Title :- CONTROVERSIAL INGREDIENTS..pptx

In this presentation, we delve into the world of personal care products, focusing on three controversial ingredients: parabens, formaldehyde liberators, and dioxane. These substances, commonly found in cosmetics and skincare items, have raised significant health concerns over recent years.
Key Points Covered:
Parabens:
Usage: Widely used as preservatives to prevent the growth of harmful bacteria and mold.
Health Impact: Linked to hormonal disruptions due to their estrogen-mimicking properties, potential carcinogenic effects, and skin irritation.
Alternatives: Natural preservatives like rosemary extract, grapefruit seed extract, and phenoxyethanol.
Formaldehyde Liberators:
Usage: Employed to release small amounts of formaldehyde over time to act as preservatives.
Health Impact: Associated with allergic reactions, skin sensitization, and considered a probable human carcinogen.
Alternatives: Ingredients such as sodium benzoate, potassium sorbate, and ethylhexylglycerin.
Dioxane:
Usage: A byproduct of ethoxylation, a process used to make other chemicals less harsh.
Health Impact: Known for being a probable human carcinogen, it can also cause kidney, liver, and respiratory issues upon prolonged exposure.
Alternatives: The use of safer, non-ethoxylated alternatives like decyl glucoside and lauryl glucoside, which are derived from natural sources.
Throughout this presentation, we not only highlight the potential dangers these ingredients pose but also emphasize the importance of transparency and informed choices in the beauty and personal care industry. By exploring safer and more sustainable alternatives, we aim to promote healthier options for consumers and advocate for more stringent regulations and better labeling practices.
Join us as we navigate through these crucial topics, aiming for a future where beauty and health can coexist harmoniously.

1. UTTARANCHAL UNIVERSITY UTTARANCHAL INSTITUTE OF PHARMACEUTICAL SCIENCES TOPIC :- CONTROVERSIAL INGREDIENTS MADY BY PRAMESH PANWAR

2. PARABENS Widely used preservative in various pharmaceutical products. They are the series of P-hydroxybenzoates or esters of P-hydroxybenzoic acid. Its antibacterial mode of action is not well understood but it is more effective against broad spectrum of micro-organism by inhabiting the synthesis of DNA and RNA. Common parabens :- Methyl parabens, Propyl parabens, Ethyl parabens According to the Research, it is found out that it is relatively safe, posing only a negligible risk to the endocrine systems by mimic the hormones in the body and disrupt the functions of endocrine system.

3. Health concern:- Parabens accumulate in the fatty cells including breast tissue, and cause breast cancer. Example :- Methyl parabens Its also affect puberty in adolescent girls and boys Alternative for parabens Sodium benzoate up to 2.5% in rinse off products. Sodium benzoate up to 1.7% in oral care products. Sodium benzoate up to 0.5% in leave on products. Benzyl alcohol up to 1% and dehydroactetic acid = 0.6%

4. FORMALDEHYDE LIBERATORS Formaldehyde is a colorless, strong smelling gas used in wide range of industries and products including building materials, cabinets furniture's and personals care products. Eg:- baby soaps, nail polish, nail glue etc Health concern :- Caner, Skin irritation Cancer – Formaldehyde is considered as a known human carcinogenic by many experts and government bodies. It is also found out that formaldehyde initiate and promotes tumor formations. Irritation:- It also results in occurrence of sensitivity Example of formaldehyde liberators :- Quaternium-15 (found in Mascara, lotion, shampoo)and glyoxal (Nail polish) Alternative :- Sorbic acid, grapefruits seed extracts.

5. DIOXANE 1-4 Dioxane is generated through a process called as “ethoxylation” in which ethylene oxide is added to other chemicals to make them hard. “ethylene oxide ” is considered as a breast carcinogens Example:- Sodium laurel sulphate- harsh on skin therefore converted – sodium laureth sulphate – less hard. According to the survey of campaign, 2017 – show that – popular brands of children – bubble bath and body wash contained 1-4 dioxane Health concern Skin cancer It is considered as a probable human carcinogen by U.S environment protection agency. Safe = 10ppm for human.

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