tooth regeneration: Between Reality and Imagination.pptx

Tooth development proceeds with reciprocal inductive interactions between stomadeum ectoderm and underlying ectomesenchymal cells in a strictly controlled temporal and spatial order.
Well studied at the molecular biologic level, over 300 genes and 100 growth and differentiation factors are implicated in the control of cellular differentiation and crosstalk in dental development that result in structures containing combination of mineralized tissues (enamel, dentine, cementum), soft connective tissues (dental pulp, periodontal ligament), blood vessels, nerves and lymphatics

1. Teeth Regeneration By Romissaa Aly Esmail Assistant lecturer of Oral Medicine, Periodontology, Diagnosis and Dental Radiology (Al-Azhar University)

2. Content: Development of Teeth—Complex Multi-tissue Structures Regeneration of Dental Tissues and Presence of Resident Stem Cells Periodontal/Endodontic Tissue Engineering Versus Whole Tooth Germ Tissue Engineering

3. Development of Teeth—Complex Multi-tissue Structures

4. Tooth development proceeds with reciprocal inductive interactions between stomadeum ectoderm and underlying ectomesenchymal cells in a strictly controlled temporal and spatial order.

5. Well studied at the molecular biologic level, over 300 genes and 100 growth and differentiation factors are implicated in the control of cellular differentiation and crosstalk in dental development that result in structures containing combination of mineralized tissues (enamel, dentine, cementum), soft connective tissues (dental pulp , periodontal ligament), blood vessels, nerves and lymphatics.

6. Regeneration of Dental Tissues and Presence of Resident Stem Cells

7. Role of Stem Cells in Dental Tissue Engineering

8. Embryonic stem cells are pluripotent, i.e. can differentiate into representatives of all three germ layers, all the somatic cells except the germ cells.

9. The difficulty is associated with the maintaining of controlled culture conditions for several months, where minor fluctuations in the environmental variables could unpredictably shift the molecular interactions at cellular level, resulting with hundreds of different morphological outcomes

10. Periodontal/Endodontic Tissue Engineering Versus Whole Tooth Germ Tissue Engineering