Thiazole.pptx

heterocyclic

1. Heterocyclic compound- Thiazole

2. Thiazole nucleus is a heterocyclic organic compound bearing both sulfur and nitrogen atom at 1,3 position with five- member heterocyclic ring

3. Thiazole molecules used as an intermediate, chemical in synthetic drugs, fungicides and dyes in industries. A thiazole ring present naturally in the essential vitamin B1 thaimin.

4. Various derivatives of thiazole nucleus is the aim of research due to their importance in various applications. Derivatives of thiazole heteroatom used as reactants, intermediaries in the various industries like agrochemical, pharmaceutical and the pesticides industry. Most of the derivatives of thiazole were synthesized to achieve the industrial, biological, and medicinal target by numerous research scholar and scientist in R&D laboratories.

5. Molecular and electronic structure Thiazole rings are planar and aromatic . Thiazoles are characterized by larger pi electron delocalization than the corresponding oxazoles and have therefore greater aromaticity . This aromaticity is evidenced by the chemical shift of the ring protons in proton NMR spectroscopy (between 7.27 and 8.77 ppm), clearly indicating a strong diamagnetic ring current . The calculated pi- electron density marks C5 as the primary site for electrophilic substitution, and C2 as the site for nucleophilic substitution.

6. Physical properties Thiazole compound have a clear to pale yellow liquid. Odor similar to pyridine and its Boiling point is 116- 118 o C. The specific gravity of thiazole is 1.2 Sparingly soluble in water. Soluble in alcohol and ether.

7. Properties 1. Aromaticity

8. Properties 1. Aromaticity

9. Synthesis 1. Gabriel synthesis

10. Synthesis 1. Gabriel synthesis Mechanism

11. Synthesis 2. From an α - Hydroxy - Carbonyl Component ( Hantzsch Thiazole Synthesis)

12. Synthesis 2. From an α - Hydroxy - Carbonyl Component ( Hantzsch Thiazole Synthesis) Mechanism

13. Synthesis 3. From an thiocyanate salts

14. Reactions Electrophilic addition to N Protonation (basic property)

15. Reactions 2. Electrophilic substitution to C

16. Reactions 2. Electrophilic substitution to C

17. Reactions

18. Diels alder reaction

19. Medicinal uses

20. Medicinal uses