingtheproblems.
Course content:
Unit-I 10 Hours
Introduction:Statistics,Biostatistics,Frequencydistribution
Measuresofcentraltendency:Mean, Median,Mode-Pharmaceuticalexamples
Measuresofdispersion: Dispersion,Range,standarddeviation,Pharmaceutical
problems
Correlation:Definition,Karl Pearson’scoefficient ofcorrelation,Multiplecorrelation-
Pharmaceuticals examples
Unit-II 10 Hours
Regression:Curvefittingbythe method ofleastsquares, fittingthelinesy=a+bxandx
=a+by, Multipleregression, standarderror ofregression–Pharmaceutical Examples
Probability:Definitionof probability,Binomial distribution, Normal distribution,
Poisson’s distribution, properties-problems
Sample,Population,largesample, smallsample,Nullhypothesis, alternativehypothesis,
sampling,essenceofsampling,types of sampling,Error-Itype, Error-IItype,Standard
errorof mean (SEM)-Pharmaceutical examples
Parametrictest: t-test(Sample,Pooled orUnpairedandPaired) , ANOVA,(Oneway
and Two way),Least Significancedifference
Unit-III 10 Hours
NonParametric tests:WilcoxonRankSumTest, Mann-WhitneyU test,Kruskal-Wallis
test,Friedman Test
156

160. Introduction to Research:Needfor research,Need fordesignof Experiments,
ExperientialDesignTechnique, plagiarism
Graphs:Histogram,PieChart, Cubic Graph,responsesurfaceplot, CounterPlotgraph
Designing themethodology:SamplesizedeterminationandPower ofastudy, Report
writingandpresentationofdata, Protocol,Cohorts studies, Observationalstudies,
Experimentalstudies, Designingclinical trial,various phases.
Unit-IV 8 Hours
Blockingand confoundingsystem for Two-levelfactorials
Regressionmodeling:Hypothesis testinginSimpleand Multipleregressionmodels
IntroductiontoPracticalcomponentsofIndustrialandClinicalTrialsProblems:
StatisticalAnalysisUsingExcel,SPSS,MINITAB
®
,DESIGNOFEXPERIMENTS,R-
Online StatisticalSoftware’s toIndustrial and Clinical trial approach
Unit-V 7Hours
DesignandAnalysis ofexperiments:
FactorialDesign:Definition,2
2
, 2
3
design. Advantageoffactorial design
ResponseSurfacemethodology:Central composite design, Historical design,
Optimization Techniques
RecommendedBooks(Latestedition):
1.Pharmaceuticalstatistics-Practicalandclinicalapplications,SanfordBolton,
publisherMarcel DekkerInc.NewYork.
2.Fundamental of Statistics– Himalaya PublishingHouse-S.C.Guptha
3. DesignandAnalysisofExperiments–PHILearningPrivateLimited,R.
Pannerselvam,
4. DesignandAnalysisofExperiments–WileyStudentsEdition,
Douglasand C. Montgomery
157

161. BP802T SOCIAL ANDPREVENTIVEPHARMACY
Hours: 45
Scope:
Thepurposeofthiscourseistointroducetostudentsanumberofhealthissuesandtheir
challenges.Thiscoursealsointroducedanumberofnationalhealthprogrammes.The
roles of thepharmacistinthese contexts are alsodiscussed.
Objectives:
Afterthe successfulcompletion ofthis course, thestudent shall beable to:
Acquirehighconsciousness/realizationofcurrentissuesrelatedtohealthand
pharmaceutical problemswithin thecountryandworldwide.
Haveacriticalwayof thinkingbased oncurrenthealthcaredevelopment.
Evaluatealternativewaysofsolvingproblemsrelatedtohealthand
pharmaceutical issues
Course content:
Unit I: 10 Hours
Conceptofhealthanddisease:Definition,conceptsandevaluationofpublichealth.
Understandingtheconceptofpreventionandcontrolofdisease,socialcausesofdiseases
and social problems ofthesick.
Socialandhealtheducation:Foodinrelationtonutritionandhealth,Balanceddiet,
Nutritional deficiencies,Vitamin deficiencies,Malnutritionandits prevention.
Sociologyandhealth:Socioculturalfactorsrelatedtohealthanddisease,Impactof
urbanization onhealthand disease,Povertyandhealth
Hygieneandhealth:personalhygieneandhealthcare;avoidable habits
Unit II: 10 Hours
Preventivemedicine:Generalprinciplesofpreventionandcontrolofdiseasessuchas
cholera,SARS, Ebolavirus, influenza,acuterespiratoryinfections, malaria,chicken
guinea,dengue,lymphaticfilariasis,pneumonia,hypertension,diabetesmellitus,cancer,
drugaddiction-drugsubstance abuse
Unit III: 10 Hours
Nationalhealthprograms,itsobjectives,functioningandoutcomeofthefollowing:
HIVANDAIDScontrolprogramme,TB,Integrateddiseasesurveillanceprogram
(IDSP),Nationalleprosycontrolprogramme,Nationalmentalhealthprogram,National
158

162. programmeforpreventionandcontrolofdeafness,Universalimmunizationprogramme,
National programmeforcontrol of blindness,Pulse polio programme.
Unit IV: 08 Hours
Nationalhealthinterventionprogrammeformotherandchild,Nationalfamilywelfare
programme,Nationaltobaccocontrolprogramme,NationalMalariaPreventionProgram,
Nationalprogrammeforthehealthcarefortheelderly,Socialhealthprogramme;roleof
WHO inIndiannational program
UnitV: 07 Hours
Communityservicesinrural,urbanandschoolhealth:FunctionsofPHC,Improvement
inruralsanitation,nationalurbanhealthmission,Healthpromotionandeducationin
school.
RecommendedBooks(Latestedition):
1.ShortTextbookofPreventiveandSocialMedicine,PrabhakaraGN,2
nd
Edition,
2010,ISBN: 9789380704104,JAYPEE Publications
2. TextbookofPreventiveandSocialMedicine(MahajanandGupta),EditedbyRoy
RabindraNath,SahaIndranil,4
th
Edition,2013,ISBN:9789350901878,JAYPEE
Publications
3.ReviewofPreventiveandSocialMedicine(IncludingBiostatistics),JainVivek,6
th
Edition, 2014,ISBN: 9789351522331,JAYPEEPublications
4.EssentialsofCommunityMedicine—APractical Approach,HiremathLalitaD,
HiremathDhananjayaA,2
nd
Edition,2012,ISBN:9789350250440,JAYPEE
Publications
5.ParkTextbookofPreventiveandSocialMedicine,KPark,21
st
Edition,2011,
ISBN-14: 9788190128285,BANARSIDASBHANOT PUBLISHERS.
6. CommunityPharmacyPractice, RameshAdepu,BSPpublishers,Hyderabad
RecommendedJournals:
1.Research in SocialandAdministrativePharmacy,Elsevier,Ireland
159

163. BP803ET.PHARMAMARKETINGMANAGEMENT (Theory)
Scope:
45 Hours
Thepharmaceuticalindustry notonlyneedshighly qualifiedresearchers,chemistsand,
technicalpeople,butalsorequiresskilledmanagerswhocantaketheindustryforward
bymanaging andtaking thecomplexdecisionswhichareimperativeforthegrowthofthe
industry.TheKnowledgeandKnow-howofmarketingmanagementgroomthepeople
fortakingachallengingrole inSalesandProductmanagement.
CourseObjective:Thecourseaimstoprovideanunderstanding ofmarketingconcepts
and techniquesand theirapplications inthe pharmaceutical industry.
Unit I 10 Hours
Marketing:
Definition,generalconceptsandscope ofmarketing;Distinctionbetweenmarketing&
selling;Marketingenvironment;Industryandcompetitiveanalysis;Analyzingconsumer
buyingbehavior; industrial buyingbehavior.
Pharmaceuticalmarket:
Quantitativeandqualitativeaspects;sizeandcompositionof themarket;demographic
descriptionsandsocio-psychologicalcharacteristicsof theconsumer;market
segmentation& targeting.Consumerprofile;Motivationandprescribinghabitsofthe
physician;patients'choiceofphysicianandretailpharmacist.AnalyzingtheMarket;Role
ofmarketresearch.
Unit II 10 Hours
Productdecision:
Classification,productlineandproductmixdecisions,productlife
cycle,productportfolioanalysis;productpositioning;Newproductdecisions;Product
branding,packagingandlabelingdecisions,Productmanagementinpharmaceutical
industry.
Unit III 10 Hours
Promotion:
Methods,determinantsof promotionalmix,promotionalbudget;Anoverviewof
personalselling,advertising,directmail,journals,sampling,retailing,medical
exhibition, public relations, onlinepromotional techniquesforOTC Products.
160

164. Unit IV 10 Hours
Pharmaceuticalmarketingchannels:
Designingchannel,channelmembers,selecting theappropriatechannel,conflictin
channels,physicaldistributionmanagement:Strategicimportance,tasksin physical
distribution management.
Professional salesrepresentative(PSR):
DutiesofPSR,purposeofdetailing,selectionandtraining,supervising,normsfor
customercalls, motivating,evaluating,compensationandfutureprospectsof thePSR.
Unit V 10 Hours
Pricing:
Meaning,importance, objectives,determinantsofprice;pricing methodsandstrategies,
issues inpricemanagementinpharmaceuticalindustry.AnoverviewofDPCO
(DrugPriceControlOrder)andNPPA (NationalPharmaceutical PricingAuthority).
Emergingconcepts inmarketing:
Vertical&HorizontalMarketing;RuralMarketing;Consumerism;IndustrialMarketing;
Global Marketing.
RecommendedBooks:(Latest Editions)
1.PhilipKotlerandKevinLaneKeller:MarketingManagement,PrenticeHallofIndia,
New Delhi
2.Walker,BoydandLarreche:MarketingStrategy-PlanningandImplementation,Tata
MCGrawHill, New Delhi.
3.Dhruv Grewal and MichaelLevy:Marketing,TataMCGraw Hill
4.Arun Kumar and NMenakshi: MarketingManagement, VikasPublishing,India
5.Rajan Saxena: MarketingManagement;TataMCGraw-Hill(India Edition)
6.Ramaswamy,U.S&Nanakamari,S:MarketingManagemnt:GlobalPerspective,
IndianContext,MacmilanIndia,NewDelhi.
7.Shanker, Ravi: ServiceMarketing, ExcellBooks, New Delhi
8.SubbaRaoChanganti,PharmaceuticalMarketinginIndia(GIFT–Excelseries)Excel
Publications.
161

165. 162

166. BP804 ET:PHARMACEUTICAL REGULATORYSCIENCE (Theory)
45Hours
Scope:Thiscourse isdesignedtoimpartthefundamentalknowledgeontheregulatory
requirementsforapprovalofnewdrugs,anddrug productsinregulatedmarketsof
India&othercountrieslikeUS,EU,Japan,Australia,UKetc.Itpreparesthestudents
tolearnindetailontheregulatoryrequirements,documentationrequirements,and
registration proceduresfor marketingthedrugproducts.
Objectives:Uponcompletion ofthe subjectstudent shall be able to;
1. Knowabout theprocessofdrugdiscoveryanddevelopment
2. Knowtheregulatoryauthorities andagenciesgoverningthemanufactureand sale
ofpharmaceuticals
3. Knowtheregulatoryapproval process and theirregistration inIndianand
international markets
Course content:
Unit I 10Hours
NewDrug Discovery and development
Stagesofdrug discovery,Drug developmentprocess,pre-clinicalstudies,non-clinical
activities,clinicalstudies,Innovatorandgenerics,Conceptofgenerics,Generic drug
product development.
Unit II 10Hours
Regulatory Approval Process
ApprovalprocessesandtimelinesinvolvedinInvestigationalNewDrug(IND),New
DrugApplication(NDA),AbbreviatedNewDrugApplication(ANDA).Changes toan
approvedNDA /ANDA.
Regulatory authoritiesandagencies
OverviewofregulatoryauthoritiesofIndia,UnitedStates,EuropeanUnion,Australia,
Japan,Canada(Organization structure andtypesofapplications)
Unit III 10Hours
RegistrationofIndiandrugproduct in overseasmarket
Procedureforexportofpharmaceuticalproducts,Technicaldocumentation,DrugMaster
Files(DMF),CommonTechnicalDocument(CTD),electronicCommonTechnical
163

167. Document(eCTD),ASEAN Common TechnicalDocument(ACTD)research.
Unit IV 08Hours
Clinicaltrials
Developingclinicaltrialprotocols,InstitutionalReviewBoard/IndependentEthics
committee-formationandworking procedures,Informedconsentprocessand
procedures,GCPobligationsofInvestigators,sponsors &Monitors,Managingand
Monitoringclinical trials,Pharmacovigilance-safetymonitoringin clinical trials
Unit V 07Hours
Regulatory Concepts
Basicterminology,guidance,guidelines,regulations,LawsandActs,Orangebook,
FederalRegister, CodeofFederalRegulatory,Purple book
Recommendedbooks(Latestedition):
1. DrugRegulatoryAffairsbySachinItkar,Dr.N.S.Vyawahare,NiraliPrakashan.
2.ThePharmaceuticalRegulatoryProcess,SecondEditionEditedbyIraR.Berryand
RobertP.Martin,DrugsandthePharmaceuticalSciences,Vol.185.InformaHealth
carePublishers.
3. New DrugApprovalProcess: AcceleratingGlobalRegistrationsByRichard A
Guarino, MD, 5
th
edition,Drugsandthe PharmaceuticalSciences,Vol.190.
4. Guidebookfordrugregulatorysubmissions /SandyWeinberg.ByJohnWiley&
Sons.Inc.
5.FDARegulatoryAffairs: aguideforprescriptiondrugs, medical devices,and
biologics/editedbyDouglasJ.Pisano, DavidMantus.
6. GenericDrugProductDevelopment,SolidOralDosageforms,LeonShargeland
IsaderKaufer, MarcelDekker series,Vol.143
7. ClinicalTrialsandHumanResearch:APracticalGuidetoRegulatoryCompliance
ByFayA. RozovskyandRodneyK.Adams
8.PrinciplesandPracticesofClinicalResearch,SecondEditionEditedbyJohnI.
Gallin andFrederickP.Ognibene
9. Drugs:From Discoveryto Approval,SecondEditionByRickNg
164

168. BP805T:PHARMACOVIGILANCE(Theory)
45 hours
Scope:Thispaperwillprovideanopportunityforthestudenttolearnaboutdevelopmentof
pharmacovigilanceasascience,basicterminologiesusedinpharmacovigilance,globalscenario
ofPharmacovigilance,trainstudentsonestablishing pharmacovigilanceprogrammeinan
organization,variousmethodsthatcanbeusedtogeneratesafety dataandsignaldetection.This
paperalsodevelopstheskillsofclassifyingdrugs,diseasesand adversedrugreactions.
Objectives:
Atcompletionofthispaperitisexpectedthatstudentswillbeableto(know,do,and
appreciate):
1.Whydrugsafetymonitoringis important?
2.Historyand developmentofpharmacovigilance
3.Nationalandinternationalscenarioofpharmacovigilance
4.Dictionaries,codingandterminologiesusedinpharmacovigilance
5.Detectionofnew adversedrugreactionsandtheirassessment
6.Internationalstandardsforclassificationofdiseasesand drugs
7.Adversedrugreaction reportingsystemsand communicationin pharmacovigilance
8.Methodstogeneratesafetydataduringpreclinical,clinicalandpostapprovalphasesof
drugs’lifecycle
9.Drugsafetyevaluationinpaediatrics,geriatrics,pregnancyand lactation
10.PharmacovigilanceProgramofIndia (PvPI) requirement forADRreportinginIndia
11.ICHguidelinesforICSR,PSUR,expeditedreporting,pharmacovigilance planning
12.CIOMS requirements forADRreporting
13.Writingcasenarrativesofadverseeventsandtheirquality.
CourseContent
UnitI 10Hours
IntroductiontoPharmacovigilance
Historyand developmentofPharmacovigilance
Importance ofsafetymonitoringofMedicine
WHOinternationaldrugmonitoringprogramme
PharmacovigilanceProgramofIndia(PvPI)
Introductionto adversedrug reactions
DefinitionsandclassificationofADRs
Detectionandreporting
MethodsinCausalityassessment
Severityandseriousnessassessment
Predictabilityandpreventabilityassessment
Managementofadversedrugreactions
Basicterminologies usedin pharmacovigilance
165

169. Terminologiesofadversemedicationrelatedevents
Regulatoryterminologies
UnitII 10 hours
Drug and disease classification
Anatomical,therapeuticand chemicalclassificationofdrugs
Internationalclassificationofdiseases
Dailydefined doses
InternationalNonproprietaryNames fordrugs
Drug dictionariesandcoding in pharmacovigilance
WHOadversereactionterminologies
MedDRAandStandardisedMedDRAqueries
WHOdrugdictionary
Eudravigilancemedicinalproductdictionary
Informationresources inpharmacovigilance
Basicdruginformationresources
SpecialisedresourcesforADRs
Establishing pharmacovigilanceprogramme
Establishingin ahospital
Establishment&operationofdrugsafetydepartmentinindustry
ContractResearchOrganisations(CROs)
Establishinga nationalprogramme
UnitIII 10Hours
Vaccinesafety surveillance
Vaccine Pharmacovigilance
Vaccinationfailure
Adverseeventsfollowingimmunization
Pharmacovigilancemethods
Passive surveillance–Spontaneousreportsandcase series
Stimulated reporting
Active surveillance–Sentinelsites,drugeventmonitoringandregistries
Comparative observationalstudies–Crosssectionalstudy, casecontrolstudyand
cohortstudy
Targeted clinical investigations
Communicationinpharmacovigilance
Effective communicationinPharmacovigilance
CommunicationinDrugSafetyCrisismanagement
CommunicatingwithRegulatoryAgencies, BusinessPartners,Healthcarefacilities &
Media
166

170. UnitIV 8Hours
Safety datageneration
Preclinicalphase
Clinicalphase
Postapprovalphase(PMS)
ICHGuidelinesforPharmacovigilance
OrganizationandobjectivesofICH
Expeditedreporting
Individualcasesafetyreports
Periodicsafetyupdate reports
Postapprovalexpeditedreporting
Pharmacovigilanceplanning
Goodclinicalpracticeinpharmacovigilancestudies
UnitV 7hours
Pharmacogenomicsofadversedrugreactions
Geneticsrelated ADR withexamplefocusingPKparameters.
Drugsafetyevaluationinspecialpopulation
Paediatrics
Pregnancyand lactation
Geriatrics
CIOMS
CIOMS WorkingGroups
CIOMS Form
CDSCO (India)andPharmacovigilance
D&CActandScheduleY
DifferencesinIndianandglobalpharmacovigilancerequirements
RecommendedBooks (Latestedition):
1. Textbook of Pharmacovigilance: SK Gupta,JaypeeBrothers,MedicalPublishers.
2.PracticalDrugSafetyfromAtoZByBartonCobert,PierreBiron,Jonesand
Bartlett Publishers.
3. Mann's Pharmacovigilance:ElizabethB. Andrews,Nicholas,WileyPublishers.
4.Stephens'DetectionofNewAdverseDrugReactions:JohnTalbot,PatrickWalle,
WileyPublishers.
5. AnIntroduction toPharmacovigilance:PatrickWaller,WileyPublishers.
6. Cobert'sManualofDrugSafetyandPharmacovigilance:BartonCobert,Jones&
Bartlett Publishers.
7. TextbookofPharmacoepidemiologedited by BrianL.Strom,StephenEKimmel,
Sean Hennessy,WileyPublishers.
8. ATextbookofClinicalPharmacyPractice-EssentialConceptsandSkills:G.
Parthasarathi,KarinNyfortHansen,Milap C. Nahata
9. NationalFormularyofIndia
10. TextBook of MedicinebyYashpal Munjal

171. 11. TextbookofPharmacovigilance:conceptandpracticebyGPMohantaandPK
Manna
167

172. 12. http://www.whoumc.org/DynPage.aspx?id=105825&mn1=7347&mn2=7259&mn
3=7297
13. http://www.ich.org/
14. http://www.cioms.ch/
15. http://cdsco.nic.in/
16. http://www.who.int/vaccine_safety/en/
17. http://www.ipc.gov.in/PvPI/pv_home.html
168

173. BP806 ET. QUALITY CONTROL AND STANDARDIZATIONOFHERBALS
(Theory)
Scope:Inthissubjectthe studentlearnsaboutthe variousmethodsandguidelinesfor
evaluationandstandardizationof herbsandherbaldrugs.The subjectalsoprovidesan
opportunityfor thestudenttolearn cGMP, GAPand GLPintraditional system of
medicines.
Objectives:Uponcompletion ofthe subjectstudent shall be able to;
1. knowWHOguidelinesforqualitycontrol ofherbal drugs
2. knowQualityassurancein herbal drugindustry
3. know theregulatoryapproval processand theirregistration inIndianand
international markets
4.appreciate EUandICHguidelinesforqualitycontrolof herbaldrugs
Unit I 10hours
Basictestsfordrugs–Pharmaceuticalsubstances,Medicinalplantsmaterialsanddosage
forms
WHOguidelinesfor qualitycontrol ofherbal drugs.
Evaluation of commercial crudedrugs intendedfor use
Unit II 10hours
QualityassuranceinherbaldrugindustryofcGMP,GAP,GMPandGLPin
traditionalsystem ofmedicine.
WHO Guidelines oncurrentgood manufacturingPractices(cGMP)for Herbal Medicines
WHO Guidelines on GACPforMedicinalPlants.
Unit III 10hours
EUandICHguidelines forqualitycontrol ofherbal drugs.
ResearchGuidelines forEvaluatingtheSafetyand EfficacyofHerbalMedicines
Unit IV 08hours
Stabilitytestingofherbalmedicines.Applicationofvariouschromatographictechniques
instandardization ofherbal products.
Preparation of documents fornew drugapplicationandexportregistration
GMPrequirementsand Drugs&CosmeticsAct provisions.
169

174. Unit V 07hours
Regulatoryrequirementsforherbal medicines.
WHOguidelines onsafetymonitoringofherbalmedicines in pharmacovigilancesystems
Comparison of variousHerbalPharmacopoeias.
Role of chemicaland biological markers in standardization ofherbal products
RecommendedBooks:(Latest Editions
1.PharmacognosybyTreaseand Evans
2.PharmacognosybyKokate, Purohitand Gokhale
3.Rangari, V.D., Text bookofPharmacognosyandPhytochemistryVol.I,Carrier
Pub., 2006.
4. Aggrawal,S.S., HerbalDrugTechnology. UniversitiesPress, 2002.
5. EMEA. Guidelines onQualityofHerbal MedicinalProducts/Traditional Medicinal
Products,
6. Mukherjee,P.W. QualityControl of HerbalDrugs: An Approach to Evaluation of
Botanicals.Business HorizonsPublishers, New Delhi,India, 2002.
7.Shinde M.V., DhalwalK.,PotdarK., Mahadik K.Application ofqualitycontrol
principles to herbal drugs.InternationalJournal ofPhytomedicine1(2009);p.4-8.
8.WHO. QualityControl Methods for MedicinalPlant Materials,WorldHealth
Organization, Geneva,1998.WHO. Guidelines forthe Appropriate UseofHerbal
Medicines.WHORegionalPublications,WesternPacific Series No 3,WHO
RegionalofficefortheWesternPacific, Manila,1998.
9.WHO. TheInternationalPharmacopeia,Vol. 2: QualitySpecifications, 3rdedn.
WorldHealth Organization, Geneva, 1981.
10.WHO. QualityControl Methods for MedicinalPlant Materials.WorldHealth
Organization, Geneva,1999.
11.WHO.WHO GlobalAtlas of Traditional, Complementaryand Alternative
Medicine. 2 vol.set. Vol.1containstext and Vol.2, maps.World Health
Organization, Geneva,2005.
12.WHO. Guidelines on GoodAgricultural andCollectionPractices(GACP)for
Medicinal Plants.WorldHealth Organization, Geneva, 2004.
170

175. BP807 ET. COMPUTER AIDED DRUGDESIGN(Theory)
45 Hours
Scope:Thissubjectisdesignedtoprovide detailedknowledgeofrationaldrugdesign
process andvarious techniques used in rational drugdesignprocess.
Objectives:Uponcompletion ofthecourse, thestudent shall beable to understand
Designand discoveryoflead molecules
The role ofdrugdesign in drugdiscoveryprocess
The concept of QSARand docking
Various strategies todevelop new druglikemolecules.
Thedesignof new drugmolecules usingmolecularmodelingsoftware
CourseContent:
UNIT-I 10 Hours
Introduction to DrugDiscovery andDevelopment
Stages ofdrugdiscoveryand development
Lead discovery andAnalogBased Drug Design
Rationalapproachestolead discoverybasedon traditional medicine,
Randomscreening,Non-randomscreening,serendipitousdrug discovery,
leaddiscovery basedondrugmetabolism,leaddiscovery basedon
clinical observation.
Analog BasedDrugDesign:Bioisosterism,Classification,Bioisosteric
replacement. Anythreecasestudies
UNIT-II 10 Hours
Quantitative Structure Activity Relationship(QSAR)
SARversusQSAR,HistoryanddevelopmentofQSAR,Typesof
physicochemicalparameters,experimentaland theoreticalapproachesfor
the determinationof physicochemicalparameterssuchasPartition
coefficient,Hammet’s substituentconstantandTaftsstericconstant.
Hansch analysis,FreeWilsonanalysis,3D-QSARapproacheslike
COMFA and COMSIA.
UNIT-III 10 Hours
MolecularModeling andvirtual screeningtechniques
VirtualScreeningtechniques:Druglikenessscreening,Conceptof
pharmacophoremappingand pharmacophorebasedScreening,
Molecular docking:Rigiddocking,flexible docking,manualdocking,
Dockingbasedscreening.Denovodrugdesign.
171

176. UNIT-IV 08 Hours
Informatics &Methods indrugdesign
IntroductiontoBioinformatics,chemoinformatics.ADMEdatabases,
chemical,biochemical and pharmaceutical databases.
UNIT-V 07 Hours
MolecularModeling:Introductiontomolecularmechanicsandquantum
mechanics.EnergyMinimizationmethodsandConformationalAnalysis,
globalconformational minimadetermination.
RecommendedBooks(Latest Editions)
1. Robert GCK,ed.,“DrugActionat theMolecularLevel”UniversityPrakPressBaltimore.
2. Martin YC. “QuantitativeDrugDesign”Dekker, New York.
3. Delgado JN,RemersWAeds“Wilson&Gisvolds’sTextBookofOrganic
Medicinal &PharmaceuticalChemistry”Lippincott, New York.
4.FoyeWO“Principles ofMedicinalchemistry‘Lea&Febiger.
5. KorolkovasA,BurckhalterJH.“EssentialsofMedicinalChemistry”Wiley
Interscience.
6.WolfME,ed“The BasisofMedicinalChemistry,Burger’sMedicinalChemistry”
JohnWiley&Sons,NewYork.
7.PatrickGraham,L.,AnIntroductiontoMedicinalChemistry,OxfordUniversity
Press.
8.SmithHJ,WilliamsH,eds,“IntroductiontotheprinciplesofDrug Design”
WrightBoston.
9.SilvermanR.B.“TheorganicChemistryofDrugDesignandDrugAction”
AcademicPress NewYork.
172

177. BP808ET: CELLANDMOLECULARBIOLOGY (Electivesubject)
45 Hours
Scope:
Cellbiologyisabranchof biologythatstudiescells–theirphysiological
properties,theirstructure,the organellestheycontain,interactionswiththeir
environment, their lifecycle, division, deathandcellfunction.
Thisis done both on a microscopicand molecularlevel.
Cellbiologyresearchencompassesboththegreatdiversityofsingle-celled
organismslikebacteriaandprotozoa,aswellasthe manyspecializedcellsin
multi-cellularorganismssuchashumans, plants,and sponges.
Objectives:Uponcompletion ofthe subjectstudent shall be able to;
Summarize cellandmolecularbiologyhistory.
Summarize cellularfunctioningandcomposition.
Describethe chemical foundationsof cell biology.
Summarizethe DNAproperties ofcell biology.
Describeproteinstructure and function.
Describe cellularmembranestructure andfunction.
Describebasic moleculargeneticmechanisms.
Summarizethe CellCycle
Course content:
Unit I 10Hours
a)Celland MolecularBiology:Definitionstheoryand basicsand Applications.
b)Celland MolecularBiology: HistoryandSummation.
c)Properties of cells andcell membrane.
d)Prokaryoticversus Eukaryotic
e)CellularReproduction
f)ChemicalFoundations–anIntroductionandReactions(Types)
Unit II 10 Hours
a)DNA and theFlow ofMolecularInformation
b)DNAFunctioning
c)DNA and RNA
d)Typesof RNA
e)Transcription and Translation
Unit III 10 Hours
a)Proteins:DefinedandAmino Acids
b)Protein Structure
173

178. c)Regularities inProteinPathways
d)CellularProcesses
e)Positive Controlandsignificanceof ProteinSynthesis
Unit IV 08 Hours
a)Science ofGenetics
b)Transgenicsand Genomic Analysis
c)CellCycleanalysis
d)Mitosis and Meiosis
e)CellularActivitiesand Checkpoints
Unit V 07 Hours
a)CellSignals:Introduction
b)ReceptorsforCellSignals
c)SignalingPathways: Overview
d)Misregulation ofSignalingPathways
e)Protein-Kinases:Functioning
RecommendedBooks(latestedition):
1.W.B. Hugoand A.D.Russel:PharmaceuticalMicrobiology,BlackwellScientific
publications, OxfordLondon.
2.Prescottand Dunn.,Industrial Microbiology, 4
th
edition,CBS Publishers &
Distributors, Delhi.
3.Pelczar, Chan Kreig,Microbiology, TataMcGrawHilledn.
4. MalcolmHarris,BalliereTindalland Cox:PharmaceuticalMicrobiology.
5. Rose:IndustrialMicrobiology.
6.Probisher, Hinsdillet al:Fundamentals of Microbiology, 9th ed.Japan
7. Cooperand Gunn’s: TutorialPharmacy,CBSPublisher and Distribution.
8.Peppler:Microbial Technology.
9. Edward:Fundamentalsof Microbiology.
10. N.K.Jain: PharmaceuticalMicrobiology,VallabhPrakashan,Delhi
11.Bergeysmanual ofsystematic bacteriology,Williams andWilkins-AWaverly
company
12.B.R.GlickandJ.J.Pasternak:MolecularBiotechnology:Principlesand
Applications of RecombinantDNA: ASMPressWashington D.C.
13. RA Goldshyet. al., : KubyImmunology.
174

179. BP809ET.COSMETICSCIENCE(Theory)
45Hours
UNITI 10Hours
Classification ofcosmetic andcosmeceutical products
DefinitionofcosmeticsasperIndianandEUregulations,Evolutionofcosmeceuticals
from cosmetics, cosmetics as quasi and OTC drugs
Cosmeticexcipients:Surfactants, rheologymodifiers, humectants,emollients,
preservatives. Classificationandapplication
Skin:Basic structure and functionof skin.
Hair:Basic structureofhair. Hairgrowthcycle.
Oral Cavity:Commonproblemassociated with teeth andgums.
UNITII 10 Hours
Principles offormulationandbuildingblocksofskincareproducts:
Facewash,
Moisturizingcream,ColdCream,Vanishingcreamandtheiradvantagesand
disadvantages.Application oftheseproductsin formulation of cosmecuticals.
Antiperspants &deodorants-Actives&mechanismofaction.
Principles offormulationandbuildingblocksofHair careproducts:
Conditioningshampoo,Hairconditioner,anti-dandruff shampoo.
Hair oils.
Chemistryandformulation ofPara-phylenediaminebased hairdye.
Principles offormulationand buildingblocks oforalcareproducts:
Toothpastefor bleedinggums, sensitive teeth.Teeth whitening,Mouthwash.
UNITIII 10 Hours
Sun protection, Classification ofSunscreensandSPF.
Roleofherbs incosmetics:
SkinCare: Aloeand turmeric
Haircare:Hennaandamla.
Oral care:Neem andclove
Analyticalcosmetics:BISspecificationandanalytical methodsfor shampoo, skin-
creamand toothpaste.
UNITIV 08 Hours.
PrinciplesofCosmeticEvaluation:Principlesofsebumeter,corneometer.Measurement
ofTEWL,Skin Color,Hair tensilestrength, Haircombingproperties
Soaps,andsyndet bars.Evolution and skin benfits.
175

180. UNITV 07 Hours
Oilyanddryskin,causesleadingto dryskin, skinmoisturisation.Basic understandingof
the terms Comedogenic,dermatitis.
Cosmetic problemsassociated with Hairandscalp: Dandruff, Hairfallcauses
Cosmeticproblemsassociated with skin:blemishes, wrinkles, acne, pricklyheat and
bodyodor.
Antiperspirants and Deodorants-Activesand mechanismofaction
References
1)Harry’s Cosmeticology,Wilkinson, Moore,Seventh Edition, GeorgeGodwin.
2)Cosmetics–Formulations,ManufacturingandQualityControl,P.P.Sharma,4
th
Edition, VandanaPublicationsPvt.Ltd.,Delhi.
3)Text book ofcosmelicologybySanjuNanda&Roop K.Khar,Tata Publishers.
176

181. BP810ET.PHARMACOLOGICAL SCREENINGMETHODS
45 Hours
Scope:Thissubjectisdesignedtoimpartthebasicknowledgeofpreclinicalstudiesin
experimental animalsincludingdesign,conductand interpretations ofresults.
Objectives
Uponcompletion ofthecoursethe student shall be able to,
Appreciatetheapplications of variouscommonlyusedlaboratoryanimals.
Appreciateanddemonstratethevariousscreeningmethodsusedinpreclinical
research
Appreciateand demonstratetheimportanceofbiostatisticsandresearchmethodology
Designandexecute aresearchhypothesisindependently
Unit–I 08 Hours
Laboratory Animals:
StudyofCPCSEAandOECDguidelinesformaintenance,breeding
andconductofexperimentsonlaboratoryanimals,Commonlab
animals:Descriptionandapplicationsofdifferentspeciesandstrains
of animals. Populartransgenic and mutant animals.
Techniquesforcollectionofbloodandcommonroutesofdrug
administrationinlaboratoryanimals,Techniquesofbloodcollection
andeuthanasia.
Unit–II 10 Hours
Preclinical screeningmodels
a.Introduction: Doseselection,calculationandconversions,
preparationofdrugsolution/suspensions,grouping ofanimalsand
importance ofshamnegativeandpositivecontrolgroups.
Rationale forselection ofanimalspeciesandsexforthe study.
b.Studyofscreeninganimalmodelsfor
Diuretics, nootropics, anti-Parkinson’s,antiasthmatics,
Preclinical screeningmodels:forCNS activity-analgesic,
antipyretic,anti-inflammatory,generalanaesthetics, sedative and
hypnotics, antipsychotic,antidepressant,antiepileptic,
antiparkinsonism, alzheimer’s disease
177

182. Unit–III
Preclinicalscreeningmodels:for ANSactivity,sympathomimetics,
sympatholytics,parasympathomimetics, parasympatholytics, skeletal
muscle relaxants, drugsactingoneye, localanaethetics
Unit–IV
Preclinical screeningmodels:forCVS activity-antihypertensives,
diuretics, antiarrhythmic,antidyslepidemic,anti aggregatory,
coagulants,andanticoagulants
Preclinical screeningmodels forotherimportantdrugslikeantiulcer,
antidiabetic,anticancerandantiasthmatics.
Researchmethodologyand Bio-statistics
Selection ofresearch topic,reviewof literature,researchhypothesis
and studydesign
Pre-clinicaldataanalysisand interpretation usingStudents ‘t’ test
and One-wayANOVA.Graphicalrepresentationofdata
05Hours
RecommendedBooks (latestedition):
1.Fundamentals ofexperimentalPharmacology-byM.N.Ghosh
2. Hand book of ExperimentalPharmacology-S.K.Kulakarni
3.CPCSEAguidelinesfor laboratoryanimal facility.
4. DrugdiscoveryandEvaluationbyVogel H.G.
5. DrugScreeningMethodsbySuresh KumarGuptaand S. K. Gupta
6.Introduction to biostatisticsand researchmethodsbyPSS SundarRaoandJ
Richard
178

183. BP811 ET.ADVANCED INSTRUMENTATION TECHNIQUES
45 Hours
Scope:Thissubjectdealswiththeapplicationofinstrumentalmethodsinqualitativeand
quantitativeanalysisofdrugs.Thissubjectisdesignedtoimpartadvancedknowledgeon
theprinciplesandinstrumentationofspectroscopicandchromatographichyphenated
techniques. Thisalsoemphasizeson theoreticaland practicalknowledgeon modern
analytical instruments that areused fordrugtesting.
Objectives:Uponcompletion ofthecoursethestudent shall beable to
understand theadvancedinstrumentsusedandits applications in druganalysis
understand thechromatographic separationandanalysisofdrugs.
understand thecalibration ofvariousanalytical instruments
know analysisofdrugsusingvariousanalytical instruments.
CourseContent:
UNIT-I 10 Hours
Nuclear MagneticResonancespectroscopy
Principlesof H-NMRandC-NMR,chemicalshift,factorsaffectingchemical
shift,couplingconstant,Spin-spincoupling,relaxation,instrumentationand
applications
Mass Spectrometry-Principles,Fragmentation,Ionization techniques–
Electron impact,chemicalionization,MALDI,FAB,Analyzers-Time of
flight and Quadrupole, instrumentation,applications
UNIT-II 10Hours
ThermalMethodsofAnalysis:Principles,instrumentationandapplications
of ThermogravimetricAnalysis(TGA), DifferentialThermalAnalysis(DTA),
DifferentialScanningCalorimetry(DSC)
X-RayDiffractionMethods:OriginofX-rays,basicaspectsofcrystals,X-
ray
Crystallography,rotatingcrystaltechnique,singlecrystaldiffraction,powder
diffraction, structural elucidation andapplications.
UNIT-III 10 Hours
Calibrationandvalidation-as perICHandUSFDAguidelines
CalibrationoffollowingInstruments
Electronicbalance,UV-Visiblespectrophotometer,IRspectrophotometer,
179

184. Fluorimeter,FlamePhotometer,HPLCand GC
UNIT-IV 08 Hours
Radio immune assay:Importance, variouscomponents, Principle, different
methods,LimitationandApplications ofRadio immunoassay
Extractiontechniques:Generalprincipleandprocedureinvolvedinthesolid
phase extractionand liquid-liquid extraction
UNIT-V 07 Hours
Hyphenatedtechniques-LC-MS/MS, GC-MS/MS, HPTLC-MS.
RecommendedBooks(Latest Editions)
1.Instrumental MethodsofChemical AnalysisbyB.K Sharma
2.Organic spectroscopybyY.RSharma
3.Text book of Pharmaceutical AnalysisbyKennethA. Connors
4.Vogel’s Text book of QuantitativeChemicalAnalysisbyA.I. Vogel
5.PracticalPharmaceuticalChemistrybyA.H.BeckettandJ.B.Stenlake
6.Organic ChemistrybyI.L.Finar
7.Organic spectroscopybyWilliam Kemp
8.Quantitative AnalysisofDrugsbyD. C. Garrett
9.Quantitative AnalysisofDrugs in PharmaceuticalFormulationsbyP.D.Sethi
10.Spectrophotometric identification of OrganicCompoundsbySilverstein
180

185. BP812 ET.DIETARYSUPPLEMENTSANDNUTRACEUTICALS
No. of hours :3 Tutorial:1 Creditpoint:4
Scope:
This subject coversfoundationaltopic that areimportant forunderstandingtheneedand
requirements of dietarysupplements amongdifferentgroups in the population.
Objective:
Thismoduleaims to provide an understandingoftheconceptsbehindthetheoretical
applications of dietarysupplements.Bytheendof the course, studentsshould beable to :
1. Understand theneed ofsupplementsbythe differentgroupof people tomaintain
healthylife.
2. Understand the outcomeofdeficiencies in dietarysupplements.
3. Appreciatethecomponentsin dietarysupplements andtheapplication.
4. Appreciatetheregulatoryandcommercial aspectsofdietarysupplements including
healthclaims.
UNITI 07hours
a.DefinitionsofFunctionalfoods,NutraceuticalsandDietary supplements.Classification
of Nutraceuticals,Healthproblemsanddiseasesthat canbepreventedorcuredby
Nutraceuticalsi.e.weightcontrol,diabetes,cancer, heartdisease,stress,osteoarthritis,
hypertensionetc.
b.Publichealthnutrition,maternalandchildnutrition,nutritionandageing,nutrition
education in community.
c.Source,Nameofmarkercompoundsandtheirchemicalnature,Medicinalusesand
healthbenefitsoffollowing usedasnutraceuticals/functionalfoods:Spirulina,
Soyabean, Ginseng,Garlic,Broccoli, Gingko,Flaxseeds
UNITII 15hours
Phytochemicalsasnutraceuticals:Occurrenceandcharacteristicfeatures(chemicalnature
medicinal benefits)offollowing
a)Carotenoids-α andβ-Carotene,Lycopene,Xanthophylls, leutin
b)Sulfides: Diallyl sulfides, Allyltrisulfide.
c)Polyphenolics:Reservetrol
d)Flavonoids- Rutin , Naringin, Quercitin, Anthocyanidins, catechins,Flavones
e)Prebiotics/Probiotics.:Fructo oligosaccharides,Lacto bacillum
f)Phytoestrogens :Isoflavones,daidzein, Geebustin, lignans
g)Tocopherols
h)Proteins, vitamins, minerals, cereal, vegetables and beverages asfunctionalfoods: oats,
wheat bran, ricebran,seafoods,coffee, tea and thelike.
UNITIII 07hours
a)Introductiontofree radicals:Free radicals,reactive oxygenspecies,productionof free
radicalsincells,damaging reactions offreeradicalson lipids, proteins,
Carbohydrates, nucleicacids.

186. b)Dietaryfibres and complexcarbohydratesas functionalfood ingredients..
UNITIV 10hours
a)Free radicalsin Diabetes mellitus,Inflammation,Ischemic reperfusion injury,Cancer,
Atherosclerosis,Freeradicalsin brainmetabolism and pathology, kidneydamage,
muscledamage.Freeradicalsinvolvementin otherdisorders.Free radicalstheoryof
ageing.
b) Antioxidants:Endogenousantioxidants–enzymaticandnonenzymaticantioxidant
defence, Superoxide dismutase,catalase,Glutathione peroxidase,Glutathione
VitaminC, Vitamin E,α-Lipoicacid,melatonin
Syntheticantioxidants:ButylatedhydroxyToluene,ButylatedhydroxyAnisole.
c)Functional foodsforchronic diseaseprevention
UNITV 06hours
a)Effectofprocessing,storageandinteractionsofvariousenvironmentalfactorsonthe
potential ofnutraceuticals.
b)RegulatoryAspects;FSSAI,FDA,FPO,MPO,AGMARK.HACCPandGMPsonFood
Safety.Adulteration of foods.
c) PharmacopoeialSpecifications for dietarysupplements and nutraceuticals.
References:
1. DieteticsbySriLakshmi
2. RoleofdietaryfibresandneutraceuticalsinpreventingdiseasesbyK.TAgustiand
P.Faizal:BSPunblication.
3. AdvancedNutritional TherapiesbyCooper.K.A.,(1996).
4. The FoodPharmacybyJean Carper, Simon &Schuster,UKLtd., (1988).
5.PrescriptionforNutritionalHealingbyJamesF.BalchandPhyllisA.Balch2
nd
Edn.,
AveryPublishingGroup,NY(1997).
6. G.Gibsonand C.williams Editors2000 FunctionalfoodsWoodheadPubl.Co.London.
7. Goldberg,I.Functional Foods. 1994. Chapmanand Hall,NewYork.
8.Labuza,T.P.2000FunctionalFoodsandDietarySupplements:Safety,Good
ManufacturingPractice(GMPs)andShelfLifeTesting inEssentialsofFunctional
FoodsM.K. Sachmidl andT.P.Labuza eds.AspenPress.
9. Handbook ofNutraceuticals andFunctionalFoods, ThirdEdition (ModernNutrition)
10.Shils,ME,Olson, JA,Shike,M.1994ModernNutritioninHealthandDisease.Eighth
edition.Lea andFebiger

187. SemesterVIII– Elective course onPharmaceuticalProductDevelopment
No ofHours: 3 Tutorial:1 Credit points:4
Unit-I 10 Hours
Introduction to pharmaceutical productdevelopment, objectives,regulations related to
preformulation,formulationdevelopment,stabilityassessment,manufacturingand
qualitycontroltestingofdifferenttypesof dosageforms
Unit-II 10 Hours
AnadvancedstudyofPharmaceuticalExcipientsinpharmaceuticalproductdevelopment
with aspecialreferenceto the followingcategories
i. Solventsand solubilizers
ii.Cyclodextrins and theirapplications
iii.Non-ionicsurfactantsand their applications
iv.Polyethyleneglycols andsorbitols
v. Suspendingandemulsifyingagents
vi.Semi solidexcipients
Unit-III 10 Hours
AnadvancedstudyofPharmaceuticalExcipientsinpharmaceuticalproductdevelopment
with a special referenceto the followingcategories
i. Tabletandcapsule excipients
ii.Directlycompressible vehicles
iii.Coat materials
iv.Excipientsin parenteral andaerosols products
v. Excipients for formulation of NDDS
Selectionandapplication ofexcipientsinpharmaceuticalformulationswithspecific
industrialapplications
Unit-IV 08 Hours
Optimizationtechniquesinpharmaceuticalproductdevelopment.Astudy ofvarious
optimizationtechniquesforpharmaceuticalproductdevelopmentwithspecific
examples.Optimizationbyfactorialdesignsandtheirapplications.AstudyofQbDandits
application in pharmaceutical product development.
Unit-V 07 Hours
Selectionandqualitycontroltestingofpackagingmaterialsforpharmaceuticalproduct
development-regulatoryconsiderations.

188. 181

189. RecommendedBooks(Latesteditions)
1.PharmaceuticalStatistics Practical and ClinicalApplicationsbyStanfordBolton,
CharlesBon;MarcelDekkerInc.
2. Encyclopediaof PharmaceuticalTechnology,editedbyJames swarbrick, Third
Edition,InformaHealthcarepublishers.
3.Pharmaceutical DosageForms, Tablets, VolumeII,editedbyHerbertA.Lieberman
andLeonLachman; Marcel Dekker,Inc.
4. TheTheoryandPracticeofIndustrialPharmacy,Fourth Edition,editedbyRoop
kKhar, S PVyas,FarhanJAhmad, Gaurav KJain;CBSPublishersand Distributors
Pvt.Ltd. 2013.
5. Martin’s PhysicalPharmacyandPharmaceuticalSciences,Fifth Edition, editedby
PatrickJ.Sinko, BIPublications Pvt.Ltd.
6. Targetedand ControlledDrugDelivery,NovelCarrierSystemsbyS.P.Vyasand
R. K.Khar, CBS Publishers andDistributors Pvt.Ltd,First Edition 2012.
7.Pharmaceutical DosageForms and DrugDeliverySystems,LoydV. AllenJr.,
NicholasB.Popovich, Howard C. Ansel, 9th Ed.40
8. Aulton’s Pharmaceutics– TheDesignandManufactureof Medicines,Michael E.
Aulton,3rd Ed.
9.Remington– TheScience andPracticeofPharmacy, 20th Ed.
10.Pharmaceutical DosageForms– Tablets Vol 1to 3, A.Liberman,LeonLachman
andJosephB.Schwartz
11.Pharmaceutical DosageForms– DisperseSystems Vol 1to 3, H.A.Liberman,
Martin, M.Rand GilbertS.Banker.
12.Pharmaceutical DosageForms–Parenteral Medication Vol 1&2, KennethE. Avis
andH.A.Libermann.
13. AdvancedReviewArticles related tothetopics.
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