Uncommon, noninfectious, neurologic syndrome characterized by acute ataxia progressing to ascending paralysis. It is caused by the salivary neurotoxin of several species of tick (over 40 species) Etiology - Dermacentor variabilis (American dog tick) & D. andersoni (Rocky Mountain wood tick), Amblyomma americanum (Lone Star tick), Ixodes scapularis (black-legged tick) & Ixodes holocyclus (scrub tick) Epidemiology – North America in spring & early summer, children & females Pathophysiology – Si/Sx after 3-7 days, Motor pathways affected with Na flux interruption &/ inhibiting release of Ach.
Si/ Sx: fatigue, weakness, ataxia, ascending paralysis, irritability, muscle pain, paresthesia DDx : Guillain-Barre syndrome, botulism, poliomyelitis, myasthenia gravis, and spinal cord lesions, Miller-Fisher syndrome. Dx: Clinical, find the tick & Electromyography – shows variable reduction in the amplitude of compound muscle action potentials Mx: Remove the tick (recovery within hours), supportive, intubate if indicated Prevention: Protective clothing, Permethrin/ diethyl-m-toluamide (DEET)