T-Type_Calcium_Channels.pptx calcium ion c

This is about calcium

1. T-Type Calcium Channels An Overview of Their Function and Significance

2. Introduction T-type calcium channels are voltage-gated channels involved in neuronal excitability, pacemaking activity, and hormone secretion.

3. Key Features - Low voltage activation (-70 mV to -40 mV) - Rapid and transient inactivation - Low conductance - Expressed in neurons, cardiac cells, and smooth muscle - Involved in pacemaking and rhythmic activity

4. Subtypes of T-Type Channels - Cav3.1 (CACNA1G): Thalamic sleep rhythms - Cav3.2 (CACNA1H): Pain perception in sensory neurons - Cav3.3 (CACNA1I): Rhythmic oscillations in the brain

5. Functions - Contributes to burst firing in neurons - Regulates cardiac pacemaking - Modulates hormone secretion - Controls smooth muscle tone

6. Clinical Significance - Epilepsy: Involved in thalamocortical seizures - Hypertension: Regulates vascular smooth muscle - Pain Modulation: Cav3.2 channels in chronic pain - Sleep Regulation: Important in thalamic slow-wave sleep

7. Treatment & Blockers - Ethosuximide: Used for absence seizures - T-type channel blockers: Potential targets for pain and hypertension treatment

8. Conclusion T-type calcium channels play a crucial role in neuronal activity, cardiac function, and disease pathology. Understanding their function can help develop targeted therapies.