Tetracycline

it contain all the details of of tetracycline

1. TETRACYCLINE PRESENTED BY: ARJITA SRIVASTAVA ROLL NO. :1355250005 SUBMITTED TO: Mr.ARUN KR. TIWARI ( Asst.Professor,CSSCP )

2. CONTENTS Introduction Classification and there structures Mechanism of action Spectrum of activity Mechanism of Resistance Pharmacokinetics Administration Adverse Drug Reactions of tetracycline antibiotics Uses and Drug Interaction Storage

3. INTRODUCTION Tetracyclines are a class of antibiotic,which are chemical substances produced by a microorganism that are able to kill other microorganisms without being toxic to the person,animal or plant. Tetracyclines are derived directly from a bacterium known as Streptomyces coelicolor . Tetracycline were discovered in 1940.

4. Classification of tetracycline

5. STRUCTURE OF TETRACYCLINE

6. MECHANISM OF ACTION Tetracyclines are specific inhibitors of bacterial protien synthesis. They bind to the 30s ribosomal subunit and thereby prevent the binding of aminoacyl tRNA to the mRNA ribosome complex . Tetracyclines also inhibit protein synthesis in the host,but are less likely to reach the concentration required because eukaryotic cells do not have a tetracycline uptake mechanism.

7. SPECTRUM OF ACTIVITY Tetracyclines are broad spectrum antibiotics,active against Gram positive and Gram negative bacteria,spirochetes,mycoplasma,rickettsie and chalmydiae .

8. Mechanism of resistance Cell become resistance to tetracycline 3 mechanisms Enzymatic rarest type of resistance,where an acetyl group is added to the molecule,causing inactivation of drug. Efflux resistance gene encodes a membrane protien that actively pumps tetracycline out of cell. Ribosomal protection which blocking tetracycline from binding to the ribosome.

9. ADMINISTRATION Oral capsules is the dosage form in which tetracyclines are most commonly administered. The capsule should be taken 1/2hr before or 2hr after food. Not recommended for i.m . route of administration .

10. ADVERSE DRUG REACTIONS OF TETRACYCLINE ANTIBIOTICS

11. Uses of tetracycline Tetracycline is used to treat wide variety of infections,including acne.It is an antibiotic that works by stopping the growth of bacteria. Venerel disease Atypical pneumonia Cholera Relapsing fever Rickettsial infections,plague

12. Drug interaction Tetracycline may interact with other medicine.Effects of one or both of drugs may change or rick of side effect may be greater. Calcium supplements Mineral supplements Mutivitamine Cholestrol lowering drugs Penicillin compounds

13. storage Keep at room temperature 68 and 77 degreeF . Keep away from heat,moisture and light.

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