System's Biology

Systems biology is the computational and mathematical modeling of complex biological systems. It is a biology-based interdisciplinary field of study that focuses on complex interactions within biological systems, using a holistic approach (holism instead of the more traditional reductionism) to biological research.

1. WELCOME TO OUR PRESENTION TOPIC : SYSTEM’ s BIOLOG Y TEAM : DOT TRIMATRIK

2. Submitted To : FARHANA SHARMIN Lecturer , Department of CSE Submitted By: Md. Ariful I slam (162-15-7885) P ritam Chandra Shil (162-15-7882) Sarwar Jahan Shajib (142-15-4045)

3. What are systems Biology….?? Systems biology  is the  Computational and Mathematical modeling of complex biological systems . Particularly from year 2000 onwards, the concept has been used widely in biology in a variety of contexts. Example: Cells, Proteins

4. In molecular biology , gene structure and function is studied at the molecular level. In systems biology , specific interactions of components in the biological systems are studied – cells , tissues, organs, and ecological webs. Molecular vs . Systems Biology Biology

5. It is highly relevant in discovering more complex relationships involving multiple genes. This may create new opportunities for drug discovery. Advantages of Systems Biology

6. Research has begun on larger-scale simulations: Biochemical network level Simulation of Epidermal Growth Factor (EGF) The Physio me Project What’s to come?

7. Languages Systems Biology Markup Language CellML Systems Biology Workbench Databases Kyoto Encyclopedia of Genes and Genomes Alliance for Cellular Signaling Signal Transduction Knowledge Environment Databases and Tools

8. Protein 53 Produces 53 proteins kilo Daltons Guardian of the genome Detects DNA damages p53

9. When multiple biological pathways interact with each other , it is called biological network . Biological pathways are far more complicated. Have no real boundaries. What’s the Biological Networks..?

10. Hi ….!! Systems Biology New?? NO and YES

11. Systems biology: studying living cells/tissues/ etc by exploring their components and their interactions Major challenge is to integrate knowledge of kinetics and genome-scale networks Even without detailed knowledge of kinetics, genome-scale modeling is still possible C onclusions

12. ANY QUESTION….??

13. fashionable catchword? a real new (philosophical) concept? new discipline in biology? just biology? ........ Hello Dear !! What is systems B iology …??

14. THANKS A LOT