Tablet

Types of tablet
Methods of preparation of tablet
Defect of tablet

1. Tablet tablets RCPIPER Presented by: Saurabh Manoj Marathe Dipesh sanjeeve Patil Suvarnsing Rajendra Pardeshi Jugal Ravindra Patil

2. Tablet Introduction Defination :- Tablets are solid unit dosage forms, in which one usual dose of drug has been accurately placed Advantages:- Portability Acquire less space Attractive Design Acurate dosing Cheapest Easily identified Drug release modification is possible Chemically&mechanically stable microbiologically stable

3. Tablet Introduction disadvantages:- More likely to cause irritation Slower acting Uneven disintegration Less palatable require coating

4. Tablet Oral tablets for ingestion Compressed tablets standard compressed tablets (CT) Multiple compressed tablets (MCT) Layered tablets Compression-coated tablets Chewable tablets Sugar- and chocolate-coated tablets 9. Film-coated tablets 10.Delayed-action 11.enteric coated tablets 11.Controlled release tablets Types of tablets

5. 12.Buccal and sublingual tablets 13.Troches and lozenges 14.Dental cones 15.Implantation tablets 16.Vaginal tablets 17.Tablets used to prepare solutions Effervescent 18.Dispensing tablets (DT) 19.Hypodermic tablets (HT) 20.Tablet triturates (TT) Types of tablets Tablet

6. Tablet TABLET DESIGN AND FORMULATION Tablet Design: Objectives: to deliver orally the correct amount of drug in the proper form at or over the proper time and in the desired location I deal characteristics of tablets: should be an elegant product havingits own identity while being freeof defects such as chips, cracks, discoloration, contamination,and the like should have the strength to withstand the rigors of mechanical shocks encountered inits production, packaging&shipping . must be able to release the medicinal agent(s) in the body in a predictable and reproducible manner

7. Tablet TABLET DESIGN AND FORMULATION must have a suitable chemical stability over time so as not to allow alteration of the medicinal agent(s). should have the chemical and physical stability to maintain its physical attributes over time.

8. Tablet TABLET DESIGN AND FORMULATION Formulation Components or Excipients :- provide essential manufacturing technology functions:-binders, lubricants, glidants modify drug release:- disintegrants , polymers enhance stability :-antioxidants enhance patient acceptance:-flavours, sweeteners aid in product identification:-colorants All nondrug components tablet excipients must meet certain criteria : 1.They must be nontoxic and acceptable to the regulatory agencies in all countries where the product is to be marketed 2. They must be commercially available in an acceptable grade in all countries where the product is to be manufactured .

9. Tablet TABLET DESIGN AND FORMULATION Exciepients :- 1.Calcium carbonate Cal- Carb , Millicarb . 2.Calcium phosphate dibasic Cyfos , Calstar , Calipharm . 3.Calcium phosphate tribasic Tricafos, Tri-Cal. 4.Cellulose, microcrystalline Avicel , Emcocel . 5.MCC silicified Prosolv .

10. Tablet Binders&Adhesives ; TABLET DESIGN AND FORMULATION 1.Carbomer Carbopo . 2.Carboxymethylcellulose sodium Nymcel . 3.Cellulose, microcrystalline Avicel , Emcocel . 4.Ethyl cellulose Aquacoat . 5.Hydroxyethyl Cellosize . 6.Hydroxypropyl cellulose Klucel . 7.Polydextrose Litesse

11. Tablet TABLET DESIGN AND FORMULATION Glidant - 1.Calcium silicate 2.Cellulose[powdered] 3.Magnesium carbonate 4.Magnesium oxide 5.Magnesium silicate

12. Tablet TABLET DESIGN AND FORMULATION Lubricant 1.Calcium stearate 2.Fumaric acid 3.Glyceryl behenate 4.Magnesium lauryl 5.sulfate 6.Magnesium stearate 7.Starch 8.Stearic acid

13. Tablet TABLET DESIGN AND FORMULATION Disintegrant 1.Alginic acid 2.Carboxymethylcellulose sodium 3.Docusate sodium 4.Guar gum 5.starch

14. Tablet TABLET DESIGN AND FORMULATION Tablet preparation techniques Compression granulation Wet granulation Direct compression

15. Tablet TABLET DESIGN AND FORMULATION Compression granulation Excipients :- Diluents+Disintegrants large size tablet sludge granules disintegrant Tablet glident lubricant slugging mixing screening compression

16. Tablet TABLET DESIGN AND FORMULATION Direct compression Excipients ;-Dc delucent Disintegrants Glident lubricant compression Tablet

17. Tablet TABLET DESIGN AND FORMULATION Wet granulation Excipents :-Diluents disintegrants mixing Binder solution Granulation Dow Screening Wet granules Drying Dry granules screening granules mixing Tablet