Transmission and pathogenesis of rabies

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1. I.P. Pathogenesis Transmission Bite transmission : Through a bite of a rapid animal in its saliva 2. Non-bite transmission “ Rare “: Corneael transplant ( Man to man ). Aerosols of bats secretions . Respiratory infection ( in laboratory animals ) Open cut in the skin mucous membrane . Transplacento .

2. I.P. Pathogenesis

3. I.P. Pathogenesis

4. Rabies I.P. Pathogenesis

5. I.P. Pathogenesis Incubation period in humans varies from 2 – 16 weeks ! Depending on : 1- The viral strain involved . 2- The amount of inoculum . 3- The severity of lacerations . 4- The host susceptibility . 5- Distance between the site of the bite and the CNS . The virus travels from the site of the bite to the C.N.S along nerve fibers by reverse axoplasmic flow . The I.P. is shorter in persons bitten on the face or head . The long I.P. gives time for effective vaccination and prevention of the virus from reaching the C.N.S .

6. 434 2 1 Multiplication Muscles and connective tissue at the site of inculation Enters the CNS through the PNS At NMJ Spreading Spreads through the PNS to the salivary glands. The organ with the highest titers of virus is the submaxillary salivary gland . I.P. Pathogenesis Pathogenesis 31 Multiplication In the CNS Causes a progressive encephalitis

7. I.P. Pathogenesis Pathogenesis

8. about history Rabies virus produces a specific eosinophilic cytoplasmic inclusions - the Negri bodies – in infected nerve cells . Negri bodies are filled with viral nucleocapsids . It is pathognomonic of rabies but is not observed in 20 % of patients .